Malignant testicular tumor. Medical search. Frequent questions

Testicular germ cell tumors are divided into two main types, seminoma and nonseminoma. (cigna.com)
Seminoma: This is a slow-growing form of testicular cancer found in men in their 40s and 50s. (medlineplus.gov)
Commonly associated cancers include SCLC, seminoma or other testicular tumors , breast cancer , Hodgkin lymphoma , and thymoma . (logicalimages.com)
Treatment with radiotherapy is highly successful when the tumor is diagnosed in localized stages, which represents the majority of presentations of seminoma. (mycancergenome.org)
There are 2 clinical trials for testicular seminoma, of which 2 are open and 0 are completed or closed. (mycancergenome.org)
Of the trials that contain testicular seminoma as an inclusion criterion, 1 is phase 3 (1 open) and 1 is no phase specified (1 open). (mycancergenome.org)
Observation and surgery are the most common interventions in testicular seminoma clinical trials. (mycancergenome.org)
Subsequent tests showed the mass to be cancerous but not malignant, a type of cancer known as smooth-type seminoma. (rockymountaincancercenters.com)
Seminoma is the most common pure germ cell tumor (GCT) of the testis, accounting for up to 50% of cases. (medscape.com)
1] Among mixed GCTs, seminoma is also commonly present in combination with teratoma, yolk sac tumor, and/or embryonal carcinoma. (medscape.com)
Such tumors are still classified as mixed GCT, even if the seminoma is the main component. (medscape.com)
Overall, 60% of germ cell neoplasms have seminoma in their composition, but pure seminomas are genetically different from those that present as a component of a mixed tumor. (medscape.com)
Well-defined associations of seminoma are: cryptorchidism, familial history or a previous testicular GCT, certain intersex syndromes, and oligospermic infertility. (medscape.com)
The mean age at presentation of patients with seminoma is 40 years, which is 5-10 years older than in patients with nonseminomatous testicular tumors. (medscape.com)
Patients with Disorders of Sex Development (DSD), especially those with gonadal dysgenesis and hypovirilization are at risk of developing malignant type II germ cell tumors/cancer (GCC) (seminoma/dysgerminoma and nonseminoma), with either carcinoma in situ (CIS) or gonadoblastoma (GB) as precursor lesion. (eur.nl)
Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) 17. (sncrf.org)
The peak incidence is in the third decade of life for non-seminomatous germ cell tumour (NSGCT) and mixed GCT patients, and in the fourth decade for seminoma testis (ST) patients. (uroweb.org)

In addition, scrotal masses that do not involve the testicle are rarely malignant. (medscape.com)
Early diagnosis and treatment mean that more than 95% of men can be cured of testicular cancer, even if it has spread beyond the testicle itself. (baus.org.uk)
This cancer causes the testicle to shrink, and the tumor essentially replaces it. (rockymountaincancercenters.com)
Since it's not a mass growing on the testicle, it does not result in the "lumps and bumps" that are the more common symptoms of testicular cancer. (rockymountaincancercenters.com)
The surgery to remove Dr. Gallizzi's cancerous testicle entailed an incision in his abdomen and the removal of the tumor, testicle, lymph nodes, and any other places where cancer cells could be hiding. (rockymountaincancercenters.com)
Testicular cancer is a malignant tumour that begins in the cells of a testicle. (westernfinancialgroup.ca)
In testicular cancer cases, this can include the removal of the affected testicle or testicles. (mdanderson.org)
Due to economic reasons, I submitted the testicular tumour and not the other atrophied scrotal testicle. (asiahomes.com)
A malignant tumor in the testicle is known as testicular cancer. (naturefrsh.com)

The two main types of stromal tumors are Leydig cell tumors and Sertoli cell tumors. (medlineplus.gov)
Less frequently, a tubular morphology can be seen (see the images below), posing a differential diagnosis with Sertoli cell tumor. (medscape.com)
From the appearance, the testicular tumour is a Sertoli cell tumour. (asiahomes.com)
Mutations in SRY as well as WT1 can lead to diminished expression and function of SRY, resulting in sub-optimal SOX9 expression, Sertoli cell formation and subsequent lack of proper testicular development. (eur.nl)
The tumor was histologically diagnosed as malignant Sertoli cell tumor pT1N0M0. (bvsalud.org)
Thoracoscopic left upper lobectomy was performed 64 months after the operation, and the pathological diagnosis was metastasis of malignant Sertoli cell tumor. (bvsalud.org)

Malignant germ cell tumors include several types of cancer, such as immature teratoma, yolk sac tumor and choriocarcinoma. (childrensoncologygroup.org)
A teratoma is a tumor that may contain several different types of tissue, such as hair, muscle and bone. (childrensoncologygroup.org)

