Mammaglobin b. Medical search. Frequent questions

There are limited data that compare the usefulness of mammaglobin with gross cystic disease fluid protein-15 (GCDFP-15) in the identification of breast carcinomas. (medscape.com)
Traditional markers such as mammaglobin and gross cystic disease fluid protein 15 can be negative in a significant number of metastatic TNBCs, as their sensitivity decreases with the lack of estrogen receptor (ER) expression. (medscape.com)

[ 3 ] In contrast, mammaglobin protein overexpression has been found in breast carcinomas. (medscape.com)

Mammaglobin (10 kD) is a breast-associated glycoprotein distantly related to secretoglobin family that includes human uteroglobin and lipophilin. (cellmarque.com)

[ 2 ] Mammaglobin is a secretory protein that has a predicted molecular mass of 10.5 kd and shares a high degree of homology with the rat prostatic steroid-binding protein subunit C3, human Clara cell 10-kd protein, and rabbit uteroglobin. (medscape.com)

A novel full-length complementary DNA clone was isolated by the same authors in 1996, which they designated as mammaglobin-1 ( MGB1 ). (medscape.com)
Breast-specific expression of MGB1/ mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers. (cellmarque.com)

The gene codifying for Mammaglobin B (MGB-2) has been selected from our previous microarray analysis performed on 19 serous papillary epithelial ovarian cancers and its expression has been further investigated on multiple histological subtypes, both at mRNA and protein level. (nih.gov)
This study tested the utility of trefoil factor 1 (TFF1) for this purpose and compared it with mammaglobin and GATA protein binding 3 (GATA-3). (ox.ac.uk)
The vaccine causes the body's immune system to hone in on a protein called mammaglobin-A, which is found almost exclusively in breast tissue. (seniorvoicealaska.com)
The vaccine activates a specific type of white blood cell to seek out and destroy cells with the mammaglobin-A protein. (seniorvoicealaska.com)

Mammaglobin expression in lymph nodes is an important marker of metastatic breast carcinoma. (cellmarque.com)
Mammaglobin, a valuable diagnostic marker for metastatic breast carcinoma. (cellmarque.com)
In the new study, 14 patients with metastatic breast cancer that expressed mammaglobin-A were vaccinated. (seniorvoicealaska.com)

To define the sensitivity of mammaglobin expression in breast tumors and in other malignancies, we studied mammaglobin expression by immunohistochemical analysis in a variety of human tumors. (medscape.com)

In addition, tissue microarrays (US Biomax, Rockville, MD) containing 544 different human tumors were also stained with the mammaglobin antibody cocktail. (medscape.com)
Positive mammaglobin staining was also seen in 44 (8.1%) of 544 nonbreast tumors. (medscape.com)
Recent studies have suggested that mammaglobin is specific for breast carcinoma and expression is associated with well-differentiated, receptor-positive tumors. (medscape.com)
La tinció immunohistoquímica es fa servir en el diagnòstic de cèl·lules anormals com les que es troben en els tumors cancerosos, entre altres afeccions. (wikipedia.org)

Cite this: Mammaglobin vs GCDFP-15: An Immunohistologic Validation Survey for Sensitivity and Specificity - Medscape - Jan 01, 2007. (medscape.com)
Conclusions: TFF1 demonstrated breast specificity but was inferior to mammaglobin and GATA-3. (ox.ac.uk)

v t e Mammaglobin is a gene that encodes a 10-kilodalton glycoprotein. (wikipedia.org)
The mammaglobin gene sequence fragments were first isolated in 1994 by Watson and Fleming [ 1 ] using a modified differential display polymerase chain reaction technique. (medscape.com)

Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence. (nih.gov)
Mammaglobin mRNA is present in high levels in human breast cancer cell lines, which has been shown to be a sensitive marker of breast cancer. (cellmarque.com)

We studied the genetic fingerprints of ovarian cancer and validated the potential of Mammaglobin b (SCGB2A1), one of the top differentially expressed genes found in our analysis, as a novel ovarian tumour rejection antigen. (nih.gov)

The vaccine targets six proteins (HER2-neu, mammaglobin-A, MAGEA3, surviving, hTERT and MUC1) that have been found through multiple studies to overexpress in breast cancers. (beyondpinkteam.org)

Whole tissue sections of 29 breast carcinomas with matched lymph node metastases and 63 breast carcinomas on tissue microarray were stained with mammaglobin cocktail and GCDFP-15 antibodies. (medscape.com)
Methods: Tissue microarrays containing 365 BCs and 338 PLCs were stained with TFF1, mammaglobin, and GATA-3, and an H-score was calculated. (ox.ac.uk)

Mammaglobin expression in primary, metastatic, and occult cancer. (cellmarque.com)

Anti-PAX-8, combined with organ system-specific markers such as anti-uroplakin III, anti- mammaglobin, and anti-TTF-1, can collectively serve as a very useful panel to determine the primary site of invasive micropapillary ovarian carcinomas from invasive carcinomas arising from bladder, lung, and breast. (pathai.com)

In the majority of cases, the staining intensity and number of cells staining were higher with mammaglobin than with GCDFP-15. (medscape.com)
The infiltrating cells completely lacked expression of p40, mammaglobin, pan-TRK, synaptophysin and chromogranin. (empiregenomics.com)
vFLIP, vCyclin, LANA, miR-Cluster or Vector (12 g each) had been transfected into 293T Rabbit Polyclonal to Mammaglobin B cells. (physiciansontherise.org)

Positive staining was seen in 67 (55.4%) of 121 breast carcinomas with mammaglobin and in 28 cases (23.1%) with GCDFP-15. (medscape.com)

However, mammaglobin has not been extensively studied by immunohistochemical analysis in human tissues. (medscape.com)