Mammalian receptor. Medical search. Frequent questions

Our goal is to decipher the highly diverse functions of vitamin A, its active derivatives (retinoic acids), and the corresponding nuclear receptors (RARs/RXRs), in neural development, aging, and in stem cell control. (igbmc.fr)

The olfactory receptors form a multigene family consisting of around 800 genes in humans and 1400 genes in mice. (wikipedia.org)
Sequence diversity and genomic organization of vomeronasal receptor genes in the mouse. (jax.org)
In addition, we discuss reports on the interactions of OXT and AVP receptor genes and genes involved in other pathways (such as those of dopamine, serotonin, and reelin), as well as research that has shed some light on the impact of gene polymorphisms on the volume, connectivity, and activation of specific neural structures, differential receptor expression, and plasma levels of the OXT and AVP peptides. (frontiersin.org)
The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. (nih.gov)
The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. (nih.gov)

Olfactory receptors (ORs), also known as odorant receptors, are chemoreceptors expressed in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants (for example, compounds that have an odor) which give rise to the sense of smell. (wikipedia.org)
Activated olfactory receptors trigger nerve impulses which transmit information about odor to the brain. (wikipedia.org)
In vertebrates, the olfactory receptors are located in both the cilia and synapses of the olfactory sensory neurons and in the epithelium of the human airway. (wikipedia.org)
In insects, olfactory receptors are located on the antennae and other chemosensory organs. (wikipedia.org)
Rather than binding specific ligands, olfactory receptors display affinity for a range of odor molecules, and conversely a single odorant molecule may bind to a number of olfactory receptors with varying affinities, which depend on physio-chemical properties of molecules like their molecular volumes. (wikipedia.org)
The primary sequences of thousands of olfactory receptors are known from the genomes of more than a dozen organisms: they are seven-helix transmembrane proteins, but there are very few solved structures. (wikipedia.org)
Golebiowski, Ma and Matsunami showed that the mechanism of ligand recognition, although similar to other non-olfactory class A GPCRs, involves residues specific to olfactory receptors, notably in the sixth helix. (wikipedia.org)
In a recent but highly controversial interpretation, it has also been speculated that olfactory receptors might really sense various vibrational energy-levels of a molecule rather than structural motifs via quantum coherence mechanisms. (wikipedia.org)
Researchers discover as much as 30% of the larger array of human olfactory receptors differ between individuals. (neurosciencenews.com)
Researchers report that in the future, olfactory receptors could serve as a target for liver cancer diagnosis and treatments. (neurosciencenews.com)
A pheromone released by female zebrafish is sensed by the olfactory receptors of males, a new study reports. (neurosciencenews.com)
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. (nih.gov)
Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. (nih.gov)
It is a specialized pseudostratified neuroepithelium containing the primary olfactory receptors. (medscape.com)
To stimulate the olfactory receptors, airborne molecules must pass through the nasal cavity with relatively turbulent air currents and contact the receptors. (medscape.com)

Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells. (bvsalud.org)
Treatment of JEG-3 cells with GRα siRNA , LY294002, XO/HX or rapamycin inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3 and mammalian target of rapamycin (mTOR) and induced the phosphorylation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex 2. (bvsalud.org)

