Malignant stem cell factor. Medical search. Frequent questions

STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
Acute lymphoblastic leukemia emerges when a single lymphoblast gains many mutations to genes that affect blood cell development and proliferation. (wikipedia.org)
FLT3 ITD triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly transform HSCs. (biomedcentral.com)
HP75 cells treated with overexpressed miR-543 exhibited increased cell proliferation, migration and invasion, while decreased cell apoptosis as well as expression of Cleaved caspase-3 and Cleaved caspase-8 were observed. (cancerindex.org)
Since pathogenic microorganisms can promote malignant tumor proliferation by inhibiting programmed cell death factor 4 (PDCD4) and the decrease of PDCD4 activity can enhance the stemness of cancer cells, we here investigated the functional mechanism by which Pg promoted ESCC chemoresistance and malignancy through inhibiting PDCD4 and enriching cancer stem cells (CSCs). (figshare.com)
This, in turn, may selectively favor the proliferation of tumor stem or progenitor cells overlying these focal disruptions. (stemcellsciencenews.com)
We tested if Tep1 acts through Yki to affect glioma growth and if in normal cells Tep1 affects neuroblast number and proliferation. (udayton.edu)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
These cells are the original precursors of various cells in a tumor, whereas other intratumoral cells are limited in terms of their potential for proliferation and pluripotent differentiation. (biomedcentral.com)
These results indicate that proliferation and self-renewal ability of CRC SCs are reduced in HOXA4 and HOXA9 knockdown cells. (stemcellsciencenews.com)
UCHL1 depletion in SF188 and SJ-GBM2 glioma cells was associated with decreased cell proliferation and invasion, along with a reduced ability to grow in soft agar and to form spheres. (stemcellsciencenews.com)
Genetic silencing of TEAD1 suppressed multiple malignant phenotypes of OS cells including cell proliferation, apoptosis resistance, and invasive potential. (stemcellsciencenews.com)
decreased cell proliferation, cell cycle arrest, and induction of apoptosis. (123dok.net)
It was suggested that HOXD9 contributes to both cell proliferation and/or cell survival. (123dok.net)
HOXD9 siRNA treatment of SK-MG-1 SP cells resulted in reduced cell proliferation. (123dok.net)
Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
Enhancement of head andneck squamous cell carcinoma proliferation, invasion, andmetastasis by tumor-associated fibroblasts in preclinicalmodels. (edu.pl)
Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)

Studies have confirmed that the colonization of Porphyromonas gingivalis (Pg) could promote the malignant evolution of esophageal squamous cell carcinoma (ESCC). (figshare.com)
Results indicated that CD44 high CD90 + sub-population may represent cancer stem cells (CSCs) in small cell lung cancer and large cell carcinoma, whereas in squamous cell carcinoma lung cancer subtype, CSC potentials were found within the CD44 high sub-population. (stemcellsciencenews.com)
Objectives: Cigarette smoking is involved in the pathogenesis of head and neck squamous cell carcinoma (HNSCC). (umn.edu)
Other types include squamous cell carcinoma (see the image below) and adenocarcinomas. (medscape.com)
Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)

Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. (nature.com)
Previous work by Karnoub revealed that MSCs respond to breast tumors akin to the way they react to a wound or infection and that these cells participate in the formation of the breast tumor stroma, the supporting network of cells and their secretions that exist in the microenvironment of cancer cells. (newswise.com)
Cancer stem cells are thought to be the most virulent cells that lie within the core of most tumors, and are believed to be responsible for the resurgence of tumors following chemotherapy treatment. (newswise.com)
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown for the first time that malignant brain tumors arise directly from brain stem cells. (dkfz.de)
Overproduction of Tlx in mice stimulates the development of malignant brain tumors from brain stem cells. (dkfz.de)
For many years now, the subventricular zone has been suspected to be the origin of specific malignant brain tumors called gliomas, the most deadly type of which is glioblastoma. (dkfz.de)
Although Î³Î´ T cells comprise a small population of T cells, they perform important roles in protecting against infection and suppressing tumors. (bvsalud.org)
With their distinct tissue-localizing properties, combined with their various target recognition mechanisms, Î³Î´ T cells have the potential to become an effective solution for tumors that do not respond to current therapeutic procedures. (bvsalud.org)
According to the American Cancer Society (ACS) , most brain tumors develop in people who do not have any risk factors. (medicalnewstoday.com)
Some people claim that electromagnetic fields from cell phones could increase the likelihood of developing brain tumors. (medicalnewstoday.com)
The existence of tumor-initiating cancer stem cells (CSC) has been shown in a variety of solid tumors (e.g. breast, prostate, glioblastoma, liver). (grantome.com)
As few as 100 cells produced tumors in ZEB-treated SP cells from all cell lines (Figure 3, as shown for Huh7), while 1000 treated non-SP cells gave rise to few or no tumors (Huh7) within 20 weeks of observation. (grantome.com)
Evolving research in stem cells and cancer biology have provided strong evidence for the existence of cancer stem cells (CSCs) in various human solid tumors, including brain, breast, bone marrow, prostrate, colon, and lung [ 3 , 4 ]. (oncotarget.com)
Tumor size and nodal metastases were previously reported to be predictive factors for early and late recurrence of ER-positive/HER2-negative tumors [ 4 , 5 ]. (biomedcentral.com)
The volume and weight of tumors was measured and analyzing the ability of purified DU145 cells isolated from the tumors to migrate and proliferate. (jcancer.org)
The volume and weight of tumors were significantly higher in mice transplanted with DU145 and stromal cells from PZ. (jcancer.org)
The purified DU145 cells isolated from the tumors with DU145 and stromal cells in PZ had increased ability to migrate and proliferate, and had increased expression of C-Kit. (jcancer.org)
The "stem cell theory of cancer" states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant tumors. (medscape.com)
Recent studies have isolated distinct cell populations from infantile hemangiomas that display properties equivalent to aberrant progenitor cells, suggesting that, in addition to malignant tumors, benign tumors may also contain a stem cell-like component. (medscape.com)
With the exception of Myc (which was only present in a subset of benign, borderline, and malignant tumors), Oct4, Nanog, Sox2, and Klf4 were detectable at variable levels across both normal and diseased tissues. (medscape.com)
Semi-quantitative evaluation of our immunohistochemical staining revealed that protein expression of Oct4, Nanog, Myc, and Sox2, but not Klf4, was significantly increased in benign, borderline, and malignant vascular tumors relative to non-diseased vascular tissue controls. (medscape.com)
These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the "stem cell theory of cancer", but additionally extends to common benign vascular tumors such as hemangiomas. (medscape.com)
The side population (SP) in human lung cancer cell lines and tumors is enriched with cancer stem cells. (stemcellsciencenews.com)
The authors report a critical role of glioma stem-like cells (GSLCs) in the formation of vasculogenic mimicry (VM), which defines channels lined by tumor cells to supply nutrients to early growing tumors and tumor initiation. (stemcellsciencenews.com)
Aberrant immune cell infiltration may have the same destructive impact on the capsule of all epithelium-derived tumors. (stemcellsciencenews.com)
Solid tumors, autoimmune diseases, graft versus host disease (GvHD), genetic diseases and neurodegenerative diseases are investigated using many types of autologous and allogeneic cells with rapidly evolving cell engineering and editing approaches. (bdbiosciences.com)
Although the incidence is lower than that of other malignant tumors, it is often accompanied by local invasion and distant metastasis during diagnosis and treatment, and the overall 5-year survival rate is only 50-55% [ 2 ]. (biomedcentral.com)
According to the hypothesis, only a small group of stem cell-like tumor cells can form new tumors. (biomedcentral.com)
Malignant glioblastomas (GBM) are highly malignant brain tumors that have extensive and aberrant tumor vasculature, including multiple types of vessels. (oncotarget.com)
Gliomas, especially glioblastomas (GBMs), are the most malignant primary brain tumors[1]. (123dok.net)
We have shown recently that in breast and prostate tumors, as well as in breast tumor cell lines, HIF-1α has a crucial role in regulating, either directly or indirectly, the expression of pro-inflammatory genes. (biomedcentral.com)
In vivo, ID1 and NF-κB acted together to generate malignant xenograft tumors, which were aggressive locally and systemically metastatic. (umn.edu)
[ 4 , 5 ] ) Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)

