• Moreover, granulosa cell tumors (GCTs) are severe ovarian neoplasms that can occur in women of all ages [2]. (cancerhugs.com)
  • Trichilemmal carcinomas (TCs) are rare, malignant, adnexal neoplasms that differentiate from the outer root sheath (ORS) of the hair follicle. (jcadonline.com)
  • Ovarian tumors account for a considerable proportion of clinically relevant neoplasms in females, exhibiting a wide range of age at presentation (from infant to elderly patients). (biomedcentral.com)
  • Epithelial neoplasms of the ovary are thought to arise either directly or indirectly from the ovarian surface epithelium according to incessant ovulation theory[ 4 ]. (biomedcentral.com)
  • Management of follicular and Hürthle cell neoplasms of the thyroid gland. (nih.gov)
  • It should be noted that the vast majority of neoplasms of the upper aerodigestive tract are epithelial and that some of these can show a spindle cell phenotype, e.g., spindle cell or sarcomatoid carcinoma and myoepitheliomas. (basicmedicalkey.com)
  • Because of this, one should be comfortable using immunohistochemistry or other methods with the diagnosis of these lesions, and to help exclude epithelial or melanocytic neoplasms ( Table 11.1 ). (basicmedicalkey.com)
  • 1 ] and was since classified in the 2008 World Health Organization classification of haematolymphoid neoplasms with tumours of histiocytes and dendritic cells, alongside other dendritic cell tumours including Langerhans cell tumours, interdigitating dendritic cell sarcoma and other rare tumours. (biomedcentral.com)
  • Although rare, trichoepitheliomas can develop high-grade carcinomas and mixed (epithelial/sarcomatous) tumors. (medscape.com)
  • Sebaceous carcinomas are common on the eyelid and tend to present with pagetoid extension of atypical sebaceous cells in the conjunctiva or in the epidermis. (medscape.com)
  • Carcinomas tend to show strong expression of p53. (medscape.com)
  • [ 32 ] Also helpful may be demonstration of lipid contents in the vacuoles of the sebaceous cells in less differentiated carcinomas. (medscape.com)
  • In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
  • However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
  • We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). (biomedcentral.com)
  • However, the vast majority of malignant ovarian tumors (80%-85%) are classified as epithelial tumors (carcinomas). (biomedcentral.com)
  • In contrast, 80%-90% of ovarian carcinomas are detected after the age of 40, and 40% of these tumors are detected after the age of 65. (biomedcentral.com)
  • Carcinomas are characterized by cell proliferation, nuclear atypia, and stromal invasion. (biomedcentral.com)
  • Indeed, it has been postulated that the possible mechanisms by which repetitive ovulation could influence the development of ovarian carcinomas include an increased formation of inclusion cysts, repeated bathing of the surface epithelium by an estrogen-rich follicular fluid, excessive production of growth factors or cytokines, and an aberration of the repetitive repair process that follows the trauma to the surface epithelium as a consequence of ovulation. (biomedcentral.com)
  • We examined 69 samples of surgically resected thymic epithelial tumors, namely, 16 thymic carcinomas and 53 thymomas, in which we immunohistochemically evaluated the presence of TAMs using CD68 and CD163 as markers and DCs using S100 as the marker in tumor tissue samples in comparison with normal thymic tissues. (biomedcentral.com)
  • The first (Type I) pathway leads to borderline tumors, which can develop into low-grade serous, mucinous, endometrioid, and clear cell carcinomas. (hindawi.com)
  • Type II tumors include high-grade serous carcinoma, malignant mixed mesodermal tumors, and undifferentiated carcinomas. (hindawi.com)
  • b Sarcomatoid carcinomas can show variable reactivity with antibodies to traditionally mesenchymal antigens (e.g. (basicmedicalkey.com)
  • Lymphovascular invasion (LVI) is an important prognostic factor in various solid tumors, however, data on the association between LVI and thyroid carcinomas are limited. (bjbms.org)
  • Other thyroid malignancies include thyroid lymphoma, various types of thyroid sarcoma, smooth muscle tumors, teratoma, squamous cell thyroid carcinoma and other rare types of tumors. (wikipedia.org)
  • Carcinoma of the thyroid with Ewing family tumor elements (CEFTE) disclosing solid nests of small cells with regular, round nuclei, and nests of papillary thyroid carcinoma (PTC) (a). (wikipedia.org)
  • the medullary thyroid carcinoma component stained positively for calcitonin mRNA while the PTC (follicular variant) component was negative (d). (wikipedia.org)
  • Intrathyroid thymic carcinoma (ITC) also known by the acronym (CASTLE) showing positivity for CD5 (inset) (e). (wikipedia.org)
  • Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a lobulated tumor composed of spindle cells and epithelioid cell component with glands, mucinous cysts, and/or squamous nests (f and g) Follicular patterned medullary thyroid carcinoma (MTC) (a). (wikipedia.org)
  • Calcitonin-negative medullary thyroid carcinoma (h) showing positivity for CGRP (i). (wikipedia.org)
  • The gene involved in basal cell carcinoma ( PTCH, human patched gene located on band 9q22.3) appears to participate in the pathogenesis of trichoepithelioma. (medscape.com)
  • Trichilemmal carcinoma (TC) is a rare cutaneous tumor thought to be derived from the follicular outer root sheath (ORS). (jcadonline.com)
  • Trichilemmal carcinoma shows many histologic features reminiscent of follicular ORS-notably, its glycogen-rich clear cells, trichilemmal keratinization, and similar immunostaining profile. (jcadonline.com)
  • 3 While the clinical differential diagnosis commonly includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and keratoacanthoma, the histopathological differential also includes trichilemmoma, trichoepithelioma, clear cell SCC, clear cell porocarcinoma, and clear cell hidradenocarcinoma. (jcadonline.com)
  • Anaplastic thyroid carcinoma (ATC) is an extremely malignant type of endocrine cancer frequently accompanied by extrathyroidal extension or metastasis through mechanisms that remain elusive. (biomedcentral.com)
  • CREB3L1 knockdown dramatically attenuated invasion of ATC cells, whereas overexpression of CREB3L1 facilitated the invasion of papillary thyroid carcinoma (PTC) cells. (biomedcentral.com)
  • Anaplastic thyroid carcinoma (ATC) is a rare but extremely malignant thyroid - cancer subtype. (biomedcentral.com)
  • To construct a prognostic signature composed of DNA repair genes to effectively predict the prognosis of patients with head and neck squamous cell carcinoma (HNSCC). (frontiersin.org)
  • Head and neck squamous cell carcinoma (HNSCC) is a type of tumor that originates from the squamous epithelium of the head and neck areas, including the mucous membranes of the lips, tongue, pharynx, larynx, and others ( 1 ). (frontiersin.org)