By identifying and evaluating proteins in close spatial proximity to Kv2.1-containing EPJs, we discovered that a significant role of Kv2.1 at EPJs is to promote the clustering and functional coupling of PM L-type Ca2+ channels (LTCCs) to ryanodine receptor (RyR) ER Ca2+ release channels. (escholarship.org)
The structures of AMPA receptors in complex with auxiliary proteins are resolved by cryo-electron microscopy, and reveal conformational and permeation pathway changes that are associated with activation and desensitization of ionotropic glutamate receptors. (nature.com)
Co-expression of accessory proteins was required to allow functional surface expression of some mouse odorant receptors. (duke.edu)
however, Fz proteins constitute a distinct group within the GPCR (G-proteincoupled receptor) superfamily, and Fz signalling can be G-proteinindependent in some experimental setups, leading to concerns about the GPCR nature of these proteins. (uni-konstanz.de)
In the present study, we demonstrate that mammalian Fz proteins act as GPCRs on heterotrimeric Go/i proteins. (uni-konstanz.de)
These responses were sensitive to a Wnt antagonist and to pertussis toxin, which decouples the Go/i proteins from their receptors through covalent modification. (uni-konstanz.de)
The large-scale expression of many membrane proteins, including the members of the G protein-coupled receptor superfamily, in a correctly folded and fully functional form remains a formidable challenge. (essex.ac.uk)
The proto-oncogene family members encodes little GTP binding proteins that transduce development indicators from cell surface area receptors in response to extracellular stimuli (1 6 37 Prior studies have recommended that aberrant activation of is certainly a crucial stage during tumorigenesis. (molecularcircuit.com)

Scholars@Duke publication: Functional analysis of a mammalian odorant receptor subfamily. (duke.edu)
We used this assay to examine the receptive ranges of all members of the mouse odorant receptor 42 (MOR42) subfamily. (duke.edu)
However, overlap between the individual receptive ranges suggests that the members of this subfamily form one contiguous subfamily receptive range, suggesting that odorant receptor subfamilies do constitute functional units. (duke.edu)

These receptors are members of the class A rhodopsin-like family of G protein-coupled receptors (GPCRs). (wikipedia.org)
Once the odorant has bound to the odor receptor, the receptor undergoes structural changes and it binds and activates the olfactory-type G protein on the inside of the olfactory receptor neuron. (wikipedia.org)
Such isotope effects are exceedingly common, and so it is well known that deuterium substitution will indeed change the binding constants of molecules to protein receptors. (wikipedia.org)
In mammals, SRP and its receptor (SR) have many additional RNA features and protein components compared to the bacterial system, which were recently shown to play regulatory roles. (nih.gov)
In primary mammalian cells oncogenic induces premature senescence depending on an active MEK-extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) pathway. (molecularcircuit.com)
In this study, we have characterized a novel approach for identification and selection of protein-protein interactions, denoted SPIRE (selection of protein interactions by receptor engagement), which is based on a mammalian expression system. (lu.se)
We have demonstrated proof of concept by creating a general plasma membrane bound decoy receptor, by displaying a protein or a peptide genetically fused to a trunctated version of the CD40 molecule. (lu.se)
When this decoy receptor is engaged by a ligand to the displayed protein/peptide, the receptor expressing cell is rescued from apoptosis. (lu.se)
G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. (mdpi.com)
These observations presented a spatial and temporal resolution of the sequence of events underlying receptor-evoked involvement of tubulin in G-protein-mediated signaling. (jneurosci.org)
It is suggested that G-protein-coupled receptors might modulate cytoskeletal dynamics, intracellular traffic, and cellular architecture. (jneurosci.org)
The HA protein revealed a Q226L mutation when compared with the putative parental avian HA protein, indicating a preferential binding to SA'2,6Gal, the mammalian influenza receptor. (usda.gov)
G Protein-coupled odorant receptors underlie mechanosensitivity in mammalian olfactory sensory neurons. (upenn.edu)
Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism. (upenn.edu)
Conserved residues control activation of mammalian G Protein-coupled odorant receptors. (upenn.edu)
Olfaktorni receptor 5I1 je protein koji je kod ljudi kodiran OR5I1 genom . (wikipedia.org)
This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. (nih.gov)
In comparison with other monosaccharides, xylose is rather unusual and, so far, only found in two different mammalian structures, i.e. in the Notch receptor and as the linker between protein and glycosaminoglycan (GAG) chains in proteoglycans. (lu.se)

Influenza A virus can infect different mammalian animals. (usda.gov)

