• Neoplasms and other masses originating from vascular or mesenchymal tissues also may be found. (medscape.com)
  • Nonmesotheliomatous cancers of the pleura include an assortment of malignant neoplasms that primarily or secondarily involve pleura. (medscape.com)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • 4 Malignant effusions caused by non-epithelial neoplasms are more frequently encountered in children than in adults. (cytojournal.com)
  • Of this uncommon group of highly malignant neoplasms, the leiomyosarcoma is the most common histiotype. (medscape.com)
  • The term osteosarcoma refers to a heterogeneous group of primary malignant mesenchymal neoplasms showing evidence of osteogenic material (1). (bvsalud.org)
  • POT1 mutation carriers had a range of benign and malignant neoplasms involving epithelial, mesenchymal, and neuronal tissues in addition to B- and T-cell lymphoma and myeloid cancers. (cdc.gov)
  • Soft tissue tumors (STT) constitute a heterogeneous group of approximately 100 distinct neoplasms, including more than 50 malignant subtypes, so-called sarcomas. (lu.se)
  • MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
  • Transgelin can inhibit the malignant progression of ESCC by inhibiting the occurrence of EMT. (figshare.com)
  • There is increasing evidence that epithelial to mesenchymal transition (EMT) is involved in cancer progression. (aacrjournals.org)
  • I-branched carbohydrates as emerging effectors of malignant progression. (nih.gov)
  • ELF3 mediates IL-1α induced differentiation of mesenchymal stem cells to inflammatory iCAFs. (nih.gov)
  • The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
  • Mesenchymal stem cells (MSCs) have been widely used in regenerative medicine and clinical therapy due to their capabilities of proliferation, differentiation, and immune regulation. (techscience.com)
  • Malignant proliferation showing large monomorphic cells with some epithelioid (A1E/AE3) or angiocentric aspects without clear vascular differentiation. (medscape.com)
  • Lymphomas, primary or ectopic endocrine tumors, and a wide variety of mesenchymal tumors can occur in the mediastinum. (medscape.com)
  • A case of malignant mesenchymoma of the bladder containing leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, osteosarcoma, and myxomatous components is described. (biomedcentral.com)
  • Chondrosarcoma , Mesenchymal C04.557.450.565.325. (nih.gov)
  • The malignant (cancerous) form of chondroma is chondrosarcoma. (abta.org)
  • Raccoon polyomavirus may contribute to the development of malignant brain tumors of raccoons. (cdc.gov)
  • A malignant neoplasm that arises from the vagina and is characterized by the presence of an epithelial and a mesenchymal component. (nih.gov)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • The term fibroma is inappropriate because the neoplasm exhibits defined histologic features that differ from those of fibromas and may express malignant behavior. (medscape.com)
  • Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
  • A rare neoplasm, usually benign, derived from mesenchymal fibroblasts located in the submesothelial lining of the PLEURA. (bvsalud.org)
  • Osteosarcoma is a malignant bone neoplasm with aggressive clinical evolution which is usually diagnosed in late stages of the disease, when primary tumor reaches significant dimensions. (bvsalud.org)
  • What is a Malignant Granular Cell Tumor? (newhopemedicalcenter.com)
  • Malignant granular cell tumor (MGCT) is a high-grade mesenchymal tumor of Schwann cell origin. (newhopemedicalcenter.com)
  • Only a noticeably growing mass in the affected area is the identifiable symptom of a high-grade malignant granular cell tumor. (newhopemedicalcenter.com)
  • Due to the critical significance of early and accurate detection in improving the survival rate of a patient with a malignant granular cell tumor, an oncologist will order a number of diagnostic tests to produce rapid correct findings. (newhopemedicalcenter.com)
  • Were you diagnosed with a malignant granular cell tumor? (newhopemedicalcenter.com)
  • Using a case series, we propose an algorithmic approach that is simple and will help identify the malignant lesions and institute appropriate management. (scirp.org)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • studies have found a high incidence of high grade pre-neoplastic lesions adjacent to malignant lesions. (vin.com)