Among others are the breast cancer stem cells (BCSCs), which are believed to have a contribution to tumorigenesis, metastasis, and resistance against chemotherapy. (hindawi.com)
Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
Environmental risk factors may include significant radiation exposure or prior chemotherapy. (wikipedia.org)
Further study is needed to clarify the prognostic significance of the heterogeneity of cancer stem cells and to confirm their role in resistance to chemotherapy. (biomedcentral.com)
For patients with estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer receiving adjuvant chemotherapy, endocrine therapy for 5 years plus additional chemotherapy for high-risk groups, such as patients with high tumor burden, advanced histological grade, and/or strong Ki-67 expression, is considered to improve survival. (biomedcentral.com)
Dr. Gary research interests includes Drug and Med-tech repurposing, Clinical trial design, Translational research, Chemotherapy/ radiation related neuropathic pain (ICD G62.0/ G62.9/ D49.9) Malignant fatigue (thrombocytopenia/ purpura) (ICD R53.0), Mechanism of botanical-derived medicines, Specialty pharmaceutical formulation, Lyophilized technologies for PRP, antibody, stem cells derived factors. (alliedacademies.com)
While there are lower-grade gliomas where coincide chemotherapy is not always part of the treatment, the aggressive nature of the malignant gliomas obligates chemotherapy usage [4]. (genesispub.org)
A Phase II Study of Daratumumab-Hyaluronidase for Chemotherapy-Relapsed/Refractory Minimal Residual Disease (MRD) in T Cell Acute Lymphoblastic Leukemia (T-ALL Rochester, Minn., Jacksonville, Fla. (mayo.edu)
Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (mayo.edu)
Treatment includes chemotherapy to achieve remission plus additional chemotherapy to avoid relapse and sometimes stem cell transplantation. (msdmanuals.com)

SOX9 depletion also suppressed the formation of cancer stem-like cells (CSCs), as determined by tumor sphere formation and aldehyde dehydrogenase (ALDH) activity (Aldefluor) assays. (cdc.gov)
Abstract: The cancer stem cell hypothesis has gained currency in recent times but concerns remain about its scientific foundations because of significant gaps that exist between research findings and comprehensive knowledge about cancer stem cells (CSCs). (ebi.ac.uk)
Cancer stem cells (CSCs) may represent targets for carcinogenic initiation by chemical and environmental agents. (oncotarget.com)
Here, we show that chronic (6-month) exposure of human lung epithelial cells to single-walled (SW) CNTs at the workplace-relevant concentration induced an emergence of lung CSCs, as indicated by the induction of CSC tumor spheres and side population (SP). (oncotarget.com)
These CSCs, which were found to overexpress tumor promoter caveolin-1 (Cav-1), displayed aggressive cancer phenotypes of apoptosis resistance and enhanced cell invasion and migration compared with their non-CSC counterpart. (oncotarget.com)
Induction of CSCs from non-tumorigenic cells may initiate carcinogenesis. (oncotarget.com)
this condition may be due to the existence of the cancer stem cells (CSCs) that are resistant to the hormone therapy. (jcancer.org)
The effects of Pg and PDCD4 on CSCs, chemoresistance and malignancy of ESCC cells were evaluated by in vitro studies. (figshare.com)
The results showed that Pg could inhibit PDCD4 expression and lead to CSCs enrichment in ESCC cells. (figshare.com)
Researchers analyzed glycosphingolipids expressed in human breast cancer stem cells (CSCs) by applying a CSC model induced through epithelial-mesenchymal transition, using mass spectrometry, TLC immunostaining, and cell staining. (stemcellsciencenews.com)
We speculate that precancerous stem cells (pCSCs) arise during the evolution of carcinomas based on long-term experimental findings, published literature, and the cancer stem cell (CSC) theory, wherein pCSCs exist in precancerous lesions and have characteristics of both CSCs and normal stem cells. (biomedcentral.com)
called either cancer stem cells (CSCs) or tumor-initiat-ing cells[3]. (123dok.net)

