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  • Cancer
  • In colorectal cancer l-kynurenine was not unequivocally associated with IDO-1 expression, suggesting that the mere expression of tryptophan catabolic enzymes is not sufficiently informative for optimal immunotherapy. (jove.com)
  • Evidence suggests that stimulating apoptosis in malignant cells without inflicting collateral damage to the host's normal tissues is a promising cancer therapy. (jove.com)
  • Immunotherapy such as cancer vaccines have shown encouraging results in phase I and II clinical trials, and have even demonstrated synergistic effects with standard therapy [ 17 , 18 , 19 , 20 , 21 ]. (mdpi.com)
  • Novel immunotherapies have recently demonstrated unprecedented success in selected cancer types ( 12 , 13 ). (frontiersin.org)
  • Heightened interest in applicability of NK cells for cancer immunotherapy has been evoked by improved methodologies for their purification, molecular and phenotypic characterization. (frontiersin.org)
  • In both animal models and cancer patients, chemotherapy has been shown to impact factors such as T-cell proliferation,15 regulatory T-cell (Treg) proportion,16 and monocyte death.17 As immunotherapeutic options for GBM patients are being expanded and investigated, the role of temozolomide as a combinatorial strategy with immunotherapy will become increasingly relevant. (deepdyve.com)
  • stem cells
  • Using cellular luminescence imaging, they found that the modified T cells killed most of the glioma cells and also glioma stem cells. (dana.org)
  • In addition to heterogenous populations of tumor cells, the glioma stem cells (GSCs) and other nontumor cells present in the glioma microenvironment serve as critical regulators of tumor progression and recurrence. (frontiersin.org)
  • In this review, we will discuss the role of key subpopulations of stem cells and their orchestrated immunological interactions with TME in gliomas. (frontiersin.org)
  • vivo
  • These cells can be expanded rapidly ex vivo to use them for adoptive cell therapy (ACT). (hindawi.com)
  • Systemic injection of the CAR T cells into an immunodeficient mouse model inhibited the growth of intracranial glioma xenografts in vivo . (aacrjournals.org)
  • Efforts are under way to improve the effectiveness of adoptive T-cell therapy by the identification and amplification of antigen-specific T cells possessing in vivo cytotoxic activity, by overcoming challenges of trafficking of the transferred T cells to the tumor bed, by overcoming activation-induced cell death (AICD) resulting from Signal 1-only stimulation, and by overcoming apoptosis resulting from growth factor deprivation. (aacrjournals.org)
  • GL261
  • Murine hosts bearing intracranial GL261 glioma or MCA 205 fibrosarcoma were treated with a combination of local cranial radiotherapy, intrasplenic vaccination with DC/tumor fusion cells, and anti-OX40R (CD134) monoclonal antibody (mAb) 7 days after tumor inoculation. (thejns.org)
  • GL261 mouse glioma was orthotopically implanted in mice expressing green fluorescent protein (GFP) under the pericyte marker regulator of G protein signaling 5 (RGS5). (jove.com)
  • mice
  • They plan to undertake three aims to test this hypothesis in a glioma cell line grown in tissue culture and in mice implanted with human glioma cells. (dana.org)
  • cytotoxic
  • Cytotoxic ionizing radiation is known to trigger pro-inflammatory signaling cascades and immune activation secondary to cell death, which can then be exploited by immunotherapies. (mdpi.com)
  • paradigm
  • We did not find any evidence that RGS5 positive pericytes adopt another phenotype within glioma in this paradigm. (jove.com)