• Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
  • SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
  • The postulated mechanisms of action of corticosteroids in brain tumors include reduction in vascular permeability, cytotoxic effects on tumors, inhibition of tumor formation, and decreased CSF production. (medscape.com)
  • Topotecan is a novel topoisomerase I inhibitor that may have a role in the adjuvant chemotherapy of several solid tumors, including malignant glioma. (aspetjournals.org)
  • Onconase is given to mesothelioma patients participating in clinical trials who do not qualify for surgical removal of malignant tumors. (mesotheliomahope.com)
  • Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and accounts for approximately 60% to 70% of all renal tumors [ 1 ]. (hindawi.com)
  • In addition, fenbendazole can improve the survival of patients with malignant brain tumors. (alexandrosampaio.com)
  • They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)
  • Malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) occur more frequently than other types of primary central nervous system tumors, having a combined incidence of 5-8/100,000 population. (ukrbiochemjournal.org)
  • Aberrant overexpression of GSK-3β has been shown to promote tumor growth and chemotherapy resistance in various solid tumors including colon, ovarian, and pancreatic cancers and glioblastoma through differential effects on the pro-survival nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and c-Myc pathways as well on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and p53-mediated apoptotic mechanisms. (outcomes4me.com)
  • 9-ING-41 has significant in vitro and in vivo activity as a single agent and/or in combination with standard cytotoxic chemotherapies in a spectrum of solid tumors and hematological malignancies including bladder, breast, glioblastoma, neuroblastoma, pancreatic, sarcomas, and renal cancers as well as lymphomas. (outcomes4me.com)
  • This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. (cincinnatichildrens.org)
  • It is not yet known whether high-dose combination chemotherapy and stem cell transplant are more effective than standard-dose combination chemotherapy in treating patients with refractory or relapsed germ cell tumors. (cincinnatichildrens.org)
  • It is known that arsenic trioxide (ATO) is able to inhibit the migration and invasion of solid malignant tumors, but its exact molecular mechanism remains unclear. (nih.gov)
  • Effective immunotherapy of stromal-rich tumors requires simultaneous targeting of cancer cells and immunosuppressive elements of the microenvironment. (aacrjournals.org)
  • Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)
  • We determined the effect of bortezomib on the cell cycle, apoptosis, and on the expression of cell cycle proteins p21/WAF1 and p27/KIP1 and on apoptosis-related proteins IAP-1, IAP-2, survivin, and XIAP. (mesothelioma-line.com)
  • Apoptosis increased in a concentration- and time-dependent manner in 3 of 4 MPM cell lines. (mesothelioma-line.com)
  • The sub G1 peaks, which signify necrosis/apoptosis, are greater in DCS taken care of 40AF cells compared with all the handle group. (cox2-inhibitors.com)
  • CD95 ligand (CD95L)-induced apoptosis was synergistically enhanced by short-term/high concentration but not long-term/low concentration exposure to topotecan, suggesting that topotecan sensitizes human malignant glioma cells to CD95L-induced apoptosis via inhibition of RNA synthesis. (aspetjournals.org)
  • Onconase (Ranpirnase) is a chemotherapy drug derived from frog eggs that has shown antitumor activity through cell-cycle interference and apoptosis (cell death). (mesotheliomahope.com)
  • It interferes with cell-cycle regulation, which is the process by which cells divide and replicate, and induces programmed cell death (apoptosis). (mesotheliomahope.com)
  • Another mechanism is up-regulation of pathways that inhibits cell apoptosis. (oncologynurseadvisor.com)
  • Since BCL2, a protein that indirectly inhibits cell apoptosis, is required for certain chemotherapies to work, the absence of BCL2 obscures their uses in prostate cancer. (oncologynurseadvisor.com)
  • 70 Mcl1 (myeloid cell leukemia differentiation protein 1) and other members of the BCL family, such as BCL-xl (B-cell lymphoma-extra-large), are also involved in resistance to Interleukin (IL)-6, stromal cell derived factor-1, and cytokine-induced apoptosis. (oncologynurseadvisor.com)
  • 75,76 Tumor necrosis factor (TNF)-α inhibits apoptosis by activating NF-κB and its downstream pathway, including IL6 and IL8, in androgen-independent prostate cancer cells, whereas it promotes apoptosis in androgen-dependent cancer cells. (oncologynurseadvisor.com)
  • Conventional cytotoxic drugs and new therapies target p53, a key regulator of apoptosis. (uni-muenchen.de)
  • As described in the literature, wildtype p53 leaded to an increase in intrinsic cell death, whereas different p53 mutations reduced apoptosis. (uni-muenchen.de)