The immune-suppressive tumor microenvironment (TME) and immune-evasive glioma stem cells are major factors in GBM immunotherapy failure. (bvsalud.org)
Using a previously published Drosophila glioma model generated by coactivation of PI3K and EGFR pathways [by downregulation of Pten and overexpression of oncogenic Ras] in glial cells, we showed that the Drosophila Tep1 gene (ortholog of human CD109) regulates Yki (the Drosophila ortholog of human YAP/TAZ) via an evolutionarily conserved mechanism. (udayton.edu)
Our data suggest that Tep1 affects Yki mediated stem cell renewal in glioma, as reduction of Tep significantly decreases the number of neuroblasts in glioma. (udayton.edu)
Scientists report that furin is unique among the proprotein convertases subtilisin/kexin in being highly expressed in human glioma-initiating cells. (stemcellsciencenews.com)
Gliomas often originate from three types of glial cells: oligodendrocytes, ependymal cells, and astrocytes - however, astrocytic gliomas hold 70% of all glioma origins [4]. (genesispub.org)
The classification of each glioma is based on its cell origin and molecular characteristics, which includes acquired mutations [4]. (genesispub.org)
Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells. (123dok.net)
Results: In this study, we found high expression of the HOXD9 gene transcript in glioma cell lines and human glioma tissues by quantitative real-time PCR. (123dok.net)
The HOXD9 gene was highly expressed in a side population (SP) of SK-MG-1 cells that was previously identified as an enriched-cell fraction of glioma cancer stem-like cells. (123dok.net)
Finally, we cultured human glioma cancer stem cells (GCSCs) from patient specimens found with high expression of HOXD9 in GCSCs compared with normal astrocyte cells and neural stem/progenitor cells (NSPCs). (123dok.net)
In glioma CSC (GCSC), the expression of some neural stem markers, such as SOX2 and Musa-shi-1, has been reported[6,7]. (123dok.net)

Karnoub's lab investigates the roles that mesenchymal stem cells (MSCs) play in the development and metastasis of breast cancer. (newswise.com)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Although the goal of Glioblastoma is not only to treat the disease but to cure it, current animal in vivo studies have shown promising therapeutic effects in mesenchymal stem cells, induced neural stem cells, and induced pluripotent stem cells. (genesispub.org)
These stem cells have self-renewal capabilities, and stem cells, like the mesenchymal stem cells, can differentiate into various lineages from the mesoderm. (genesispub.org)
In this study, we show that human glioblastoma cells secrete soluble factors that alter the phenotype and cytokine secretion profile of both macrophages and mesenchymal stem cells (MSCs). (edu.pl)
Recently obtained evidence reveals that epithelial-mesenchymal transition (EMT) of tumor cells causes metastasis, which is detrimental to patients' survival. (biomedcentral.com)
During cancer progression, some tumor cells acquire new characteristics, such as over-expression of epithelial-mesenchymal transition (EMT) markers, and undergo profound morphogenetic changes. (biomedcentral.com)
EMT is a process in which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties, becoming mesenchymal cells [ 3 , 4 ]. (biomedcentral.com)

Tlx also plays an important role in glioblastoma, the most malignant of human brain cancers. (dkfz.de)
As a result, cell division activity in the subventricular zone increased, the cells left their habitual environment called stem cell niche, and started forming glioblastoma-like tissue lesions. (dkfz.de)
One such tumor, glioblastoma (GBM), is a malignant brain tumor with the highest World Health Organization grade and therefore the worst prognosis. (bvsalud.org)
Glioblastoma Multiforme (GBM) is the most common form of malignant brain tumor with a poor prognosis. (udayton.edu)
Lin A, Gallicchio VS. (2023) Stem Cell Therapy for Glioblastoma. (genesispub.org)
This review outlines the research, progress, and potential therapeutic effects different stem cells have on Glioblastoma. (genesispub.org)
This study aimed to review the current progress researchers have made regarding stem cell therapeutic effects for Glioblastoma, how it is applied, and to discover the potential future progress and treatments these stem cells can create. (genesispub.org)
This review focuses on recent discoveries that the angiogenic factor YKL-40 (CHI3L1) acts on glioblastoma-stem like cells (GSCs) to drive the formation of two major forms of tumor vascularization: angiogenesis and vasculogenic mimicry (VM). (oncotarget.com)
The aim of our study was to analyze the hypoxic and pro-inflammatory microenvironment in GBMs and to demonstrate that in a stem/progenitor cell line derived from human glioblastoma (GBM-SCs), hypoxia activates a coordinated inflammatory response, evidencing an invasive and migratory phenotype. (biomedcentral.com)
We suggest that, as has been previously described for prostatic and mammary carcinoma, in human glioblastoma acquisition of a proinflammatory phenotype may be relevant for malignant progression. (biomedcentral.com)
Glioblastoma multiforme (GBM) is the most common and malignant type of brain tumor in adults and is characterized on histologic examination according to hypercellularity, nuclear atypia, mitotic figures, and evidence of angiogenesis and/or necrosis. (biomedcentral.com)

Ibudilast showed modest anti-proliferative activity however, when combined with TMZ, significant synergism was observed, resulting in cell cycle arrest and apoptosis. (nature.com)
MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. (cancerindex.org)
Increasing tumor size requires that GBM tumor cells maintain a balance between adaptation to hypoxia and cell death (apoptosis and central necrosis) through activation of hypoxia-inducible transcription factor 1 (HIF-1). (biomedcentral.com)

