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  • migrate
  • Remember, they have incorporated much of them related to both the pronephric rudiment in these crosses of the glomerulus and entirely restore the depleted intraglomerular mesangium becomes severely injured these mesangial reserve cells migrate into the molecules involved in the presence of characteristics of the. (medinahealthcare.org)
  • Bladder scaffold has the ability to induce blastema cells as they differentiate and migrate. (zjrms.com)
  • salamander
  • Although infiltrating immune cells play a major role in determining the variable outcome of mammalian wound repair, little is known about the modulation of immune cell signaling in efficiently regenerating species such as the salamander, which can regrow complete body structures as adults. (pnas.org)
  • Fibroblasts are essential for salamander regeneration, but the mechanisms underlying their role in the formation of a regeneration blastema remain unclear. (jcancer.org)
  • limbs
  • Fibroblast dedifferentiation is a crucial step for the formation of a regeneration blastema, a mass of undifferentiated proliferating cells responsible for the regeneration of complex structures such as limbs. (jcancer.org)
  • Position-specific induction of ectopic limbs in non-regenerating blastemas on Axolotl forelimbs. (uci.edu)
  • We have found that pseudotyped Maloney Murine Leukemia Virus (MMLV) retroviruses can very efficiently infect axolotl cells in vitro and in vivo , and can be used for both lineage and functional analyses in regenerating limbs. (biologists.org)
  • tissues
  • Dedifferentiation of stump tissues, such as skeletal muscle, precedes blastema formation, but it was not known whether dedifferentiation involves stem cell activation. (rupress.org)
  • It is unclear to what extent differentiated cells reverse mature phenotypes and to what extent undifferentiated cells, such as stem cells, residing within differentiated tissues become activated, followed by their incorporation into the blastema. (rupress.org)
  • Once wounded, their cells become activated and start to remodel tissues and organs back to the pre-existing state. (wikipedia.org)
  • : 873 During the developmental process, genes are activated that serve to modify the properties of cell as they differentiate into different tissues. (wikipedia.org)
  • Adult animals consist of many organized differentiated tissues and cell types that are basal to the Bilaterian lineage. (biologists.org)
  • Recent studies provide evidence that this blueprint is encoded in part by an information-rich extracellular matrix (ECM) within the loose connective tissues that controls the behavior of regeneration-competent cells. (springer.com)
  • Therefore, we can use extracellular matrix from different tissues to study cell behavior interaction in vitro . (zjrms.com)
  • basal
  • As reported here, MRL fibroblast-like cells have a distinct cell-cycle (G2/M accumulation) phenotype and a heightened basal and wound site DNA damage/repair response that is also common to classical regenerators and mammalian embryonic stem cells. (pnas.org)
  • For granulosa cells from all classes of follicles, the basal E₂ production was high during day 1 culture. (ubc.ca)
  • These results indicated that a serum-free culture system can support basal granulosa cell steroidogenesis and can be used to study the effects of FSH, LH, IGF-I, and IGF-II on bovine granulosa cell steroidogenesis. (ubc.ca)
  • Fgf20a
  • Associate Professor Atsushi Kawakami, who teaches Life Science and Technology, and colleagues at Tokyo Institute of Technology and the Graduate University for Advanced Studies (SOKENDAI) identified fgf20a and fgf3/10a as major fgf ligands in wound epidermis and blastemas, respectively. (titech.ac.jp)
  • proliferative
  • This process is reliant on the presence of the overlaying nail organ and is mediated by a proliferative blastema. (nih.gov)
  • 1. A pharmaceutical composition comprising a cell extract and a pharmaceutically acceptable carrier, for use in the treatment of a proliferative disease. (google.es)
  • wound
  • Certain commonalities, such as blastema formation and basement membrane breakdown at the wound site, suggest that MRL mice may share other features with classical regenerators. (pnas.org)
  • After wound closure, the regeneration process proceeds to the second phase, in which a population of undifferentiated cells migrates under the wound epidermis, leading to the formation of a structure called a blastema. (jcancer.org)
  • fibroblasts
  • Similar to mouse ES cells, the p53-target p21 was not expressed in MRL ear fibroblasts. (pnas.org)
  • Each individual bony ray consists of two concave hemirays that enclose a mesenchymal compartment composed of blood vessels, nerves, pigment cells, fibroblasts, and osteoblasts. (biomedcentral.com)
  • Although other cell types contribute to blastema formation, fibroblasts appear to play a central role [ 5 , 6 ]. (jcancer.org)
  • Anodic silver causes cells such as mammalian fibroblasts to assume a simpler, relatively unspecialized form and to resemble dedifferentiated or embryonic cell types. (curearchives.com)
  • contrast
  • In contrast, we find that Lgr6 is expressed within cells of the nail matrix portion of the nail epithelium, as well as in a subset of cells in the bone and eccrine sweat glands. (nih.gov)
  • In contrast, the young members of old/young mouse pairs exhibited fewer new nerve cells in the dentate gyrus than did young mice untethered to elders. (fightaging.org)
  • functionally
  • Because the p53/p21 axis plays a central role in the DNA damage response and cell cycle control, we directly tested the hypothesis that p21 down-regulation could functionally induce a regenerative response in an appendage of an otherwise nonregenerating mouse strain. (pnas.org)
  • microenvironment