  • No chromosome was found contrary to an extra chromosome 5 in the basal cell carcinoma. (globale-dermatologie.com)
  • Sebaceous carcinoma is an outright malignant neoplasm with prominent cellular pleomorphism and anaplasia. (medscape.com)
  • Diagnosis of TBL is challenging given its resemblance to basal cell carcinoma (BCC) but is important given possible malignant transformation and potential metastasis. (karger.com)
  • Recent data suggest that OLR present a greater percentage of malignant transformation than OLP and, although the association between cancer and OLP has been documented in scientific reports, there is no association between squamous cell carcinoma and cutaneous lichen planus [ 4 - 6 ]. (ecancer.org)
  • The increased expression of COX-2 has been reported in pre-cancerous lesions, in several forms of cancer, including squamous cell carcinoma and in OLP [ 7 ]. (ecancer.org)
  • Because of their (1) growth potential, (2) recurrence rate, and (3) association with nevoid basal cell carcinoma syndrome. (easynotecards.com)
  • A number of skin tumors show differentiation toward hair matrix components, including Gardner syndrome cysts, basal cell carcinoma, purely matrical tumors (pilomatricoma, matricoma, melanocytic matricoma, and pilomatrix carcinoma), and even some mixed tumors. (actasdermo.org)
  • We present the case of a 75-year-old woman with a history of basal cell carcinoma and actinic keratoses who presented with an asymptomatic papular lesion on her forehead that had been growing progressively for several weeks and was clinically suggestive of basal cell carcinoma ( Fig. 1 A). The lesion was excised. (actasdermo.org)
  • The malignant lesions comprised three cases of ductal carcinoma in situ (DCIS) and 22 cases of infiltrating ductal carcinoma, not otherwise specified, IDC (NOS). (ijpmonline.org)
  • Like most other epithelial tumors, ovarian carcinoma spreads initially into adjacent organs, specially the fallopian tubes and uterus. (biomedcentral.com)
  • and the shedding of malignant cells from the surface of the ovarian tumor into the peritoneal cavity is a common scenario in the progression of ovarian carcinoma [ 6 , 8 ]. (biomedcentral.com)
  • To the best of our knowledge, we are the first to show a high percentage of CD163+ TAMs and a low percentage of S100+ DCs in thymic carcinoma samples, and our findings may provide an idea for future targeted therapeutic strategies for thymic carcinoma using antibodies that inhibit monocyte differentiation to TAMs, thereby skewing TAMs differentiation toward DCs. (biomedcentral.com)
  • Thymic epithelial tumors are rare mediastinal tumors and can be classified into thymoma and thymic carcinoma. (biomedcentral.com)
  • Here, we immunohistochemically examined tumor tissue samples to characterize TAMs and DCs in thymoma and thymic carcinoma by comparing them with those in normal thymic tissues. (biomedcentral.com)
  • Thyroid carcinoma (THCA) is a common endocrine malignant tumor. (peerj.com)
  • Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
  • Basal cell carcinoma of the right lower lid. (medscape.com)
  • The incidence of oral squamous cell carcinoma (OSCC) has been increasing for several decades and is predicted to rise 33% by 2035 [ 1 ]. (biomedcentral.com)
  • Conclusions Our present study reveals a novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via the regulation of EGFR. (cancerhugs.com)
  • This obtaining contributes to the knowledge of the pro-proliferation effect of HOXA7 in granulosa cell growth and differentiation. (cancerhugs.com)
  • HOX genes exert pleiotropic functions in many cell types and may control cell proliferation, differentiation, adhesion, and migration [7]. (cancerhugs.com)
  • This differential localization indicated that HOXA7 underwent cell type- and stage-specific adjustments during ovarian folliculogenesis, which most likely led to the rules of granulosa cell proliferation. (cancerhugs.com)
  • If altered, cellular proliferation may be up-regulated because of a poorly functioning or absent tumor suppressor. (medscape.com)
  • Bowen, 2004} detected keratinocyte proliferation by PCNA (proliferating cell nuclear antigen) marking, 13,9% of keratinocytes were stained, compared with 6,4% in normal skin. (globale-dermatologie.com)
  • Exhibiting high consistence in sequence and structure, S100 family members are interchangeable in function and they show a wide spectrum of biological processes, including proliferation, apoptosis, migration, inflammation and differentiation and the like. (cancerindex.org)
  • Ovarian epithelial tumors are subclassified into several categories based on two criteria: 1) the degree of epithelial proliferation and invasion and 2) the histotype of the epithelium composing the tumor. (biomedcentral.com)
  • Benign epithelial tumors (adenoma and cystadenoma) are characterized by the absence of cell proliferation and invasion. (biomedcentral.com)
  • Borderline tumors are characterized by cell proliferation and a minor degree of nuclear atypia without stromal invasion. (biomedcentral.com)
  • Signal transduction plays an important role in activating cellular functions, cell differentiation , and cell proliferation . (lookformedical.com)
  • These are for the most part low-grade tumors that are characterized by a high frequency of mutations of KRAS , BRAF, ERBB2, CTNNB1 (the gene encoding beta catenin), and PIK3CA , low proliferation, and a 5-year survival of approximately 55% [ 2 ]. (hindawi.com)
  • The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. (lookformedical.com)
  • By focusing on the critical roles of different metabolic programs, such as glycolysis, oxidative phosphorylation, fatty acid oxidation, fatty acid synthesis, and amino acid metabolism, as well as their essential regulators in modulating Treg proliferation, migration, and function, we hope to provide new insights into Treg cell-targeted antitumor immunotherapies. (biomedcentral.com)
  • By using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), both GHR106 Mabs and the GnRH decapeptide antagonist, Antide, were shown to be bioequivalent in terms of their respective effects on genes involved in the proliferation and apoptosis of cancer cells. (annexpublishers.co)
  • Anti-proliferation effects of GnRH or its analogs on cancer cells of different human tissue origins have been reported and have been the molecular basis for cancer therapy [ 4 , 7-9 ]. (annexpublishers.co)
  • It is hypothesized that the epithelium covering the ovarian surface and the peritoneum retains the potential for Müllerian differentiation given the proximity to the coelomic epithelium from which the Müllerian ducts are derived. (biomedcentral.com)
