Malignant epithelial cell tumors. Medical search. Frequent questions

Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
Notch signaling has been implicated in many microenvironmental processes associated with cancer progression such as vascular remodeling, immunosuppression, epithelial to mesenchymal transition (EMT), as well as maintenance of the CSC pool 21 . (nature.com)
The remaining urine will be stored to evaluate biomarkers for the detection of tumor presence or progression using protein-based analyses. (centerwatch.com)
It has been suggested that, in a proportion of fibroadenomas, a somatic mutation can result in a monoclonal proliferation, histologically indistinguishable from the polyclonal element, but with a propensity to local recurrence and progression to a phyllodes tumor which has also been supported by clonal analysis. (hindawi.com)
Propidium iodide staining and flow cytometry analysis of Annexin V binding was utilized to measure the progression of the cell cycle and the induction of apoptosis. (techscience.com)
These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
In tumor tissues, lncRNAs are markedly deregulated and pervasively involved in development and progression of cancers [ 6 - 8 ]. (jcancer.org)
both E2F1 and c-Myc are stimulating factors of H19 expression, and the H19 lncRNA functions as a downstream effector of c-Myc and E2F1 in tumor development and progression [ 11 ]. (jcancer.org)
The availability of a sophisticated genetic tool box makes Drosophila an excellent genetic model well suited to studying the biology of Lunasin and its effect on tumor progression in an in vivo model organism. (weeksmd.com)
This upregulation was correlated with tumor progression. (molvis.org)
[ 14 ] Subsequent work in our laboratory demonstrated that K17 serves as a nuclear shuttle of p27KIP1, resulting in sustained cell cycle progression. (medscape.com)
Are longitudinal changes in circulating tumor DNA (ctDNA) methylation effective in monitoring disease progression from molecular residual disease to recurrence? (cdc.gov)
opment and progression including a The specimens were collected dur- Positive cells were counted in 10 possible viral etiology (5) . (who.int)

CTCs that originate from carcinomas (cancers of epithelial origin, which are the most prevalent) can be classified according to the expression of epithelial markers, as well as their size and whether they are apoptotic. (wikipedia.org)
In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
Even some cancers seem to be unable to significantly do damage that permanently impairs genetic function given the healthy clone obtained out of a cancer cell. (fightaging.org)
Research from 2017 found that in women aged 40 and below, 72% of ovarian cancers were epithelial tumors. (medicalnewstoday.com)
Around 80% of all human cancers develop in the epithelium, and of the different epithelial cancer types, Squamous Cell Carcinoma (SCC) is the most deadly. (ukri.org)
Around 80% of human cancers are epithelial in origin. (ukri.org)
As with epithelial ovarian cancers, it is a good idea to consult with a gynecologic oncologist for treating malignant germ cell tumors, especially because these are so uncommon. (cancer.org)
About 2-3% of all ovarian cancers are germ cell tumors. (cancer.org)
Most types and stages of germ cell cancers of the ovary are treated the same way, with surgery and chemotherapy (chemo). (cancer.org)
Germ cell cancers can raise blood levels of the tumor markers human chorionic gonadotropin (HCG), alpha-fetoprotein (AFP), and/or lactate dehydrogenase (LDH). (cancer.org)
Most ovarian cancers are either epithelial carcinomas (cancer that begins in the cells on the surface of the ovary) or malignant germ cell tumors (cancer that begins in egg cells). (cancer.gov)
They are very different from high-grade cancers and represent about 10% to 15% of epithelial ovarian/fallopian tube neoplasms, which are abnormal growths of cells. (cancer.net)
Genetic and phenotypic cell-to-cell variability have been observed in numerous studies both within the same type of cancer cells and across different types of cancers. (umd.edu)
In addition, we show that MDA-MB-231 cells and MDA-MB-436 cells which are both epithelial breast cancer cell lines with a mesenchymal-like phenotype derived from metastatic cancers are mechanically more different from each other than from non-malignant epithelial MCF-10A cells. (umd.edu)
Ovarian cancers represent several distinct diseases, which are named after the type of cell they come from: epithelial, germ cell and stromal. (kucancercenter.org)
Epithelial ovarian cancers, which represent 85 to 90 percent of malignant ovarian cancers, are a complex group of tumors that arise from multiple different precursor tissues, and the most common and deadly subtype (high-grade serous) is thought to originate primarily in the fallopian tubes. (kucancercenter.org)
More than 95% of thyroid cancers are derived from thyroid follicular epithelial cells and are classified into differentiated thyroid cancer (DTC), including papillary and follicular thyroid cancer (PTC and FTC), poorly differentiated thyroid cancer (PDTC), and anaplastic thyroid cancer (ATC). (oncotarget.com)
The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
Epithelial ovarian carcinomas (EOC's) account for 85 to 90 percent of all cancers of the ovaries. (news-medical.net)
L'objectif de cette étude était de déterminer la fréquence des cancers gynécologiques en pratique oncologique à Lomé et d'en étudier les aspects épidémiologiques et histo-cliniques. (bvsalud.org)
Il s'agitd'une étude rétrospective et descriptive portant sur tous les cancers gynécologiques reçus en oncologie entre le 1erJanvier 2016 et le 31 Décembre 2021. (bvsalud.org)
ces cancers ont ete diagnostiques au stade avance d'ou les difficultes dans leur prise en charge chirurgicale. (bvsalud.org)
En consequence notre objectif a ete d'etudier la place et les caracteres de la chirurgie dans la prise en charge de ces cancers. (bvsalud.org)