  • We documented an absolute requirement for macrophages in the orchestration of postamputation immune microenvironment and blastema formation, providing direct evidence for the immunological control of successful regeneration in an adult vertebrate. (pnas.org)
  • Cellular
  • I'm interested in the autophagy pathway- a highly conserved means for the cell to recycle cellular material during times of stress by promoting vesicle formation and subsequent degradation of cytoplasmic contents. (jccfund.org)
  • and it has remained unsettled whether adult newts possess a cellular population that is equal to mammalian satellite cells. (rupress.org)
  • this is such a fundamental piece of cellular machinery that there is no expectation that cancer cells could find a way around it. (fightaging.org)
  • Neural cells, for example, express growth-associated proteins, such as GAP-43 , tubulin , actin , an array of novel neuropeptides , and cytokines that induce a cellular physiological response to regenerate from the damage. (wikipedia.org)
  • Meanwhile, cellular studies ongoing at Wistar revealed that MRL cells behaved very differently than cells from "non-healer" mouse strains in culture. (thinkatheist.com)
  • gonadal
  • As a consequence of genetic sex determination, the indifferent gonadal blastema normally becomes either a testis or an ovary. (royalsocietypublishing.org)
  • In this context also, serological H-Y antigen is discussed as a possible factor acting on primordial gonadal cells and inducing differential growth or morphogenesis or both. (royalsocietypublishing.org)
  • The most common in disease generally associated with long wave far red detection is being routinely relocated within the intermediate mesoderm into nephron epithelia later in this book in the recovery room should have a better indicator of the vhl tumor suppressor gene v c and kaplan gincidence of renal and gonadal dysgenesis or normal genital development in mammals is however clear that the higher the potency of the. (nationalnewstoday.com)
  • structures
  • Finally, the TALE (three amino acid loop extension) class homeodomain transcription factor prep is required for promoting anterior fates, with knockdown leading to a lack of anterior structures in the anterior blastema but without conversion to posterior fates ( Felix and Aboobaker, 2010 ). (biologists.org)
  • Much less is known about the cells that are specialized to generate and regenerate the blueprint (the pattern-forming cells) in order to instruct the pattern-following cells as to how and where to rebuild the structures. (springer.com)
  • As we know interaction between cells and ECM provides suitable three-dimensional structures. (zjrms.com)
  • cytokines
  • Macrophages are an important source of both inflammatory and anti-inflammatory signals, arriving in mammalian wounds 48-96 h after injury, where they clear dead cells, release proinflammatory cytokines, and subsequently produce factors that dampen inflammation and stimulate angiogenesis, fibroblast migration, and replication ( 17 ). (pnas.org)
  • stem cell
  • Try to do something different and your path will be longer and more challenging - see, for example, the fact that early stage stem cell therapies still cannot be obtained in US clinics, despite having been available overseas for a number of years now. (fightaging.org)
  • molecular
  • The lack of molecular markers has also obstructed the prospective isolation of blastema progenitors. (rupress.org)
  • The subsequent availability of more advanced molecular technologies paved the way in the 1980s and 1990s for the identification of additional human tumor viruses-human T-cell leukemia virus type 1, hepatitis C virus, and Kaposi's sarcoma virus. (aacrjournals.org)
  • However, very few molecular tools exist for studying crucial cell lineage relationships over regeneration or for robust and sustained misexpression of genetic elements to test their function. (biologists.org)
  • Interestingly, a considerable portion of the molecular clock (14 genes) is light-induced in the pineal gland. (uni-heidelberg.de)
  • lineage
  • I am interested in developing methods for recording lineage and transcriptional event histories within the genome of the cells. (jccfund.org)
  • Genetic lineage analysis reveals that Lgr6-expressing cells give rise to the nail during homeostatic growth, demonstrating that Lgr6 is a marker of nail stem cells. (nih.gov)
  • genes
  • To address the mechanisms by which viruses induce and interact with the autophagy pathway, I am using poliovirus infection in HeLa cells that have several key autophagy genes knocked out by Crispr-Cas9. (jccfund.org)
  • Somatic
  • Somatic cells that change from one mature phenotype to another exhibit the property of plasticity. (jci.org)
  • genetic
  • Khamilia Bedebaeva, M.D., Ph.D., having studied genetic effects following the Chernobyl reactor radiation accident, noticed immediately that these cells were atypical, showing profound differences in cell cycle characteristics and DNA damage. (thinkatheist.com)
  • mammalian cells
  • No. 4,528,265) has disclosed processes and products that involve subjecting mammalian cells to the influence of electrically-generated silver ions. (curearchives.com)
  • endothelial cells
  • It is increasingly clear that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by studying the process of epithelial-mesenchymal transition (EMT). (jci.org)
  • As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype. (jci.org)
  • First, we observe that endothelial cells (ECs) grow coordinately with the kidney bud as early as {{ME10.5}}, and begin to show signs of specification by {{ME13.5}} when the first arteries can be identified. (edu.au)
  • phenotype
  • These cell extracts can direct epigenetic reprogramming of the cancer cells and thereby reverse their neoplastic phenotype. (google.es)