In the United States, the age-adjusted incidence rate for testicular cancer has been estimated at 5.5 cases per 100,000 men per year. (medscape.com)
[ 4 ] Testicular cancer is common in the United States, with almost 8,000 new cases presenting each year, although the death rate is relatively low at 370 deaths per year. (medscape.com)
With regard to racial distribution in the United States, testicular cancer has a clearly higher predisposition in whites. (medscape.com)
With regard to age-related statistics, the median age for diagnosis for cancer of the testes in the United States has reported at 33 years and for death from testicular cancer at 40 years. (medscape.com)
Testicular cancer rates in developed European countries are slightly higher than in the United States, at 8-9 cases per 100,000 men per year. (medscape.com)
The key anatomical factor in testicular cancer is that the lymphatic drainage of the scrotum is into the lower legs, while the lymphatic drainage of the testicles is into the abdomen and retroperitoneal lymph nodes. (medscape.com)
More than 95% of testicular parenchymal abnormalities are identifiable on routine sonograms, but several other lesions commonly mimic testicular cancer. (medscape.com)
Guidelines for the Implementation of a Testis-sparing Approach to Testicular Cancer. (medscape.com)
1999) Incidence of testicular cancer in the United States: has the epidemic begun to abate? (medscape.com)
2005) Risk of contralateral testicular cancer: a population-based study of 29,515 U.S. men. (medscape.com)
2003) Histology and clinical outcomes in patients with bilateral testicular germ cell tumors: the Memorial Sloan Kettering Cancer Center experience 1950 to 2001. (medscape.com)
1995) Bilateral synchronous testicular germ cell cancer. (medscape.com)
1999) Semen quality and reproductive hormones before orchiectomy in men with testicular cancer. (medscape.com)
2006) Management of bilateral testicular germ cell tumours-experience of the German Testicular Cancer Study Group (GTCSC) [abstract]. (medscape.com)
Testicular cancer is cancer that starts in the testicles. (medlineplus.gov)
The exact cause of testicular cancer is poorly understood. (medlineplus.gov)
Testicular cancer is the most common cancer in young and middle-aged men. (medlineplus.gov)
There is no link between vasectomy and testicular cancer. (medlineplus.gov)
Nonseminoma: This more common type of testicular cancer tends to grow more quickly than seminomas. (medlineplus.gov)
Testicular cancer is one of the most treatable and curable cancers. (medlineplus.gov)
If your GP is concerned that you could have testicular cancer, you may be referred urgently to the urology department using the fast-track ( 2-week wait ) referral system. (baus.org.uk)
In clinical practice, she concentrates on germ cell tumors, while her epidemiologic research primarily focuses on colorectal cancer screening and prevention. (dana-farber.org)
Our objective was to determine if CDK2AP1 mRNA expression levels were consistent with tumour-suppressive functions in breast cancer. (cancerindex.org)
Borussia Dortmund striker Sebastien Haller made his competitive return following testicular cancer in Sunday's thrilling 4-3 Bundesliga victory over Augsburg. (independent.co.uk)
In honor of Testicular Cancer Awareness Month, Dr. Michael Gallizzi, MD, MS, FAAOS , of Denver, Colorado, wants everyone to learn one new thing: "Know that there are different types of testicular cancer. (rockymountaincancercenters.com)
A Minimally Invasive Spine Surgeon at Sky Ridge Medical Center, Dr. Gallizzi's knowledge of testicular cancer was purely academic until the age of 39. (rockymountaincancercenters.com)
Though testicular cancer has a very high treatment success rate, Dr. Gallizzi says each appointment for ongoing monitoring is intense and nerve-wracking. (rockymountaincancercenters.com)
Neutering male dogs can significantly reduce the chance of developing testicular cancer and other prostate problems. (petinsurancereview.com)
The fact that latent periods for testicular cancer were very short, for hematolymphatic tumors longer and solid tumors still longer suggests a coherent and biologically plausible pattern of latency in relation to the onset of exposure to electromagnetic fields and other agents. (stopumts.nl)
For the 12 cancer sites with at least 50 cases identified by the algorithm, the PPV ranged from a high of 99.6% for breast and testicular cancers (95% CI: 97.8-100.0 and 97.7-100.0, respectively) to a low of 78.1% (95% CI: 71.3-83.9) for non-Hodgkin lymphoma. (health.mil)
The Automated Central Tumor Registry (ACTUR) has been the centralized cancer registry for the Department of Defense since its launch in 1986. (health.mil)
Researchers in Australia compared the qualities of testicular mesothelioma with more common types of this cancer. (survivingmesothelioma.com)
Neutering your male companion prevents testicular cancer and some prostate problems. (aspca.org)
Let's talk about the diseases that can afflict the male population: Prostate Cancer, Testicular Cancer and Penile Cancer. (westernfinancialgroup.ca)
In 2015, it is estimated that 1,050 Canadian men were diagnosed with testicular cancer. (westernfinancialgroup.ca)
Testicular cancer is the most common cancer in young Canadian men aged 15 - 29 years. (westernfinancialgroup.ca)
What is testicular cancer? (westernfinancialgroup.ca)
Children's Cancer Hospital offers the most up-to-date and advanced chemotherapy options for childhood germ cell tumors. (mdanderson.org)
New radiation therapy techniques and remarkable skill allow Children's Cancer Hospital doctors to target tumors more precisely, delivering the maximum amount of radiation with the least damage to healthy cells. (mdanderson.org)
Children's Cancer Hospital is committed to providing the most advanced treatments for childhood germ cell tumors with the least impact on your child's body, today and in the future. (mdanderson.org)
Children's Cancer Hospital offers a range of clinical trials for childhood germ cell tumors. (mdanderson.org)
Childhood germ cell tumors are treated in our Children's Cancer Hospital and our Proton Therapy Center. (mdanderson.org)
This form of dog cancer is an incurable tumor of cells that line blood vessels, called endothelial cells. (newportharborvets.com)
