• As little is known about epithelial-stromal interactions in vivo, it is necessary to visualize the stroma surrounding normal epithelium and mammary tumors in intact tissues to better understand how matrix organization, density, and composition affect tumor formation and progression. (biomedcentral.com)
  • Epithelial-stromal interactions in normal mammary glands, mammary tumors, and tumor explants in three-dimensional culture were studied with histology, electron microscopy, and nonlinear optical imaging methodologies. (biomedcentral.com)
  • We used both laser-scanning multiphoton and second harmonic generation microscopy to determine the organization of specific collagen structures around ducts and tumors in intact, unfixed and unsectioned mammary glands. (biomedcentral.com)
  • One important step to elucidating these signaling interactions is to determine the organization of the collagenous stroma surrounding both normal mammary glands and tumors within intact tissue so as to better understand the cell-matrix interaction and how matrix organization, density, and composition affect tumor formation and progression. (biomedcentral.com)
  • The incidence of metastatic origin from solid tumors ranges from breast cancer 5-8%, lung cancer 9-25%, and up to 30% in melanomas [ 1 ]. (journalmc.org)
  • The primary source of metastatic tumors is more oftentotal is squamous cell carcinoma of the cervix, then - cancer of the endometrium, bladder and urethra. (med-blog.com)
  • In addition, metastatic sites may re-seed primary tumors in a multi-directional fashion [ 8 ]. (oncotarget.com)
  • it usually develops from an earlier ductal carcinoma in situ and is rarely metastatic. (en-academic.com)
  • Mammary ductal carcinoma - Ductal Carcinoma Classification and external resources Histopathologic image from ductal cell carcinoma in situ (DCIS) of breast. (en-academic.com)
  • Un noventa por ciento, aproximadamente, tienen su origen en el epitelio ductal. (en-academic.com)
  • Endoscopic ultrasonography, combined with hybrid fuzzy logic methodology, has made it possible to create a model for differentiating between chronic focal pancreatitis and pancreatic ductal adenocarcinoma. (bvsalud.org)
  • The majority of malignant tumours arise from epithelial tissue and metastasise to the lungs or other organs [1]. (scienceexhibitions.org)
  • carcinoma - Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell c. (en-academic.com)
  • In a widely used mouse model of breast cancer, mammary gland-specific expression of the polyoma middle T (PyMT) oncoprotein under the control of the MMTV promoter/enhancer in transgenic mice (MMTV-PyMT) results in widespread transformation of the mammary epithelium and subsequent development of multifocal mammary adenocarcinomas and metastatic lesions in the lymph nodes and in the lungs [ 2 ]. (biomedcentral.com)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • Epithelial cells in these lesions show an increase in DNA damage and have higher levels of proliferation, but also elevated apoptosis. (prolekarniky.cz)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • This antibody has applications in the detection of normal and neoplastic epithelial cells, and distinguishing carcinomas from non-epithelial neoplasms (Momburg et al, 1987). (absoluteantibody.com)
  • Squamous cell carcinomas stain less strongly than adenocarcinomas, and keratinizing areas of tumor masses remain negative (Momburg et al, 1987). (absoluteantibody.com)
  • Tipos anatomopatológicos de cáncer de mama - Los carcinomas de mama pueden encontrarse en dos formas principales según su origen. (en-academic.com)
  • Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (academicinfluence.com)
  • Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • Increased E-cadherin and reduced fibronectin and vimentin indicated inhibition of epithelial-mesenchymal transition. (oncotarget.com)
  • One important insight came from the discovery that the increased motility and invasiveness of cancer cells is reminiscent of the epithelial-mesenchymal transition (EMT) that occurs during embryonic development ( 2 ). (spandidos-publications.com)
  • The epithelial-mesenchymal transition (EMT) is an example of cellular plasticity, where an epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and invasive properties. (mdpi.com)
  • However, a number of groups have recently reported that mesenchymal-epithelial transition (MET) is required for efficient metastatic colonization and that EMT may be not necessarily associated with stemness. (mdpi.com)
  • A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer. (lu.se)
  • The MCF-7 cell line has retained several characteristics that are particular to mammary epithelium, including the ability to grow as a monolayer, form domes, and respond to hormones. (mybio.ie)
  • Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in the epithelium with a molecular weight of approximately 40 kDa, which functions as an epithelial cell adhesion molecule. (thermofisher.com)
