Loading...
  • tumors
  • Although previous researches have demonstrated that GINS2 express abundantly and abnormally in many malignant solid tumors, such as breast cancer, melanoma and hepatic carcinoma. (medsci.org)
  • Rarely there can be a metastatic neoplasm with no known site of the primary cancer and this is classed as a cancer of unknown primary origin Neoplastic tumors are often heterogeneous and contain more than one type of cell, but their initiation and continued growth is usually dependent on a single population of neoplastic cells. (wikipedia.org)
  • Vascular tumors (formed from blood vessels) are thus looked at as being amalgams of a solid skeleton formed by sticky cells and an organic liquid filling the spaces in which cells can grow. (wikipedia.org)
  • Benign conditions that are not associated with an abnormal proliferation of tissue (such as sebaceous cysts) can also present as tumors, however, but have no malignant potential. (wikipedia.org)
  • Human endogenous retrovirus K (HERV-K) is a family of human endogenous retroviruses associated with malignant tumors of the testes. (wikipedia.org)
  • Cells in pre-malignant and malignant neoplasms (tumors) evolve by natural selection. (wikipedia.org)
  • The earliest ideas about neoplastic evolution come from Boveri who proposed that tumors originated in chromosomal abnormalities passed on to daughter cells. (wikipedia.org)
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • molecular
  • Institute of Cell and Molecular Pathology, Hannover Medical School, Carl-Neuberg-Str. (mdpi.com)
  • The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
  • They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • Molecular Cell. (wikipedia.org)
  • Nature Reviews Molecular Cell Biology. (wikipedia.org)
  • However, the molecular makeup of these cells, including gene expression and epigenetic marks, was somewhere between that of a fibroblast and an ESC, and the cells failed to produce viable chimeras when injected into developing embryos. (wikipedia.org)
  • 2011). Histology : a text and atlas : with correlated cell and molecular biolog. (wikipedia.org)
  • gene
  • CML is a cancer initiated by a mutant gene called BCR-ABL in blood forming stem cells that leads to an expansion of white blood cells and their precursors. (labspaces.net)
  • Chronic myeloid leukemia develops when a gene mutates and causes an enzyme to become hyperactive, causing blood-forming stem cells in the bone marrow to grow rapidly into abnormal cells. (medicalxpress.com)
  • What's more, ATM, CHK2, and P53 gene could involve in the pathogenic signaling pathways of HL60 cells when GINS2 gene was down-regulated. (medsci.org)
  • On the contrary, after HL60 cells were infected by recombinant adenovirus vector which contained GINS2 gene, we observed that over-expression of GINS2 could promote HL-60 cell proliferation. (medsci.org)
  • Four submits of GINS complexes initiate a cyclic structure which plays a significant role in the beginning of DNA replication [ 9 , 10 ].GINS2, also known as Psf2, is encoded by GINS2 gene locates on human chromosome 16q24 which performs in both initiation of DNA replication and the cell cycle process [ 11 ]. (medsci.org)
  • In contrast several studies have shown a significant proportion (44-55%) of cytogenetic alterations in MDS-derived MSC ( 9 , 14 ), and more recent studies involving the use of genomic tools have demonstrated alterations at the gene expression level in these cells ( 15 ). (pubmedcentralcanada.ca)
  • In addition to the cumulative acquisition of DNA mutations with increasing age, changes in chromatin structure can also enforce stable changes in gene expression programs, that can in turn lead to altered cell biology and disease. (dkfz.de)
  • As part of a multi-group consortium, this data was combined with gene expression and proteome data from the same cell populations and published as a comprehensive resource article in the journal Cell Stem Cell1 in 2014. (dkfz.de)
  • Along with a follow up publication in Cell Cycle2, this work provides a unique insight into the differential regulation of gene expression across several highly related cell populations that together form the apex of the murine hematopoietic system. (dkfz.de)
  • For lymphoid neoplasms, e.g. lymphoma and leukemia, clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for T cell lesions). (wikipedia.org)
  • Disruption of a single gene may also result from integration of genomic material from a DNA virus or retrovirus, and such an event may also result in the expression of viral oncogenes in the affected cell and its descendants. (wikipedia.org)
  • Hematopoietic progenitor cell antigen CD34 also known as CD34 antigen is a protein that in humans is encoded by the CD34 gene. (wikipedia.org)
  • The fibroblasts were engineered so that any cells reactivating the ESC-specific gene, Fbx15, could be isolated using antibiotic selection. (wikipedia.org)
  • Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. (wikipedia.org)
  • In addition, ATRX undergoes cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. (wikipedia.org)