Germ cell tumors generally only affect one ovary. (medicalnewstoday.com)
subsequently, this group of tumors of the ovary were classified in 1973 by the World Health Organization as "low malignant potential ovarian tumor" [ 2 ] and, finally, in 2003 WHO separates them from carcinomas and call them borderline tumors. (intechopen.com)
Women with benign (non-cancerous) germ cell tumors such as mature teratomas (dermoid cysts) are cured by removing the part of the ovary that has the tumor (ovarian cystectomy) or by removing the entire ovary. (cancer.org)
The tumor wall is ruptured before surgery, or there is cancer on the surface of the ovary or fallopian tube. (cancer.net)
Some are benign, or noncancerous, and the patient can be cured by surgically removing one ovary or the part of the ovary containing the tumor. (news-medical.net)
Epithelial ovarian tumors develop from the cells that cover the outer surface of the ovary. (news-medical.net)
The stage of the tumor can be ascertained during surgery, when it can be determined how far the tumor has spread from where it started in the ovary. (news-medical.net)
Stage IA - Growth is limited to one ovary and the tumor is confined to the inside of the ovary. (news-medical.net)
Ovarian cancer is a cancerous tumor that forms in the tissues of an ovary. (medlineplus.gov)
It begins in the cells that cover the ovary. (medlineplus.gov)
The 5-year survival rate is 96% if the tumor is confined to the ovary and 63% if extension occurs beyond the ovaries. (medscape.com)
Treatment of malignant germ cell tumors of the ovary with bleomycin, etoposide, and cisplatin. (medscape.com)
Mutation of FOXL2 in granulosa-cell tumors of the ovary. (cancercentrum.se)
A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary. (cancercentrum.se)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. (cancercentrum.se)
Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)

Small CTCs have been implicated in progressive disease and differentiation into small cell carcinomas, which often require a different therapeutic course. (wikipedia.org)
Approximately 90% of malignant tumors arising in the bladder are of epithelial origin, the majority being transitional cell carcinomas. (centerwatch.com)
Squamous cell carcinomas, adenocarcinomas, and small cell carcinomas of the urinary bladder are rare and account for less than 5, 2, and 0.5% of all bladder carcinomas, respectively. (cytojournal.com)
Unlike the invasive carcinomas, borderline ovarian tumors are characterized by cytoplasmic and nuclear atypia, (element of differential diagnosis with benign tumors), absence of stromal invasion, (element of differential diagnosis with malignant tumors), unusual degree of proliferation of the epithelial cells with cellular stratification including remarkable architectural atypia and the formation of papillary protuberances. (intechopen.com)
Cancerous epithelial tumors are carcinomas. (news-medical.net)
Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)
We found that Wnt-5a protein expression is reduced in many invasive breast carcinomas and that reduced Wnt-5a expression in the primary tumour strongly correlates with an increased risk of metastatic disease and shorter survival. (lu.se)

MTT assay was performed to determine the proliferation of cancer cells. (techscience.com)
In addition, overexpression of ZYX in hepatoma cell lines (PLC/PRF/5, HCCLM3) enhanced their proliferation, migration and invasion, whereas ZYX knockdown had the opposite effects (SK HEP-1, Huh-7). (techscience.com)
It is involved in the proliferation, invasion, apoptosis and epithelial mesenchymal transformation of malignant tumor cells. (techscience.com)
Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
By definition, serous tumors are characterized by a proliferation of epithelium resembling that lining the fallopian tubes. (medscape.com)
Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)
In contrast, silencing of UASR1 suppressed cell proliferation and migration. (jcancer.org)
Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
The framework will allow to label for up to 10 markers to visualize at the same time ANXA1, centrosomes, chromosomes, cell-cell adhesion molecules, differentiation markers, proliferation, and apoptosis. (southampton.ac.uk)
Knockdown of nuclear PATZ1 by siRNA in an immortalized normal follicular epithelial cell line (Nthy-ori 3-1) altered cellular morphology and significantly increased cell proliferation, migration, and invasion. (oncotarget.com)
When PATZ1 was silenced in differentiated thyroid cancer (DTC) cell lines (TPC-1 and FTC-133), proliferation, cellular motility, and expression of uPA and MMPs were significantly increased. (oncotarget.com)
Forced expression of exogenous PATZ1 decreased proliferation, cellular motility, and the expression of uPA and MMPs in ATC cell lines (ACT-1 and FRO). (oncotarget.com)

Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
CSCs are enriched near macrophages, particularly near macrophage-containing intravasation sites called Tumor Microenvironment of Metastasis (TMEM) doorways. (nature.com)
In addition, lung metastasis was observed in nude mice in T-16HBE-C1, 3 and 4 groups.In vitrocell migration assay results indicated that T-16HBE-C2?5 cells showed much lower migration capabilities than 16HBE cells. (eurekamag.com)
The histologic diagnosis was granulosa cell tumor with metastasis to the fat body. (avma.org)
Each stage describes how far the original tumor has invaded, whether the cancer involves lymph nodes, and whether it has progressed to metastasis. (mesothelioma.net)
When cancer spreads to the lymph nodes, metastasis is usually not far behind because the lymphatic system allows cancer cells to travel to more distant parts of the body. (mesothelioma.net)
Epithelial mesothelioma is the most common, and these cancer cells cling more strongly to each other, so metastasis is slower with this type of mesothelioma. (mesothelioma.net)
The epithelial‑mesenchymal transition (EMT) serves vital roles in the angiogenesis, cell invasion and metastasis of various malignant tumors, including bladder cancer. (spandidos-publications.com)
TP53 is a tumor suppressor gene that functions in modifying DNA errors and/or inducing apoptosis of damaged cells, and both APC and BECN1 genes are involved in CRC and are of importance in cellular growth and metastasis. (scielo.br)
Although all grades are capable of metastasis, the low-grade tumors are generally locally invasive but lowly aggressive. (bvsalud.org)
Routine tumor-node-metastasis (TNM) staging of colorectal cancer is imperfect in predicting survival due to tumor pathobiological heterogeneity and imprecise assessment of tumor spread. (cdc.gov)

Cytokeratin-negative CTCs are characterised by the lack of EpCAM or cytokeratins, which may indicate an undifferentiated phenotype (circulating cancer stem cells) or the acquisition of a mesenchymal phenotype (known as epithelial-mesenchymal transition or EMT). (wikipedia.org)
These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
FOXC1 silencing inhibits the epithelial‑to‑mesenchymal transition of glioma cells: Involvement of β‑catenin signaling. (cancerindex.org)
Mesenchymal stem cells up-regulate the invasive potential of prostate cancer cells via the eotaxin-3/CCR3 axis. (cancerindex.org)
This study aimed to clarify the role of mesenchymal stem cells (MSCs) as a component of the cancer microenvironment. (cancerindex.org)
Mechanism of miR-455-3 in suppressing epithelial-mesenchymal transition and angiogenesis of non-small cell lung cancer cells. (nih.gov)
MiR-455-5p upregulation in umbilical cord mesenchymal stem cells attenuates endometrial injury and promotes repair of damaged endometrium via Janus kinase/signal transducer and activator of transcription 3 signaling. (nih.gov)
A Systematic Review of Mesenchymal Epithelial Transition Factor (MET) and Its Impact in the Development and Treatment of Non-Small-Cell Lung Cancer. (lu.se)