  • Using the Drosophila ovarian follicular epithelium as a model, we found that posterior follicle cells with loss of lethal giant larvae (lgl) or Discs large (Dlg) accumulate apically toward germline cells, whereas cells with loss of Bazooka (Baz) or atypical protein kinase C (aPKC) expand toward the basal side of wildtype neighbors. (bvsalud.org)
  • Further studies revealed that these distinct multilayering patterns in the follicular epithelium were determined by epidermal growth factor receptor (EGFR) signaling and its downstream target Pointed, a zinc-finger transcription factor. (bvsalud.org)
  • Chemo-radio therapeutic outcomes are poor in CCA patients because the tumor is highly desmoplastic with fibrogenic connective tissue and immune cells such as T lymphocytes, natural killer (NK) cells and macrophages that infiltrate the tumor epithelium [ 4 ]. (aging-us.com)
  • A malignant tumor composed of cells showing differentiation toward sebaceous epithelium. (nih.gov)
  • However, others believe it is unlikely that CICs are precursors and have instead proposed that ovarian epithelial tumors develop from müllerian-type epithelium lining paraovarian and paratubal cysts (the so-called secondary müllerian system) [ 6 ]. (hindawi.com)
  • Most oral cancers are preceded by long-standing clinical changes of the oral mucosa, mainly white (leukoplakia) and red (erythroplakia) patches, with progression from normal epithelium to invasive OSCC occurring through sequential stages of histological intra-epithelial changes including mild, moderate, and severe dysplasia. (biomedcentral.com)
  • In addition, the differential immune cell infiltration between UL and ULMS tissues was investigated using the CIBERSORT algorithm. (biomedcentral.com)
  • We found a higher infiltration of five types of cells (memory B cells, M0-type macrophages, mast cells activated, M1-type macrophages, and T cells follicular helper) in ULMS tissues than NL tissues, while the infiltration of two types of cells (NK cells activated and mast cells resting) was lower than in NL tissues. (biomedcentral.com)
  • Bowen, 2004} to detect apoptosis in fixed tissues, but no statistically significant results between SKs and normal skin samples were shown. (globale-dermatologie.com)
  • however, the expression in normal and malignant adult tissues has not been examined in detail. (nature.com)
  • Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
  • Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
  • A stringent characterization pipeline demonstrated that donor cells efficiently (up to 90%) incorporated into various tissues (including the gonads and placenta) of the chimeric monkeys. (bvsalud.org)
  • We identified 96 differentially expressed genes (DEGs), including 13 upregulated and 83 downregulated genes, in CCA tissues as regulatory T cells were significantly higher and the proportions of activated natural killer cells and monocytes were significantly lower in CCA tissues than the precancerous tissues. (aging-us.com)
  • Functional enrichment analysis of the DEGs in the high OSM-expressing CCA tissues showed that pathways related to tumor progression and immune response were significantly upregulated. (aging-us.com)
  • CCA patients with a higher proportion of neutrophils and T-regulatory cells (Tregs) and lower proportion of CD8 + T cells in the tumor tissues are associated with poor prognosis [ 5 ]. (aging-us.com)
  • However, only limited types of tumor-infiltrating immune cells have been analyzed in CCA tissues and the mechanisms regulating the tumor infiltration of immune cells are poorly understood. (aging-us.com)
  • Recent studies demonstrate that somatic mutations in the tumor tissues influence immunotherapeutic response in several cancers [ 6 , 7 ]. (aging-us.com)
  • Increased numbers of highly fucosylated Haptoglobin alpha isoforms in ascitic fluids and the presence of fucosylated Haptoglobin in tumor tissues of ovarian cancer Mexican patients associated with advanced stages of the disease, reinforce the potential of fucosylated Haptoglobin alpha isoforms to be characterized as biomarkers for disease progression. (biomedcentral.com)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
  • On the other hand, dendritic cells (DCs) that infiltrate tumor tissues are involved in tumor suppression. (biomedcentral.com)
  • Macrophages that infiltrate tumor tissues are referred to as tumor-associated macrophages (TAMs) and are closely involved in tumor progression by inducing angiogenesis, immunosuppression, and invasion [ 1 ]. (biomedcentral.com)
  • The structure and structure-based modulation of ADAM17 are also described for better understanding of the various ADAM17 regulatory pathways in different cell types or tissues. (frontiersin.org)
  • The GSE3467 , GSE3678 , GSE33630 and GSE53157 were obtained from the GEO database, including 100 thyroid tumors and 64 normal tissues to obtain the intersection of differentially expressed genes, and a protein-protein interaction network was constructed to obtain the HUB gene. (peerj.com)
  • In tumour tissues, 43.6% of samples expressed COM-1, at a level of 98.9 copies of COM-1 transcript per sample (p=0.012). (iiarjournals.org)
  • Normal tissues demonstrated strong nuclear and peri-nuclear staining for COM-1 on immunohistochemistry (IHC) and in tumour tissues, the level of staining was found to be much greater, with a greater degree of cytoplasmic staining and little nuclear staining. (iiarjournals.org)
  • In breast cancer, for example, COM-1 mRNA was shown to be expressed in cancer tissues more frequently than in the normal tissues of the same patient ( 1 ). (iiarjournals.org)
  • In pancreatic cancer, some studies have associated overexpression of COM-1 with pancreatic cancer tissues ( 4 , 5 ) and others have found the reverse, in that knockout of COM-1 in pancreatic cancer cell lines resulted in increased growth rates ( 6 ). (iiarjournals.org)
  • In prostate tissues, we have shown that cancer tissues have significantly reduced expression of COM-1 protein compared to normal prostate tissue whereas prostate cancer cell lines widely expressed COM-1. (iiarjournals.org)
  • In this review, we discuss the common and distinct metabolic profiles of Tregs in peripheral tissues and the TME, as well as the differences between Tregs and other conventional T cells in their metabolic preferences. (biomedcentral.com)
  • Subsequent studies revealed that GnRH and its receptor also play extra-pituitary roles in numerous normal and malignant cells or tissues, the mechanisms of which are still being actively explored [ 4-6 ]. (annexpublishers.co)
  • Meanwhile, the on-target/off-tumor toxicity caused by relative expression of target on normal tissues is another issue that should be reckoned. (ijbs.com)
  • Granulosa cells surround the developing oocyte, providing a critical microenvironment for follicular growth. (cancerhugs.com)
  • These results demonstrate that CREB3L1 maintains the CAF - like property of ATC cells by activating the ECM signaling, which remodels the tumor stromal microenvironment and drives the malignancy of ATC. (biomedcentral.com)