In this study, we sought to assess the epidemiology of GC, its clinicopathological profiles, and its association with risk factors as well as to identify premalignant gastric lesions (PGL) and examine neoplastic progression. (mdpi.com)
A team of researchers led by Dr. Cristian Bellodi recently discovered a hardwired genetic control mechanism modulating individual spliceosomal components, known as splicing factors, in cells harboring oncogenic lesions common in human cancers. (lu.se)
Patients with malignant lesions typically present after age 60 years, whereas those with benign lesions usually present when older than 40 years. (medscape.com)
The study also reported that recurrence risk factors for these lesions included positive and uncertain resection margins, as well as younger age at diagnosis. (medscape.com)
In addition, the investigators found that 0.15% of the lesions underwent malignant transformation. (medscape.com)

Hematopoietic stem cell transplantation (HSCT) results in the alteration of several components of the immune system. (medscape.com)
Transplantation can result in granulocytopenia as well as impairment of barrier defenses, cell-mediated immunity, and humoral immunity. (medscape.com)
Risks of infection also vary with the type of transplant, the indication for transplantation, and other host factors. (medscape.com)
In order to assess the incidence and analyze reasons which cause prolongation of hospital stay in patients engrafted after peripheral blood stem cell transplantation (PBSCT), we performed this retrospective analysis. (nature.com)
OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)
Introduction To observe the short-term and long-term effects of extensive fascial resection combined with autologous limbal stem cell sharing transplantation for pterygium. (researchsquare.com)
Methods A retrospective case series analysis was performed with 403 patients (420 eyes) who underwent extensive fascial resection combined with autologous limbal stem cell sharing transplantation in the Department of Ophthalmology, Second People's Hospital of Yunnan Province from January 2017 to June 2018. (researchsquare.com)
Discussion and conclusion Extensive fascial resection combined with autologous limbal stem cell sharing transplantation for the treatment of pterygium, the patient's appearance satisfaction is higher, and the recurrence probability is lower than the average recurrence rate of limbal stem cell transplantation. (researchsquare.com)
Pterygium excision combined with autologous conjunctival flap transposition, pterygium excision combined with amniotic membrane transplantation, pterygium excision combined with autologous limbal stem cell transplantation and so on [12] . (researchsquare.com)
Consistent in all three HCC cell lines, an overall increase in tumor frequency was observed for SP cells regardless of ZEB treatment during the first 8 wk after transplantation. (grantome.com)
The first-ever online and open-access education e-course, brought to you by The EBMT Trainee Committee, designed to cover all aspects surrounding hematopoietic cell transplantation and cellular therapy with a focus on trainee-relevant knowledge and skills. (ebmt.org)
Identifying and understanding acute complications after allogeneic haematopoietic cell transplantation (alloHCT). (ebmt.org)
A Multicenter, Pivotal Phase 3 Study of Iomab-B Prior to Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia (SIERRA) Jacksonville, Fla., Rochester, Minn. (mayo.edu)
WO 2001/046401 discloses embryonic or stem-like cells produced by cross species nuclear transplantation. (justia.com)
Stem cell transplantation may be an option in cases of severe recalcitrant ALPS. (medscape.com)

Our scientists have developed a wide array of stem cell-focused reagents and resources for many applications including flow cytometry , western blotting , ELISAs , and recombinant proteins for cell differentiation. (biolegend.com)
RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. (biolegend.com)
These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages 2,3 . (biolegend.com)
ALDH1 has a role in early stem cell differentiation through its function in the oxidation of retinol to retinoic acid, proposed to be a strong candidate for breast cancer stem cells. (hindawi.com)
Led by Dr. Paula Sotomayor, researchers in the Department of Urologic Oncology at the Roswell Park Cancer Institute in Buffalo, New York have identified Oct4A in a small subset of prostate cells which were negative for many other types of more conventional cancer stem cells markers, such as markers of luminal epithelial and basal epithelial cell differentiation, including the markers ABCG2, NANOG, CD133 and AMACR. (cellmedicine.com)
Yet another subpopulation was found to co-express synaptophysin, while the majority of the Oct4A-expressing cells were found to co-express chromagranin A, both of which are neuroendocrine differentiation markers. (cellmedicine.com)
Further investigations will be focused especially on those various subpopulations of the cells that co-express the neuroendocrine differentiation markers chromagranin A and synaptophysin, both of which offer new and important pieces in the puzzle. (cellmedicine.com)
Different mechanisms could explain the origin and heterogeneity of CSC such as (i) differentiation arrest (stem cells), (ii) dedifferentiation (mature cells) and (iii) transdifferentiation (bone marrow stem cells). (grantome.com)
In addition, normal adult stem cells (ASCs) self-renew, proliferate infinitely, have a multidirectional differentiation potential, similar to that of tumor cells, and can transform more easily into tumor stem cells than non-stem cells [ 20 , 21 ]. (biomedcentral.com)
The authors found that paired related homeobox 1, a homeodomain transcription factor that was previously reported to control skeletal development, is expressed in cortical neural progenitors and is required for their self-renewal and proper differentiation. (stemcellsciencenews.com)
We examined the effects of cigarette smoke condensate (CSC) on the formation of cancer stem-like cells, which are rich in octamer-binding transcription factor (OCT)-4, inhibitor of differentiation 1 (ID1), nuclear factor (NF)-κB, and B lymphoma Mo-MLV insertion region 1 homolog (BMI-1). (umn.edu)

In this study, we linked SOX9, a stem cell associated transcription factor, to the neoplastic-like properties of human lung epithelial cells chronically exposed to a low-dose of single-walled carbon nanotube s (SWCNTs). (cdc.gov)
The loose connective tissue under the epithelium contains a large number of fibroblasts and abundant capillaries, which indicates that the pterygium epithelial cells have a strong ability to proliferate and migrate. (researchsquare.com)
Most human prostate cancers are adenocarcinomas, which originate from the epithelial cells that line the glands and ducts of prostate [ 2 ]. (jcancer.org)

Investigators used SF188 and SJ-GBM2 cell lines to study the function of UCHL1, a deubiquitinase de-regulated in several cancers, in pediatric high-grade gliomas. (stemcellsciencenews.com)
Malignant, or grade IV, gliomas are the invasive and lethal form with the shortest prognosis [4]. (genesispub.org)
Immunohistological studyof mononuclear cell infiltrate in malignant gliomas. (edu.pl)