  • Although the mechanisms mediating the effects of the extracellular matrix (ECM) on breast carcinoma development in vivo are largely unknown, contributing factors may be adhesion mediated signaling and mechanical signals imparted on mammary epithelial cells from surrounding type-I collagen-rich stroma, either directly or across basement membrane proteins. (biomedcentral.com)
  • In this study, differences in choline membrane metabolism were characterized in breast cancer cells and normal human mammary epithelial cells (HMECs) labeled with [1,2- 13 C]choline, using 1 H and 13 C magnetic resonance spectroscopy. (aacrjournals.org)
  • These cells also display a low metastatic potential, leading to the assumption that they represent an early epithelial adenocarcinoma phenotype. (mybio.ie)
  • Like mammary epithelial cells, MCF-7 cells are sensitive to estrogen. (mybio.ie)
  • Conclusion: By this methodology, cells from mammary carcinoma cell lines can be detected in blood samples. (iiarjournals.org)
  • As early as 1869, cells with the morphology of cancer cells had been found by Thomas Ashworth in the blood of a person who died from metastatic cancer ( 1 ). (iiarjournals.org)
  • Nowadays, a huge body of literature describes CTCs as cells that, after detaching from the primary tumour and circulating through the blood or lymphatic system, are the main cause of the occurrence of metastases in patients with epithelial cancer ( 2 - 4 ). (iiarjournals.org)
  • Most human prostate cancers are adenocarcinomas, which originate from the epithelial cells that line the glands and ducts of prostate [ 2 ]. (jcancer.org)
  • Results Immunocytochemical analysis WIKI4 revealed CA 15-3 expression in all examined canine mammary cancer cell lines whereas its expression was confirmed by immunoblot only in the most invasive cells (CMT-W1 CMT-W1M CMT-W2 and CMT-W2M). (scienceexhibitions.org)
  • CD326 is expressed on the majority of epithelial cells, and is considered a pan-carcinoma antigen. (thermofisher.com)
  • Ep-CAM functions as a homotypic calcium-independent cell adhesion molecule, and has a direct impact on cell cycle, proliferation and metabolism of epithelial cells and fibroblasts due to its ability to rapidly induce the proto-oncogene c-myc and the cell cycle regulating genes cyclin A and E. Ep-CAM mediates Ca2+-independent homotypic interactions. (thermofisher.com)
  • Formation of Ep-CAM-mediated adhesions have a negative regulatory effect on adhesions mediated by classic cadherins, which may have strong effects on the differentiation and growth of epithelial cells. (thermofisher.com)
  • Circulating PSA-positive cells are also strongly associated with metastatic prostate cancer [ 8 ]. (hindawi.com)
  • Study of the Effects of Homeopathic Medicine Carcinosinum on Mammary Adenocarcinoma (4T1 cells) in vitro. (highdilution.org)
  • In this process, epithelial cells acquire fibroblast-like properties such as the functional loss of E-cadherin. (spandidos-publications.com)
  • 1. an adenocarcinoma in which the cells are arranged in the form of tubules. (en-academic.com)
  • adenoid cystic carcinoma - carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. (en-academic.com)
  • Initial works revealed that activation of the EMT program in epithelial cells induces the acquisition of stem cell properties, which in the context of cancer may contribute to the appearance of tumor initiating cells (TIC). (mdpi.com)
  • Various cell lineages such as the epithelial glandular cells and the stromal spindle cells are involved. (ijpmonline.org)
  • Stromal-epithelial interactions are of particular significance in breast tissue as misregulation of these interactions can promote tumorigenesis and invasion. (biomedcentral.com)
  • Fatty acid analysis showed that CLA was incorporated predominantly in mammary tissue neutral lipids, while the increase in CLA in mammary tissue phospholipids was minimal. (integratedhealthblog.com)
  • A number of PSPs have been defined over the years that include, but not limited to, promoters of prostate-specific antigen (PSA), probasin (PB), mouse mammary tumor virus (MMTV LTR), prostate-specific membrane antigen (PSMA), human glandular kallikrein 2 (hK2), and prostatic steroid-binding protein C3. (hindawi.com)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • Description: The G8.8 monoclonal antibody reacts with the 40 kDa mouse EpCAM (epithelial cellular adhesion molecule), also known as EGP40 (epithelial glycoprotein 40), 17-1A antigen, TACSTD1 (tumor-associated calcium signal transducer 1), and CD326. (thermofisher.com)
  • Transgenic mice bearing PB promoter fused to simian virus 40 large tumor antigen gene all consistently develop prostate adenocarcinoma [ 13 ]. (hindawi.com)
  • Conclusions The results of this study reveal that CA 15-3 is expressed in both canine mammary tumour cell lines and tissues and that serum levels significantly correlate with the histological grade of the malignancy. (scienceexhibitions.org)
