• Fetal Bovine Serum (FBS) is a complex mixture with low and high molecular weight biomolecules exhibiting optimal growth-enhancing and growth-suppressing functions. (sigmaaldrich.com)
  • We identify the main binding sites of a catalytically inactive Cas9 (dCas9) protein in bovine fetal fibroblast cells (BFFs) with chromatin immunoprecipitation sequencing (ChIP-seq). (biomedcentral.com)
  • In this work, surface of the formed nanoparticles was opsonized with proteins available in the fetal bovine blood serum. (cyberleninka.ru)
  • Therefore, DMEM/F-12 may require supplementation, commonly with 10% Fetal Bovine Serum (FBS). (genaxxon.com)
  • Dulbeccos revised essential medium (DMEM), F12, and fetal bovine serum (FBS) were from Life Systems. (researchhunt.com)
  • Adult bovine serum contains a variety of nutrients including inorganic minerals, vitamins, salts, proteins and lipids as well as growth factors that promote animal cell growth. (sagepub.com)
  • Proteins present in MS, FS and CMS but absent in fetal bovine serum (FBS) were selected by two-dimensional gel electrophoresis and identified by peptide mass fingerprinting. (sagepub.com)
  • The silkworm-derived cell line BmN was maintained at 27°C in TC-100 medium (Gibco, USA) supplemented with 10% fetal bovine serum (FBS). (hindawi.com)
  • To achieve optimal growth, a common approach is to supplement DMEM with 10% Fetal Bovine Serum (FBS). (cytion.com)
  • Ticks were washed with sterile phosphate-buffered saline and homogenized in 500 μL of culture medium containing 4% fetal bovine serum and 500 IU/mL penicillin and streptomycin by the use of glass beads in a cell disrupter. (cdc.gov)
  • 2006 cells from individual E9 Specifically.5 embryos had been dissociated by passage through Gauge 20 needles and plated in DMEM/F12 supplemented with 15% fetal bovine serum (FBS) nonessential amino acid sodium pyruvate Glutamax and antibiotics at 37°C and 5% CO2. (techuniq.com)
  • DMRT1 is a dose sensitive transcription factor protein that regulates Sertoli cells and germ cells. (wikipedia.org)
  • At the molecular level, Cul3 regulates cytoskeletal and adhesion protein abundance in mouse embryos. (nature.com)
  • The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
  • The Hedgehog (Hh) family of secreted proteins regulates mammalian development and malignancy formation through Gli transcription factors which exist in both activator and repressor forms. (techuniq.com)
  • DMEM/F-12 contains no proteins, lipids, or growth factors. (genaxxon.com)
  • DMEM (Dulbecco's Modified Eagle Medium) is a highly versatile and widely utilized basal medium designed to support the growth of a diverse range of mammalian cells in biological research. (cytion.com)
  • The expression of HMGB1, c-Jun N-terminal kinase (JNK), extracellular-signal-regulated kinase (ERK), and p38 mitogen-activated protein kinase (p38 MAPK) was assessed with immunofluorescence and western blot analysis. (molvis.org)
  • Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
  • The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
  • This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
  • Cell numbers, protein synthesis and degradation, as well as total and phosphorylated levels of mTOR, ribosomal protein S6 kinase 1 (p70S6K) and eukaryotic initiation factor 4E-binding protein-1 (4EBP1), were determined. (tamu.edu)
  • The compound is an inhibitor of mammalian protein kinase and has been applied topically for the treatment of skin metastasis showing good local tolerability [5]. (who.int)
  • The toxicity data of protein kinase inhibitors in humans is also well established [5]. (who.int)
  • However, the comprehensive chromatin state has not yet been analyzed for human fetal germ cells (FGCs). (nature.com)
  • Therefore, it appears that on some occasions in the course of mammalian evolution, env genes from endogenous retroviruses have been "co-opted" by their host to participate in the formation of the syncytiotrophoblast layer, at the maternal-fetal interface, by mediating the fusion of mononucleated cytotrophoblasts. (biomedcentral.com)