While the inflammatory transcription factor nuclear factor of activated T-cells 2 ( NFAT2 , NFATC1 ) is overexpressed in AML, it is unknown whether it plays a role in FLT3 ITD -induced HSC transformation. (biomedcentral.com)
We find that NFATC1 governs FLT3 ITD -driven precursor cell expansion and transformation, causing a fully penetrant lethal AML. (biomedcentral.com)
Can precancerous stem cells be risk markers for malignant transformation in the oral mucosa? (biomedcentral.com)
Predicting malignant transformation in potentially malignant oral illnesses would allow for focused treatment, prognosis, and secondary prevention. (biomedcentral.com)
Moreover, malignant transformation cannot be accurately predicted in individual patients using either technique [ 6 , 7 ]. (biomedcentral.com)
This transformation depends on various factors related to the tumor (such as the over expression or not of N-myc, the presence or absence of Treks and their receptors), the host (the intervention of the immune system) and to other external factors. (lupinepublishers.com)
Scientists debate whether GBs arise from a subculture of neural stem cells or from the transformation of differentiated astrocytes [6]. (genesispub.org)
With Prof. Eva Hellström-Lindberg's group at the Karolinska Institute, Maciej Cieśla and coworkers discovered dynamic regulation of SF3B1 levels during the malignant transformation from MDS to leukemia. (lu.se)

The lymphocytic clusters in SM contained nearly equal numbers of mature T and B cells, the latter with no coexpression of aberrant antigens, such as CD5 or CD23. (bmj.com)
The model predicts the evolution of an aberrant environment in which the malignant population particularly in the bone marrow shows tendencies of reaching an uncontrollable equilibrium state. (ebi.ac.uk)
The authors analyzed the potential to therapeutically target aberrant tyrosine kinase (TK) signaling and to eliminate leukemia stem cells via the multi-TK inhibitor Debio 0617B. (stemcellsciencenews.com)
IRF4 has been determined to be an essential multiple myeloma cell survival factor with aberrant activation during pathogenesis and progression of the disease. (scienceboard.net)
Accumulating evidence is highlighting a role for aberrant splicing in cancer even in the absence of splicing factors mutations. (lu.se)

Currently, encouraged by the strong anti-tumoral function of Î³Î´ T cells revealed at the preclinical and clinical levels, several research groups have shown progression of Î³Î´ T cell-based GBM treatment. (bvsalud.org)
Tumor-Infiltrating Immune Cells: Triggers for Tumor Capsule Disruption and Tumor Progression? (stemcellsciencenews.com)
Adaptation to hypoxia and consequent pro-inflammatory gene expression of prostate and breast carcinomas have been implicated in the progression toward cancer malignant phenotype. (biomedcentral.com)
Our results suggest that the orchestrated response of macrophages and stromal elements to neoplastic cells enhances tumor progression through the release of soluble factors. (edu.pl)
FunctionalRelationship between Tumor-Associated Macrophages andMacrophage Colony-Stimulating Factor as Contributors toCancer Progression. (edu.pl)
In multiple myeloma, proinflammatory cytokines and antiviral interferons derived from bone marrow play a key role in disease progression, including activation of interleukin 6 (IL-6) with downstream interferon-response factor (IRF) signaling. (scienceboard.net)
US 20130022666 provides compositions comprising a lipid carrier and mitochondria as well as methods of delivering exogenous mitochondria to a cell and methods of treating or reversing progression of a disorder associated with mitochondrial dysfunction in a mammalian subject in need thereof. (justia.com)
EMT plays an important role in cancer progression and provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states [ 3 , 4 ]. (biomedcentral.com)

Cancer stem cells are thought to be the source of some types of primary and recurrent cancers and are characterized by their high degree of potency and self-renewing capacity. (cellmedicine.com)
In embryonic stem cells and germ cells, properties of self-renewal and pluripotency are regulated by the Oct4A gene, a marker which has been suspected of playing a role in the origin of some cancers. (cellmedicine.com)
As the authors describe in their publication, "rare cells that express Oct4 were identified in several somatic cancers, however, the differential contributions of the Oct4A and Oct4B variants were not determined. (cellmedicine.com)
Conventionally, lung cancers have been divided into non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). (biomedcentral.com)
Almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. (medscape.com)
Overview of Leukemia Leukemias are cancers of white blood cells or of cells that develop into white blood cells. (msdmanuals.com)

The significance of the expression of aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, for predicting the recurrence of estrogen receptor (ER)-positive/human epidermal growth factor receptor type 2 (HER2)-negative breast cancer is still poorly understood. (biomedcentral.com)
Amplification of Epidermal Growth Factor Receptor (EGFR), and mutations leading to activation of Phosphatidyl-Inositol-3 Kinase (PI3K) pathway are commonly associated with GBM. (udayton.edu)
An epidermal growth factor receptor (EGFR) is a typical influencer, where phenotypic changes occur by over expression, amplification, and mutation [5]. (genesispub.org)

After we found that miRNA-199a instigated in the cancer cells by MSCs was indeed promoting these cancer stem cells phenotypes and was facilitating cancer metastasis, we probed the mechanistic details of miR-199a's actions, " explains Karnoub. (newswise.com)
A common theme in cell therapy is the need to characterize and understand cell phenotypes and heterogeneity at every step of the process. (bdbiosciences.com)

Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
The workshop is targeted at discussing the scientific and research experience to date, the accumulating evidence and factors related to the mechanisms of action, and the therapeutic potential of stem cells in the treatment of a number of diseases. (mu-varna.bg)
Furthermore, the scientists are going to exchange practical experience related to the therapeutic application of stem cells in clinical transplantations in patients with haematological and malignant diseases. (mu-varna.bg)
Cancer therapies involving the immune system is believed to be a milestone for cancer treatment advances, and the development of multiple immune cells as a therapeutic tool. (benitonovas.com)
Natural killer cells have emerged as the newest promising therapeutic approach to cancer. (benitonovas.com)
While research has shown that each stem cell poses its own risk to the disease, their therapeutic effects have also shown encouraging and promising results. (genesispub.org)
January 21, 2021 -- Using an engineered DNA therapeutic agent to silence transcription factor genes reduced myeloma stem cell abundance and increased the survival of mice bearing human myeloma, according to preclinical study data published in Cell Stem Cell on January 20. (scienceboard.net)
The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)

Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
NFAT proteins are expressed in normal and malignant lymphatic hematopoiesis. (biomedcentral.com)
These CD proteins bind to a factor called stem cell factor, thus, enabling certain cells to grow. (flebo.in)

Cells expressing Oct4A have been found in both benign and malignant prostate glands. (cellmedicine.com)
Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)
PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)

Building off experience in hematopoietic stem cell transplant and exploiting advances in genetic engineering, genome editing, immunology, immunotherapy, stem cell biology, understanding disease mechanisms and cell therapy manufacturing, considerable progress has been made with hundreds of clinical trials underway. (bdbiosciences.com)
The primary objective of this study is to demonstrate the efficacy of Iomab-B, in conjunction with a Reduced Intensity Conditioning (RIC) regimen and protocol-specified allogeneic hematopoietic stem cell transplant (HCT), versus Conventional Care. (mayo.edu)
The purpose of this study is to compare relapse-free survival between participants with FLT3/ITD AML in first morphologic complete remission (CR1) who undergo hematopoietic stem cell transplant (HCT) and are randomized to receive gilteritinib or placebo beginning after the time of engraftment for a two year period. (mayo.edu)

The technique has also shown preliminarily promising outcomes in B cell acute lymphoblastic leukemia (B-ALL), B cell non-Hodgkin's lymphoma (B-NHL), chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma and multiple myeloma in clinical trials targeting CD19, CD20, CD22, CD30 and B-cell maturation antigen (BCMA), with many more under investigation. (bdbiosciences.com)
Investigators showed that SL-401 also decreases the viability of interleukin-3R-expressing cancer stem-like cells in multiple myeloma. (stemcellsciencenews.com)
In this review, recent advances achieved in the characterization of cancer stem cells derived from hematological malignancies, with a particular focus on multiple myeloma, are discussed and major natural products that target cancer stem cells are presented. (stemcellsciencenews.com)
Yet the role of IRF activation in the maintenance of malignant progenitors in multiple myeloma has not been explore. (scienceboard.net)
The researchers tested a panel of human-specific antisense oligonucleotide agents targeting IRF4 in vitro and profiled their effects on multiple myeloma cell viability and IRF4 expression to determine a candidate that selectively inhibits human IRF4. (scienceboard.net)
The antisense oligonucleotides dramatically reduced survival of multiple myeloma cells and decreased human IRF4 messenger RNA (mRNA) and protein expression, as well as lowered expression of the IRF4 target gene MYC. (scienceboard.net)
To confirm their results, the team conducted ex vivo treatments using patient-derived xenograft human multiple myeloma cells. (scienceboard.net)

GSCs possess multipotent cells able to transdifferentiate into vascular pericytes or smooth muscle cells (PC/SMCs) that either coordinate with endothelial cells (ECs) to facilitate angiogenesis or assemble in the absence of ECs to form blood-perfused channels via VM. (oncotarget.com)

Rb homeostasis is also essential for self-renewal and survival of human embryonic stem cells 10 . (biolegend.com)

Whereas normal CD34 + /CD38 − bone marrow stem cells displayed only low amounts of CD25 or lack CD25, CD34 + /CD38 − leukemic stem cells strongly expressed CD25 in over 90% of all patients with untreated chronic myeloid leukemia. (stemcellsciencenews.com)

Additional treatments such as Chimeric antigen receptor T cell immunotherapy are being used and further studied. (wikipedia.org)
In this review, we summarize the effector functions of Î³Î´ T cells in tumor immunity and discuss current advances and limitations of Î³Î´ T cell-based GBM immunotherapy. (bvsalud.org)
Additionally, we suggest future directions to overcome the limitations of Î³Î´ T cell-based GBM immunotherapy to achieve successful treatment of GBM. (bvsalud.org)
One of these promising cancer treatment advances is the natural killer (NK) cell-based immunotherapy. (benitonovas.com)

We found that SOX9 is upregulated in SWCNT-exposed cells, which is consistent with their abilities to induce tumor formation and metastasis in vivo. (cdc.gov)
Indeed, SOX9 knockdown inhibited anchorage-independent cell growth in vitro and lung colonization in vivo in a mouse xenograft model. (cdc.gov)
Consistent with our in vivo and in vitro results, ZEB treatment significantly amplified the differences in the expression levels of CSC and stemness associated genes between SP and non-SP cells. (grantome.com)
Scientists tested the effects of estrogen on cancer stem cell activity in vitro and in vivo and investigated which paracrine signaling pathways locally mediate estrogen effects. (stemcellsciencenews.com)
T cells are modified ex vivo by transduction with viral vectors containing CAR or other modifications of interest. (bdbiosciences.com)
Materials and Methods: We used in vitro, in vivo, and archival human HNSCC tissue analysis to evaluate the effects of CSC on cancer stem-like cell formation. (umn.edu)

Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)

Rb , or retinoblastoma protein, is a key regulator of the cell cycle, particularly during the transition from the G1 to S phases. (biolegend.com)
Within the brain, the protein is involved in the development of specialized cells that process smell. (biolegend.com)
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
In the adult brain, the Tlx protein is responsible for generating new neurons from tissue stem cells. (dkfz.de)
Scientists from the divisions of Professor Dr. G nther Sch tz and Professor Dr. Peter Lichter at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have recently shown in mouse brains that brain stem cells in the subventricular zone are characterized by a specific molecule: Protein Tlx, a transcription factor, which stimulates the activity of various genes. (dkfz.de)
Functioning of the stem cells thus appears to depend on the presence of this protein. (dkfz.de)
CD117 is a protein that is found on the surface of certain cells. (flebo.in)
Antigenicity for each protein was quantified based on staining intensity and percentage of tissue positive for each antigen, and subsequently compared to data obtained from two control tissue sets: 10 vascular tissues and a panel of 58 various malignant sarcomas. (medscape.com)
The red dots represent the IRF4 protein within human myeloma cells, which are much sparser after ION251 treatment. (scienceboard.net)
Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts. (msdmanuals.com)