In 1981 [ 6 ] the World Health Organization adopted the term phyllodes tumor and as described by Rosen [ 7 ] subclassified them histologically as benign, borderline, or malignant according to the features such as tumor margins, stromal overgrowth, tumor necrosis, cellular atypia, and number of mitosis per high power field. (hindawi.com)
The majority of phyllodes tumors have been described as benign (35% to 64%), with the remainder divided between the borderline and malignant subtypes. (hindawi.com)
Epithelial tumors can be benign, borderline, or malignant. (medicalnewstoday.com)
A borderline tumor is one that has a small chance of developing into a malignant tumor. (medicalnewstoday.com)
A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)
Borderline ovarian tumors represent 10-20% of epithelial ovarian neoplasm's [ 5 ] with an incidence of 1.8-4.8 out of 100.000 women per year [ 6 ] and typically have an excellent prognosis. (intechopen.com)
Some tumors are called borderline tumors, which are tumors of low malignant potential (LMP). (cancer.net)
these are called borderline tumors or tumors of low malignant potential (LMP tumors). (news-medical.net)

The preoperative diagnosis and proper management are crucial in phyllodes tumours because of their tendency to recur and malignant potential in some of these tumours. (hindawi.com)
More aggressive tumours have low T 1 - and T 2 -characteristics while high signal is observed on both T 1 - and T 2 -weighted images if there has been recent haemorrhage within the tumour. (ispub.com)
Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
NUT protein immunoreactivity in ovarian germ cell tumours. (medscape.com)
One study finds that the loss of the entire Y chromosome in some cells - which occurs naturally as men age - raises the risk of aggressive bladder cancer and could allow bladder tumours to evade detection by the immune system2. (cdc.gov)
This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)

At present, the most popular models are cell lines, derived from human tissues, which are mentioned in this paper. (karger.com)
A malignant cancer is one that spreads to other tissues. (medicalnewstoday.com)
Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. (techscience.com)
Of the different tumour types arising in epithelial tissues, squamous cell carcinoma (SCC) is the most malignant and has the highest metastatic potential. (ukri.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Tissues and Cells. (lu.se)
Only 3 benign breast tumour tissues (12.5%) and none of the healthy breast tissue specimens were HPV-DNA-positive. (who.int)
A further 20 blocks from The ISH results were given percentage vanced stages with a likely prevalence samples from normal breast tissues scores based on positive signals and of more aggressive tumour forms were labelled as a control group (i.e. number of cells that gave these signals. (who.int)

Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain complex and challenging problems for the head and neck surgeon. (medscape.com)

By contrast, analysis of solid tumors necessitates invasive procedures that might limit patient compliance. (wikipedia.org)
Most solid tumors including lung cancer cells are believed to contain poorly differentiated cancer stem-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. (cdc.gov)
It's pipeline products include Voyager-V1 for solid tumors, MV-NIS for bladder cancer, Voyager-V1 + pembrolizumab for non-small cell lung cancer, head and neck cancer, Voyager-V1 + cemiplimab for multiple cancer indications among others. (pharmaceutical-technology.com)

Early stage bladder tumors have been classified into two groups with distinct behaviors and different molecular profiles: Low-grade tumors (always papillary and usually superficial), and high-grade tumors (either papillary or non-papillary and often invasive). (centerwatch.com)
Clinically, superficial bladder tumors (stages Ta, Tis and T1) account for 75-80% of bladder neoplasms, while the remaining 15-20% are invasive (T2, T3, T4) or metastatic lesions at the time of presentation. (centerwatch.com)
The primary objective of this study is to evaluate the utility of emerging technologies in the detection of bladder tumor cells using non-invasive approaches utilizing voided urine samples. (centerwatch.com)
Rats do well when having these tumors removed, especially since the tumor tends to remain localized and is less invasive. (ratguide.com)
Nasal tumors are primarily locally invasive and infrequently metastasize. (vin.com)
The data presented in this edition of Cancer Incidence in Five The CI5 data include all invasive malignant neoplasms and Continents (CI5) are mainly organised according to anatomical some non-invasive malignant neoplasms For most morphology site However, for some sites, the histological type of cancer codes, a fifth digit /1 or /2 automatically excludes the data entry. (who.int)
Staining tended to be strongest at the periphery of pseudoglandular groups and at the invasive front of tumors. (medscape.com)
Cervical cancer has multiple histologic subtypes, with squamous cell carcinoma (SCC) accounting for approximately 75% of cases and invasive adenocarcinoma accounting for 10% to 15% of cases. (medscape.com)

The rate of occurrence of these tumors is highest in the developed countries, ranking as the sixth most frequent neoplasm. (centerwatch.com)
Although the number of reported cases is low, mucoepidermoid carcinoma is the most common malignant salivary gland neoplasm in the oral cavity. (bvsalud.org)
Mucoepidermoid carcinoma (MEC), the most frequent malignant salivary gland neoplasm in the oral cavity, was studied and described as a distinct entity for the first time by Stewart et al. (bvsalud.org)
Other specified malignant neoplasm (Other specified cancer tumour Other codes are obsolete, ie the entities have been in the previous edition). (who.int)

CSCs display the slow-migratory, invadopod-rich phenotype that is the hallmark of disseminating tumor cells. (nature.com)
Furthermore, macrophages were shown to contribute to a niche that can support and maintain a breast CSC (BCSC) phenotype through heterotypic CD90/EphA4 signaling between macrophage and tumor cell 14 . (nature.com)
In the last few years, it has become clear that activation events associated with FGFR-3 can be found associated with 40%-60% of low-grade, low-stage bladder tumors whilst p53 mutations are linked to a more aggressive phenotype progressing via the CIS pathway. (centerwatch.com)
Our study demonstrates that PATZ1 knockdown enhances malignant phenotype both in thyroid follicular epithelial cells and thyroid cancer cells, suggesting that PATZ1 functions as a tumor suppressor in thyroid follicular epithelial cells and is involved in the dedifferentiation of thyroid cancer. (oncotarget.com)
Restitution of Wnt-5a signalling in breast tumour cells confer better adhesion and ability to activate DDR1 as well as a less malignant-looking phenotype. (lu.se)