  • Lipids, polysaccharides and nucleic acids bind to proteins which increases the viscosity of the samples and often results in horizontal streaking on the 2D-PAGE. (hindawi.com)
  • however, growth hormone-insulin-like growth factor axis disturbance by fetal programming and accelerated postnatal weight gain contributed to central adiposity in SGA children. (e-apem.org)
  • Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. (nih.gov)
  • E3 ubiquitin ligases regulate cellular protein composition by providing target recognition and specificity to the ubiquitin-dependent proteasomal degradation pathway 12 . (nature.com)
  • CUL3 is a conserved protein of the Cullin family, comprising eight members, which contain a conserved cullin homology domain, named after its ability to select cellular proteins for degradation. (nature.com)
  • Despite the well-understood process of CUL3-mediated protein ubiquitination and degradation 12 , its target proteins in the developing central nervous system and its role in brain development remain utterly understudied. (nature.com)
  • Autophagy represents a caspase-independent process characterized by accumulation of autophagosomes in the cytoplasm and their subsequent fusion with lysosomes for degradation of unused or misfolded proteins or damaged structures such as ribosomes (ribophagy) and mitochondria (mitophagy). (aging-us.com)
  • Taken with the present results, this suggests that the potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein. (embl.de)
  • Addition of 100 and 350 M Arg to culture medium dose-dependently increased (a) protein synthesis and decreased protein degradation and (b) the abundance of total and phosphorylated mTOR, p70S6K and 4EBP1 proteins. (tamu.edu)
  • In order to gain the best possible protein separation on 2D-PAGE, an optimized sample preparation protocol for placental proteins was developed. (hindawi.com)
  • Due to the large number of proteins, no protein array platform has yet been designed that covers the entire human placental proteome. (hindawi.com)
  • The causes of IUGR are generally described under 3 main categories: maternal, fetal, and placental [ 5 ]. (ijbs.com)
  • At day 17 of gestation, LPD- and Emb-LPD-fed conceptuses displayed smaller placentas and larger fetuses respectively, resulting in increased fetal:placental ratios in both groups compared with NPD conceptuses. (manchester.ac.uk)
  • Analysis of placental and yolk sac nutrient signalling within the mammalian target of rapamycin complex 1 pathway revealed similar levels of total and phosphorylated downstream targets across groups. (manchester.ac.uk)
  • Finally, in situ hybridization of rabbit placenta sections with a syncytin-Ory1 probe revealed specific expression at the level of the junctional zone between the placental lobe and the maternal decidua, where the invading syncytial fetal tissue contacts the maternal decidua to form the labyrinth, consistent with a role in the formation of the syncytiotrophoblast. (biomedcentral.com)
  • These fetuses with impaired fetal programming and growth restriction are at a risk for developing chronic diseases of adulthood, including various neurological disorders and cardiovascular diseases [ 3 , 4 ]. (ijbs.com)
  • Results of recent studies indicate that administration of L-arginine (Arg) to gestating pigs or sheep with IUGR fetuses can enhance fetal growth. (tamu.edu)
  • The majority of DMRT1 protein is located in the testicular cord and Sertoli cells, with a small amount in the germ cells. (wikipedia.org)
  • Expression levels of PER2, a clock protein, were elevated in Sik3 -knockdown cells but down-regulated in Sik3 -overexpressing cells, which could be attributed to a phosphorylation-dependent decrease in PER2 protein stability. (elifesciences.org)
  • Mammalian placentation is dependent upon the action of trophoblast cells at the time of implantation. (manchester.ac.uk)
  • Measured by the ability of the immobilized protein to enhance BMP2-induced alkaline phosphatase activity in C3H10T1/2 mouse embryonic fibroblast cells.The ED50 for this effect is typically 4-20 ug/mL. (betalifesci.com)
  • The protein synthesis machinery in mammalian cells is also very sophisticated, allowing much greater levels of the essential building blocks for human tissues, sarms punisher stack. (laeticiamaraishugo.com)