One specific peptide-displaying cell could be identified and amplified, based on a specific receptor engagement, in a background of 12 500 wild-type cells after four selections. (lu.se)
Methiothepin also antagonized AC-coupled dopamine receptors but not AC-coupled small cardioactive peptide receptors. (johnshopkins.edu)
Although a large body of research, ranging from rodents to humans, has reported on the effects of OXT and AVP administration on affiliative and trust behaviors, and has highlighted the genetic contributions of OXT and AVP receptor polymorphisms to both social behaviors and to diseases related to social deficits, the consequences of peptide administration on psychiatric symptoms, and the impact of receptor polymorphisms on receptor function, are still unclear. (frontiersin.org)

The results of the present study provide the longawaited biochemical proof of the GPCR nature of Fz receptors. (uni-konstanz.de)
Approximately half of the members of the human GPCR superfamily are chemosensory receptors, including odorant receptors (ORs), trace amine-associated receptors (TAARs), bitter taste receptors (TAS2Rs), sweet and umami taste receptors (TAS1Rs). (mdpi.com)

A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres. (uea.ac.uk)

Receptor constructs included the N-terminal 20 residues of human rhodopsin and were co-expressed with Galphaolf and the cystic fibrosis transmembrane regulator to allow electrophysiological measurement of receptor responses. (duke.edu)

The butyrophenone domperidone also binds to central dopamine receptors 12 , but it is a very weak antagonist of dopamine-sensitive adenylate cyclase 13 (Table 1), suggesting that it may bind only to D-2 receptors. (nature.com)

Although metabotropic glutamate receptor (mGluR) modulation has been studied extensively in neurons, it has not been investigated in astrocytes. (jneurosci.org)
These data suggest that glutamate, acting at several metabotropic receptors expressed by astrocytes, could modulate glial activity evoked by neurotransmitters and thereby influence the ongoing modulation of neurons by astrocytes. (jneurosci.org)

Testing this idea requires an assay allowing detailed functional characterization of odorant receptors. (duke.edu)
For most mouse odorant receptors tested, these conditions were sufficient for functional expression. (duke.edu)
Background The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as for example cancer is unsettled. (careersfromscience.org)
We have studied if Pm affects nicotinic acetylcholine receptors (nAChRs), since they play broad functional roles, both in the nervous system and non-neuronal tissues. (mdpi.com)
The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. (medlineplus.gov)

Transient Receptor Potential Canonical 7 (TRPC7). (booksca.ca)
The mammalian transient receptor potential melastatin channel 8 (TRPM8), highly expressed in trigeminal and dorsal root ganglia, mediates the cooling sensation and plays a significant role in the cold hypersensitivity characteristic of some types of neuropathic pain, aswell such as cancer. (conferencedequebec.org)
The mechanism of activation of the transient receptor potential vanilloid 4 (TRPV4) channel by 4α-phorbol esters was investigated by combining information from chemical modification of 4α-phorbol-didecanoate (4α-PDD, 2a ), site-directed mutagenesis, Ca 2+ imaging, and electrophysiology. (acs.org)

It was also abolished by the glucocorticoid receptor inhibitor, mifepristone, and a monoclonal antibody against the receptor. (uea.ac.uk)
Yet another theory points to an autoimmune mechanism, as suggested by the findings of monoclonal antibodies with cross-reactivity between T cruzi and mammalian nervous tissue. (medscape.com)

We attempted to identify compounds that are effective in blocking the serotonin (5-hydroxytryptamine, 5-HT) receptor(s) that activate adenylyl cyclase (AC) in Aplysia CNS. (johnshopkins.edu)
Loss of striatal serotonin synaptic receptor binding induced by kainic. (erowid.org)

The voltage-gated K+ channel Kv2.1 serves a major structural role in the soma and proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to endoplasmic reticulum (ER). (escholarship.org)

In mammals, the perception of smell starts with the activation of odorant receptors (ORs) by volatile molecules in the environment. (duke.edu)
The mammalian olfactory system uses a large family of odorant receptors to detect and discriminate amongst a myriad of volatile odor molecules. (duke.edu)