  • As a next step we studied the influence of cell cycle arrest induced by p53 activation on TRAIL apoptosis sensitivity (Ehrhardt/Wachter et al. (uni-muenchen.de)
  • 2013). Cell cycle arrest was induced in tumor cell lines and patient samples in G0, G1 or G2 with cytostatic drugs, phase-specific inhibitors or RNA interference against cyclinB and E. Molecular or biochemical arrest at any point of the cell cycle augmented the rate of apoptosis by TRAIL. (uni-muenchen.de)
  • The extrinsic apoptosis by TRAIL was increased in senescent tumor cells. (uni-muenchen.de)
  • The impact of the p53 status of tumor cells on extrinsic apoptosis signaling should be considered, especially in the context of therapeutic approaches that aim to restore p53 function to enable cell death. (uni-muenchen.de)
  • The promotion phase is characterized by the clonal expansion of initiated cells due to suppressed apoptosis. (iiarjournals.org)
  • In many cases the antiproloferation action is caused by damage to DNA, which initiates apoptosis and cell death [4]. (savedelicious.com)
  • It regulates HLA class I and induces apoptosis in HER2/neu beneficial tumor cell lines. (mirnamimics.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • TMZ caused apoptosis in glioma cells via activation of MAPK signaling pathway, inhibition of STAT3, and affected a transition through G2/M phase of cell cycle. (ukrbiochemjournal.org)
  • Roos WP, Batista LF, Naumann SC, Wick W, Weller M, Menck CF, Kaina B. Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. (ukrbiochemjournal.org)
  • Apoptosis of the cells was analyzed by flow cytometry using an Annexin V and propidium iodide binding method. (nel.edu)
  • Total apoptosis (about 12%) and no significant alteration in cell cycle were confirmed for SGE of A. variegatum and R. appendiculatus, and additionally SGE of 5-day fed I. ricinus females (IC(50) 0.64 mg/ml). (nel.edu)
  • Expression of cell cycle inhibitors, P21 and P27, and activation of apoptosis executer enzyme, caspase-3, were also induced by TCEE. (hindawi.com)
  • This TCEE also demonstrates antitumor properties such as the induction of cell cycle arrest and activation of apoptosis on human colon, lung, melanoma, osteosarcoma, and pancreatic cancer cells [ 16 - 19 ]. (hindawi.com)
  • The primary pathogenic event that causes the generation of aberrant B cells remains to be decided, but impaired apoptosis results in increased survival of circulating CLL cells. (eotp.org)
  • Apoptosis can be induced via two main pathways: interference with mitochondrial function, also called the intrinsic pathway, or triggering of cell surface death receptors, also called the extrinsic pathway (2,3). (eotp.org)
  • Thus, the induction of apoptosis via the extrinsic pathway requires additional cleavage of the proapoptotic Bcl-2 family member BID through caspase 8, which activates the intrinsic pathway and subsequently apoptosis (type II cell mechanism) (7,8). (eotp.org)
  • Nonspecific cytotoxic drugs such as alkylating agents or purine analogs have commonly been used to induce apoptosis via the intrinsic pathway. (eotp.org)
  • In malignant cells, HDACIs induce apoptosis SMIP004 by upregulation of proapoptotic and repression of antiapoptotic genes (14C16). (eotp.org)
  • It was our goal to further elucidate the effects of VPA on apoptosis in these SMIP004 cells. (eotp.org)
  • Similar findings were made in bone marrow cells from gene-targeted mice lacking Bim and/or Puma infected with FLT3-ITD and treated with inhibitor, where loss of Puma only provided transient protection from apoptosis, but loss of Bim preserved clonal survival upon FLT3-ITD inhibition. (ashpublications.org)
  • Their antitumor activities include inhibition of tumor cell proliferation, induction of tumor cell apoptosis and tumor angiogenesis, modulation of host immune responses, anti-inflammatory and anti-oxidative properties, and protective autophagy. (baituxiao.com)
  • Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
  • During the initial treatment, six cycles of docetaxel and carboplatin (DC) combination chemotherapy were administered followed by two cycles of docetaxel maintenance therapy. (frontiersin.org)
  • Malignant pleural mesothelioma (MPM) is a highly lethal neoplasm that is resistant to chemotherapy. (mesothelioma-line.com)
  • Chemotherapy is used in intervals called cycles, carried out with treatment phases alternating with pauses phases. (drsymptoms.com)
  • This is an important study, and ultimately, I think our goal is to overcome the use of chemotherapy and radiation, which can destroy healthy cells along with malignant ones," commented Catherine Bollard, MD, MBChB, a bone and marrow transplant specialist at George Washington University/Children's National Medical Health System, Washington, DC. (medscape.com)
  • Chemotherapy is a class of anticancer medications that slow or stop cancer cells from replicating and infecting other parts of the body. (mesotheliomahope.com)