The American Cancer Society states that around 5% of ovarian stromal tumors occur in young females. (medicalnewstoday.com)
Ovarian stromal tumors can produce the hormone estrogen. (medicalnewstoday.com)
Some other rarer types of ovarian cancer are malignant germ cell tumors and stromal tumors. (medlineplus.gov)

It is well known that caloric intake affects tumor incidence in rats. (ratguide.com)
Rats fed ad libitum (free-fed) have lower survival and a higher incidence of pancreatic, mammary, and pituitary tumors than rats fed a moderate dietary restriction of identical diets (Boorman & Everitt, 2006). (ratguide.com)
In addition to increasing tumor incidence, high caloric intake decreases latency and enhances tumor growth (Keenan et al, 1995). (ratguide.com)
They make up 0.3 to 0.5% of female breast tumors [ 1 ] and have an incidence of about 2.1 per million, the peak of which occurs in women aged 45 to 49 years [ 2 , 3 ]. (hindawi.com)
Choline kinase (ChoK) is increased in human mammary tumors with high incidence, and this activation is associated with clinical variable indicators of greater malignancy. (aacrjournals.org)
That is, as the size of the gland decreases, the incidence of malignancy of a tumor in the gland increases in approximately these proportions. (medscape.com)
Incidence and occurrence of second primary tumors. (cancercentrum.se)

Extracranial and extragonadal germ cell tumors and melanoma were both significantly decreasing. (cdc.gov)
Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)

KA lesions can easily be mistaken for squamous cell carcinoma (SCC). (medscape.com)
Between the period of 1983 and 2009, there were a total of 25 cases of small cell carcinoma, 20 of squamous carcinoma, and 10 of adenocarcinoma, wherein prediagnosis urine cytology was available. (cytojournal.com)
There were eight cases (12 samples) of small cell carcinoma, four cases (6 samples) of squamous cell carcinoma and four cases (5 samples) of adenocarcinoma. (cytojournal.com)
Of the nine samples of small cell carcinoma, categorized as atypical, suspicious for carcinoma, three (33%) were categorized as suspicious for small cell carcinoma, while the others were not further classified, due to limitations of cellular preservation. (cytojournal.com)
In the squamous cell carcinoma subgroup, the samples with 'atypical, suspicious for carcinoma' diagnoses did not show any keratinization and were interpreted as atypical urothelial cells. (cytojournal.com)
None of the samples of small cell carcinoma had a false negative diagnosis on cytology, while only one case of squamous cell carcinoma was diagnosed as negative. (cytojournal.com)
He demonstrated that the roundworm which he called Spiroptera carcinoma (but correctly named Gongylonema neoplasticum ) could cause stomach cancer ( squamous cell carcinoma ) in rats and mice. (wikipedia.org)
ASPP2: A molecular switch of cancer initiating cells in Squamous Cell Carcinoma? (ukri.org)
It is a category that includes many different kinds of cancer and is dominated by renal cell carcinoma. (cancer.gov)
SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
Similarly, under Carcinoma, specific renamed or deleted in later revisions of tumour classifications. (who.int)
Previous work in our laboratory identified keratin 17 (K17) as a specific and sensitive biomarker for high-grade squamous intraepithelial lesions and cervical squamous cell carcinoma (SCC). (medscape.com)
[ 11-13 ] By contrast, we discovered, using laser capture microdissection and mass spectrometry, that keratin 17 (K17) could predict the overall survival of patients with cervical squamous cell carcinoma more accurately than grade, stage, or any other clinicopathologic features. (medscape.com)
[ 15 ] Other studies have shown K17 to be a negative prognostic indicator in gastric adenocarcinoma, bladder carcinoma, epithelial ovarian carcinoma, and triple-negative breast carcinoma. (medscape.com)

In breast cancer, lncRNAs are abnormally expressed and demonstrate differential expression in subtypes of tumors [ 9 , 10 ]. (jcancer.org)
Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. (medscape.com)

Salivary gland neoplasms make up 6% of all head and neck tumors. (medscape.com)
An estimated 700 deaths (0.4 per 100,000 for males and 0.2 per 100,000 for females) related to salivary gland tumors occur annually. (medscape.com)
Almost half of all submandibular gland neoplasms and most sublingual and minor salivary gland tumors are malignant. (medscape.com)
In children, 35% of salivary gland neoplasms are malignant. (medscape.com)
Successful diagnosis and treatment of patients with salivary gland tumors require a thorough understanding of tumor etiology, biologic behavior of each tumor type, and salivary gland anatomy. (medscape.com)
In the multicellular theory, each tumor type is associated with a specific differentiated cell of origin within the salivary gland unit. (medscape.com)
Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)

At present time, the exact etiology of phyllodes tumor and its relationship with fibroadenoma are unclear. (hindawi.com)
The etiology of oral granular cell tumors is unknown. (medscape.com)
The exact etiology of dysgerminomas has not been determined, although recent molecular studies have implicated loss of function with potential tumor suppressor gene TRC8/RNF139 as a possible etiology. (medscape.com)

Although mammary tumors can occur at a younger age, they have a higher occurrence after 18 months of age. (ratguide.com)
It has also been postulated that stromal induction of phyllodes tumors can occur as a result of growth factors produced by the breast epithelium. (hindawi.com)
Germ cell tumors are more likely to occur in younger females than older females. (medicalnewstoday.com)
Approximately 70% of oral granular cell tumors occur in the tongue. (medscape.com)
Nasal tumors occur most commonly in the nasal cavity with secondary extension into the frontal and other paranasal sinuses. (vin.com)
Transmissible venereal tumor (TVT) has been reported to occur in the nasal cavity although it is more commonly found on the external genitalia. (vin.com)
These tumors mostly occur in women, although the disease also occurs in pseudohermaphrodites and patients with gonadal dysgenesis (see Complications). (medscape.com)
Benign neoplasms occur more frequently in women than in men, but malignant tumors are distributed equally between the sexes. (medscape.com)
Malignant neoplasms of the salivary glands are rare and represent 3 to 5% of all malignant tumors that occur in the head and neck region. (bvsalud.org)
However, 2 conditions-synovial chondromatosis and tenosynovial giant cell tumor (pigmented villonodular synovitis)-occur in the lining (synovium) of joints. (msdmanuals.com)
Tenosynovial giant cell tumor (previously called pigmented villonodular synovitis) is considered a benign neoplastic tumor of the synovium that can occur around as well as in a joint. (msdmanuals.com)

Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
How dysregulation in these mechanisms contributes to malignant transformation and tumour heterogeneity also remains an open question in cancer research. (southampton.ac.uk)
centrosome dynamics), and tumour cell fate, behaviour and heterogeneity. (southampton.ac.uk)
Our work will lay the foundation for a more ambitious, collaborative project bringing together expertise in cell and molecular biology, cancer biology, physics, and mathematics, to investigate the causal relationship between ANXA1-mediated defects in cell divisions and tumour heterogeneity, and the underlying mechanisms. (southampton.ac.uk)
Cellular heterogeneity in tumor cells is a well-established phenomenon. (umd.edu)
However, the heterogeneity of mechanical properties in tumor cells are not widely studied. (umd.edu)
Here we analyzed single-cell optical stretcher data with machine learning algorithms on three different breast tumor cell lines and show that similar heterogeneity can also be seen in mechanical properties of cells both within and between breast tumor cell lines. (umd.edu)
PDX Mouse Models: PDX models are commonly used in many clinically relevant research applications including characterization of tumor heterogeneity, in vivo therapeutic target validation studies, therapeutic mechanism of action studies, and therapeutic sensitivity and resistance studies. (sbir.gov)
3D human tissue model culture systems: While immortalized cell lines have been standard practice in cancer research for decades, adequate modeling of the heterogeneity of human cancer is an unmet need. (sbir.gov)

Results of cytologic evaluation of the mass were suggestive of malignant epithelial neoplasia, but neoplastic cells were not found in the effusion. (avma.org)
Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
The tumors arise from neoplastic synovial cells that overexpress a growth factor CSF-1 (colony stimulating factor-1). (msdmanuals.com)

Epithelial cystic tumors account for about 60% of all true ovarian neoplasms. (medscape.com)
Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
In fact, dysgerminomas make up two thirds of all malignant ovarian neoplasms in women younger than 20 years. (medscape.com)

Histologically, the fully formed domelike lesion reveals a mass of proliferating squamous epithelial cells, which created the central core of keratin. (medscape.com)
[ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
Due to changes in their epigenetic regulation, differentiated keratin 1-positive squamous epithelial cells may start to re-express keratin 14 and p63 to gain a proliferative potential. (ukri.org)