This form of dog cancer develops slowly and is essentially painless, so clinical signs are usually not evident until the advanced stages when the tumors are resistant to most treatments. (newportharborvets.com)
This form of dog cancer is the most common type of primary bone cancer in dogs, accounting for up to 85% of tumors that originate in the skeletal system. (newportharborvets.com)
Approximately 50% of these tumors are malignant, and complete surgical removal is recommended if the cancer has not metastasized. (newportharborvets.com)
Testicular cancer and infections that can lead to malignant or benign swelling of the prostate. (westernvet.com)
Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (sncrf.org)
Epithelial tumors of nasal cavity, sinuses, nasopharynx: A) Squamous cell carcinoma with variants of nasal cavity, sinuses, and nasopharynx and trachea (excluding laryngeal, nasopharyngeal cancer [NPC], and squamous cell carcinoma of the head and neck [SCCHN]) B) Adenocarcinoma and variants of nasal cavity, sinuses, and nasopharynx (closed to accrual 07/27/2018) 2. (sncrf.org)
Unfortunately, there continues to be a lack of clinical insight into the unique needs of younger men with testicular cancer. (bvsalud.org)
Providers and clinicians need to approach testicular cancer survivors with the tools and strategies that meet these unmet needs for navigation from diagnosis through survivorship. (bvsalud.org)
Testicular cancer represents 1% of adult neoplasms and 5% of urological tumours, with three to ten new cases per 100,000 males/per year in Western societies [ 6 ]. (uroweb.org)
Testicular cancer has increased during recent decades, predominantly in industrialised countries [ 7 , 8 ], and it continues to rise. (uroweb.org)
Some of the symptoms of testicular cancer are lumps in any of the testicles, enlarged testicles, fluid retention in the scrotum, heaviness in the scrotum, pain the lower abdomen and groin and lower back pain. (naturefrsh.com)
There is no fixed diet that prevents testicular cancer, but consuming certain foods can reduce the risk of the same. (naturefrsh.com)
Consuming food rich in selenium such as Brazil nuts, wild salmon, shrimp, and sardines helps to reduce the chances of testicular cancer occurring. (naturefrsh.com)
It has the ability to slow the growth of tumors, prevent DNA damage, normalize cell growth, promote programmed cancer cell death, improve the body's ability to detect cancer cells and inhibit cancer stem cells. (naturefrsh.com)
Consume whole grains such as oatmeal, brown rice, quinoa, and air-popped popcorn to stay protected against testicular cancer. (naturefrsh.com)
Methods: In a pooling project of nine population-based cancer registries in Germany for the years 1998-2008, 16,883 malignant GCTs and their topographical sites were identified using ICD-O morphology and topography for persons aged 15 years and older. (uni-luebeck.de)
General reference Testicular cancer begins as a scrotal mass, which is usually not painful. (msdmanuals.com)
Testicular cancer is the most common solid cancer in males aged 15 to 35. (msdmanuals.com)
The cause of testicular cancer is unknown. (msdmanuals.com)
Key statistics for testicular cancer. (msdmanuals.com)
The data presented in this edition of Cancer Incidence in Five The CI5 data include all invasive malignant neoplasms and Continents (CI5) are mainly organised according to anatomical some non-invasive malignant neoplasms For most morphology site However, for some sites, the histological type of cancer codes, a fifth digit /1 or /2 automatically excludes the data entry. (who.int)
Other specified malignant neoplasm (Other specified cancer tumour Other codes are obsolete, ie the entities have been in the previous edition). (who.int)
Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)
Testicular cancer: the perfect paradigm for marker combinations. (cancercentrum.se)
CHICAGO - A substantial percentage of testicular cancer survivors have low testosterone levels, which in turn puts them at risk for a plethora of chronic health conditions, including hypertension , diabetes, erectile dysfunction , anxiety , and depression , according to findings from a large multicenter study. (medscape.com)
Testicular cancer occurs at a young age and is highly curable, and patients can expect to live for 40 years after their diagnosis, but there is a long-term risk for late complications from treatment," said lead study author Mohammad Issam Abu Zaid, MBBS, an assistant professor of medicine at the Indiana University School of Medicine in Indianapolis. (medscape.com)
Clinical and genetic factors can increase the risk for hypogonadism, and providers should screen testicular cancer survivors for hypogonadism and treat those with symptoms," he said. (medscape.com)
As previously reported by Medscape Medical News, survivors of testicular cancer face a worrisome risk of developing certain metabolic effects, such as hypertension, that are tied to platinum-based chemotherapy. (medscape.com)
Although it's been known for some time that low testosterone levels occur in a significant proportion of survivors of testicular cancer, the current study is one of the first to examine its relationship with long-term health complications in North American patients. (medscape.com)
One European study , for example, reported that the prevalence of metabolic syndrome was higher among survivors of testicular cancer who were homozygous for a single-nucleotide polymorphism (SNP), rs523349 (V89L), in 5-α-reductase gene ( SRD5A2 ). (medscape.com)
In the current study, Dr Zaid and his colleagues evaluated the first 491 patients who are participants in the Platinum Study, which aims to be the largest study of survivors of testicular cancer worldwide. (medscape.com)
SHBG polymorphisms appear important in survivors of testicular cancer, but the study was underpowered to confirm an association, Dr Zaid commented. (medscape.com)
Our findings underscore the need for clinicians to assess testicular cancer for physical signs or symptoms of hypogonadism and to measure testosterone in those who do," he concluded. (medscape.com)
Examining cancer incidence (i.e., diagnoses) in addition to deaths from cancer is preferable when assessing risks of cancers that tend to have higher survival rates, such as testicular, bladder, breast, and prostate cancers. (cdc.gov)

