• Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. (uniprot.org)
  • Orthologous to human M6PR (mannose-6-phosphate receptor, cation dependent). (mcw.edu)
  • A detailed description of the mechanism of phosphomannose isomerase may be found in the 1968 Journal of Biological Chemistry paper written by Robert W. Gracy and Ernst A Noltmann titled "Studies on Phosphomannose Isomerase: A Mechanism for Catalysis and for the Role of Zinc in the Enzymatic and the Nonenzymatic Isomerization. (wikipedia.org)
  • The isomerization energy, for example, for converting from a stable cis isomer to the less stable trans isomer is greater than for the reverse reaction, explaining why in the absence of isomerases or an outside energy source such as ultraviolet radiation a given cis isomer tends to be present in greater amounts than the trans isomer. (wikipedia.org)
  • Isomerases can increase the reaction rate by lowering the isomerization energy. (wikipedia.org)
  • iii) Perturbations in pathways relying on commonly shared and limiting metabolites, like undecaprenyl phosphate (Und-P), can lead to pleotropic phenotypes in unrelated pathways. (asm.org)