CTCs can extravasate and become seeds for the subsequent growth of additional tumors (metastases) in distant organs, a mechanism that is responsible for the vast majority of cancer-related deaths. (wikipedia.org)
the obvious benefits of avoiding the surgery include avoiding the risk related to the innate tumor-genicity of cancer surgeries. (wikipedia.org)
Otherwise, their morphology, gene expression and genomics are similar to those of other cancer cells. (wikipedia.org)
Measuring the ratio of traditional CTC to apoptotic CTCs-from baseline to therapy-provides clues to treatment efficacy in targeting and killing cancer cells. (wikipedia.org)
Mechanistically, stemness is induced in non-stem cancer cells upon their direct contact with macrophages via Notch-Jagged signaling. (nature.com)
90% of cancer-related deaths, is a multi-step process involving cancer cell intravasation into the bloodstream, dissemination to distant sites, and seeding in new organs 1 . (nature.com)
At the apex of the hierarchy are the cancer stem cells (CSCs). (nature.com)
The cancer assays to be tested use DNA analysis and antibodies to specific proteins as well as functional assays for proteins to attempt to identify bladder tumor presence. (centerwatch.com)
Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
C - L ) Cancer cells were plated in the bottom chamber 1 day prior to seeding MS-1 cells (5 × 10 5 cells/well) and macrophages (1 × 10 5 cells/well) atop the membrane chamber in Transwell and incubated for 18-24 hours ( C ). ( D - K ) Representative images of multiple independent experiments. (jci.org)
Succesful cloning from a cancer cell, succesful cloning from old adult organisms, repeated cloning of old adult organisms without compromising health(that is clones from clones from clones, second and third generation clones), and the like have shown, unless I missed some news, that IMHO it seems no permanent or at least significantly impairing damage at a genetic level seems to be occuring with aging. (fightaging.org)
As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
Unfortunately, patients are already in the terminal stage at this time, and the cancer cells have already invaded the surrounding organs or metastasized far away, which leads to the loss of the curative chance for most patients ( 1 ). (frontiersin.org)
Cancer develops due to the growth of abnormal cells in areas of a person's body. (medicalnewstoday.com)
Germ cell tumors are a rare form of ovarian cancer. (medicalnewstoday.com)
Dysgerminomas are a rare form of germ cell cancer that generally affects females in their teens or 20s. (medicalnewstoday.com)
Endodermal sinus tumor (yolk sac tumor) and choriocarcinoma are two other rare forms of ovarian cancer. (medicalnewstoday.com)
Induction of lung cancer stem-like cells by chronic exposure to carbon nanotube s. (cdc.gov)
Similar to human non-small cell lung cancer H460 cells, SWCNT-transformed lung epithelial BEAS-2B cells but not its passage-matched control cells formed tumor spheres in stem cell-selective conditions, indicating the existence of lung CSCs. (cdc.gov)
Lung CSCs have previously been reported to reside in the side population (SP) of parental lung cancer cells. (cdc.gov)
Fruits and seed extracts of Annona montana have significant cytotoxic potential in several cancer cells. (techscience.com)
This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1 (IGF-1) stimulation. (techscience.com)
Fra-1 is highly expressed in gastric cancer (GC), affects the cycle distribution and apoptosis of GC cells, and participates in GC occurrence and development. (techscience.com)
Breast cancer is still one of the most important tumors among women in industrialized countries. (aacrjournals.org)
We investigated the homing-related chemokine expression levels of MSCs treated with a prostate cancer cell line (PC-3) -conditioned medium. (cancerindex.org)
Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
The present study aimed to screen the sensitivity of bladder cancer to natural compounds by using six classic anti‑inflammatory and detoxifying herbs, including the ethanol extract of Paris polyphylla (PPE), Scutellaria barbata, Pulsatillae decoction, Dahuang Huanglian Xiexin decoction, Bazhengsan and Hedyotis diffusa combined with S. barbata, were used to treat bladder cancer cells in vitro. (spandidos-publications.com)
Bladder cancer was more sensitive to PPE compared with the other tested herbs, and PPE significantly suppressed bladder cancer cell migration and invasion. (spandidos-publications.com)
Bladder cancer cells were treated with monomer components of PPE, including polyphyllin (PP) I, PPII, PPVI and PPVII. (spandidos-publications.com)
The results demonstrated that PPII treatment significantly inhibited cancer cell migration and invasion, increased the expression level of E‑cadherin and decreased the levels of N‑cadherin, snail family transcriptional repressor 2, twist family bHLH transcription factor 1, matrix metallopeptidase (MMP) 2 and MMP9 compared with those in the control group (untreated cells). (spandidos-publications.com)
These results suggested that PPII treatment may suppress bladder cancer cell migration and invasion by regulating the expression of EMT‑associated genes and MMPs. (spandidos-publications.com)
Chronic inflammation increases the risk of cancer and contributes to tumor development through the induction of oncogenic mutations, enhanced angiogenesis and early tumor promotion ( 7 ). (spandidos-publications.com)
In general, all women with malignant germ cell tumors will have the same staging surgery that is done for epithelial ovarian cancer. (cancer.org)
Most women with germ cell cancer will need to be treated with combination chemo for at least 3 cycles. (cancer.org)
In the present study, the effect of MSG on cell viability and its effect on expression of APC , BECN1 , and TP53 genes in SW620 and SW480 colon cancer cell lines were studied. (scielo.br)
Cancer cell viability was analyzed using MTT assay, and the results showed a significant increase in the number of viable cells after 24 h of treatment with MSG with different concentrations (0.5, 1.0, 10, 50, and 100mM). (scielo.br)
Cancer cells are found in fluid buildup in the abdominal cavity, called ascites, or in the samples of fluid from the peritoneal cavity taken during surgery. (cancer.net)
The grade describes how much cancer cells look like healthy cells when viewed under a microscope. (cancer.net)
If the cancer looks similar to healthy tissue and has different cell groupings, it is called "well differentiated" or a "low-grade tumor. (cancer.net)
Earlier this year, a team from the European Cancer Moonshot Lund Center at Lund University published proteomics and corresponding proteogenomic integration studies for malignant melanomas (MM). The twin publications represent an effort to map protein. (cancer.gov)
At present, conventional HER2-targeting therapies improve outcomes for patients with HER2-positive breast cancer, defined as tumors having. (cancer.gov)
Polarised epithelial cell divisions represent a critical mechanism for correct partitioning of fate determinants and genomic material into the daughter cells during tissue homeostasis and morphogenesis, and their disruption can lead to severe developmental disorders and diseases such as cancer. (southampton.ac.uk)
It was under development for the treatment of relapsed or refractory multiple myeloma, glioblastoma multiforme, blood cancer, metastatic non-small cell lung cancer and malignant pleural mesothelioma. (pharmaceutical-technology.com)
Vyriad conducts investigator sponsored trials targeted against myeloma, endometrial cancer, multiple myeloma, T cell lymphoma medulloblastoma, and others. (pharmaceutical-technology.com)
Cancer cell lines: The use of immortalized cell lines in cancer research has been standard practice for decades. (sbir.gov)
Notably, the scientific integrity of cancer cell lines is critical for maintaining high standards in research. (sbir.gov)
One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
Immunostimulatory cytokines can enhance anti-tumor immunity and are part of the therapeutic armamentarium for cancer treatment. (weeksmd.com)
Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
Unlike breast, cervical or colorectal cancer, there is no reliable screening test to detect epithelial forms of ovarian cancer. (kucancercenter.org)
Epithelial ovarian cancer is referred to as the "silent killer" due to its lack of overt clinical symptoms. (kucancercenter.org)
Most women with epithelial ovarian cancer will be diagnosed at a later stage when it has spread and become much more difficult to treat," Dr. Godwin said. (kucancercenter.org)
They are the courier of the cells - exosomes derived from cancer cells shuttle data that can be received by surrounding cells and promote signals to help the tumor grow and spread. (kucancercenter.org)
In thyroid cancer cell lines, PATZ1 functioned as a tumor suppressor regardless of p53 status. (oncotarget.com)
Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
Unfortunately, almost 70 percent of women with the common epithelial ovarian cancer are not diagnosed until the disease is advanced in stage - i.e., has spread to the upper abdomen (stage III) or beyond (stage IV). (news-medical.net)
Some are malignant or cancerous.The treatment options and the outcome for the patient depend on the type of ovarian cancer and how far it has spread before it is diagnosed. (news-medical.net)
We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
Cancer is a disease in which abnormal cells in the body grow out of control and form a tumor. (medlineplus.gov)
The most common type is epithelial cancer. (medlineplus.gov)
En 11 annees (1er janvier 1998-31 decembre 2008) 9946 patientes ont ete operes dans notre servie dont 29 pour le cancer de l'ovaire soit 0;29. (bvsalud.org)
It is a monomorphic blue spindle cell soft tissue cancer with variable degree of epithelial differentiation characterized by the specific SS18-SSX/1/2/4 fusion gene but is often biphasic with both spindle cell and glandular-like components. (msdmanuals.com)
arations verified the presence of cancer cells in all samples. (lu.se)
Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)
Non-epithelial ovarian cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. (cancercentrum.se)
Early Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation. (cdc.gov)
In this cohort study of 299 patients with colorectal cancer, circulating tumor DNA status was evaluated with 6 DNA methylation markers. (cdc.gov)
L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)

The most common tumor of the parotid gland is the pleomorphic adenoma , which represents about 60% of all parotid neoplasms, as seen in the image below. (medscape.com)
The main structure of the histological grouping is that Morphology codes specific types of malignant neoplasms are listed as wel as Grouping of morphological codes presents several difficulties. (who.int)