  • The extracellular matrix (ECM) is a fundamental part of the tumor microenvironment. (biomedcentral.com)
  • A known characteristic of ATC is its ability to easily shape the tumor matrix microenvironment. (biomedcentral.com)
  • Advances in immunotherapy have shed greater focus on the role of tumor-infiltrating immune cells, which are vital components of the tumor immune microenvironment (TIME). (aging-us.com)
  • TP53 mutations are also associated with the infiltration of immune cells into the tumor microenvironment [ 10 - 12 ]. (aging-us.com)
  • It has been argued that changes in the microenvironment of the ovarian stroma surrounding the CICs leads to müllerian-type differentiation. (hindawi.com)
  • γδ T cells recruited into the tumor microenvironment can act as effector cells to mediate cancer immune surveillance. (explorationpub.com)
  • Therefore, an in-depth understanding of γδ T cells that play conflicting roles in the tumor microenvironment is necessary. (explorationpub.com)
  • Targeting Tregs to reestablish the proinflammatory and immunogenic tumor microenvironment (TME) is an increasingly attractive strategy for cancer treatment and has been emphasized in recent years. (biomedcentral.com)
  • Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)
  • Immunohistochemistry may be helpful in the differential diagnosis between benign and malignant sebaceous lesions. (medscape.com)
  • Interestingly, such lesions appear to show normal nuclear mismatch repair protein expression, thus suggesting a different neoplastic pathway. (medscape.com)
  • Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. (biomedcentral.com)
  • The term organoid nevus may be used to emphasize the admixture of epidermal cells often evident in individual lesions of epidermal nevi. (medscape.com)
  • Enormous efforts in the search for objective measures that can differentiate benign from malignant thyroid lesions have been recently undertaken, mainly involving immunohistochemical markers and molecular markers, using somatic mutation, gene expression, and microRNA analyses. (touchendocrinology.com)
  • Immunohistochemical staining for cytokeratin 5/6 was applied on cell block sections of 23 cases of benign and 25 cases of malignant breast lesions using avidin biotin peroxidase technique. (ijpmonline.org)
  • All benign lesions showed positive immunoreaction, with the staining index varying from 6-9, except lactating adenoma. (ijpmonline.org)
  • The staining reaction in the malignant lesions was only cytoplasmic and the intensity was significantly less than that of benign lesions. (ijpmonline.org)
  • This antibody is also used as a component of panels to differentiate benign and malignant breast lesions. (ijpmonline.org)
  • Likewise, bispecific antibodies for engagement of other cytotoxic immune cells were constructed, for instance, targeting Fcγ RI/CD64 on macrophages and Her2/neu or EGFR on tumor cells. (aacrjournals.org)
  • Macrophages play a critical role in the inflammatory response and tumor development. (bvsalud.org)
  • In vitro macrophage models could be derived from mouse bone marrow cells stimulated with two types of differentiation factors: GM-CSF (GM-BMDMs) and M-CSF (M-BMDMs), to represent M1- and M2-like macrophages, respectively. (bvsalud.org)
  • In a number of human malignancies, tumor-associated macrophages (TAMs) are closely involved in tumor progression. (biomedcentral.com)
  • Loss of CREB3L1 inhibited metastasis and tumor growth of ATC xenografts in zebrafish and nude mouse model. (biomedcentral.com)
  • After CREB3L1 knockdown, the presence of CAFs inhibited the growth of ATC spheroids and the metastasis of ATC cells. (biomedcentral.com)
  • Overexpression of COX-2 is important in tumour growth, invasion and metastasis, angiogenesis, and inhibition of apoptosis, all important steps in the development of cancer. (ecancer.org)
  • patients with type E (AD) tumor had higher incidence of nodal metastasis at MGCD0103 cell line TGF-beta inhibitor mediastinal lymph node than did patients in tumor groups, and all mediastinal positive nodes existed in lower mediastinal area. (hsdpathway.com)
  • Because no cervical or mediastinal lymph node metastasis was recognized in the type G tumor group, we should not perform subtotal esophagectomy for type G tumor. (hsdpathway.com)
  • and distant metastasis (M category) were significantly prognostic factors in the univariate analysis, tumor type (types E (SQ), E (AD), Ge and G) and depth of tumor invasion (pT3-4 tumor) were significant in the multivariate analysis in this study. (hsdpathway.com)
  • More recent data show that OPG is also produced in breast tumor cells, and that it can promote tumor growth and metastasis [ 5 , 6 ]. (biomedcentral.com)
  • Single - cell RNA-sequencing analysis revealed that CREB3L1 expression gradually increased during the neoplastic progression of a thyroid follicular epithelial cell to an ATC cell, accompanied by the activation of the extracellular matrix (ECM) signaling. (biomedcentral.com)
  • In a primary tumor mass, the ECM is strictly modulated in a tumor - permissive way, which in turn facilitates tumor progression and influences cancer cell invasion. (biomedcentral.com)
  • S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. (cancerindex.org)
  • Tissue detection of Haptoglobin and its fucosylated form, by histo-immunofluorescence in biopsies of ovarian cancer, also showed a correlation with ovarian cancer progression. (biomedcentral.com)
  • Recently, accumulating preclinical studies have illustrated the feasibility of slowing tumor progression by either overexpressing tumor suppressive miRNAs, or by neutralizing the activities of oncogenic miRNAs in cell- and animal-based models of cancer. (biomedcentral.com)
  • A recent systematic review suggests that OED is associated with oral cancer development in 12.1% of cases, with severe OED showing higher rates of progression compared to mild and moderate dysplasia (24.1% vs 10.3%) [ 3 ]. (biomedcentral.com)
  • Other benign and malignant cutaneous proliferative entities where the growth hormone receptor was present included histiocytomas, melanomas and acrochordons. (globale-dermatologie.com)
  • My research interests comprise cutaneous tumors with emphasis in lymphomas and melanoma. (mdanderson.org)
  • In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
  • This ulcerated nodule of localized primary cutaneous CD30+ anaplastic large cell lymphoma is relatively nonspecific in appearance. (medscape.com)
  • PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
  • As most malignant ovarian tumors are epithelial in origin, most studies of ovarian malignancy do not include GCTs [3]. (cancerhugs.com)
  • Additionally, the manifestation of HOXA7 was recognized in ovarian tumors exhibiting mullerian-like features and correlated with the era of anti-HOXA7 antibodies in individuals [10]. (cancerhugs.com)
