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  • Mucinous
  • Microscopic characteristics of rhabdoid cells include: Oval to polygonal cell shape Eosinophilic, hyaline-like perinuclear agglomerations of intermediate filaments Compressed, eccentric nuclei Prominent central macronucleoli (one or two) Abundant eosinophilic cytoplasm Reticular chromatin pattern The differential diagnosis of LCLC-RP includes secondary metastatic lesions, melignant melanoma of the lung with rhabdoid phenotype, mucinous adenocarcinomas (particularly those featuring signet-ring cells), rhabdomyosarcoma, epitheloid angiosarcoma, pleural mesothelioma, and plasmacytoma. (wikipedia.org)
  • Mucinous cystadenoma is a benign cystic tumor lined by a mucinous epithelium. (wikipedia.org)
  • Mucinous adenocarcinoma Grubor, NM. (wikipedia.org)
  • salivary glands
  • 2000). "Utilisation des neutrons rapides dans le traitement des tumeurs des glandes salivaires : rationnel, revue de la littérature et expérience d'Orléans" [Use of fast neutrons in the treatment of tumors of the salivary glands: rationale, review of the literature and experience in Orleans]. (wikipedia.org)
  • Apocrine
  • Apocrine gland anal sac adenocarcinomas first appear as small lumps associated with one of the anal sacs (rarely bilateral), but they can grow to a large size. (wikipedia.org)
  • Apocrine gland anal sac adenocarcinomas also have a tendency to metastasize to the regional lymph nodes, spleen, and eventually lungs and, less commonly, bones. (wikipedia.org)
  • submandibular
  • Ultrasound: Ultrasound can be used to initially assess a tumour that is located superficially in either the submandibular or parotid gland. (wikipedia.org)
  • suppressor
  • In humans, aberrant expression of miRNAs contributes to carcinogenesis by promoting the expression of proto-oncogenes (a normal gene that has the potential to become an oncogene [a gene that can cause a cell to become malignant]) or by inhibiting the expression of tumor suppressor genes. (eurekalert.org)
  • induction of increased production of inhibitory guanine nucleotide regulatory proteins and components of extracellular signal-regulated kinase-mitogen-activated protein kinase signaling accumulation of iron and associated oxidative stress inactivation of the tumor suppressor gene BRCA1 and increased estrogen responsiveness (primarily in breast) impairment of retinoic acid metabolism. (wikipedia.org)
  • prognosis
  • By following a given procedure for each location in the large intestine, the number of lymph nodes can be analyzed for each location to find out if this differs and if prognosis is affected by lymph node numbers according to tumor site. (knowcancer.com)
  • Microscopic
  • The name of the tumor derives from the fact that: It has a varied microscopic architectural appearance, i.e. it is polymorphous. (wikipedia.org)
  • lymph
  • 9 In addition, capsule endoscopy has limited ability to evaluate submucosal lesions, or to fully characterize the invasive nature of a small bowel tumor, while MRI can delineate lesion extent as well as localize potential regional (lymph node or mesenteric) or even distal metastases (such as to the liver). (appliedradiology.com)
  • Aggressive surgical removal of the tumor and any enlarged sublumbar lymph nodes is essential for treatment of the tumor and associated hypercalcaemia. (wikipedia.org)
  • Metastases
  • Patients may survive for years with metastases because this tumor is generally well-differentiated and slow growing. (wikipedia.org)
  • histological
  • LCLC-RP were first recognized as a distinct entity under the 3rd (published in 1999) revision of the World Health Organization (WHO) lung tumor histological typing scheme. (wikipedia.org)
  • lungs
  • For example, X-rays of the chest may be taken to evaluate for spread of a tumor to the lungs. (petplace.com)
  • structures
  • In order for a LCLC to be subclassified as the rhabdoid phenotype variant, at least 10% of the malignant tumor cells must contain distinctive structures composed of tangled intermediate filaments that displace the cell nucleus outward toward the cell membrane. (wikipedia.org)
  • cells
  • Expression of immunomarkers in the rhabdoid cells, however, have often been noted to be weaker and more diffuse than those in the more differentiated tumor cells. (wikipedia.org)
  • metastasis
  • In fact, the prevalence of latent prostate cancer is high: 15% to 30% of men over 50 will have a prostatic adenocarcinoma that is thought to have low potential for growth and metastasis ( 3 ). (tumorijournal.com)