Histopathological changes in the tumors indicated nests growth, high nuclear-cytoplasmic ratios, coarse and clumped chromatin, numerous and distinctly atypical mitoses, cell necrosis and surrounding normal adipose, muscle and connective tissue immersed. (eurekamag.com)
All the adenocarcinomas categorized as negative by urine cytology had sparse cellularity and did not reveal any atypical cells on slide review. (cytojournal.com)
These cells generally are uniform and do not exhibit significant atypical features. (medscape.com)
Oncolytic Virus to Target CD46 and SLC5A5 for Oncology is under clinical development by Vyriad and currently in Phase I for Atypical Teratoid Rhabdoid Tumor. (pharmaceutical-technology.com)
According to GlobalData, Phase I drugs for Atypical Teratoid Rhabdoid Tumor does not have sufficient historical data to build an indication benchmark PTSR for Phase I. (pharmaceutical-technology.com)

Abstract Fos-related antigen 1 (Fra-1) is a nuclear transcription factor that regulates cell growth, differentiation, and apoptosis. (techscience.com)
The AF form of SALSA had a more intact structure and contained peptides from the zona pellucida domain, which is involved in cell differentiation and oligomerization. (researchgate.net)
While it is possible that SCCs initially develop in basal cells, it is unclear why such basal cells in SCCs begin to express differentiation markers. (ukri.org)
Our preliminary results show that the tumour suppressor ASPP2 is able to repress p63 expression, is highly expressed in keratin 1-positive and keratin 14-negative stratified epithelial cells, and that differentiation induces ASPP2's expression in vitro. (ukri.org)
Yet, the precise mechanisms coordinating cell polarity and correct mitotic spindle dynamics and chromosome segregation fidelity, to ensure proper epithelial integrity and differentiation remain ill defined. (southampton.ac.uk)

Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)

In this study, the human bronchial epithelial cells (16HBE) were treated five times with 1 ?M benzo(a)pyrene (BaP), followed by 2 passages culture, and thein vitroBaP-induced malignant transformation of 16HBE cells was established. (eurekamag.com)
Our results demonstrated that BaP could induce the malignant transformation of 16HBE cells, and p53 and p-Akt (Ser473) might play crucial roles in BaP-induced carcinogenesis. (eurekamag.com)
Oral blue nevi are not reported to undergo malignant transformation. (medscape.com)
Our previous studies have shown that chronic exposure to single-walled carbon nanotube s (SWCNTs) induces malignant transformation of human lung epithelial cells. (cdc.gov)
It is mostly benign but there are reports of its malignant transformation as well. (ispub.com)

The majority of ovarian tumors are epithelial tumors. (medicalnewstoday.com)

The majority of germ cell tumors are benign, which means they do not spread. (medicalnewstoday.com)
However, some germ cell tumors can be life-threatening. (medicalnewstoday.com)
Both of these germ cell tumors usually affect young females. (medicalnewstoday.com)
The 3 major types of ovarian tumors are epithelial, sex cord, and germ cell. (medscape.com)
Conversely, germ cell tumors (GCTs) are rare, comprising approximately 20% of all ovarian tumors, both benign and malignant. (medscape.com)
If the germ cells survive, rapid growth ensues, owing to the lack of normal contact inhibition, hence germ cell tumor (GCT) formation. (medscape.com)
To date, no racial predilection exists for ovarian germ cell tumors (GCTs). (medscape.com)
Reproductive and sexual function after platinum-based chemotherapy in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group Study. (medscape.com)
Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors. (medscape.com)
Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)

Phyllodes tumors are rare fibroepithelial lesions. (hindawi.com)
With the nonoperative management of fibroadenomas widely adopted, the importance of phyllodes tumors today lies in the need to differentiate them from other benign breast lesions. (hindawi.com)
Granular cell tumors are uncommon lesions, although the head and neck region accounts for approximately 50% of all lesions. (medscape.com)
Granular cell tumors are slow-growing lesions (0.5-1 mm per year) that are neither painful nor tender. (medscape.com)
Patients with malignant lesions typically present after age 60 years, whereas those with benign lesions usually present when older than 40 years. (medscape.com)
K17 was not detected in the epithelial cells of benign glandular lesions, but groups of cuboidal cells, residing beneath the epithelial layer of benign glands, were frequently positive for K17, especially in cases of microglandular hyperplasia. (medscape.com)

The head and neck region accounts for approximately 45-65% of all sites for granular cell tumors. (medscape.com)

In order to distinguish between KA and SCC, further histologic studies can be used, including proliferating-cell nuclear antigen immunostaining. (medscape.com)
Malignant granular cell tumors, which fortunately are rare, may have a very benign histologic appearance. (medscape.com)

A teratoma is a tumor that can contain different types of benign tissue. (medicalnewstoday.com)
There are several types of benign epithelial tumors, including serous adenomas, mucinous adenomas, and Brenner tumors. (news-medical.net)

A circulating tumor cell (CTC) is a cell that has shed into the vasculature or lymphatics from a primary tumor and is carried around the body in the blood circulation. (wikipedia.org)
Primary cutaneous CD30+ anaplastic large cell lymphomas mimicking KAs have been reported. (medscape.com)
CSCs have an enhanced ability to self-renew, which makes them uniquely capable of initiating and sustaining primary and metastatic tumor growth 3 . (nature.com)
There are several categories of human disease models to study respiratory diseases and drug development: cell lines, primary cells, 3D cell models, cell co-cultures, explants and in silico models [ 4 ]. (karger.com)
Microcrystalline silica particles induce inflammatory response via pyroptosis in primary human respiratory epithelial cells. (nih.gov)
Choroidal melanoma is the most common primary malignant ocular tumor in human adults. (molvis.org)
Malignant tumors may be primary or metastatic. (msdmanuals.com)
some are malignant primary tumors (eg, osteosarcoma. (msdmanuals.com)

Clinical Relevance -Granulosa cell tumors are uncommon in reptiles, and this was the first granulosa cell tumor described antemortem cytologically, histologically, and ultrastructurally in an iguana. (avma.org)
Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome. (cancercentrum.se)

In addition, benign tumors (fibroadenomas) exhibit growth primarily due to increased influence of circulating prolactin. (ratguide.com)