  • This is especially important during fetal development, when human cells require a lot of protein synthesis for their continued health and development, sarms wat is het. (laeticiamaraishugo.com)
  • It is a widely used basal medium for supporting the growth of many different mammalian cells. (genaxxon.com)
  • The VEGF-A protein and mRNA levels in conditioned medium of RGC-5 cells incubated with AGE-modified BSA (AGE-BSA) were examined with real-time PCR and enzyme-linked immunosorbent assay (ELISA), and BSA-treated cells were used as controls. (molvis.org)
  • Compared with the BSA controls, the RGC-5 cells incubated with AGE-BSA showed a dose- and time-dependent increase in VEGF-A mRNA and VEGF-A protein secretion in the supernatant, with the highest levels achieved at 24 h. (molvis.org)
  • In addition, NS5A significantly increases the expression of inducible nitric oxide synthase, cyclin D1 and nuclear factor-κB, but decreases p53 protein expression in HepG2 cells ( 6 ). (spandidos-publications.com)
  • L-Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells. (tamu.edu)
  • The present study tested the hypothesis that Arg stimulates the mammalian target of rapamycin (mTOR) signaling pathway and protein synthesis in porcine conceptus trophectoderm (pTr2) cells. (tamu.edu)
  • The Oocyte Mosaicism Selection theory [6] suggests that "the incidence of trisomy 21 mosaicism in a cohort of normal fetal ovarian samples, indicating that an accumulation of trisomy 21 germ cells does indeed take place during fetal oogenesis, i.e., from the first to the second trimester of pregnancy. (edu.au)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)
  • Regulative germ cell specification in axolotl embryos: a primitive trait conserved in the mammalian lineage. (ox.ac.uk)
  • These data demonstrate that early post-implantation embryos modify trophoblast phenotype to regulate fetal growth under conditions of poor maternal nutrition. (manchester.ac.uk)
  • Finally we found that the ratio between your activator and repressor types of Gli3 proteins aswell as the full total degree of Gli3 proteins in the embryos is certainly drastically suffering from the increased loss of Sufu function in the existence and lack of cilia. (techuniq.com)
  • In the second trimester, amniotic fluid derives primarily from fetal lung and kidney. (lecturio.com)
  • After that, fetal urine production is the predominant mechanism that determines the amniotic fluid volume. (medscape.com)
  • It is believed that adequate space in the fetal thorax and the movement of amniotic fluid into the fetal lungs is required for the normal development of lungs. (medscape.com)
  • FBS derived from clotted blood is the most widely used undefined supplement in eukaryotic, especially mammalian, cell culture. (sigmaaldrich.com)
  • can improve manifestation levels [6], it lacks the machinery for introducing post-translational modifications necessary for proper folding of many eukaryotic proteins, often resulting in insoluble, unstable, or non-functional protein [7]. (researchhunt.com)
  • 1994). The initial reaction results in the formation of a reactive intermediate, which gives off hydrochloric acid to form phosgene, which is then free to react with cellular macromolecules (including GSH, proteins, and nucleic acids) or conjugate with water to form carbon dioxide and hydrochloric acid (Ade et al. (cdc.gov)
  • Immunocytochemical studies showed marked activation of microglia and astroglia, and cytokine profiling indicated that macrophage chemoattractant protein (MCP)-1 and tumor growth factor-beta1, derived from neuroglia, were the most prevalent cytokines in brain tissues. (blogspot.com)
  • Appropriate fetal growth, regulated by maternal nutrition and nutrient transport across the placenta, is a critical factor for adult offspring long-term health. (manchester.ac.uk)
  • We have demonstrated that a mouse maternal low-protein diet (LPD) fed exclusively during preimplantation development (Emb-LPD) increases offspring growth but programmes adult cardiovascular and metabolic disease. (manchester.ac.uk)