  • a cellular tumor exhibiting the characteristics of anaplasia and invasion and the potential for metastasis . (in.gov)
  • A term describing stage of disease for a malignant neoplasm that has spread to parts of the body remote from the primary tumor either by direct extension (beyond immediately adjacent organs or tissues) or by discontinuous metastasis (e.g., implantation or seeding) to distant organs, tissues, or via the lymphatic system to distant lymph nodes. (in.gov)
  • In advanced gastric cancers, the prognosis for patients with the SRCCs was significantly worse than for the other histological types, which can be explained by the finding that advanced SRCC gastric cancers have a larger tumor size, more lymph node metastasis, a deeper invasive depth and more Borrmann type 4 lesions than other types. (wikipedia.org)
  • mucinous tumors of the ovary have also been implicated, although in most cases ovarian involvement is favored to be a metastasis from an appendiceal or other gastrointestinal source. (wikipedia.org)
  • The sublumbar (iliac) lymph nodes are the most common site of metastasis and can become larger than the original tumor. (wikipedia.org)
  • A poorer prognosis is associated with large tumor size (greater than 10 cm), hypercalcaemia, and distante metastasis. (wikipedia.org)
  • Also indirectly VEGF-C can be responsible for hereditary lymphedema: The rare Hennekam syndrome can result from the inability of the mutated CCBE1 to assist the ADAMTS3 protease in activating VEGF-C. While a lack of VEGF-C results in lymphedema, too much VEGF-C is implicated in tumor angiogenesis and metastasis. (wikipedia.org)
  • VEGF-C can act directly on blood vessels to promote tumor angiogenesis and it can promote lymphangiogenesis, which might result in increased metastasis. (wikipedia.org)
  • metastatic tumor
  • Thus, we can conclude that insufficiency of immunological defense mechanisms leading to disruption of maligned cell elimination process is the primary pathogenic factor for metastatic tumor development. (ssmj.ru)
  • Several studies of the use of dendritic cell (DC) vaccines to attempt to treat measurable metastatic tumor deposits have been unsuccessful. (aacrjournals.org)
  • mucin
  • Highly differentiated adenocarcinomas form SRCCs via a loss of adherens and tight junctions that typically separate MUC4, a mucin protein, and ErbB2, an oncogenic receptor. (wikipedia.org)
  • The tumors cause fibrosis of tissues and impede digestion or organ function, and if left untreated, the tumors and mucin they produce will fill the abdominal cavity. (wikipedia.org)
  • resection
  • The Intergroup US 0116 Trial (INT 0116)[ 7 ] demonstrated survival improvement with the addition of chemoradiotherapy after negative-margin resection of tumors without distant metastases. (springer.com)
  • A tumor vaccine consisting of irradiated autologous tumor cells plus Bacillus Calmette-Guerin (BCG) has been used in phase III trials to treat patients after resection of primary colon cancer ( 6 , 7 ). (aacrjournals.org)
  • blood vessels
  • Tumors induce the proliferative vascular response of host blood vessels by influencing the local balance of angiogenic regulators, a rate-limiting step termed the angiogenic switch [ 9 , 10 ]. (hindawi.com)
  • The instability of tumor blood vessels is associated with the absence of a smooth muscle cell sheath [ 11 ]. (hindawi.com)
  • proliferative
  • Patients with evidence of a vaccine-induced, tumor-specific T-cell proliferative or IFNγ response 1 week after vaccination had a markedly better recurrence-free survival (RFS) at 5 years (63% versus 18%, P = 0.037) than nonresponders. (aacrjournals.org)
  • induce
  • We show that an autologous tumor lysate-pulsed DC vaccine can induce immune responses against autologous tumor in a high proportion of patients. (aacrjournals.org)
  • tissues
  • The naming issue to a certain extent reflects histological characteristics and development of the tumors, in which the different types of tissues are believed to either develop separately and join into a single mass (the "collision" theory), that an adenocarcinoma stimulates the stroma to create a tumor (the "composition" theory), or that the tumor is the result of a stem cell that differentiates into different cell types (the "combination" theory). (wikipedia.org)
  • adenoma
  • a malignant adenoma. (in.gov)
  • 2007) argued that continued use of non-malignant terms, i.e., adenoma, for those frequent cases with low-grade features (such as DPAM), is misleading because pseudomyxoma peritonei is a disease state that results from invasion of the abdominal cavity by cells with uncontrolled growth. (wikipedia.org)