The identified ASPP2-regulated genes will then be analysed further to determine whether or not they are involved in epithelial stratification. (ukri.org)
In particular, genes involved in epithelial stratification and that are targets of the p63, Notch and Wnt signaling pathways will be examined to determine the molecular mechanisms by which ASPP2 is able to suppress the development of SCC. (ukri.org)
TP53 é um gene supressor de tumor que atua modificando erros de DNA e/ou induzindo apoptose de células danificadas, estando os genes APC e BECN1 envolvidos no CRC e sendo importantes no crescimento celular e metástase. (scielo.br)
In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)

the development of cancerous cells from normal ones. (wordsmyth.net)
The book provides a description of noninvasive imaging modalities in diagnosing cancerous tumors of the skin, proffers an analytic framework for assessing the applications of the imaging modalities, and summarizes the state of ongoing research. (e-booksdirectory.com)
If the cancerous tissue looks very different from healthy tissue, it is called "poorly differentiated" or a "high-grade tumor. (cancer.net)
Ovarian tumors are named according to the type of cells the tumor started from and whether the tumor is benign or cancerous. (news-medical.net)

Patients with oral malignant melanoma often recall having an existing oral pigmentation months to years before diagnosis, and the condition may even have elicited prior comment from examining physicians and dentists (or healthcare providers, when considering the auxiliaries). (medscape.com)

Due to its great biological diversity, treatment and prognosis depend on the histological grade, location, and tumor stage. (bvsalud.org)

Together, our results indicate the ability of SWCNT to transform human lung epithelial cells and induce CSCs which could represent a novel mechanism of carcinogenesis induced by CNTs. (cdc.gov)
Proteolysis targeting chimera (PROTAC) is a hot branch of the TPD strategy, and it has been shown to induce the degradation of target proteins by activating the inherent ubiquitin-proteasome system (UPS) in tumor cells. (bvsalud.org)

Mammary adenocarcinomas: A malignant growth in glandular organs and arising from epithelium. (ratguide.com)
Over 90% of tumour-bearing ASPP2 heterozygous mice developed spontaneous SCC in less than 1 year, indicating that ASPP2 is able to suppress the development of SCC and that this model system is ideal for investigating the origin of SCC within the epithelium. (ukri.org)
In normal breast epithelium, Wnt-5a is important for cell-ECM adhesion and activation of the collagen receptor DDR1. (lu.se)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

The diagnosis and treatment of these cutaneous tumors is constantly evolving, and the role of clinicians relies on accurate diagnosis and a thorough understanding of the clinical sequelae. (medscape.com)
The role of urinary cytology in the preoperative diagnosis of the above-mentioned tumors has rarely been reported. (cytojournal.com)
Although the sample size is small, this study highlights the relevance of urine cytology in the preoperative diagnosis of these rare non-urothelial tumors of the bladder. (cytojournal.com)
Cytologically the presence of both epithelial and stromal elements supports the diagnosis. (hindawi.com)
The value of FNAC in diagnosis of phyllodes tumour remains controversial, but core needle biopsy has high sensitivity and negative predictive value. (hindawi.com)
Accurate preoperative pathological diagnosis allows correct surgical planning and avoidance of reoperation, either to achieve wider excision or for subsequent tumor recurrence [ 8 - 10 ]. (hindawi.com)

The concentrations of these hormones are found to be higher in hormone dependent tumors, whereas in hormone independent tumors (as seen in latter stages of mammary adenocarcinoma) they tend to be lower. (ratguide.com)
Pancreatic adenocarcinoma is a highly lethal disease that is histologically characterized by a dense desmoplastic reaction (DR) surrounding malignant epithelial cells. (e-booksdirectory.com)
The most common type of pancreatic tumor, Pancreatic Ductal Adenocarcinoma (PDAC), has distinctly poor patient outcomes due to its. (cancer.gov)

ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)

Another known fact for metastatic tumor cells is that they tend to be softer than their normal or non-metastatic counterparts. (umd.edu)

The most common mammary tumor found in rats is the mammary fibroadenoma, a benign encapsulated tumor. (ratguide.com)
Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)

The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma. (medscape.com)

While extensive surgery is not indicated, recurrence of granular cell tumors has been reported several years after removal. (medscape.com)
Diffuse tenosynovial giant cell tumor has a high local recurrence rate that often leads to further surgery and morbidity. (msdmanuals.com)

Malignant mixed tumour, on the other hand, is characterized by perivascular and perineural invasion, significant cellular atypia and mitosis( 2 ). (ispub.com)

In contrast, benign phyllodes tumors on clinical, radiological, and cytological examination are often indistinguishable from fibroadenomas and can be cured by local surgery. (hindawi.com)
An ovarian tumor was suspected on the basis of clinical signs, clinicopathologic findings, and results of cytologic evaluation of the mass. (avma.org)
On clinical presentation, features like facial weakness, pain and paresthesia hint towards invasion by a malignant tumour. (ispub.com)
Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells. (google.com)
Clinical photograph of a granular cell tumor on the tongue of a 38-year-old man. (medscape.com)
The most common clinical signs at presentation in dogs with nasal planum tumors include ulceration, bleeding and sneezing. (vin.com)
There is variability in clinical signs based on whether there is a nasal or nasopharyngeal tumor present. (vin.com)
To obtain an independent test set, the remaining 11 of the 58 tumors were selected from an ongoing clinical trial and used here as a blinded sion via ER,3 however the details of the estrogen effect on down- test set. (lu.se)

Anatomy5

Diseases13

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Disciplines and Occupations1

Progression13

Cancers23

Ovary22

Carcinomas9

Proliferation13

Metastasis11

Mesenchymal8

Borderline8

Tumours6

Tissues8

Group of tumors1

Solid tumors3

Invasive8

Neoplasm4

Phenotype5

Stromal tumors3

Incidence7

Extragonadal germ cell t2

Carcinoma14

Subtypes2

Salivary gland7

Etiology3

Occur11

Heterogeneity9

Neoplastic3

Ovarian neoplasms3

Squamous epithelial cells3

Cancer71

Neoplasms2

Atypical5

Differentiation5

Microenvironment1

Transformation5

Majority of ovarian1

Germ cell10

Lesions6

Head and neck1

Histologic2

Types of benign2

Primary8

Granulosa cell2

Benign tumors1

Genes6

Cancerous4

Melanoma1

Prognosis1

Induce2

Epithelium4

Diagnosis6

Adenocarcinoma3

Angiogenesis1

Metastatic tumor1

Mammary tumor2

Suppressor gene1

Recurrence2

Cellular1

Clinical8