The transplant procedure requires the harvesting of hematopoietic stem cells from a donor. (medscape.com)
In these mice, only a microbiota transplant from a fiber-rich diet-fed mouse and a fiber-rich diet can restore T cell development. (bvsalud.org)
Understand the processes involved in stem cell transplant. (ebmt.org)
Familiarize trainees with important clinical aspects of stem cell transplant and cellular therapy, including pharmacology, patient monitoring, and recognition and basic management of complications. (ebmt.org)

Increase of bone marrow lymphocytes in systemic mastocytosis: reactive lymphocytosis or malignant lymphoma? (bmj.com)
To clarify the nature (reactive or neoplastic) of lesional, perifocally aggregated lymphocytes in bone marrow infiltrates of systemic mastocytosis (SM), the histopathology of which can resemble malignant lymphoma with focal bone marrow involvement, particularly low grade malignant B cell lymphoma of lymphoplasmacytic immunocytoma subtype, which frequently exhibits increased mast cell (MC) numbers. (bmj.com)
Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
CAR-T cells, which incorporate an antibody-derived extracellular receptor and T cell derived intracellular signaling domains, have shown convincing outcomes in certain types of leukemia and lymphoma, including commercial licensure of CD19 CAR-Ts for the treatment of relapsed/ refractory large B cell lymphoma and acute lymphoblastic leukemia. (bdbiosciences.com)
This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)

SOX9 regulates cancer stem-like properties and metastatic potential exposed cells. (cdc.gov)
Now a research team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) has identified an unexpected link between a transcription factor known to regulate speech and language development and metastatic colonization of breast cancer. (newswise.com)
The induction by MSCs of one such miRNA, miR199a, facilitated the acquisition of malignant properties by the cancer cells, including cancer stem cell and metastatic traits. (newswise.com)
Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. (ersjournals.com)

BCSC is a subset of tumor cells that has stem cell-like characteristics, such as a high capacity for self-renewal and tumor initiation, which implies that BCSC may cause aggressiveness of TNBC. (hindawi.com)
ii) ZEB treatment can significantly reduce the heterogeneity of SP cells thus increasing the frequency of CSC;and (iii) the combination of an isolation procedure based on stem-like functional characteristics with epigenetic modulation provides an important tool for investigating cancer stem cells biology. (grantome.com)
There are several subtypes of AML, which are identified based on characteristics of the leukemia cells. (msdmanuals.com)

Furthermore, SOX9 knockdown suppressed tumor metastasis and the expression of the stem cell marker ALDH1A1. (cdc.gov)
Newswise - BOSTON - It is an intricate network of activity that enables breast cancer cells to move from the primary breast tumor and set up new growths in other parts of the body, a process known as metastasis. (newswise.com)
Cav-1 not only promoted tumorigenesis in a xenograft mouse model but also metastasis of the transformed cells to neighboring tissues. (oncotarget.com)
Small cell lung cancer (SCLC) is an aggressive malignant disease, with the majority of patients presenting with distant metastasis at diagnosis. (ersjournals.com)
Recent data suggest that the tumour, node, metastasis classification traditionally reserved for the staging of nonsmall cell lung cancer (NSCLC) can also be applied for the staging of SCLC 3 . (ersjournals.com)
These proliferating epithelial tumor cells subsequently disseminate from the focal disruption leading to tumor invasion and metastasis. (stemcellsciencenews.com)
Emerging roles ofthe tumor-associated stroma in promoting tumor metastasis.Cell Adh Migr. (edu.pl)

Various studies have shown that ALDH1 is one of the markers of CSC that can be used as a prognosis indicator because it can be a biological marker for poor prognostic factors in TNBC. (hindawi.com)
The majority of the biologic markers that are proven to have an association with TNBC resistance against therapy are found in the cytoplasm of TNBC cells. (hindawi.com)
Although a variety of different stem cell markers have been used to isolate and characterize CSC from HCC, none of them seemed to be specific for liver malignancies and none of the isolated fractions showed uniform properties. (grantome.com)

Pterygium is a non-malignant, slow-growing conjunctival fibrous vascular tissue of the conjunctiva. (researchsquare.com)

Overexpression of macrophage migration inhibitory factor (MIF) was identified in human GBM specimens that were MGMT methylated but showed poor survival. (nature.com)
In multivariate analysis, ALDH1 was not a factor independently predicting overall survival after the detection of recurrence (adjusted OR 1.451, 95 % CI 0.985-2.085, p = 0.059). (biomedcentral.com)

Engineered chimeric antigen receptor (CAR) T cell therapies (CAR-T) are now commercially available to treat certain leukemias and lymphomas. (bdbiosciences.com)
Using a 3D fibrin gel model, researchers showed that IFN-γ induces tumor-repopulating cells to enter dormancy through an indolamine 2,3-dioxygenase 1 (IDO1)-kynurenine-aryl hydrocarbon receptor (AhR)-p27 dependent pathway. (stemcellsciencenews.com)
Analysis using sphere-formation culture revealed that Tie receptor 1 (Tie1)-positive cells are enriched within the population of tumor cells with cancer stemness properties. (stemcellsciencenews.com)

We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. (jcancer.org)
The C-Kit inhibitor, imatinib mesylate, was administrated to confirm the effect of stromal cells on the tumorigenesis. (jcancer.org)
Their findings indicated that basal stem/progenitor cells are the cells of origin of squamous carcinoma and that cooperation between Sox2 and microenvironment-activated Stat3 is required for Sox2-driven tumorigenesis. (stemcellsciencenews.com)