  • In this study, we investigate the impact of maternal nutrition on post-implantation trophoblast phenotype and fetal growth. (manchester.ac.uk)
  • This protein serves as a transcriptional activator of cell growth. (spandidos-publications.com)
  • Storage protein 2 (SP2) not only is an important source of energy for the growth and development of silkworm but also has inhibitory effects on cell apoptosis. (hindawi.com)
  • This review summarizes evidence for the role of proteolytic enzymes that degrade and inactivate insulin-like growth factor binding proteins (IGFBP) during follicular development in mammals. (bioone.org)
  • A heterozygous mutation defect of the growth factor bone morphogenetic protein 4 (bmp 4) leads to renal hypoplasia or dysplasia, ureterovesicular junction obstruction, hydronephrosis, or the bifid/duplex kidney. (medscape.com)
  • Doublesex and mab-3 related transcription factor 1, also known as DMRT1, is a protein which in humans is encoded by the DMRT1 gene. (wikipedia.org)
  • CUL3 ASD-associated genetic variants are most often de novo missense or loss of function (loF) mutations, dispersed throughout the entire gene and affecting distinct protein domains. (nature.com)
  • Subsequently, we demonstrate that a single Cas9n-induced single-strand break can stimulate the insertion of the natural resistance-associated macrophage protein-1 ( NRAMP1 ) gene with reduced, but still considerable, off-target effects. (biomedcentral.com)
  • After a systematic selection of target sites and transgenic colonies, we successfully obtained nine exogenous natural resistance-associated macrophage protein-1 ( NRAMP1 ) gene-inserted cows through the Cas9n strategy. (biomedcentral.com)
  • Beclin l, the mammalian counterpart of the yeast Atg6 gene, is an essential protein in autophagy ( 10 ). (spandidos-publications.com)
  • In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
  • In this study, the sp2 gene was cloned and expressed in Escherichia coli to produce a 6xHis-tagged fusion protein, which was then used to generate a polyclonal antibody. (hindawi.com)
  • PCRs were performed by using 2 different pairs of primers: 1 pair of degenerated primers for the 5′ end of the envelope (E) gene ( 11 ) and 1 pair from the C-terminal part of the nonstructural protein 5 (NS5) gene ( 12 ). (cdc.gov)
  • You can choose options such as endotoxin removal, liquid or lyophilized forms, preferred tags, and the desired functional sequence range for proteins. (betalifesci.com)
  • Background The functional interchangeability of mammalian Notch receptors (Notch1-4) in normal and pathophysiologic contexts such as for example cancer is unsettled. (careersfromscience.org)
  • The DM Domain Protein DMRT1 Is a Dose-sensitive Regulator of Fetal Germ Cell Proliferation and Pluripotency. (wikipedia.org)
  • Here we use nucleosome occupancy and methylation sequencing method to analyze both the genome-wide chromatin accessibility and DNA methylome at a series of crucial time points during fetal germ cell development in both human and mouse. (nature.com)
  • As a matter of fact, of all mammalian organs the placenta shows the greatest variation in terms of anatomy. (hindawi.com)
  • In order to prevent rejection of the fetus, the placenta expresses an intricate pattern of major histocompatibility complex molecules, immunizing the mother against the foreign fetal tissue [ 3 ]. (hindawi.com)
  • It contributes to placenta-fetal communication, and plays an indispensable role in the intrauterine embryonic development. (ijbs.com)
  • Advanced maternal age and risk of non-chromosomal anomalies: data from a tertiary referral hospital in Turkey [8] "The purpose of this study is to determine if there is a relationship between non-chromosomal fetal anomalies of various organ systems and advanced maternal age. (edu.au)
  • Taken collectively, the design features and molecular development of HT7 have resulted in a superior alternative to common tags for the overexpression, detection, and isolation of target proteins. (researchhunt.com)
  • Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)