  • As they are stimulated to become plasma cells, B cells refashion parts of their genome in efforts to create a new gene that encodes a functional antibody. (wikipedia.org)
  • If these gene alterations are successful in coding for a functional antibody (termed Ig for immunoglobulin), the maturing B cells and to a greater extent their plasma cell descendants make and secrete an intact antibody, initially IgM but after class switch recombinations, either IgG, IgA, IgE, or IgD. (wikipedia.org)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • genes
  • Further laboratory experiments propose possible mechanistic insight into genomic instability of bone marrow cells derived from patients with critically short telomeres and/or mutation in telomerase genes. (springer.com)
  • A series of several mutations to certain classes of genes is usually required before a normal cell will transform into a cancer cell. (wikipedia.org)
  • In either case, expression of these genes promotes the malignant phenotype of cancer cells. (wikipedia.org)
  • They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
  • iPSCs are typically derived by introducing products of specific sets of pluripotency-associated genes, or "reprogramming factors", into a given cell type. (wikipedia.org)
  • They hypothesized that genes important to embryonic stem cell (ESC) function might be able to induce an embryonic state in adult cells. (wikipedia.org)
  • The second way is found in birds and mammals, where germ cells are not specified by such determinants but by signals controlled by zygotic genes. (wikipedia.org)
  • novel
  • This work suggests a novel mechanism for overcoming cancer stem cell resistance to therapy that may prevent relapse and progression. (labspaces.net)
  • Our results indicate that Th22 and pure Th17 cells conjointly contribute to the pathogenesis of AML and might be promising novel clinical index for AML. (mdpi.com)
  • Th17 cells are novel CD4 + T cells that are characterized by the production of interleukin-17 (IL-17) [ 6 ]. (mdpi.com)
  • promotes
  • An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is increasing in prevalence. (labspaces.net)
  • An international team has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML). (medindia.net)
  • benign
  • ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of uncertain or unknown behavior. (wikipedia.org)
  • tissue
  • Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or dysplasia. (wikipedia.org)
  • In newts, muscle tissue is regenerated from specialized muscle cells that dedifferentiate and forget the type of cell they had been. (wikipedia.org)
  • To fuse the cells, biologists combined isolated mouse cells, with the same kind of tissue, and induced fusion of their outer membrane using the Sendai virus (a respiratory virus in mice). (wikipedia.org)
  • self-renewal
  • Despite the emergence of new therapies, such as tyrosine kinase inhibitors, CML and other leukemias remain problematic because some cancer stem cells avoid destruction and eventually regenerate themselves, a stem cell process known as self-renewal that can result in a return and spread (metastasis) of the disease. (labspaces.net)
  • It is important to mention that Long-Term Hematopoietic Stem Cells (LT-HSCs) in mice and humans are the hematopoietic cells with the greatest self-renewal capacity. (wikipedia.org)
  • autologous
  • 20. A method of claim 1, wherein said uncoated particle encapsulates an autologous erythrocyte in addition to the donor cell. (google.com)
  • Autologous stem cell transplantation is considered investigational and not medically necessary for individuals with AML. (unicare.com)
  • These unlimited supplies of autologous cells could be used to generate transplants without the risk of immune rejection. (wikipedia.org)
  • peripheral
  • Here, we investigated frequencies of Th22, Th17, pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. (mdpi.com)
  • Injection of CD34+ hematopoietic Stem Cells has been clinically applied to treat various diseases including Spinal Cord Injury, Liver Cirrhosis and Peripheral Vascular disease. (wikipedia.org)
  • transplantation
  • Allogeneic (ablative or non-myeloablative) stem cell transplantation is considered medically necessary for individuals with AML that does not fall into a favorable classification and the AML is in any phase after induction treatment. (unicare.com)
  • Allogeneic (ablative or non-myeloablative) stem cell transplantation is considered investigational and not medically necessary for individuals who do not meet the above criteria. (unicare.com)
  • Treatments may include supportive care, drug therapy, and stem cell transplantation. (wikipedia.org)
  • Some people have a history of exposure to chemotherapy (especially alkylating agents such as melphalan, cyclophosphamide, busulfan, and chlorambucil) or radiation (therapeutic or accidental), or both (e.g., at the time of stem cell transplantation for another disease). (wikipedia.org)
  • human