Childhood extracranial germ cell tumors are grouped as gonadal or extragonadal extracranial tumors. (cigna.com)
Gonadal germ cell tumors form in the gonads (testicles and ovaries). (cigna.com)
Müllerian duct structures typically develop on the gonadal side not containing testicular tissue. (medscape.com)
Wolffian duct structures tend to be observed on the gonadal side containing functioning testicular tissue. (medscape.com)
Malignant gonadal tumors are rare (less than 3% of cases). (orpha.net)
Definitive diagnosis is based on gonadal histology (testicular and ovarian tissue). (orpha.net)
Differential diagnoses include other DSD, including mixed gonadal dysgenesis and 46,XX testicular DSD. (orpha.net)
Differences in behavior and clinical outcome suggest that mediastinal seminomas are biologically different from gonadal seminomas and can develop de novo without a testicular primary focus. (medscape.com)
Frasier syndrome (FS) is characterized by gonadal dysgenesis with a high risk for development of GB as well as chronic renal failure in early adulthood, and is known to arise from a splice site mutation in intron 9 of the Wilms' tumor 1 gene (WT1). (eur.nl)
Background: Malignant gonadal (GGCT) and extragonal germ cell tumors [GCT (EGCT)] are thought to originate from primordial germ cells. (uni-luebeck.de)
Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)