  • One challenging feature of head and neck pathology is that a dizzying array of spindle cell lesions occurs here which ranges all the way from reactive, very aggressive forms to malignant lesions. (oldcitypublishing.com)
  • Soft tissue sarcomas are malignant tumors of mesenchymal origin, which may present in many anatomic locations [ 1 ]. (allenpress.com)
  • Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. (bvsalud.org)
  • As a common malignant tumor in the upper respiratory tract, laryngocarcinoma accounts for approximately 25 to 30% of cancer cases worldwide [ 1 , 2 ]. (hindawi.com)
  • Glioblastoma multiforme (GBM) is the most common malignant tumor with high morbidity and mortality. (spandidos-publications.com)
  • Malignant Pleural Mesothelioma (MPM) is a dreadful disease escaping the classical genetic model of cancer evolution and characterized by wide heterogeneity and transcriptional plasticity. (nih.gov)
  • Malignant pleural mesothelioma (MPM) is an aggressive inflammatory cancer with a poor survival rate. (frontiersin.org)
  • Benign and malignant tumors of muscle and other mesenchymal origin usually do not distinguish themselves from other malignancies based on appearance alone. (radiologykey.com)
  • ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate. (nih.gov)
  • Mesenchymal tumors include structures arising from mesodermal-derived precursor cells that develop into cartilage, bone, or other connective tissues. (newhopemedicalcenter.com)
  • Methylated DNA can prevent transcription factors from binding to it, resulting in low or no gene expression, which is an important alteration in the early initiation and development of malignant neoplastic diseases [ 7 ]. (hindawi.com)
  • The histogenesis of malignant mesenchymomas and their optimal management strategy and prognosis remain uncertain. (biomedcentral.com)
  • Increased expression and methylation level of GRHL2 are closely associated with the prognosis and malignant phenotype of acute leukemia patients and play an irreplaceable role in the occurrence and development of patients with acute leukemia. (hindawi.com)
  • The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
  • We previously demonstrated that mesenchymal stem cells (MSCs) ameliorated experimental autoimmune uveoretinitis (EAU) in rats. (nature.com)
  • Malignant mesenchymoma, which was described by Stout in 1948, is defined as a malignant soft tissue tumor that consists of two or more distinctly different mesenchymal components in addition to fibrosarcomatous elements. (biomedcentral.com)
  • They consist of epithelial tissue, and stromal or mesenchymal tissue. (wikipedia.org)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • Small gastrointestinal stromal tumors (GISTs) are rare and malignant tumors that originate in the mesenchymal tissue. (spandidos-publications.com)
  • A gastrointestinal stromal tumor (GIST) is a spindle cell tumor of the gastrointestinal tract derived from mesenchymal tissue and accounts for ~0.2% of gastrointestinal tumors worldwide ( 1 ). (spandidos-publications.com)
  • Soft tissue sarcoma is a disease in which malignant (cancer) cells form in the soft tissues of the body. (dana-farber.org)
  • The 86 specimens contained the cellular tumor and adjacent non-malignant tissue from the surgical margin. (ucsf.edu)
  • This article investigates the role of Transgelin (TAGLN) in the epithelial-mesenchymal transition (EMT) of esophageal squamous cell carcinomas (ESCC) and its possible mechanism of inhibiting the invasion of these cancers. (figshare.com)
  • Bioincompatible dialysis fluid causes mesothelial cells to undergo uncontrolled mesothelial-to-mesenchymal transition triggered by Transforming growth factor-β1, which leads morphological and functional disruption of membrane. (ukessays.com)
  • This literature review is about mechanism of mesothelial -mesenchymal transition (MMT), myofibroblasts and its origin hypothesis, clock genes and their cross relation with organ fibrosis. (ukessays.com)
  • GCNT2 induces epithelial-mesenchymal transition and promotes migration and invasion in esophageal squamous cell carcinoma cells. (nih.gov)
  • Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. (rupress.org)
  • The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal-epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. (rupress.org)
