• It consists of ∼30 proteins (circulating in the serum or membrane bound) forming a sophisticated molecular network capable of recognizing, tagging, and eliminating invading pathogen microorganisms and altered host cells (e.g., apoptotic and necrotic cells) via Ab-independent mechanisms ( 1 ). (jimmunol.org)
  • Collectins, also known as defense collagens, are a multifunctional family of proteins with C-type lectin domains and pattern recognition capability thought to be involved in the role of the innate immune system in protection from infectious organisms ( 1 )( 2 ). (rupress.org)
  • Members of the family include mannose binding lectin (MBL), surfactant proteins A and D (SP-A and SP-D), and bovine conglutinin. (rupress.org)
  • A wide variety of clinical isolates of bacteria, fungi, viruses, and parasites are bound by MBL. (nih.gov)
  • C1q, a member of the first component of the classical complement pathway, is related to this family as it shares structural and functional homology with the collectins, although it does not exhibit lectin activity ( 3 ). (rupress.org)
  • Complement activation can be triggered via three different, however interconnected routes: the classical, lectin, and alternative pathways, then the three routes converge into the common terminal pathway. (frontiersin.org)
  • When the classical or lectin pathways are activated, it results in the formation of the C3 convertase, C4bC2a, composed of the cleaved forms of complement factors C4 and C2 ( 4 ). (frontiersin.org)
  • The complement system, an essential part of the innate immune system, can be activated through three distinct routes: the classical, the alternative, and the lectin pathways. (jimmunol.org)
  • Mannose binding lectin levels in spondyloarthropathies. (radiopaedia.org)
  • The C allele of rs10082466 exhibited a binding affinity of miR-27a and this allele was associated with both lower MBL plasma levels and activity. (aacrjournals.org)
  • To understand the mechanism of lectin pathway inhibition by E. faecalis, we purified and characterized cell wall carbohydrates of E. faecalis wild type and V583ΔtagB. (sigmaaldrich.com)
  • Ingestion of the apoptotic cells through calreticulin/CD91 stimulation is further shown to involve the process of macropinocytosis, implicated as a primitive and relatively nonselective uptake mechanism for C1q- and MBL-enhanced engulfment of whole, intact apoptotic cells, as well as cell debris and foreign organisms to which these molecules may bind. (rupress.org)
  • Our studies demonstrate that C1q and MBL can bind to, and initiate uptake of, apoptotic cells into macrophages. (rupress.org)