  • According to the 2014 World Health Organization (WHO) classification and tumor morphology, primary ovarian tumors are subdivided into three categories: epithelial (60%), germ cell (30%), and sex-cord stromal tumors (8%)[ 1 ]. (biomedcentral.com)
  • Malignant germ cell and sex-cord stromal tumors comprise approximately 10% of all malignant ovarian tumors. (biomedcentral.com)
  • Approximately two-thirds of ovarian tumors occur in women during reproductive age, whereas less than 5% occur in children. (biomedcentral.com)
  • Approximately 75%-80% of ovarian tumors are benign, occurring in patients under 40 years of age. (biomedcentral.com)
  • It can be a benign tumor such as thyroid adenoma, or it can be a malignant neoplasm (thyroid cancer), such as papillary, follicular, medullary or anaplastic thyroid cancer. (wikipedia.org)
  • Paraganglioma (j) typically shows negativity for calcitonin and S100-positive sustentacular cells (inset) Hyperfunctioning follicular adenoma typically shows follicles with papillary infoldings and bubbly, pale colloid with peripheral scalloping (a). (wikipedia.org)
  • Histologic section of sebaceous adenoma showing a predominance of sebaceous cells with prominent cytoplasmic vacuoles. (medscape.com)
  • Sebaceous epithelioma (also known as sebaceoma) differs from sebaceous adenoma mainly in regards to the degree of differentiation. (medscape.com)
  • Sebaceous epithelioma lacks the lobular architecture and sebaceous maturation of sebaceous adenoma, and contains an obvious preponderance of undifferentiated cells. (medscape.com)
  • Thyroid neoplasm is a neoplasm or tumor of the thyroid. (wikipedia.org)
  • citation needed] Thyroid neoplasm might be classified as benign or malignant. (wikipedia.org)
  • Thyroid cancers are mainly papillary, follicular, medullary or anaplastic thyroid cancer. (wikipedia.org)
  • The classification is determined by looking at the sample of cells under a microscope and determining the type of thyroid cell that is present. (wikipedia.org)
  • Thyroid nodules are common, but only 5% are malignant. (scirp.org)
  • Thyroid nodules are common and frequently benign, with approximately 5-10% being malignant. (touchendocrinology.com)
  • Pitfalls in the diagnosis of follicular epithelial proliferations of the thyroid. (nih.gov)
  • In thyroid cancers, COM-1 has been found to be overexpressed in papillary and follicular tumours but to a much lower degree in anaplastic tumours, this is together with a change in location of COM-1 expression on immunohistochemical (IHC) staining from nuclear (found in normal tissue and follicular tumours) to cytoplasmic (in papillary and anaplastic tumours) locations ( 9 ). (iiarjournals.org)
  • In brief, frozen sections of profiled tumors were examined by hematoxylin-and-eosin, and areas rich in neoplastic cells were cut from the frozen blocks. (nature.com)
  • Cells grown in vitro from neoplastic tissue. (lookformedical.com)
  • Typically, neoplastic cells lack CD1a, desmin and CD45 staining. (biomedcentral.com)
  • The rare cases of trichoepithelioma described as having aggressive behavior (ie, ulceration, recurrence) are probably follicular tumors within the basal cell nevus syndrome and not trichoepithelioma. (medscape.com)
  • Following reconstruction, the patient has shown no signs of recurrence of the lesion at 24 months. (karger.com)
  • However some patients have a more aggressive tumour with local recurrence occurring in up to 43 %, distant metastases in 21-24 % and disease-related mortality in 13-17 % [ 5 - 7 ]. (biomedcentral.com)
  • HNSCC is highly malignant, and there are no specific prognostic-related biomarkers for clinical application. (frontiersin.org)
  • Cholangiocarcinoma (CCA) is a highly malignant tumor originating from the intra- or extra-hepatic bile ducts that has shown increasing morbidity and mortality rates worldwide in the last few years [ 1 ]. (aging-us.com)
  • Tangential shave biopsy of the lesion was performed and the histopathologic report revealed an adnexal neoplasm with trichilemmal differentiation, desmoplastic component, and atypia with margins involved (Figures 2A, 2B, 3A, and 3B). (jcadonline.com)
  • Follicular dendritic cell sarcoma (FDCS) is an uncommon neoplasm of mesenchymal stem cell origin whose clinical course displays much variability. (biomedcentral.com)
  • In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
  • B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
  • Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
  • The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
  • A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
  • A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • The morphology codes of the ICD- the volume also includes some cancers classified according to O-2 corresponding to these categories are shown in Table 4.2. (who.int)
  • Furthermore, the subcellular localization of HOXA7 changed from nuclear to cytoplasmic during follicular maturation [13] predominantly. (cancerhugs.com)
  • Lobules contain basaloid cells at the periphery and mature sebaceous cells, with characteristic cytoplasmic vacuoles toward the center. (medscape.com)
  • Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
  • An alternative approach to engage T cells for cancer therapy are antibodies, which are bispecific for a surface target antigen on cancer cells, and for CD3 on T cells. (aacrjournals.org)
  • These are capable of connecting any kind of cytotoxic T cell to a cancer cell, independently of T-cell receptor specificity, costimulation, or peptide antigen presentation. (aacrjournals.org)
  • Pioneering work by Kufer and colleagues ( 6 ) showed that CD3/target antigen-bispecific antibodies of this particular design had an exceptionally high potency, and could likewise engage CD8 + and CD4 + T cells for redirected lysis of cancer cells at very low effector to target (E:T) ratios. (aacrjournals.org)
  • Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
  • The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
  • Follicular dendritic cells (FDC) form a tight meshwork in primary and secondary lymphoid follicles and interact with T and B lymphocytes through antigen presentation and generation and regulation of the germinal centre reaction [ 2 , 3 ]. (biomedcentral.com)
  • Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)
  • Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)
  • ALCL was recognized in 1985, when tumor cells consistently demonstrated labeling by the monoclonal antibody Ki-1, a marker later shown to recognize the CD30 antigen. (medscape.com)
  • Yet, how polarity loss cooperates with intrinsic signals to control directional invasion toward neighboring epithelial cells remains elusive. (bvsalud.org)
  • The peritoneum is a common site of metastases for gastrointestinal tumors that predicts a poor outcome. (stanford.edu)