  • A British scientist who won this year's Nobel prize for medicine has predicted that human clones will be allowed and accepted within 50 years. (medindia.net)
  • Scientists identify two signaling proteins in cancer cells that make them resistant to chemotherapy, and show that blocking the proteins along with chemotherapy eliminate human leukemia in mouse models. (medicalxpress.com)
  • 5. A method of claim 4, wherein the donor cell is a genetically altered human cell. (google.com)
  • For instance, multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant adult human stem cells that can self-renew. (wikipedia.org)
  • hESCs can be generated by SCNT using dermal fibroblasts nuclei from both a middle-aged 35-year-old male and an elderly, 75-year-old male, suggesting that age-associated changes are not necessarily an impediment to SCNT-based nuclear reprogramming of human cells. (wikipedia.org)
  • Acquired mutations in ATRX have been reported in a number of human cancers including pancreatic neuroendocrine tumours, gliomas, astrocytomas, osteosarcomas, and malignant pheochromocytomas. (wikipedia.org)
  • cytokine
  • IL-17, the main effector cytokine of Th17 cells, is responsible for inflammatory and autoimmune diseases [ 8 , 9 ]. (mdpi.com)
  • leukemia
  • This shows chronic myeloid leukemia blood cells. (labspaces.net)
  • Immunophenotypes of leukemia can identify cells which cannot be identified by morphology, and it can promote diagnosis for leukemia and play a certain prognosis judgment [ 5 , 6 ]. (alliedacademies.org)
  • pancreatic
  • 10. A method of claim 8, wherein the donor cell is a pancreatic islet cell. (google.com)
  • Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. (wikipedia.org)
  • leukemic
  • Furthermore, the immune system, both adaptive and innate, encompassing mesenchymal-derived cells, has been shown to take part to the leukemic niche. (hindawi.com)
  • In addition, it has not been completely elucidated whether cancer-associated MSCs belong primarily to the abnormal clone or emerge after leukemic stem cell induced environmental damage. (hindawi.com)
  • monoclonal
  • Flow cytometer detection was given after using monoclonal antibody of living cells immunofluorescent. (alliedacademies.org)
  • Plasma cell dyscrasias (also termed plasma cell disorders and plasma cell proliferative diseases) are a spectrum of progressively more severe monoclonal gammopathies in which a clone or multiple clones of pre-malignant or malignant plasma cells (sometimes in association with lymphoplasmacytoid cells or B lymphocytes) over-produce and secrete into the blood stream a myeloma protein, i.e. an abnormal monoclonal antibody or portion thereof. (wikipedia.org)
  • overexpression
  • Furthermore, overexpression of the HERV-K accessory protein Rec increases IFITM1 levels on the cell surface and inhibits viral infection. (wikipedia.org)
  • Genomic
  • There is a diverse classification scheme for the various genomic changes that may contribute to the generation of cancer cells. (wikipedia.org)
  • Genomic amplification occurs when a cell gains many copies (often 20 or more) of a small chromosomal region, usually containing one or more oncogenes and adjacent genetic material. (wikipedia.org)
  • chronic
  • The antibiotic tigecycline, when used in combination with current treatment, may hold the key to eradicating chronic myeloid leukaemia (CML) cells, according to new research. (medicalxpress.com)
  • precursors
  • Finally, recent data suggest CD34 may also play a more selective role in chemokine-dependent migration of eosinophils and dendritic cell precursors. (wikipedia.org)
  • precursor
  • Primordial germ cells, germ cells that still have to reach the gonads, also known as PGCs, precursor germ cells or gonocytes, divide repeatedly on their migratory route through the gut and into the developing gonads. (wikipedia.org)
  • marrow
  • Older study patients with AML presented with poorer performance status, lower white blood cell counts, and a lower percentage of marrow blasts. (bloodjournal.org)
  • In terms of morphology, as well as the expression of certain cell markers, no differences were observed between MSC from MDS patients and those derived from normal marrow ( 9 ). (pubmedcentralcanada.ca)
  • germ cell
  • A germ cell is any biological cell that gives rise to the gametes of an organism that reproduces sexually. (wikipedia.org)
  • Germ cell specification begins during cleavage in many animals or in the epiblast during gastrulation in birds and mammals. (wikipedia.org)
  • The end-products of the germ cell cycle are the egg or sperm. (wikipedia.org)
  • There are two mechanisms to establish the germ cell lineage in the embryo. (wikipedia.org)
  • The first way is called preformistic and involves that the cells destined to become germ cells inherit the specific germ cell determinants present in the germ plasm (specific area of the cytoplasm) of the egg (ovum). (wikipedia.org)
  • citation needed] In the Xenopus egg, the germ cell determinants are found in the most vegetal blastomeres. (wikipedia.org)