  • These paracrine (cell extrinsic) signals stimulated the activator protein (AP1) pathway, leading to mesenchymal transition, therapy resistance and tumor recurrence. (ucsf.edu)
  • Abnormal methylation of Grainyhead-like 2 (GRHL2) is associated with a substantial role in the malignant phenotype of tumor patients. (hindawi.com)
  • They found that some cells shift to a mesenchymal, radiation-resistant phenotype (state) as a stress response following standard therapy. (ucsf.edu)
  • Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)
  • This category includes adenosarcoma, carcinosarcoma, and malignant mixed tumor resembling synovial sarcoma. (nih.gov)
  • The exosomes (Exo) from human bone marrow mesenchymal stem cells (hBMSCs) after the transfection of miR mimics/inhibitor/si-PTEN were isolated and used to stimulate M4E and Hep2 cells. (hindawi.com)
  • Previous studies indicated that exosomal miR-29a-3p derived from human bone mesenchymal stem cells (hBMSCs) could efficiently suppress cell migrative ability and vasculogenic mimicry in glioma [ 15 ]. (hindawi.com)
  • Tumors originating from lymphatic, vascular, or mesenchymal tissues can also be found in this compartment. (medscape.com)
  • Pro-growth signals from the tumor microenvironment, as well as the cell-intrinsic response to radiation therapy, drove the mesenchymal shift through a stress-response pathway mediated by AP1. (ucsf.edu)
  • Müllerian adenosarcoma (MA) is a rare mixed and low malignant tumor of female genital system, and is a biphasic differential tumor that is composed of admixed benign epithelial and sarcomatoid mesenchymal components. (scirp.org)
  • It spite of its various synonyms, it has no features of mesothelial cells and is not related to malignant MESOTHELIOMA or asbestos exposure. (bvsalud.org)
  • In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
  • Rhabdomyosarcoma Rhabdomyosarcoma is a cancer arising from embryonal mesenchymal cells that have potential to differentiate into skeletal muscle cells. (msdmanuals.com)
  • Mesenchymal stem cell (MSC)-based therapy for the treatment of autoimmune diseases has demonstrated a particular promise after its successful applications in both animal models and patients. (nature.com)
  • Herein, we present the fifth case of malignant mesenchymoma of the urinary bladder to be reported in the literature, which presented five unrelated differentiated tissues more than did previously reported cases. (biomedcentral.com)
  • Using immunohistochemistry in a well-characterized set of adenocarcinoma tissues, we showed down-regulation of epithelial markers (E-cadherin and cytokeratin 18) and up-regulation of mesenchymal markers (vimentin and α-smooth muscle actin) with concomitant transforming growth factor-β1 (TGF-β1) expression at the invasive margin compared with the central tumor. (aacrjournals.org)
  • Müllerian adenosarcomas are rare mixed tumors with low malignant potential, and occur mainly in the uterus. (scirp.org)
  • Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. (mdpi.com)
  • The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
  • The presence of numerous plurinucleate, bizarre cells made it very difficult to determine the malignant potential. (bmj.com)
  • They found that cells in this surgical margin acted as niches of recurrence where non-malignant glia were broadcasting pro-growth signals that influenced the tumor cells to regrow. (ucsf.edu)
  • These mesenchymal transitions were apparent in the tumor samples after therapy, along with increased numbers of cycling mesenchymal cells. (ucsf.edu)
  • Hofvander J, Jo VY, Fletcher CDM, Puls F, Flucke U, Nilsson J, Magnusson L, Mertens F. PHF1 fusions cause distinct gene expression and chromatin accessibility profiles in ossifying fibromyxoid tumors and mesenchymal cells. (lu.se)
  • The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
  • However, malignant SFTs, which comprise 10%-15% of SFTs, not only aggressively infiltrate adjacent structures but are also capable of metastatic spread. (medscape.com)
  • Orbital tumors can be benign or malignant and arise primarily within the orbit or secondarily from an adjacent source, such as the eyelid, paranasal sinus, or intracranial compartment. (msdmanuals.com)
  • Mixed mesenchymal and epithelial tumors are of Mullerian origin. (cytojournal.com)
  • [ 1 ] Intestinal leiomyosarcomas are mesenchymal tumors of smooth muscle origin. (medscape.com)