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  • embryo
  • They entail nuclear reprogramming, a term that describes a switch in nuclear gene expression of one kind of cell to that of an embryo or other cell type. (sciencemag.org)
  • Briggs and King ( 1 ) first succeeded in producing normal swimming tadpoles of Rana pipiens by transplanting the nuclei of embryo (blastula) cells. (sciencemag.org)
  • The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to became quiescent. (todayinsci.com)
  • Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. (todayinsci.com)
  • There is a vast difference between cloning an embryo that is made up of immature, undifferentiated cells and cloning adults cells that have already committed themselves to becoming skin or bone or blood. (apologeticspress.org)
  • The PAR clan of polarity regulating genes was initially discovered in a genetic screen searching for genes involved in asymmetric cell divisions in the Caenorhabditis elegans embryo. (royalsocietypublishing.org)
  • mammal
  • Dolly , female Finn Dorset sheep that lived from 1996 to 2003, the first clone of an adult mammal , produced by British developmental biologist Ian Wilmut and colleagues of the Roslin Institute , near Edinburgh , Scotland . (britannica.com)
  • An adult mammal had been cloned! (apologeticspress.org)
  • The news was that a mammal had been cloned from an adult cell-something that even scientists like James Watson and Francis Crick (who were awarded the 1962 Nobel Prize in Physiology or Medicine for their elucidation of the molecular structure of DNA) had gone on record as stating was very likely impossible. (apologeticspress.org)
  • 3. The method of claim 1 , wherein the device is first prevascularized by implanting in the mammal before introducing progenitor cells. (google.es)
  • biology
  • Critical and cutting edge, Protocols for Adult Stem Cells is an essential guide which provides groundbreaking and novel techniques certain to redefine the field of stem cell biology. (worldcat.org)
  • Mailing address: Department of Anatomy and Structural Biology and Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461. (pubmedcentralcanada.ca)
  • Three-dimensional organotypic culture: experimental models of mammalian biology and disease. (nih.gov)
  • Alberts B, Bray D, Lewis J, Raff M, Roberts K and Watson JD (eds) (1989) Molecular biology of the cell. (springer.com)
  • The past ten years of planaria research have shown that planarians use pretty much the same molecular toolkit for building their bodies as other animals," says first author Jochen Rink, Ph.D., formerly a postdoctoral researcher in the Sanchéz lab and now a group leader at the Max-Planck-Institute of Molecular Cell Biology and Genetics in Dresden, Germany. (innovations-report.com)
  • The Department of Cell Biology and the Albert Einstein College of Medicine offer outstanding state-of-the-art facilities to conduct molecular and cellular biology studies. (yu.edu)
  • Interested individuals should contact one of the above faculty members at Department of Cell Biology, Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, New York, NY 10461. (yu.edu)
  • Learn about the faculty's research programs at http://www.einstein.yu.edu/departments/cell-biology/ . (yu.edu)
  • nucleus
  • Wilmut and his team of researchers at Roslin created her by using electrical pulses to fuse the mammary cell with an unfertilized egg cell, the nucleus of which had been removed. (britannica.com)
  • The fusion process resulted in the transfer of the mammary cell nucleus into the egg cell, which then began to divide. (britannica.com)
  • In order for the mammary cell nucleus to be accepted and functional within the host egg, the cell first had to be induced to abandon the normal cycle of growth and division and enter a quiescent stage. (britannica.com)
  • Dolly the sheep was successfully cloned in 1996 by fusing the nucleus from a mammary-gland cell of a Finn Dorset ewe into an enucleated egg cell taken from a Scottish Blackface ewe. (britannica.com)
  • In other words, they have not matured to the point where they have been able to carry out the instructions contained in the DNA within their nucleus that direct them to become skin cells, brain cells, eye cells, etc. (apologeticspress.org)
  • kidney
  • Planarian protonephridia are so far the only invertebrate model system that combines pressure filtration with filtrate modification similar to mammalian nephrons, the basic functional unit of the kidney," explains Rink. (innovations-report.com)
  • This suggests to us that the mammalian kidney originated before the branches split," says Sanchéz Alvarado. (innovations-report.com)
  • Fetal
  • The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells. (todayinsci.com)
  • 1987
  • Avery L and Horwitz HR (1987) A cell that dies during wild-type C. elegans development can function as a neuron in a ced-3 mutant. (springer.com)
  • species
  • In animals, the production of clones from fully differentiated (adult) cells (e.g., skin or muscle cells) had been carried out successfully only in lower species , such as frogs . (britannica.com)
  • Here, we focus on the PAR-4 identity of LKB1, discussing the weight of evidence indicating a role for LKB1 in regulation of cell polarity and epithelial integrity across species and highlight recent investigations providing new insight into the old question: does the PAR-4 identity of LKB1 matter in cancer? (royalsocietypublishing.org)