The sternal puncture showed a very poor marrow with the presence of rarely isolated malignant cells often grouped in rosettes evoking an invasion by a neuroblastoma. (lupinepublishers.com)

Mastocytosis (mast cell disease) is a relatively uncommon haematological tumour of bone marrow origin. (bmj.com)

Breast cancer stem cell is a subset of tumor cells that has a characteristic of stem cells, having a high capacity of self-renewal and tumor initiations, which imply that BCSC may cause aggressiveness of TNBC [ 5 ]. (hindawi.com)
A further subpopulation of the cells expressing Oct4A were also found to co-express the embryonic stem cell marker Sox2, which is a transcription factor necessary for the self-renewal of undifferentiated cells. (cellmedicine.com)

CSC-associated genes, such as ABCG2, CD133, GPC3 and c-KIT, as well as pluripotency related genes (OCT4, NANOG) were selectively overexpressed in the SP cells. (grantome.com)

Understand the general concepts about stem cell biology, emerging concepts in the field of HSC biology, niche components, and regulation. (ebmt.org)

This article focuses on the common infections in patients who have undergone HSCT, the risk factors for these infections, and the approaches to their prevention and treatment. (medscape.com)
The conclusion of this study is that ALDH1 can be used as a poor prognostic factor in TNBC patients although it cannot be an independent prognostic factor. (hindawi.com)
There has been considerable enthusiasm to use MGMT as a predictive biomarker for GBM patients, with the long-term scope for its use as a biomarker to assign alkylating therapy to individual patients, and it is an important stratification factor in current clinical trials. (nature.com)
Contrasting information was derived through a literature review by Louredo et al, which indicated that in pediatric patients, most salivary gland neoplasms (75.4%) are malignant. (medscape.com)
Likewise, in asplenic ALPS patients with, stress the infection risks, including the pneumococcal sepsis associated with asplenia (which may be compounded by lack of memory B cells and autoimmune neutropenia). (medscape.com)
Because of deficient memory B-cell function, these patients are often unable to produce or maintain protective antibodies against polysaccharide antigens after vaccination. (medscape.com)

in small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC). (ersjournals.com)
Here researchers examined the hypothesis that tissue inhibitor of matrix metalloproteinase-2 antitumor activity may involve regulation of the SP in human lung cancer cells. (stemcellsciencenews.com)

RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (biolegend.com)
RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)

The resultant activation of T cells is then exploited for tumor elimination. (bdbiosciences.com)
Hypoxic stem cell lines showed a clear time-dependent activation of the entire panel of pro-inflammatory genes as compared to differentiated tumor cells. (biomedcentral.com)
Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
When this immune system is unable to recognize these cells as abnormal, cellular growth will occur, causing uncontrolled growth and division of cells, that will, in turn, lead to cancer. (benitonovas.com)
Although cancer treatment is dependent on the stage and type, we need a wide range of therapies that work on cellular level like NK cell and stem cell therapies, wide enough to cover the whole spectrum of cancer. (benitonovas.com)

The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
These genes, in turn, increase the risk that more mutations will occur in developing lymphoid cells. (wikipedia.org)
The expression patterns of stem cell-specific genes of these DU145 cells were examined. (jcancer.org)
Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
We have also evidenced a similar pattern of overexpressed genes in GBM-SCs after hypoxic treatment, showing also a gain of invasive and migratory function that was lost when these stem cells differentiated. (biomedcentral.com)
IRF4 is known to drive expression of stem cell reprogramming genes such as the oncogenes MYC and KLF4. (scienceboard.net)
Importantly, they found that treatment reduced the expression of IRF4 target genes, as well as other microenvironment-responsive and cell cycle regulatory transcripts but spared normal hematopoietic cells. (scienceboard.net)

Investigational cell therapies are addressing a wide range of hematological malignancies. (bdbiosciences.com)
Splicing factor mutations are particularly prevalent in MDS, a group of heterogeneous hematological disorders characterized by defective blood stem cells and a high risk of leukemia development. (lu.se)

[ 1 ] The incidence of salivary gland neoplasms as a whole is approximately 5.5 cases per 100,000 individuals in the United States, with malignant neoplasms accounting for 0.9 cases per 100,000. (medscape.com)
In children, 35% of salivary gland neoplasms are malignant. (medscape.com)

The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
View our full list of available antibodies for transcription factors . (biolegend.com)
Investigators explored the potential involvement of the nuclear factor-κB (NF-κB) family of transcription factors in tumor-initiating cells in cell lines that are representative of basal-like and claudin-low breast cancer. (stemcellsciencenews.com)
Because transcription factors (such as IRF4) are difficult to target with traditional small-molecule strategies, researchers from the University of California (UC) San Diego School of Medicine and Ionis Pharmaceuticals used an antisense oligonucleotide-based inhibitory platform to reduce the stability of IRF4 transcripts for the purpose of disrupting cancer metabolism. (scienceboard.net)

Anatomy21

Organisms1

Diseases1

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes7

Disciplines and Occupations1

Proliferation19

Squamous cell carc5

Tumors34

Chemotherapy12

CSCs12

Glioma11

Mesenchymal9

Glioblastoma11

Apoptosis3

Lesions5

Transplantation18

Differentiation11

Epithelial cells3

Gliomas3

Transformation8

Aberrant5

Progression8

Cancers6

Epidermal growth f3

Phenotypes2

Therapeutic9

Proteins3

Benign3

Hematopoietic stem cell3

Multiple myeloma7

Angiogenesis1

Embryonic stem1

Bone marrow stem cells1

Immunotherapy4

Vivo6

Autologous1

Protein10

Transplant4

Lymphoma6

Metastatic4

Characteristics3

Metastasis7

Markers3

Vascular1

Survival2

Receptor3

Tumorigenesis3

Invasion1

Tumour1

Self-renewal2

Oct41

Biology1

Patients6

Lung cancer2

Regulates2

Activation3

Cellular3

Genes7

Hematological2

Neoplasms2

Transcription factors5