  • Resistance to chemotherapy is when the cancer cells do not respond to the drugs. (savedelicious.com)
  • Drugs used in chemotherapy, such as paclitaxel, ifosfamide, cisplatin, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (cincinnatichildrens.org)
  • Giving chemotherapy before a stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them. (cincinnatichildrens.org)
  • Giving colony-stimulating factors, such as filgrastim or pegfilgrastim, and certain chemotherapy drugs, helps stem cells move from the bone marrow to the blood so they can be collected and stored. (cincinnatichildrens.org)
  • Chemotherapy is then given to prepare the bone marrow for the stem cell transplant. (cincinnatichildrens.org)
  • The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. (cincinnatichildrens.org)
  • Treatment of MB generally involves surgery followed by a combination of radiotherapy and cytotoxic chemotherapy. (biomedcentral.com)
  • The aims of this study are to clarify the antitumor effects of TCEE on human hepatocellular carcinoma cells and also evaluate the combination drug effects with conventional chemotherapy agents, cisplatin and doxorubicin. (hindawi.com)
  • In contrast, the antitumor effects and related biological mechanism of TCEE as well as the combination drug effects with conventional chemotherapy agents remain unclear particularly in human hepatocellular carcinoma cells. (hindawi.com)
  • Furthermore, the combined drug effects of TCEE with conventional chemotherapy agents, cisplatin and doxorubicin, were also analyzed to clarify whether TCEE enhances or antagonizes the cytotoxicity of the selected chemotherapy agents in hepatocellular carcinoma cells. (hindawi.com)
  • The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
  • Prior to the advent of cytotoxic chemotherapy, lung cancer at all stages was treated surgically or by radiation alone ( 5 , 6 ). (frontiersin.org)
  • The case-group underwent oral hygiene control associated with the use of chamomile tea before starting the first cycle of chemotherapy, while the control group, there were no previous guidelines and prescriptions. (bvsalud.org)
  • BT-ON013 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)
  • In addition, it can enhance the cytotoxic effects of other agents, such as radiation and anti-tumor immunotherapy. (alexandrosampaio.com)
  • Moreover, treatment with TCEE is found to enhance the cytotoxic effects of amphotericin B in human colon cancer cell both in vitro and in vivo [ 17 ]. (hindawi.com)
  • Thus, they have a greater toxic effect on rapidly dividing cells (such as malignant and myeloid cells, and GI & oral mucosa), which replicate their DNA more frequently, and thus inhibits the growth and proliferation of these non-cancerous cells as well as causing the side-effects listed. (wikipedia.org)
  • Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
  • These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
  • Alterations in redox cell signalling produce changes that, synergistically with DNA alterations, induce deregulation of cell cycle control and cell proliferation ( 1 ). (iiarjournals.org)
  • Relationships between ROS, uncontrolled cell proliferation, activation of NF-κB and overexpression of p53 point to the significance of oxidative stress in cancer development. (iiarjournals.org)
  • Cell proliferation was examined by MTT and cell count assays. (biomedcentral.com)
  • erbB 2 antisense oligonucleotides inhibit proliferation of breast cancer cells with erbB oncogene amplification rkungsfaktorsteuerung second Br J Cancer. (mirnamimics.com)
  • Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
  • GSK-3β helps maintain malignant cell survival and proliferation, particularly in terms of mediating resistance to standard anti-cancer therapies, through the NF-κB pathway. (outcomes4me.com)
  • SGE of all ticks examined suppressed HeLa cell proliferation in a dose dependent manner. (nel.edu)
  • Astragalus polysaccharides (APS) have been shown to regulate the immune function by enhancing the immune organ index, promoting the proliferation of immune cells, stimulating the release of cytokines, and affecting the secretion of immunoglobulin (Ig) and conduction of immune signals. (baituxiao.com)
  • Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)
  • Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)
  • Epithelioid angiosarcoma (EA) is a rare variant of angiosarcoma, which is characterized by a high-grade malignant neoplasm, which consists of an atypical, multilayered, or solid endothelial proliferation and vasoformative architecture, presenting necrosis and an area of hemorrhage 1-5 . (bvsalud.org)
  • AuNPL cytotoxicity against HeLa, human malignant melanoma A375, and normal human keratinocytes HaCaT cells was tested by MTT cell survival assay, and their IC50 values were determined. (ac.rs)
  • Here, we have characterized the time- and concentration-dependent toxicity of topotecan in four human malignant glioma cell lines, LN-18, LN-229, LN-308 and T98G. (aspetjournals.org)