The disease-free survival rate for Stage II and III cancers is slightly lower, depending on the size of the tumor and when treatment is begun. (medlineplus.gov)
Many of the patients were young (7 patients under 20 years and 17 patients between 20 and 29 years) and had extremely short latent periods, especially for hematolymphatic tumors and testicular cancers. (stopumts.nl)
Most testicular cancers originate in primordial germ cells. (msdmanuals.com)
Significant differences in survival were revealed when comparison was made with developing countries, for people with cancers that can be successfully treated by chemotherapy (malignant lymphomas, leukaemia, testicular tumours) and modest differences for neoplasms that can be cured by early detection and surgical intervention. (who.int)

Neutering your male dog at a young age will have reduced the chances of the dog developing circum-anal tumours and testicular tumours. (asiahomes.com)
An introduction to the WHO 5th edition 2022 classification of testicular tumours. (who.int)

these are rare tumors that are malignant in only about 10% of the cases. (medscape.com)
In addition, she is cochair of two national protocols that opened in 1999 for the treatment of low-risk and high-risk pediatric germ cell tumors and chair of the COG Germ Cell subcommittee in COG Rare Tumors. (dana-farber.org)
This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. (sncrf.org)
Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: [email protected]] (closed to accrual 03/15/2019) 34. (sncrf.org)

In female Pitbulls, spaying decreases the incidence of breast tumors, which are usually malignant or cancerous in roughly 50% of dogs. (petinsurancereview.com)
Spaying prevents uterine infections and decreases the incidence of breast tumors, which are malignant or cancerous in about 50 percent of dogs and 90 percent of cats. (aspca.org)
Results: Among males, the incidence of testicular GCTs increased over time. (uni-luebeck.de)
Conclusions: Our results underline different incidence trends and distinct age-specific incidence patterns of malignant GGCTs and EGCTs, as reported recently by several population-based registries. (uni-luebeck.de)
Incidence and occurrence of second primary tumors. (cancercentrum.se)

Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. (sncrf.org)

Most affected patients require surgery and chemotherapy because of the aggressive nature of the tumors, but the overall prognosis is excellent. (medscape.com)
The former West Ham player underwent chemotherapy after a malignant tumour was discovered in July, just days after he joined the German club from Ajax in a reported £27million deal. (independent.co.uk)
Recently suggested associations include high estrogen levels, previous radiotherapy or chemotherapy, exposure to organochlorine,[11] abusive use of marijuana,[12] testicular microlithiasis, and nutrition status during infancy, but these reports lack confirmation. (medscape.com)
Although some oral chemotherapy and radiation therapy can control some inoperable tumors, surgical intervention may be recommended if the tumor is operable. (newportharborvets.com)
Since the discovery of platinum-based chemotherapy, testicular germ cell tumors are a highly curable disease. (urotoday.com)
Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)

A stromal tumor is a rare type of testicular tumor. (medlineplus.gov)
Stromal tumors usually occur during childhood. (medlineplus.gov)
Gastrointestinal stromal tumor (GIST) (closed to accrual 09/26/2018) 38. (sncrf.org)
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)

Evaluation of prevalence and outcomes of serial tyrosine kinase inhibitor use in pediatric patients with advanced solid tumors. (dana-farber.org)
Context Therapeutics Inc. is a biopharmaceutical company focused on improving the lives of patients living with solid tumors. (stockhouse.com)
CLDN6 is a tight junction membrane protein target expressed in multiple solid tumors, including ovarian, lung, and testicular, and absent from or expressed at low levels in healthy adult tissues. (stockhouse.com)
Claudin 6 is expressed on multiple solid tumors such as ovarian, lung and testicular. (stockhouse.com)

age range, 14-61 years) with nonpalpable testicular lesions were consecutively enrolled between 2006 and 2012 and underwent unenhanced scrotal US, contrast-enhanced US, surgical enucleation, and at least 18 months of follow-up. (ox.ac.uk)
Quantitative scrotal contrast-enhanced US is a noninvasive diagnostic tool that could improve the differential diagnosis and individualized management of small testicular lesions. (ox.ac.uk)
Scrotal trauma (testicular hematoma). (dawasante.net)

60%). Nonseminomas include teratomas, embryonal carcinomas, endodermal sinus tumors (yolk sac tumors), and choriocarcinomas. (msdmanuals.com)

In contrast, tumors arising in the retroperitoneum are virtually always associated with premalignant lesions in one of the testes and behave clinically similar to metastatic testicular seminomas. (medscape.com)