  • It may be achieved, at least partially, by more extensive basic studies investigating the spatiotemporal dynamics of T cell activation by CARs and unraveling the connection between T cell migration in solid tumors and the effectiveness in eradication of solid tumors and metastases [ 5 ]. (ijbs.com)
  • HNSCC is currently one of the most common malignant tumors worldwide, with morbidity and mortality accounting for 3.6 and 3.4% of all malignant tumors in 2020, respectively ( 2 ). (frontiersin.org)
  • Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering a spectrum from indolent to aggressive disease. (biomedcentral.com)
  • We describe a case of progressive follicular dendritic cell sarcoma of the lung and pleura, treated based on knowledge of the tumour's molecular aberrations. (biomedcentral.com)
  • One method is to target senescent T cells which have selective apoptosis function. (hindawi.com)
  • Recently, a study showed that FOXO4/p53 was interfered by an engineered peptide, which caused targeted apoptosis of the senescent fibroblasts [ 11 ]. (hindawi.com)
  • Indeed apoptosis is inhibited in senescent cells. (globale-dermatologie.com)
  • Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). (biomedcentral.com)
  • Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
  • Fibroblasts transfected with COM-1 have been shown to grow more slowly and those with COM-1 knockout grow more rapidly and are more resistant to chemically induced apoptosis ( 7 , 8 ). (iiarjournals.org)
  • Similar to decapeptide GnRH analogs, both Mabs were shown to induce apoptosis to cultured cancer cells of various tissue origins, including those from the ovary, breast, prostate, and lung. (annexpublishers.co)
  • Brooke-Spiegler syndrome patients have a high incidence of multiple skin appendage tumors such as cylindroma , trichoepithelioma, and spiradenoma . (medscape.com)
  • These patients may show mutations of the CYLD gene (cylindromatosis gene) that map to 16q12-q13. (medscape.com)
  • 1,2 These tumors predominantly occur in elderly patients on sun-exposed areas, specifically on the head and neck, with the face being the most common location. (jcadonline.com)
  • There is increasing evidence that T cells are able to control tumor growth and survival in cancer patients, both in early and late stages of the disease. (aacrjournals.org)
  • However, tumor-specific T-cell responses are difficult to mount and sustain in cancer patients, and are limited by numerous immune escape mechanisms of tumor cells selected during immunoediting. (aacrjournals.org)
  • T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. (hindawi.com)
  • We also analyzed the tumor-infiltrating immune cells, immune-related gene expression, tumor mutation burden, and drug sensitivity of patients with HNSCC in the high- and low-risk groups. (frontiersin.org)
  • The results showed that the risk model composed of DNA repair genes could effectively distinguish patients with different clinical outcomes and has independent predictive prognostic ability. (frontiersin.org)
  • The transcriptome profiling (RNA-seq) data harmonized to fragments per kilobase million (FPKM), clinical information, and tumor mutations in patients with HNSCC were downloaded from the Cancer Genome Atlas (TCGA) database ( https://portal.gdc.cancer.gov/ ) in March 2021 ( 9 ). (frontiersin.org)
  • There is a major problem with the latter method in that mutations are seen in sebaceous tumors in patients without the syndrome. (medscape.com)
  • These tumors are primarily found in elderly patients with a median age of 60 years. (biomedcentral.com)
  • In this study, we used bioinformatics tools to analyze transcriptome data from cholangiocarcinoma (CCA) patients in multiple datasets (Sun Yat-sen University, TCGA and GSE32225 cohorts) to identify mechanisms that regulate tumor infiltration by immune cells and survival outcomes. (aging-us.com)
  • The survival outcomes of CCA patients were associated with the TP53 gene mutation status, levels of Oncostatin M (OSM) expression, and the proportions of tumor-infiltrating immune cell types, including dendritic cells, monocytes, and T follicular helper cells. (aging-us.com)
  • Although it seems reasonable to unite type E (AD) and Ge tumors as a group on the basis of lymphadenectomy extent, the patients with type E (AD) tumor showed significantly lower survival rates than other type tumor groups. (hsdpathway.com)
  • In multivariate analysys, tumor type (type E (AD)) was an independent risk factor for survival of the patients with EGJC in this study. (hsdpathway.com)
  • Therefore, Branched chain aminotransferase extended gastrectomy with or without lower click here esophagectomy, according to tumor location, and lower mediastinal and abdominal lymphadenectomy is thought to be adequate for patients with EGJC, including type E (SQ) tumor. (hsdpathway.com)
  • In this study, we examined samples from 69 patients diagnosed and treated for primary thymic epithelial tumors at Showa University Northern Yokohama Hospital, Showa University Hospital, and Showa University Fujigaoka Hospital from August 2003 to June 2014. (biomedcentral.com)
  • Postoperative radiation can also be a useful adjunct when patients have aggressive tumors that were treated surgically or when surgery has failed to clear the margins of the tumor. (medscape.com)
  • SAVER is a phase IIb open-label, randomised control trial of VPA as a chemopreventive agent in patients with high-risk oral epithelial dysplasia (OED). (biomedcentral.com)
  • Around 25% of patients with PC-ALCL show spontaneous regression. (medscape.com)
  • Background Ovarian follicular maturation represents one of the most complex and clinically important developmental processes during the reproductive life of women. (cancerhugs.com)
  • Nevus comedonicus is evident clinically as confluent clusters of dilated follicular orifices plugged with keratin, giving the appearance of aggregated open comedones. (medscape.com)
  • However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. (ijbs.com)
  • Optimization of the design of CAR vectors, exploration of new targets, addition of safe switches and combination with other treatments bring new vitality to the CAR-T cell based immunotherapy against solid tumors. (ijbs.com)
  • In this review, we focus on the major obstacles limiting the application of CAR-T cell therapy toward solid tumors and summarize the measures to refine this new cancer therapeutic modality. (ijbs.com)
  • And much work remains to be done to improve the efficacy of CAR-T cell therapy for solid tumors. (ijbs.com)
  • In this review, we discuss the current status and major obstacles for the treatment of solid tumors with CAR-T cells, thus provide some potential measures to refine this novel therapeutic modality. (ijbs.com)
  • Homeobox (HOX) genes encode evolutionarily conserved transcription factors that are essential for embryonic morphogenesis and differentiation [5]. (cancerhugs.com)