  • Bradley states that an adenoma, by definition, is a tumor confined to the appendiceal mucosa with absolutely no evidence of invasion beyond the muscularis mucosae. (wikipedia.org)
  • Sarcoma
  • The behavior of MMMT overall is more related to the type and grade of the epithelium than the sarcoma, which suggests the sarcomal portion is an atypical "bystander" than primary driver of the tumor. (wikipedia.org)
  • abnormal
  • While it may seem that an increase in blood vessel quantity would provide sufficient oxygen to tumors, the abnormal vessels deliver less oxygen leading to a hypoxic tumor environment [ 13 ]. (hindawi.com)
  • lesions
  • the term carcinosarcoma was formerly used to describe lesions with homologous tumors, and "malignant mixed Müllerian tumor" or "mixed mesodermal tumor" was used to describe heterologous tumors. (wikipedia.org)
  • While this constitutes only 0.000165% of the human genome's approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumor suppressor genes) can impede a cell's ability to carry out its function and appreciably increase the likelihood of tumor formation and contribute to tumour heterogeneity. (wikipedia.org)
  • survival
  • Patients with node-positive disease had improved survival with adjuvant chemoradiotherapy, especially when we grouped patients with N1 and N2 tumors and a higher N-ratio. (springer.com)
  • We found an association between induction of an autologous tumor-specific immune response and improved recurrence-free survival. (aacrjournals.org)
  • In these trials, although overall survival was not increased, the patients who developed an immune response to their autologous tumor manifested improved survival compared with those who did not, suggesting that treatment with more potent vaccines could improve survival. (aacrjournals.org)
  • citation needed] Tumor development is a complex process that requires cell division, growth, and survival. (wikipedia.org)
  • One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. (wikipedia.org)
  • therapeutic
  • We suggest that vessel normalization could improve delivery of therapeutic drugs to brain tumors. (hindawi.com)
  • Pathologic examination of the specimen showed a well-differentiated adenocarcinoma ypT3N0 (12N−/12N) with a poor therapeutic response Dworak 1. (springeropen.com)
  • The failure of grading systems to predict accurately the malignant potential of individual tumors and the paucity of therapeutic options available have prevented many urologists from adopting these systems. (mysciencework.com)
  • Lung
  • For example, one group found a positive correlation between persistently activated tyrosine-phosphorylated STAT3 (pSTAT3), found in 50% of lung adenocarcinomas, and IL-6. (wikipedia.org)
  • Cancer
  • This retrospective study included patients with pathologically confirmed gastric adenocarcinoma who underwent surgical treatment with curative intent in a single cancer center in Brazil, between 1998 and 2008. (springer.com)
  • This is a retrospective study, which included patients with pathologically confirmed gastric adenocarcinoma who underwent surgical treatment with curative intent in a single cancer center in Brazil, in the period between September 1998 and December 2008. (springer.com)
  • cancer (or tumor) registry. (in.gov)
  • A data system designed for the collection, management, and analysis of data on persons with the diagnosis of a malignant disease ( cancer ). (in.gov)
  • The development of tumors in the thyroid is not a straightforward process, and several factors must come together before cancer can form. (vetinfo.com)
  • However, since many of the cancer cases are caught when it is too late, early check ups at the first signs are recommended, to help catch and remove tumors before they become life-threatening. (vetinfo.com)
  • Low-grade mucinous adenocarcinoma is used by the American Joint Committee on Cancer and World Health Organization and is nearly or completely synonymous with the DPAM designation. (wikipedia.org)
  • Autocrine signaling plays critical roles in cancer activation and also in providing self-sustaining growth signals to tumors. (wikipedia.org)
  • Another group found that high serum levels of IL-6 correlated with poor outcome in breast cancer tumors. (wikipedia.org)
  • This can eventually lead to malignant tumors, or cancer as per the two hit hypothesis. (wikipedia.org)
  • More recently CIP2A has been shown to regulate phosphorylation and activity of many other oncoproteins and to drive malignant cell growth and tumorigenesis in various human cancer types. (wikipedia.org)