Germ cell tumors (GCTs) account for nearly all (95%) primary testicular tumors. (medscape.com)
2002) Bilateral testicular germ cell tumors. (medscape.com)
2005) Management and outcome of bilateral testicular germ cell tumors: twenty-five year experience in Munich. (medscape.com)
1988) Simultaneous bilateral testicular germ cell tumors with dissimilar histology: case report and review of the literature. (medscape.com)
Weissbach L (1995) Organ preserving surgery of malignant germ cell tumors. (medscape.com)
1995) A conservative approach to bilateral testicular germ cell tumors. (medscape.com)
Childhood extracranial germ cell tumors form from germ cells in parts of the body other than the brain. (cigna.com)
This summary is about germ cell tumors that form in parts of the body that are extracranial (outside the brain). (cigna.com)
Extracranial germ cell tumors are most common in adolescents, with rates in this age group lower for females than males. (cigna.com)
For information on intracranial (inside the brain) germ cell tumors, see Childhood Central Nervous System Germ Cell Tumors Treatment. (cigna.com)
Childhood extracranial germ cell tumors may be benign or malignant. (cigna.com)
Malignant extracranial germ cell tumors are tumors that form outside the brain. (cigna.com)
Testicular germ cell tumors usually occur before the age of 4 years or in adolescents and young adults. (cigna.com)
Testicular germ cell tumors in adolescents (11 years and older) and young adults are different from those that form in early childhood. (cigna.com)
Ovarian germ cell tumors are more common in adolescent girls and young women. (cigna.com)
Most ovarian germ cell tumors are benign mature teratomas (dermoid cysts). (cigna.com)
Extragonadal extracranial germ cell tumors form in areas of the body other than the brain or gonads (testicles and ovaries). (cigna.com)
Most extragonadal extracranial germ cell tumors form along the midline of the body. (cigna.com)
In children younger than 11 years, extragonadal extracranial germ cell tumors usually occur at birth or in early childhood. (cigna.com)
In older children, adolescents, and young adults (11 years and older), extragonadal extracranial germ cell tumors are often in the mediastinum. (cigna.com)
and (3) treatment of germ cell tumors in pediatric patients. (dana-farber.org)
In clinical care, Dr. Frazier is the national expert on germ cell tumors in pediatric patients and oversees the care of these patients referred to DFCI. (dana-farber.org)
A malignant germ cell tumor arising from the testis. (mycancergenome.org)
Following intravenous bolus administration of 30 units of bleomycin to one patient with a primary germ cell tumor of the brain, a peak CSF level was 40% of the simultaneously-obtained plasma level and was attained in two hours after drug administration. (nih.gov)
Germ cell tumors are growths that occur in children, teens and adults. (childrensoncologygroup.org)
Germ cell tumors are rare, about 900 children and adolescents are diagnosed in the United States each year. (childrensoncologygroup.org)
Germ cell tumors most commonly appear in the gonads (sex organs). (childrensoncologygroup.org)
Germ cell tumors can be malignant (life-threatening) or benign (not life-threatening). (childrensoncologygroup.org)
Benign germ cell tumors include certain kinds of teratomas. (childrensoncologygroup.org)
Although not as difficult to treat as malignant tumors, benign germ cell tumors can cause problems because of their size. (childrensoncologygroup.org)
These may require taking samples for blood chemistry, blood cell count, genetics and certain proteins called tumor markers such as AFP and bhCG that are produced by some germ cell tumors. (childrensoncologygroup.org)
After a germ cell tumor is diagnosed, doctors need to assess how advanced it is, which is called staging the tumor. (childrensoncologygroup.org)
Because germ cell tumors can vary greatly, and can arise in different parts of the body, they can be difficult to stage. (childrensoncologygroup.org)
However, the Children's Oncology Group (COG) developed the following system for staging germ cell tumors. (childrensoncologygroup.org)
The exact cause of germ cell tumors is not completely understood. (childrensoncologygroup.org)
Treatment for germ cell tumors depends upon the child's age and overall health, the types of tissues in the tumor, the tumor's location, the child's tolerance for specific types of procedures and the overall prognosis. (mdanderson.org)
Treatment for childhood Germ Cell Tumors often includes surgery. (mdanderson.org)
Malignant germ cell tumors can spread to other parts of the body before they are diagnosed. (mdanderson.org)
Non-epithelial tumors of the ovary: A) Germ cell tumor of ovary B) Mullerian mixed tumor and adenosarcoma (closed to accrual 03/30/2018) 14. (sncrf.org)
Most malignant post-pubertal GCTs originate from germ cell neoplasia " in situ " (GCNIS). (uroweb.org)
Testicular germ cell tumors make up 0.5% of pediatric malignancies, and 14% of adolescent malignancies. (urotoday.com)
however, adolescent histology is mostly mixed nonseminomatous germ cell tumor. (urotoday.com)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)

Testicular adrenal rest tumors (TARTs), commonly occurring in males with congenital adrenal hyperplasia, may arise from chronic stimulation of adrenocorticotropic hormone (ACTH)-sensitive cells in the testes. (bvsalud.org)

Commonly seen as a painless mass in the scrotum (the skin that holds the testicles), parents are most likely to notice the development of these tumors in small boys. (childrensoncologygroup.org)
There may be signs of diseases that caused a decrease in the number of sperm: pain in the groin, discharge from the urethra, enlarged scrotum, testicular edema. (dawasante.net)