  • Furthermore, the data demonstrated that UCB derived miRNAs participate in fetal epigenetic regulation during pregnancy, suggesting a novel possible explanation for abnormal embryologic vascular development and several congenital cardiovascular diseases. (ijbs.com)
  • This protease activity has recently been ascribed to serine metalloprotease(s), including pregnancy-associated plasma protein-A (PAPP-A), which was first detected in human follicular fluid nearly 20 yr ago. (bioone.org)
  • The umbilical cord changes, with respect to the physical dimensions and composition, can be considered reflective of changes in the fetal cardiovascular system [ 7 ]. (ijbs.com)
  • JAG1/Jagged 1 seems to be involved in early and late stages of mammalian cardiovascular development. (betalifesci.com)
  • To investigate whether immune-mediated mechanisms are involved in the pathogenesis of autism, we used immunocytochemistry, cytokine protein arrays, and enzyme-linked immunosorbent assays to study brain tissues and cerebrospinal fluid (CSF) from autistic patients and determined the magnitude of neuroglial and inflammatory reactions and their cytokine expression profiles. (blogspot.com)
  • Fresh-frozen tissues available from seven patients and CSF from six living autistic patients were used for cytokine protein profiling. (blogspot.com)
  • JAG1/Jagged 1 is widely expressed in adult and fetal tissues. (betalifesci.com)
  • Recently, new evidence suggests that PIWI proteins and piRNAs also play important roles in various somatic tissues, including neurons. (molcells.org)
  • Highly sensitive and specific recombinant antibody microarrays allowing screening of crude protein extracts are also being developed [ 14 ]. (hindawi.com)
  • Endogenous Sufu was precipitated using a goat polyclonal antibody (M-15 Santa Cruz Biotech) immobilized on proteins A-Agarose beads (Santa Cruz Biotech). (techuniq.com)
  • Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) modulates cellular apoptosis, which is involved in the occurrence and development of liver cancer. (spandidos-publications.com)
  • Additional studies have also shown that hemolymph from the silkworm ( Bombyx mori ) can inhibit insect and mammalian cell apoptosis that is induced by viruses and several chemical inducers, such as staurosporine, camptothecin, and actinomycin D [ 6 - 8 ]. (hindawi.com)
  • A recent study showed that another protein in silkworm hemolymph, storage protein 2 (SP2), can also inhibit staurosporine-induced HeLa cell apoptosis and ROS generation [ 8 ]. (hindawi.com)
  • Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
  • Various interior dynamics including self organization of macromolecules, protein conformation, movement of human thoracic diaphragm, formation of logarithmic spiral in nature were discussed in the light of potential energy of self gravity and kinetic energy of metabolic energy. (webmedcentral.com)
  • After whole-body autoradiography to study the distribution of inhaled 14C-labeled chloroform in mice, most of the radioactivity was found in fat immediately after exposure, while the concentration of radioactivity in the liver increased during the postanesthetic period, most likely due to covalent binding to lipid and protein in the liver (Cohen and Hood 1969). (cdc.gov)
  • B) Fetal liver organ hematopoietic progenitors transduced with MigRI, MigRI-ICN1, or MigRI-ICN4 had been utilized to reconstitute irradiated thymic lobes extracted from the same donor pets. (careersfromscience.org)
  • Although injuries in the mammalian central nervous system lead to profound proliferation of astrocytes, which cluster at the lesion site to form a gliotic scar, neurogenesis does not take place. (frontiersin.org)
  • The γ-Fe 2O 3@PDMAAm and γ-Fe 2O 3@SiO 2 nanoparticles, in contrast to the neat nanoparticles were shown to be non-cytotoxic and intensively phagocytozed by the mammalian macrophages. (cyberleninka.ru)
  • The PIWI protein was initially described in Drosophila , and its name, P-element-induced wimpy testis (PIWI), was assigned as a result of the destructive effect on testis development observed in PIWI knockout ( Lin and Spradling, 1997 ). (molcells.org)