  • In cancer, AXL is expressed on the tumor cells as well as adjacent immune cells including dendritic cells, macrophages, and NK cells. (wikipedia.org)
  • thyroid
  • The paper also contains an in-depth analysis of results of authors' own observations and study of immunological protection mechanisms of a significant number of patients diagnosed with oncopathologies of mammary and thyroid glands as well as adenocarcinoma of ascending colon. (ssmj.ru)
  • Malignant canine thyroid tumors are fairly common in dogs. (vetinfo.com)
  • Colloid goitre can occur in hypothrydoid dogs, and often occurs when tumors in the pituitary gland suppress the ability of the thyroid gland to produce the correct amount of hormones. (vetinfo.com)
  • Such malignant growth is known as thyroid adenocarcinoma. (vetinfo.com)
  • Frequent blood and urine tests may be used to establish the presence of a thyroid tumor. (vetinfo.com)
  • Treatment largely depends on the type of tumor present in the dog's thyroid. (vetinfo.com)
  • If the thyroid tumor is movable, this means it can likely be extracted in surgery. (vetinfo.com)
  • Also called malignant thyroid tumors, fixed tumors have spread into the surrounding areas. (vetinfo.com)
  • Approximately nine of 10 thyroid tumors are malignant and it is too late to completely remove or cure them. (vetinfo.com)
  • murine
  • In view of the 20- to 80-fold elevation of deoxycytidine-5'-phosphate (dCMP) deaminase in many human malignant tumors, we have utilized 5-fluorodeoxycytidine ( FdCyd ) coadministered with tetrahydrouridine ( H4Urd ) as a combination of antitumor agents against two murine solid tumors which possess high levels of dCMP deaminase. (semanticscholar.org)
  • In a murine model, we found that a tumor lysate-pulsed dendritic cell (DC) vaccine generated an order of magnitude greater antitumor immunity than immunization with irradiated tumor cells plus the classic adjuvant, Corynebacterium parvum ( 8 ). (aacrjournals.org)
  • ovaries
  • The SRCC tumor is often seen in the peritoneum and has also been known to spread to lymphatic permeation of the lungs and to the ovaries, creating Krukenberg tumors. (wikipedia.org)
  • characteristic
  • The infiltration and active destruction of tissue below the basement membrane , a characteristic of a malignant growth. (in.gov)
  • SRCC tumors grow in characteristic sheets, which makes diagnosis using standard imaging techniques, like CT and PET scans, less effective. (wikipedia.org)
  • Pancreas
  • Odze and Goldblum, Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas, 2nd ed.) also use the term mucinous adenocarcinoma when referring to low-grade, well-differentiated tumors lacking high-grade features. (wikipedia.org)
  • growth
  • Colocalization of vascular endothelial growth factor receptor 2 (VEGFR-2) and platelet-derived growth factor receptor beta (PDGF-R β ) reduces pericyte ensheathment of tumor vessels. (hindawi.com)
  • Modern views on the mechanisms of malignant growth. (ssmj.ru)
  • Moreover, CIP2A is required for the malignant cellular growth and for in vivo tumor formation. (wikipedia.org)
  • mutations
  • In striking contrast to the tumor suppressor p53, which in human tumors is mainly inactivated by mutations, PP2A complex proteins are mutated at low frequency (http://www.cbioportal.org) and rather seem to be inhibited by overexpression of PP2A inhibitor proteins such as CIP2A, PME-1 and SET. (wikipedia.org)
  • diagnosis
  • Anal sac adenocarcinomas are often suspected due to location (palpable masse in anal sac) and behavior, but a biopsy and histopathology is necessary for a definitive diagnosis. (wikipedia.org)
  • Develop
  • Between 25 and 40 percent of dogs with these tumors will also develop hypercalcaemia through secretion of parathyroid hormone-related protein by the tumor. (wikipedia.org)
  • therapies
  • Use of 5-fluorodeoxycytidine and tetrahydrouridine to exploit high levels of deoxycytidylate deaminase in tumors to achieve DNA- and target-directed therapies. (semanticscholar.org)
  • Risk factors are similar to those of adenocarcinomas and include obesity, exogenous estrogen therapies, and nulliparity. (wikipedia.org)
  • curative
  • The patient underwent a curative proctectomy followed by a hand-sewn coloanal anastomosis using Lone Star Retractor™ 2 years ago for a tumor of the lower rectum. (springeropen.com)
  • mechanism
  • Because the presence of PTPkappa at the cell membrane was shown to sequester β-catenin to the plasma membrane, these data suggest that one mechanism whereby PTPkappa functions as a tumor suppressor is by regulating the intracellular localization of free-β-catenin. (wikipedia.org)