Cancerous mammary tumors that can spread to other parts of the body. (westernvet.com)

Additionally, testicular and ovarian tissue may develop on the same side of the pelvis as a separate ovary and testis. (medscape.com)
The testis is usually enlarged, and the tumor nodule may distort the external appearance of the organ (see the image below). (medscape.com)
Testicular mesothelioma is also called paratesticular or mesothelioma of the tunica vaginalis testis. (survivingmesothelioma.com)

Most tumors originate from either the PLEURA or PERITONEUM, tumors may also originate in the PERICARDIUM or testicular tissue. (bvsalud.org)

An adenomatoid tumor is a benign neoplasm of mesothelial origin that can be found in both female and male genital tracts, but it is more commonly found in the male adnexa, where it is the most common benign neoplasm. (medscape.com)

Ultrasonography is the standard imaging technique used to identify testicular carcinoma. (medscape.com)
The malignant lesions comprised three cases of ductal carcinoma in situ (DCIS) and 22 cases of infiltrating ductal carcinoma, not otherwise specified, IDC (NOS). (ijpmonline.org)
Rare pancreatic tumors including acinar cell carcinoma, mucinous cystadenocarcinoma or serous cystadenocarcinoma. (sncrf.org)
Epithelial tumors of penis - squamous adenocarcinoma cell carcinoma with variants of penis (closed to accrual) 18. (sncrf.org)
Pancreatic neuroendocrine tumor (PNET) (formerly named: Endocrine carcinoma of pancreas and digestive tract. (sncrf.org)
Similarly, under Carcinoma, specific renamed or deleted in later revisions of tumour classifications. (who.int)

Adenomatoid tumors are most commonly located in the male genital tract, in the lower pole of the epididymis, followed by the tunica vaginalis and spermatic cord. (medscape.com)

Yolk sac tumors, which are also known as endodermal sinus tumors, are the most common prepubertal GCTs. (medscape.com)

Differential diagnosis of nonpalpable testicular lesions: qualitative and quantitative contrast-enhanced US of benign and malignant testicular tumors. (ox.ac.uk)
This antibody is also used as a component of panels to differentiate benign and malignant breast lesions. (ijpmonline.org)

on rare occasions, it may extend to the testicular parenchyma (most often tumors of the upper pole). (medscape.com)
H&E stain of ovotestis demonstrating ovarian parenchyma (left) with multiple primary follicles and testicular parenchyma (right). (medscape.com)
It replaces most of the testicular parenchyma but is organ confined. (medscape.com)

Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)

Non-spayed female dogs are at high risk for developing malignant mammary tumors, but all female dogs regardless of reproductive state remain at risk. (newportharborvets.com)

In a new study published in Archives of Pathology & Laboratory Medicine , researchers looked at nine cases of testicular mesothelioma. (survivingmesothelioma.com)

Testicular tumor of the adrenogenital syndrome (TTAGS) has also been referred to as testicular adrenal rest tumors (TARTs). (clinicalpub.com)
Adrenal cortical tumors (closed to accrual 06/27/2018) 32. (sncrf.org)

Teratomas and teratocarcinomas are considered malignant in adults and constitute 30% of nonseminomatous lesions. (medscape.com)
Most of these tumors are benign teratomas in the sacrum or coccyx. (cigna.com)

Mutation of FOXL2 in granulosa-cell tumors of the ovary. (cancercentrum.se)
Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. (cancercentrum.se)
Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)

Seven out of the nine cases of testicular mesothelioma were of the epithelioid cell type, while the other two cases were biphasic. (survivingmesothelioma.com)

A diagnosis of OT-DSD is based solely on the presence of ovarian and testicular tissue in the gonad and not on the characteristics of the internal and external genitalia, even if ambiguous. (medscape.com)
Patients with ovotesticular disorder of sexual development are individuals who have both ovarian and testicular tissue. (medscape.com)
Development of external genitalia ranges from apparent female to male genitalia with hypospadias or isolated bilaterally undescended ovotestes (gonads containing ovarian and testicular elements). (orpha.net)

Testicular GCT is the most prevalent solid malignancy affecting young male adults (most commonly from age 30 to 49 years). (medscape.com)

Ovotestis refers to the histology of a gonad that contains both ovarian follicles and testicular tubular elements. (medscape.com)

Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome. (cancercentrum.se)
Bjorkholm E, Silfversward C. Granulosa- and theca-cell tumors. (cancercentrum.se)

These tumors form in the part of the chest between the breastbone and spinal column and can grow without symptoms until they become quite large. (childrensoncologygroup.org)

