Mouse mammary tumor virus (MMTV) is a milk-transmitted retrovirus like the HTL viruses, HI viruses, and BLV. (wikipedia.org)
citation needed] Endogenous MMTV reacts to the whole range of hormones that regulate normal mammary development and lactation, response has been demonstrated to steroid hormones (androgens, glucocorticoids and progestins), as well as prolactin. (wikipedia.org)
Mouse mammary tumor virus (MMTV) is a betaretrovirus that causes breast cancer in mice. (utexas.edu)
Completion of the MMTV life cycle is linked to the differentiation status of the mammary gland. (utexas.edu)
Virus expression is low during early stages of mammary development, but high levels of MMTV transcription occur during lactation to ensure optimal viral transmission through maternal milk to the offspring. (utexas.edu)
Virgin mammary glands have high levels of full-length CDP that binds to negative regulatory elements (NRE) to repress MMTV transcription. (utexas.edu)
This study demonstrated that reduction of full-length CDP levels in two independent strains of CDP knockout mice increased endogenous MMTV and other mammary-specific cellular genes in undifferentiated mammary glands, suggesting a critical role for CDP in the MMTV life cycle. (utexas.edu)
Furthermore, the loss of DNA-binding activity correlates with increased expression of MMTV and other mammary-specific genes, including β-casein, whey acidic protein and α-lactalbumin, indicating that CDP150 is a developmentally controlled, naturally occurring dominant-negative protein. (utexas.edu)
Therefore, MMTV has adopted a normal cellular process to control viral expression during mammary differentiation. (utexas.edu)
This genus includes Jaagsiekte sheep retrovirus (JSRV) and mouse mammary tumor virus (MMTV)--both of which are pathogenic--as well as many endogenous retroviruses, including the HERV-K(HML2) family that has proliferated in the primate lineage over a period of more than 30 million years. (tufts.edu)
Structural studies of intasomes revealed different number of IN subunits ranging from 4 for the PFV and delta-retroviruses human T-cell leukemia virus type 1 (HTLV-1) (3) and simian T-lymphotropic virus type 1 (4), 8 for alpha-retrovirus RSV (5) and beta-retrovirus mouse mammary tumor virus (MMTV) (6). (nature.com)
During puberty, the virus enters the mammary glands with migrating lymphocytes and infects proliferating mammary gland epithelial cells. (wikipedia.org)
Endogenous1
This includes a few exogenous, vertically transmitted and endogenous viruses of mice (type B) and some primate and sheep viruses (type D). MAMMARY TUMOR VIRUS, MOUSE is the type species. (bvsalud.org)
Retrovirus1
As a result, after puberty all mammary cells will contain the active retrovirus and begin to replicate in the genome and express viral messenger RNA in all new mammary tissue cells. (wikipedia.org)
Viruses1
The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
Mouse1
The majority of mammary tumors in mice are caused by mouse mammary tumor virus. (wikipedia.org)
Mice1
Mice that become infected in this way have higher rates of occurrence of tumors. (wikipedia.org)
Virus1
Género de la familia RETROVIRIDAE, que consta de virus con morfología de tipo B o D. Comprende unos pocos virus exógenos transmitidos verticalmente y virus endógenos de ratón (tipo B) y algunos virus de primates y ovejas (tipo D). La especie tipo es el VIRUS DEL TUMOR MAMARIO DEL RATÓN. (bvsalud.org)
Development1
This study reveals a novel posttranslational cleavage event that controls CDP activity and gene expression during normal development of the mammary gland. (utexas.edu)
Cells2
In addition the expression of the genome is activated specifically in the mammary gland cells. (wikipedia.org)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma . (lookformedical.com)
Mouse mamma1
The majority of mammary tumors in mice are caused by mouse mammary tumor virus. (wikipedia.org)
Epithelial2
During puberty, the virus enters the mammary glands with migrating lymphocytes and infects proliferating mammary gland epithelial cells. (wikipedia.org)
The extract of A. baicalense disrupted the recruitment of epithelial progenitor cells and angiogenesis precursors to the mammary gland preventing neovascularization and transformation of epithelial cells into tumor cells. (bvsalud.org)
Lymph2
7. Mast cell density in the primary tumor predicts lymph node metastases in patients with breast cancer . (nih.gov)
The majority of patients with PBC was reported to have both RT-PCR and immunohistochemistry evidence of human betaretrovirus infection in lymph nodes or in 2008, the patient who developed PBC with high HIV viral load had an antiviral therapy and recovered. (hindawi.com)
Gland2
In addition the expression of the genome is activated specifically in the mammary gland cells. (wikipedia.org)
The extract reduced inflammatory activity and tumor growth in the mammary gland. (bvsalud.org)
Patients1
A Phase I Study of the Non-Receptor Kinase Inhibitor Bosutinib in Combination with Pemetrexed in Patients with Selected Metastatic Solid Tumors. (nih.gov)
Molecular1
He directed national projects on molecular diagnostics and on hereditary breast/ovarian tumors of the National Research Council (CNR), the Italian Association for Cancer Research (AIRC), the Ministry of Health. (biomedcentral.com)
Combination1
The present study is an effort to reveal the antiproliferative and antioxidant actions of mango seed kernel extract (KE), peel extract (PE), and their combination (KEPE) on mammary tumors induced by 7,12 dimethylbenz[a]anthracene (DMBA). (bvsalud.org)
Breast1
Many of the DEGs and 6 of the 12 hub genes identified in this study showed expression profile similar to that observed in the PyMT mouse model of breast cancer, especially during tumor progression. (bvsalud.org)