• Although 9-carbon sugars do not occur naturally, neuraminic acid may be regarded as a theoretical 9-carbon ketose in which the first link of the chain (the -CH2OH at position 1) is oxidised into a carboxyl group (-C(=O)OH), the hydroxyl group at position 3 is deoxidised (oxygen is removed from it), and the hydroxyl group at position 5 is substituted with an amino group (-NH2). (wikipedia.org)
  • Like amino acids and nucleic acids, sugars are the major contributors in nature many natural products contain oligosaccharides that are important for their biological and biochemical activity and carbohydrates have major roles in a wider range of biological processes including signal transduction mechanisms and immune responses. (biochemistryconferences.com)
  • Sialylated glycans can enhance immune evasion by interacting with sialic acid-binding immunoglobulin-like lectin (Siglec) receptors on tumor-infiltrating immune cells. (bvsalud.org)
  • Mammalian cells express sialic acids to confer self to the immune system, a trait being exploited by some pathogens that use sialic acid on their cell surface to hide themselves from the hosts immune system. (uit.no)
  • Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a monosaccharide with a nine-carbon backbone and are found widely distributed in animal tissues and to a lesser extent in some other organisms, ranging from fungi,plants,yeasts and bacteria, mostly in glycoproteins and gangliosides. (biochemistryconferences.com)
  • I. Preparation, amino acid composition and molecular weight. (qmul.ac.uk)
  • A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. (lookformedical.com)
  • Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
  • Sialic acids are family of nine carbon α-keto acids found to have important roles mammals and bacteria. (uit.no)
  • In many cases, these events begin with the transfer of a virus from an avian reservoir host to mammals or domestic poultry, whereas other events result from the transfer of a virus infecting mammals into a new mammalian host. (cdc.gov)
  • Any mammalian metabolite produced during a metabolic reaction in humans ( Homo sapiens ). (ebi.ac.uk)
  • Any mammalian metabolite produced during a metabolic reaction in a mouse ( Mus musculus ). (ebi.ac.uk)
  • The neuramininc acid synthase responsible for the reaction that synthesises neuraminic acid from ManNAc and PEP have been successfully cloned and expressed in two constructs NHis and CHis which coded for a TEV cleavable His-tag and a non-cleavable His-tag. (uit.no)
  • Neuraminic acid (5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid) is an acidic (in particular ulosonic) amino sugar with a backbone formed by nine carbon atoms. (wikipedia.org)
  • An N -acylneuraminic acid where the N -acyl group is specified as acetyl. (ebi.ac.uk)
  • The overexpression of sialic acids on glycans, called hypersialylation, is a common alteration found in cancer cells. (bvsalud.org)
  • The IUPAC symbol used for neuraminic acid is Neu, and the residue is typically found with additional chemical modifications in biological systems. (wikipedia.org)
  • This bacteria have been found to have the genes necessary to synthesise sialic acids. (uit.no)
  • It consists of five major components each with a different fatty acid moiety. (lookformedical.com)
  • Like amino acids and nucleic acids, sugars are the major contributors in nature many natural products contain oligosaccharides that are important for their biological and biochemical activity and carbohydrates have major roles in a wider range of biological processes including signal transduction mechanisms and immune responses. (myconferencepass.com)
  • A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided. (justia.com)
  • The complex is comprised of A) said nucleic acid composition and B) a transfer moiety comprising 1) one or more cationic polyamines bound to said nucleic acid composition, 2) one or more endosome membrane disrupting components attached to at least one nitrogen of the polyamine and 3) one or more receptor specific binding components. (justia.com)
  • CONTENTS Foreword National Cancer Institute Introduction Specific highlights Natural history of the disease Acute leukemia Multiple myeloma Head and neck cancer Cervical cancer Infection in surgery Theory of basal cell cancer Therapy Biochemical and physiological studies Immunological Steroid chemistry Pyrimidine metabolism Pharmacology Normal skin Lymphangiography White cells and platelets Carcinogenesis Metabolism service Amino acid transport Gamma globulin structure Gamma globulin metabolism Albumin metabolism Immunological studies Nucleic acid and pyrimidine metabolism. (nih.gov)
  • 85 Cardioglobulin 86 CONTENTS IX Page Laboratory of metabolism 86 Pathway and inhibitors of cholesterol biosyn- thesis 87 Normal pathway of cholesterol biosyn- thesis 87 Desmosterol reductase 87 Desmosterol as precursor of adrenal ste- roids and bile acids 88 Sterol metabolism in skin and optic lens. (nih.gov)
  • 93 Alkaloid work 93 Kallikrein-kallidinogen-kallidin system 93 Informal collaborative research 93 Laboratory of clinical biochemistry 94 Am ine biogenesis and metabolism 94 Collagen and hydroxyproline 95 Proteins and peptides 95 Amino acid uptake by animal tissues 96 Biosynthesis of phospholipids and other lipids- 97 Vitamin B 12 97 Development of analytical procedures 98 Section on biochemical genetics 98 RNA and genetic code 98 Cell-free assay for messenger RNA. (nih.gov)
  • So the study of glycan structures is also complicated by the lack of a proper and direct template for their biosynthesis, contrary to the case with amino acids and proteins. (myconferencepass.com)
  • The mutations change amino acids in the antigenic segments of HA and NA proteins, therefore, the strains can evade population immunity. (qualityessay.net)
  • Neuraminic acid does not occur naturally, but many of its derivatives are found widely distributed in animal tissues and in bacteria, especially in glycoproteins and gangliosides. (wikipedia.org)
  • This kit has been developed for the quantitative analysis of sialic acids and contains all the reagents necessary for the release of sialic acids from glycoproteins and their conjugation with DMB dye by an amination-cyclization reaction. (ludger.com)
  • The strategy involves orthogonal techniques: total N-glycan profiling and quantitative analysis of neutral monosaccharides and sialic acids, where a mAb is used as a model glycoprotein and this workflow can be applied throughout a biopharmaceutical's product life cycle. (ludger.com)
  • Humans lack the common mammalian cell surface molecule N-glycolylneuraminic acid (Neu5Gc) due to a CMAH gene inactivation, which occurred approximately three million years ago. (anthropogeny.org)
  • The viruses, in addition to humans, infect large number of warm blooded animal hosts, including more than 100 avian species, many mammalian species with numerous species of wild aquatic birds serving as the major natural reservoirs (Schwartzman et al. (qualityessay.net)
  • In many cases, these events begin with the transfer of a virus from an avian reservoir host to mammals or domestic poultry, whereas other events result from the transfer of a virus infecting mammals into a new mammalian host. (cdc.gov)
  • polyribosomal and particulate distribution of lysyl- and phenylalanyl-transfer ribonucleic acid synthetases. (liverpool.ac.uk)