Additional risk factors include a family history of TC among first-degree relatives and the presence of a contralateral testicular tumour or GCNIS [ 15-22 ]. (uroweb.org)

Even with treatment, this tumor has a very poor prognosis with a median survival of about 23 months. (survivingmesothelioma.com)

Molecular Characterization of Testicular Mesothelioma and the Role of Asbestos as a Causative Factor [published online ahead of print, 2023 Feb 16]. (survivingmesothelioma.com)

Results -We detected MAGE-B mRNA in canine testicular tissue but not in melanoma biopsy specimens. (avma.org)

Adenomatoid tumors represent 30% of the tumors of the testicular adnexa and 60% of benign tumors of these structures. (medscape.com)
The mesothelial origin of adenomatoid tumors is currently accepted based on ultrastructural and immunohistochemical analyses. (medscape.com)
[ 4 ] Adenomatoid tumors typically have no distinct growth pattern. (medscape.com)
The three patterns of adenomatoid tumors recognized by Taxy et al are plexiform, tubular, and canalicular, with most cases showing a mixture of multiple patterns. (medscape.com)

Objective -To develop a reverse transcriptase-polymerase chain reaction (RT-PCR) assay to detect canine melanoma-associated antigens (MAAs) and to use this technique to screen aspirates of lymph nodes (LNs) for evidence of metastatic spread of oral malignant melanoma. (avma.org)
Animals -7 dogs with oral malignant melanoma and 4 dogs with multicentric lymphosarcoma. (avma.org)
Procedures -We prepared cDNA from melanoma tumor biopsies and fine-needle aspirates obtained from submandibular LNs of dogs with oral malignant melanoma or multicentric lymphosarcoma. (avma.org)
Tyrosinase, Melan-A, gp100, and TRP-2 mRNAs were detected in tumor biopsy specimens and in 2 of 5 LN aspirates from dogs with melanoma, suggesting metastatic spread in those 2 dogs. (avma.org)
Conclusions and Clinical Relevance -Clinical staging of dogs with oral malignant melanoma is useful to assist in designing appropriate treatments. (avma.org)

Ovotestes are usually compartmentalized, with connective tissue separating the ovarian components from the testicular components. (medscape.com)
A rare disorder of sex development (DSD) characterized by histologically confirmed testicular and ovarian tissue in an individual with a 46,XX karyotype. (orpha.net)

To stage the tumor, doctors will need to know the size of the tumor, if it has spread (metastasized) and if it has affected lymph nodes and other tissues. (childrensoncologygroup.org)

Testicular malignancies appear as a hypoechoic mass in the vast majority of cases. (medscape.com)

Salivary gland type tumors of head and neck, lip, esophagus, stomach, trachea and lung, breast and other location (closed to accrual) 4. (sncrf.org)

If germ cells do not reach their intended destination, tumors occur wherever these cells end up. (childrensoncologygroup.org)

For this reason, transscrotal testicular biopsy is not recommended. (medscape.com)

About half of all malignant mesotheliomas are epithelioid. (survivingmesothelioma.com)
Perivascular epithelioid cell tumor (PEComa) 39. (sncrf.org)

2006) Value of frozen section analysis with suspected testicular malignancy. (medscape.com)

The 2022 World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs-Part B: Prostate and Urinary Tract Tumors. (who.int)

Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of 23 cases of benign and 25 cases of malignant breast lesions using avidin biotin peroxidase technique. (ijpmonline.org)

Anatomy4

Organisms1

Diseases22

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes2

Disciplines and Occupations1

Health Care1

Seminoma17

Testicle9

Sertoli6

Teratoma2

Cancer77

Gonadal11

Cancers4

Tumours2

Rare tumors4

Incidence5

Choriocarcinoma1

Chemotherapy6

Stromal5

Solid tumors4

Scrotal3

Embryonal1

Seminomas1

Germ cell45

Testes1

Scrotum2

Cancerous1

Testis3

Originate1

Neoplasm1

Carcinoma6

Epididymis1

Endodermal sinus tumors1

Benign and malignant2

Parenchyma3

GCTs2

Mammary tumors1

Pathology1

Adrenal2

Teratomas2

Ovary4

Cases of testicular1

Ovarian and testicular3

Commonly1

Histology1

Granulosa2

Symptoms1

Contralateral1

Prognosis1

20231

Canine testicular1

Adenomatoid tumors4

Melanoma5

Tissue2

Size of the tumor1

Malignancies1

Lung1

Occur1

Biopsy1

Epithelioid2

Malignancy1

Prostate1

Breast1