  • The name Carcinosinum refers to any homeopathic preparation of epithelial cancerous tissues and is especially indicated when there are any hereditary and familial antecedents of cancer, tuberculosis, diabetes, pernicious anemia or a combination of two or more of these diseases. (highdilution.org)
  • Local alterations in collagen density were clearly seen, allowing us to obtain three-dimensional information regarding the organization of the mammary stroma, such as radiating collagen fibers that could not have been obtained using classical histological techniques. (biomedcentral.com)
  • Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
  • This epithelial glycoprotein is now recognized as having an important role in tumor biology. (thermofisher.com)
  • Tumor formation and progression in these mice can be divided into four stages: hyperplasia, adenoma/mammary intra-epithelial neoplasia, early carcinoma, and late carcinoma [ 4 ] (we refer to all these four stages as tumor in this study). (biomedcentral.com)
  • Using this technique, it has been shown that the existence of CTCs is a prognostic factor for overall survival in patients with epithelial cancer types, such as breast, colon or prostate cancer ( 11 - 15 ). (iiarjournals.org)
  • Prostate cancer progresses through a pathologically defined series of steps involving increasing grades of PIN, invasive adenocarcinoma and metastatic cancer [1] . (prolekarniky.cz)
  • The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
  • EXKIVITY is a kinase inhibitor indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or after platinum-based chemotherapy. (nih.gov)
  • Patients with mammary Paget disease (PD) present with a relatively long history of an eczematous skin lesion or persistent dermatitis in the nipple and adjacent areas. (medscape.com)
  • She was one of the first to establish a cell line (MAC-21) from a human mucinous adenocarcinoma. (wikipedia.org)
  • Active Motif's MCF-7 nuclear extract (Estradiol treated) was prepared from cell cultures of the human MCF-7 breast adenocarcinoma cancer cell line. (mybio.ie)
  • This antibody is specific for the extracytoplasmic part of human EpCAM, a stable and widely-distributed marker expressed on the surface of many adenocarcinomas. (absoluteantibody.com)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • Some examples of the 20 lines that were isolated are as follows: MDA-MB -468 The MDA-MB-468 cell line was established from a pleural effusion of a 51 year old black woman with metastatic breast adenocarcinoma. (wikipedia.org)
  • The MCF-7 cell line was originally derived from a pleural effusion of a 69-year old Caucasian woman with metastatic breast cancer. (mybio.ie)
  • Background Spontaneous mammary tumours are commonly observed in female dogs particularly in many European countries where animals are not routinely spayed at a young age. (scienceexhibitions.org)
  • Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. (academicinfluence.com)
  • We also investigated serum CA 15-3 activity to establish whether its expression could be assigned WIKI4 to several tumour characteristics to evaluate its potential use as a serum tumour marker in the canine mammary oncology field. (scienceexhibitions.org)
  • The analysis of HER-2 expression and metastatic skill will be the next step of this research. (highdilution.org)
  • Currently there is a lack of scientific documentation regarding the application of serum tumour markers in the canine mammary oncology WIKI4 field and only one preliminary report describing the possible use of serum CA 15-3 in dogs has been published [15]. (scienceexhibitions.org)
  • The timing of this treatment corresponds to maturation of the mammary gland to the adult stage, suggesting that CLA may have a direct effect in reducing the cancer risk of the target organ. (integratedhealthblog.com)
  • A primary objective of this report was to investigate how the timing and duration of CLA feeding might affect the development of mammary carcinogenesis in the methylnitrosourea (MNU) model. (integratedhealthblog.com)
  • Mammary Paget disease (PD) affecting 48-year-old woman. (medscape.com)
  • No recurrence or metastatic disease was noted at 6-year follow-up. (medscape.com)
  • Beyond single DTCs, death from bone metastasis may also be due to dissemination of disease via metastatic re-seeding from other secondary sites [ 7 , 8 ]. (oncotarget.com)
  • This period incidentally corresponds to a time of active morphological development of the mammary gland to the mature state. (integratedhealthblog.com)
  • Background Mammary tumours are the most common malignancy diagnosed in female dogs and a significant cause of mortality and morbidity in this species. (scienceexhibitions.org)
  • Advances in the understanding of may be more susceptible at a par- sembled for IARC Group 1 carcino- host susceptibility in tandem with the ticular site (i.e. the mammary gland gens contains information on mecha- evolution of the knowledge on the in females). (who.int)