  • carcinomas
  • In human breast cancer, overexpression of the PRA isoform is related to more aggressive carcinomas making the dog a unique model to study PRA-related mammary cancer. (frontiersin.org)
  • Dolly
  • Dolly was cloned from a mammary gland cell taken from an adult Finn Dorset ewe. (britannica.com)
  • Shortly after the details of the procedure used to produce Dolly were published, scientists began to report one success story after another using the same procedure (or ones similar to it) to clone additional mammals from adult cells, including mice (Wakayama, et al. (apologeticspress.org)
  • organism
  • As a fertilized egg develops into an adult organism, specialized cells are formed by a one-way process, and they become increasingly, and normally irreversibly, committed to their fate. (sciencemag.org)
  • All cells contain within their DNA the information required to reproduce the entire organism, but in adult cells access to parts of that information has somehow been switched off. (apologeticspress.org)
  • uterus
  • That zygote-which then contained the full complement of 54 chromosomes (as if it had been fertilized by a sperm cell)-was placed into the uterus of a second Scottish Blackface sheep that served as a surrogate mother. (apologeticspress.org)
  • Molecular
  • The involvement of NF-κB and cell-cycle regulators such as Cdh1 in regenerative processes of non-replicative neurons suggests novel mechanisms by which molecular reprogramming might be executed to stimulate adult axoneogenesis and treat central nervous system (CNS) axonopathies. (biologists.org)
  • genetic
  • Scottish embryologist Ian Wilmut and his colleagues had taken a mammary gland cell from a six-year-old Scottish Finn Dorset ewe and, via a process known as "nuclear transfer," succeeded in placing the genetic material from that cell into a hollowed-out egg cell from a Scottish Blackface sheep. (apologeticspress.org)
  • Headed by embryologist Ian Wilmut, Scottish scientists produced a lamb using genetic material from the mammary cell of an adult ewe. (apologeticspress.org)
  • Polyploidization is a widely accepted mechanism for increasing genetic variation in unicellular organisms and for the acquisition of new properties in a variety of cell types (e.g., osteoclast fusion in bone resorption and myoblast fusion in muscle development) and is considered a physiological process. (yu.edu)
  • acinar cells
  • Based on the presence of α-smooth muscle actin (SMA) in these cells, it is believed that they contract to squeeze the secretory products out of the acinar cells and into the ducts. (arvojournals.org)
  • types
  • Eventually, it may be possible to derive replacement heart, pancreas, or other types of cells from the skin of the same individual, thereby avoiding the need for immunosuppression. (sciencemag.org)
  • 2009 ). However, the significance of individual NF-κB subunits, their activation in separate cell types and their impact on axonal regeneration and Wallerian degeneration currently remain undefined. (biologists.org)
  • But more importantly, they noticed that the endothelia forming the tubules are composed of a fixed succession of different cell types along their length reminiscent of the mammalian condition. (innovations-report.com)
  • regeneration
  • This review describes the current knowledge of the roles of Wnt signaling and Wnt-responsive cells in hair cell development and regeneration. (frontiersin.org)
  • We also discuss possible future directions and the potential application and limitation of Wnt signaling in augmenting hair cell regeneration. (frontiersin.org)
  • Cell-type-specific deletion of transactivating RelA in neurons and/or macroglia stimulated axonal regeneration in a distinct and synergistic pattern. (biologists.org)
  • progenitor cell
  • 4. The method of claim 1 , wherein the device comprises a plurality of welds for maximizing surface area to volume ratio of the human PDX1-positive pancreatic progenitor cell population in the device. (google.es)
  • 12. The method of claim 1 , wherein providing a human PDX1-positive pancreatic progenitor cell population comprises thawing a cell population. (google.es)
  • 13. The method of claim 1 , wherein providing a human PDX 1-positive pancreatic progenitor cell population further comprises enriching the cell population for PDX1/NKX6.1 co-positive pancreatic progenitor cells. (google.es)
  • 14. The method of claim 1 , wherein providing a human PDX1-positive pancreatic progenitor cell population further comprises enriching the cell population for PDX1/NKX6.1 co-positive pancreatic progenitor cell by contacting the cell population with an antibody that binds to CD142 antigen and enriching for said CD142 binding cells. (google.es)
  • humans
  • The concept of mammalian clones, even humans, was not new at the time of Dolly's birth. (britannica.com)
  • Now, with reports arriving almost daily about proposals to clone humans, and with similar reports surfacing with disturbing frequency about scientists' planned use of human-derived stem cells, I believe that an in-depth analysis of these two subjects is both timely and warranted. (apologeticspress.org)