Crabtree, in 1978, had previously suggested that Cu(I) is "the most likely candidate for a metallo-receptor site in olfaction" for strong-smelling volatiles which are also good metal-coordinating ligands, such as thiols. (wikipedia.org)
Personal receptor repertoires: olfaction as a model. (nih.gov)
Odorants can also be perceived by entering the nose posteriorly through the nasopharynx to reach the olfactory receptor via retronasal olfaction. (medscape.com)

Neonatal exposure to a Type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. (cdc.gov)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)

Together, these findings uncover a novel mode of LTCC regulation and establish a unique mechanism whereby Kv2.1-associated EPJs provide a molecular platform for localized somatodendritic Ca2+ signals in mammalian brain neurons. (escholarship.org)

Thus, by using a chemical that binds to copper in the mouse nose, so that copper wasn't available to the receptors, the authors showed that the mice couldn't detect the thiols. (wikipedia.org)
An olfactory cilia pattern in the mammalian nose ensures high sensitivity to odors. (upenn.edu)

The long-term goal of this project is to elucidate the molecular mechanism by which autophagy receptors effect selective autophagy in both normal and disease conditions. (grantome.com)
In Aim 3, I will use a novel cell free assay for ULK1/2 activity to identify substrates of these autophagy kinases and determine the mechanism by which ULK1/2 activation by receptors drives selective autophagy. (grantome.com)
In this study, we investigated the localisation and the mechanism(s) underlying the non-genomic physiological functions of these receptors in mouse skeletal muscle cells. (uea.ac.uk)

Researchers explore the triggers for specific odor receptors and find no two people smell things the same way. (neurosciencenews.com)
The sense of smell is mediated through stimulation of the olfactory receptor cells by volatile chemicals. (medscape.com)

Effects of steroids on gamma-aminobutyric acid receptors expressed in Xenopus oocytes by poly(A)+ RNA from mammalian brain and retina. (aspetjournals.org)
Electrical recordings were made in Xenopus oocytes to study the modulatory effects of steroids on gamma-aminobutyric acid (GABA) receptors expressed by RNA from mammalian brain and retina. (aspetjournals.org)
The cAMP opens cyclic nucleotide-gated ion channels which allow calcium and sodium ions to enter into the cell, depolarizing the olfactory receptor neuron and beginning an action potential which carries the information to the brain. (wikipedia.org)

Sperm cells also express odor receptors, which are thought to be involved in chemotaxis to find the egg cell. (wikipedia.org)
In Aim 2, I will use CRISPR/Cas9 technology to screen for novel modulators of selective autophagy in mammalian cells, including screens for suppressors of disease- associated alleles. (grantome.com)
Interactions between neutral endopeptidase-24.11 (NEP) and the substance P receptor (SPR;NK 1 ) were investigated by examining substance P (SP) degradation, SP binding and SP-induced Ca 2+ mobilization in epithelial cells transfected with cDNA encoding the rat SPR and rat NEP. (nyu.edu)
The results show that the receptors were localised in the cytoplasm in myoblasts, in the nucleus in myotubes and in the extracellular matrix, in satellite cells and in the proximity of mitochondria in adult muscle fibres. (uea.ac.uk)
From these results we conclude that the non-genomic/non-canonical physiological functions of glucocorticoids, in adult skeletal muscle fibres are mediated by a glucocorticoid receptor localised in the extracellular matrix, in satellite cells and close to mitochondria and involve activation of the MAPK pathway. (uea.ac.uk)
Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotube s in mammalian tissue culture cells. (cdc.gov)
Receptor binding of GnRH is connected with the stimulation of pituitary gonadotropic cells leading to both the release and bio. (nel.edu)
This was studied in SK-N-SH neuroblastoma cells, which possess a muscarinic receptor-regulated PLCβ 1 -signaling pathway. (jneurosci.org)
Xylose is one of the few monosaccharidic building blocks that are used by mammalian cells. (lu.se)