  • Latest research claim that HOX genes might play essential jobs in ovarian cancer differentiation [9-11]. (cancerhugs.com)
  • However, the part of HOX genes in developing granulosa cells isn't well known. (cancerhugs.com)
  • We proven that three HOXA genes previously, HOXA4, HOXA7 and HOXA10, had been overexpressed in serous ovarian adenocarcinomas in comparison with harmless serous tumors or tumors with low malignant potential. (cancerhugs.com)
  • Because several tumor suppressor genes (ie, p16, p15, and the gene for the basal cell nevus syndrome) are in this region, the gene for the development of familial trichoepithelioma also encodes for a tumor suppressor. (medscape.com)
  • This study aimed to screen the hub genes and the immune cell infiltration pattern in ULMS by bioinformatics methods. (biomedcentral.com)
  • Finally, we used western blot to preliminarily detect the hub genes in cell lines. (biomedcentral.com)
  • Finally, the correlation analysis results indicate that NK cells activated and mast cells activated positively correlated with the hub genes. (biomedcentral.com)
  • A series of evidence confirm that the five hub genes and the infiltration of seven types of immune cells are related to USML occurrence. (biomedcentral.com)
  • These findings provide insight into how cell polarity genes and receptor tyrosine kinase signaling interact to govern epithelial cell organization and directional growth that contribute to epithelial tumor formation. (bvsalud.org)
  • Correlation analysis with the proteomic data showed high consistency in the mRNA and protein levels of metabolic genes. (bvsalud.org)
  • The patterns of multiple expressed genes that correspond to benign or malignant processes are identified by messenger RNA (mRNA) expression profiles. (touchendocrinology.com)
  • Indeed, emerging evidence indicates that miRNAs function as a molecular rheostats that serve in fine-tuning cell signaling pathways [ 10 , 11 ], doing so by modulating the expression of large numbers of genes and, consequently, impacting the flux through essential regulatory nodes of vast signaling networks. (biomedcentral.com)
  • The age-specific incidence of ovarian epithelial cancer rises from the age of 20 to 80 and subsequently declines[ 2 ]. (biomedcentral.com)
  • The main differentiating histological feature in a TC is the evidence of trichilemmal keratinization, where the tumor exhibits an absence of granular layer between the stratum spinosum and stratum corneum. (jcadonline.com)
  • But ULMS has not been intensively investigated because they are given the few tumor intratumoral lymphocytes (TILs) on H&E sections and the low mutational burden [ 12 ]. (biomedcentral.com)
  • A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
  • They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
  • A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
  • A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
  • A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
  • Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)
  • Originally described by Headington in the 1970s, trichoblastoma (TBL) is now appreciated as a rare benign tumor that originates from the follicular germ cell line [1, 2]. (karger.com)
  • These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. (biomedcentral.com)
  • CREB3L1 knockdown significantly decreased the expression of collagen subtypes in ATC cells and the fibrillar collagen in xenografts. (biomedcentral.com)
  • This study observed reduced breast cancer risk among women with comparatively high OPG concentrations, but given a small number of incident cases ( n = 76), risk by tumor subtypes (e.g., by estrogen (ER) and progesterone (PR) receptor status) was not investigated. (biomedcentral.com)
  • Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). (cancerindex.org)
  • Liu Q , Lan T , Song Y , Cai J , Yu X , Chen W , . Oncostatin M expression and TP53 mutation status regulate tumor-infiltration of immune cells and survival outcomes in cholangiocarcinoma. (aging-us.com)
  • Our study demonstrates that OSM expression and TP53 mutation status regulate the tumor infiltration by immune cells and survival outcomes in CCA. (aging-us.com)
  • Cell survival. (lookformedical.com)
  • It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION . (lookformedical.com)
  • Although the mortality rate is decreased due to early diagnosis, the survival rate varies depending on the type of tumor. (peerj.com)
  • Adipophilin and periplipin are two such antigens associated with sebaceous differentiation. (medscape.com)
  • TBL is classified in the latest skin tumor classification by the World Health Organization as one with a favorable outcome. (karger.com)
  • 4 Melanocytic matricoma, which was described by Carlson 5 and is included in the World Health Organization classification of skin tumors, is a similar tumor, but with pigmented dendritic melanocytes (i.e., it has a dual population of epithelial and melanocytic cells). (actasdermo.org)
  • It is of great significance to gain insight into the classification of γδ T cell subsets. (explorationpub.com)
  • Non-hyperfunctioning adenomas with papillary hyperplasia usually show a more predominantly papillary pattern without vacuolated cytoplasm and scalloping colloid (b). (wikipedia.org)
  • The mutations are present in the tumor, even though the patient does not have germline mutation or neurofibromatosis. (medscape.com)
  • Their advantage lies in the ability to perceive tumors with a low mutation load, thus establishing the first line of defense against pathogens. (explorationpub.com)
  • Nevertheless, small is well known regarding the precise pathways regulated by HOXA7 that promote the success and development of granulosa cells. (cancerhugs.com)
  • these pathways are also shown to donate to the irregular development of various kinds human being malignancies [20]. (cancerhugs.com)
  • Early-stage tumours showed a greater degree of staining on IHC compared to those at an advanced stage of disease. (iiarjournals.org)
  • Although it was initially thought to play a role in the development and maintenance of metastatic tumours and to have some mitogenic activity ( 1 - 3 ), subsequent investigations have demonstrated a much more diverse role in cancer and cell growth for COM-1. (iiarjournals.org)
  • The expression of COM-1 in various malignant tumours with a variable pattern of expression has been identified. (iiarjournals.org)
  • For this reason, the CD-ROM accompanying malignant vascular tumours. (who.int)
  • OPG binds RANKL as a decoy receptor, inhibiting the activation of RANK by RANKL and preventing the differentiation of bone marrow precursor (monocyte/macrophage) cells to osteoclasts - cells that are central in the process of bone resorption [ 2 ]. (biomedcentral.com)
  • Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)
  • γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
  • Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
  • Both Mabs in murine (mGHR106) or humanized (hGHR106) forms were shown to have comparable specificity and affinity to intact GnRH receptor on cancer cells or to N1-29 synthetic peptides from humans and monkeys. (annexpublishers.co)
  • Gonadotropin releasing hormone (GnRH), both types I and II, is a decapeptide hormone that stimulates the release of gonadotropin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the anterior pituitary through specific binding to the GnRH receptor located on the external membrane of selected cell types [ 1-3 ]. (annexpublishers.co)
  • Recent results from clinical studies with a CD19/CD3-bispecific BiTE antibody suggest that this therapeutic paradigm is finally showing promise for treatment of both bulky and minimal residual disease. (aacrjournals.org)
  • We discuss the implications of our results in terms of the potential role for HE4 in histopathologic diagnosis, as a serum tumor biomarker, and as a therapeutic target. (nature.com)
  • Recent years, we have witnessed significant progresses in both basic and clinical studies regarding novel therapeutic strategies with genetically engineered T cells. (ijbs.com)
  • The emerging therapeutic approach of CAR-T cell therapy has sparked great interests, extensive studies in preclinical and clinical trials have revealed encouraging therapeutic efficacy in treating a variety of cancers, particularly in treating B-cell hematologic malignancies with CD19 CAR-T cells [ 3 ]. (ijbs.com)
  • Further cytokine array screening showed that ATC cells activated α - SMA - positive CAFs through CREB3L1 - mediated IL - 1α production. (biomedcentral.com)
  • However, CAR-T cells can also produce some adverse events after treatment of hematological malignancies, such as cytokine release syndrome (CRS), neurotoxicity, and on-target/off-tumor toxicity, which may cause systemic immune stress inflammation, destruction of the blood-brain barrier, and even normal tissue damage. (hindawi.com)
  • Oncostatin M (OSM) is a cytokine secreted by differentiated histiocytic lymphoma cells [ 14 ]. (aging-us.com)
  • First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)
  • However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. (hindawi.com)
  • Traditionally, the treatment of hematological malignancies is administrated by chemotherapy, radiotherapy, and stem cell transplantation. (hindawi.com)
  • It is noted that T cell has great potential for immunotherapy of hematological malignancies. (hindawi.com)
  • In addition, the isolation and storage of umbilical cord blood hematopoietic stem cells have been used to rebuild the immune system for the treatment of hematological malignancies and might be promising for the dynamic equilibrium expansion of functional T cells [ 12 ]. (hindawi.com)
  • Fibroblastic or myofibroblastic tumors make up the majority of soft tissue tumors of the aerodigestive tract and range from nonneoplastic or benign proliferations (fibromas) to high-grade malignancies (undifferentiated high-grade pleomorphic sarcomas). (basicmedicalkey.com)
  • Lymphoid cells concerned with humoral immunity. (lookformedical.com)
  • Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
  • Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
  • B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
  • Of note, CD19, CD20, CD30, CD33, CD123, and CD269 as ideal targets have shown extraordinary potential for CAR-T cell therapy and other targets such as CD23 and SLAMF7 have brought promising future for clinical trials. (hindawi.com)
  • However, the clinical application of tumor-infiltrating γδ T cells has certain limitations. (explorationpub.com)
  • Finally, it retrospectively analyze the activation strategies and clinical relevance of existing γδ T cell adoptive immunotherapies. (explorationpub.com)
  • CAR-T cell therapy has achieved outstanding progresses in clinical observations, which makes it even more attractive in the development of cancer adoptive immunotherapy. (ijbs.com)
  • While their cellular components are similar to those of pilomatricoma, they have a different silhouette, 2,3 as they are solid nodules composed of matrical and supramatrical cells located in the dermis that occasionally extend into the subcutaneous tissue. (actasdermo.org)
  • T hyroid nodules are common and frequently benign, with approximately 5-10% being malignant. (touchendocrinology.com)
  • Although fine-needle aspiration biopsy and cytologic examination have emerged as the gold standard in separating benign from malignant nodules, cytology is limited and challenging when it is reported as indeterminate. (touchendocrinology.com)
  • Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
  • mucinous and Brenner malignant tumors potentially develop from the Walthard nests. (biomedcentral.com)
  • One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
  • Somatic mutations can reduce or abolish the ability of immune cells to recognize neoantigens on the tumor cells [ 8 ]. (aging-us.com)
  • This review further emphasizes the diversified cross-talk between γδ T cells and other immune cells. (explorationpub.com)
  • Occasionally, the tumor invades the adipose tissue of the orbit. (medscape.com)
  • This noninflamed cyst shows a thin, nonkeratinized epithelial lining and a loosely arranged fibrous connective tissue wall. (easynotecards.com)
  • In breast tissue, the luminal epithelial cells express CK 8/18, CK 7 and CK 19, while basal/myoepithelial cells express CK 5/6, CK 14 and CK 17. (ijpmonline.org)
  • However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. (lu.se)
  • Although genetic and epigenetic aberrations that occur in components of the central dogma clearly elicit disease development in humans, recent findings also point to a prominent role for non-protein-coding regions of the genome in regulating cell and tissue homeostasis, as well as in contributing to the formation of human tumors. (biomedcentral.com)
  • All categories of soft tissue tumors have been reported to involve the upper aerodigestive tract. (basicmedicalkey.com)
  • These tumors have markedly different prognoses and require different treatments than those for soft tissue tumors. (basicmedicalkey.com)
  • This inflamed cyst shows a thick epithelial lining with hyperplastic rete ridges and diffuse chronic inflammatory infiltrate. (easynotecards.com)
  • A cystic epithelial cavity can be seen below the mucosal surface with inflammatory cell infiltrate in lamina propria. (easynotecards.com)
  • mRNA microarray analyses of A549, PC14, and PC14CDDP cells that were transiently transfected with either pre-miR-197 or LNA-miR-197 and their controls. (nih.gov)
  • Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. (cancerindex.org)
  • The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). (cancerindex.org)
  • check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)