  • 1997 Individual and mouse had been cloned into mammalian appearance vectors with Myc (computers2+) FLAG (pFLAG-CMV2 Sigma) or GFP (pEGFPC1 Invitrogen) tags. (techuniq.com)
  • Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface. (lookformedical.com)
  • Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. (lookformedical.com)
  • Mammalian cell lines were from ATCC. (researchhunt.com)
  • However, substitution of serum in cell culture blood from slaughter-houses is used currently for the media has not been successful due to the presence of production of plasma proteins (Belhocine et al. (sagepub.com)
  • This control is propagated through the alpha-subunit of prolyl 4-hydroxylase where protein levels were previously shown to rise fivefold with increasing cell density. (embl.de)
  • Open up in another window Amount 2 Mammalian ICNs Induce T Cell Advancement in the Bone tissue Marrow and in Fetal Thymic Body organ Cultures. (careersfromscience.org)
  • Once the provirus is integrated into the host cell DNA, it is transcribed using typical cellular mechanisms to produce viral proteins and genetic material. (msdmanuals.com)
  • Therefore, PIWI proteins play a crucial role in fertility and germline development across both vertebrate and invertebrate animals. (molcells.org)
  • This work will lay a foundation for the development and utilization of protein drugs from economically important insects for treatment of vascular diseases. (hindawi.com)
  • Two compounds, Compound 1 (1,4-dihydrophenanthrolin-4-one-3-carboxylic acid) and Compound 5 [8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenathrolin-4-one-3-carboxylic acid], with comparable potencies in vivo, were chosen to investigate the effect of the inhibition of the hydroxylation of newly synthesized uterine collagen on the turnover of this protein in vivo. (embl.de)
  • Glycation, the result of a protein or lipid molecule bonding with sugar molecules, is a consequence of the aging process. (molvis.org)
  • Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)
  • Effects of 350 M Arg on intracellular protein turnover were only modestly affected when nitric oxide synthesis was inhibited. (tamu.edu)
  • Our fundamental understanding of proteins and their biological significance has been enhanced by genetic fusion tags, as they provide a convenient method for introducing unique properties to proteins so that they can be examinedin isolation. (researchhunt.com)
  • Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates , however they are not considered lectins . (lookformedical.com)
  • To improve upon current tags, we used a protein design concept based on hydrolytic enzymes to enable 26544-34-3 IC50 quick and irreversible attachment to a unique synthetic ligand. (researchhunt.com)
  • The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight. (lookformedical.com)
  • PIWI Argonaute proteins and Piwi-interacting RNAs (piRNAs) are expressed in all animal species and play a critical role in cellular defense by inhibiting the activation of transposable elements in the germline. (molcells.org)
  • According to the latest taxonomy on flaviviruses, TBE virus is a species in the mammalian tick-borne virus group and has 3 subtypes: European, Far Eastern, and Siberian ( 1 ). (cdc.gov)
  • In addition, the expressed protein in the silkworm baculovirus system was used to study the anti-apoptotic effects of SP2 on human umbilical vein ECs (HUVECs) induced by peroxidation. (hindawi.com)
  • Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
  • Previous reports have suggested that protein kinases play important roles in the regulation of circadian clocks ( Reischl and Kramer, 2011 ). (elifesciences.org)
  • Luciferase reporter assays demonstrated that the Adcy1 promoter is selectively activated by neuronal PAS-domain protein 2 (NPAS2)/BMAL1. (jneurosci.org)
  • Ectoplacental cone explants were isolated at day 8 of gestation from female mice fed either normal protein diet (NPD: 18% casein), LPD (9% casein) or Emb-LPD and cultured in vitro. (manchester.ac.uk)
  • It also is reported that anti-TAPA-1 induce protein tyrosine phosphorylation that is prevented by increased intercellular thiol levels. (techuniq.com)