D-2 receptors are characterised by a high affinity for the buty-rophenones haloperidol 9 and spiperone 10 , but these ligands also apparently bind to D-1 receptors 11 . (nature.com)

This reduction in potency appears to be due to effects of the high ionic strength of physiological saline on the binding of this antagonist to the receptor. (johnshopkins.edu)

Chemical substances originating from the environment stimulate a variety of receptors hosted in the nasobuccal cavity. (frontiersin.org)
Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (ebi.ac.uk)

Here we show that a variety of Class I and Class II mouse odorant receptors can be functionally expressed in Xenopus laevis oocytes. (duke.edu)

Extreme variability among mammalian V1R gene families. (jax.org)

An agent that selectively binds to and activates alpha -adrenergic receptors. (ebi.ac.uk)

2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . (wikipedia.org)
The olfactory receptor gene family is the largest in the genome. (nih.gov)

We report here that there is no significant receptor-specific binding of 3 H-domperidone to retinal membranes, thus suggesting the absence of D-2 receptors in this tissue. (nature.com)
During the early stage of this award, I will gain valuable technical skills, including in mammalian tissue culture, CRISPR screening and mass spectrometry, that will enable me to develop a unique research program. (grantome.com)
Open up in another window Amount 2 Mammalian ICNs Induce T Cell Advancement in the Bone tissue Marrow and in Fetal Thymic Body organ Cultures. (careersfromscience.org)

However, even at concentrations as high as 50 microM, 3 alpha-OH-DHP did not itself elicit appreciable membrane current responses through direct activation of the cortex GABAA receptors. (aspetjournals.org)
Specifically, in Aim 1, I will biochemically characterize the role of autophagy receptors in ULK1/2 activation. (grantome.com)

Odorants diffuse into the mucous and are transported to the olfactory receptor. (medscape.com)

The goal of this proposal is to take an autophagy-receptor- centric approach to understanding selective autophagy in mammalian systems. (grantome.com)
The proposed research will elucidate the role of autophagy receptors in selective autophagy, focusing on the effects of disease- associated mutations in autophagy receptors. (grantome.com)

Differential binding of mammalian and salmon GnRHs with rat and carp pituitary receptors. (nel.edu)

Association constants ( K ass , 1/μM sialic acid) of virus complexes with sialylglycopolymers conjugated to 3′-sialyllactose (avian-like Neu5Acα2,3Gal-containing receptor, white bars) and 6′-sialyllactosamine (human-like Neu5Acα2,6Gal-containing receptor, black bars). (cdc.gov)
Pigs have been suggested to be the mixing vessel for avian and human influenza viruses because the porcine trachea contains binding receptors with preferences for human and avian influenza viruses. (usda.gov)

I will then determine the effect of receptor mutations associated with human disease. (grantome.com)
To date, HPAI A(H5N1) viruses currently circulating in birds and poultry, with spillover to mammals, and those that have caused human infections do not have the ability to easily bind to receptors that predominate in the human upper respiratory tract. (cdc.gov)

Our studies of specific retinoid receptors and bioactive metabolites in control of diverse biological processes should contribute to a better understanding of the mechanisms underlying development and function of specific cell types and relevant neural circuits. (igbmc.fr)

Anatomy24

Organisms18

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes54

Disciplines and Occupations1

Information Science4

Nuclear Receptors1

Genes5

Olfactory receptors15

Target of rapamycin2

Proteins8

Odorant receptor3

Protein18

Different mammalian1

Peptide3

GPCR2

Glucocorticoid receptors1

Residues1

Dopamine receptors1

Modulation2

Functional5

Transient3

Monoclonal2

Serotonin2

Plasma membrane1

Molecules2

Olfaction3

Induces2

Neurons1

Nose2

Mechanism3

Smell2

Brain3

Cells9

Affinity1

Antagonist1

Stimulate2

Xenopus1

Variability1

Binds1

Gene2

Tissue3

Activation2

Odorants1

Autophagy2

Differential1

Avian2

Human2

Neural1