  • Here, we present data about an enhancement of TMZ treatment effect towards rat and human glioma cells in vitro by immobilizing this drug with a new nanoscale polymeric-phospholipidic delivery system. (ukrbiochemjournal.org)
  • Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. (ukrbiochemjournal.org)
  • The selectivity in the cytotoxic action of AuNPL on HeLa and A375 cancer cells compared with their cytotoxicity on normal keratinocytes HaCaT was observed. (ac.rs)
  • Normal killer T-cell cytotoxicity ENMD-2076 t Of breast cancer targets is by two unique mechanisms surveilance old K Entire body surveilance-Dependent cytotoxicity t Re Improves cellular communication LFA towards t 3 and HER2/neu. (mirnamimics.com)
  • The cytotoxicity of etoposide and VPA to a UKF-NB-4 neuroblastoma cell line was evaluated with MTT assay. (nel.edu)
  • They also indicate that the impact of VPA on cytotoxicity of etoposide in these tumor cells varies depending on the sequence of cultivation of the cells with the drugs. (nel.edu)
  • In contrast, the reversed combination (preincubation of the cells with VPA before their treating with etoposide) did not give any increase in etoposide cytotoxicity. (nel.edu)
  • The addition of essential amino acids, but not non-essential amino acids to the cell culture medium resulted in the cancellation of this pronounced cytotoxicity. (spandidos-publications.com)
  • Autophagic cell death was excluded as the inhibition of autophagy did not attenuate the cytotoxicity. (spandidos-publications.com)
  • High micromolar concentrations of topotecan, which are unlikely to be achieved in plasma in human patients in vivo , were cytotoxic within 48 hr, induced DNA fragmentation, did not induce major cell cycle changes, failed to consistently alter BCL-2 or BAX protein levels but inhibited RNA synthesis and induced cleavable DNA/topoisomerase I complex formation. (aspetjournals.org)
  • In this study, we aimed to assess the neoplastic-like transformation potential of two forms of CNC derived from wood (powder and gel) in human pulmonary epithelial cells (BEAS-2B) in comparison to fibrous tremolite (TF), known to induce lung cancer. (cdc.gov)
  • Dietary data mas (HNSCC) are malignant tumours the University of Damascus Dental were collected by a face-to-face interview arising most frequently in the non- Hospital, Al-Bayrouny Hospital and Al- using a validated, semi-quantitative food keratinized epithelial tissue of the upper Mojtahed Hospital, which are the only frequency questionnaire ( 8 ). (who.int)
  • The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers. (outcomes4me.com)
  • It's modes of action include downregulation of NF-κB and decreasing the expression NF-κB target genes including cyclin D1, Bcl-2, anti-apoptotic protein (XIAP) and B-cell lymphoma-extra large (Bcl-XL) leading to inhibition of tumor growth in multiple solid tumor cell and lymphoma lines and patient derived xenograft (PDX) models. (outcomes4me.com)
  • Another study found that extracts of Astragalus membranaceus overcome tumor immune tolerance by inhibition of tumor programmed cell death protein ligand-1 expression. (baituxiao.com)
  • Chang HL, Kuo YH, Wu LH, Chang CM, Cheng KJ, Tyan YC, Lee CH. The extracts of Astragalus membranaceus overcome tumor immune tolerance by inhibition of tumor programmed cell death protein ligand-1 expression. (baituxiao.com)
  • Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. (wikipedia.org)
  • Antifolates act specifically during DNA and RNA synthesis, and thus are cytotoxic during the S-phase of the cell cycle. (wikipedia.org)
  • These actions block DNA synthesis, causing a block at G2 phase and subsequently apoptotic cell death. (savedelicious.com)
  • Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
  • For this patient, we hypothesized that an altered FA pathway resulted in genomic instability, hypersensitivity to DNA-crosslinking agents or cytotoxic chemotherapeutics, and unsuccessful DNA damage repair. (frontiersin.org)
  • She developed ovarian cancer, and then the altered FA pathway plus exposure to cytotoxic drugs promoted the emergence of acquired somatic mutations and the NUP98-HOXC11 fusion, all of which contributed to the development of secondary t-CMML. (frontiersin.org)
  • The DNA- damage response gene, p53 , is an important mediator of this cell-death pathway. (the-scientist.com)
  • 13 So, in one,25D resistant 40AF cells HPK1 doesn't seem inhibitor checkpoint inhibitors to signal differentiation with the JNK pathway. (cox2-inhibitors.com)
  • High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
  • Whilst U87MG shared the same dampened p53 activity, upon chemotherapeutic drug treatment in chronic hypoxic conditions, these cells used a different mechanism, independent of the DNA damage pathway. (biomedcentral.com)
  • Furthermore, ATO dysregulated microtubule polymerization via the CLIP170/LIS1/NDEL1/dynein signaling pathway in Cal27 cells as a functional consequence of CLIP170 zinc finger disruption. (nih.gov)
  • Inactivation of the PI3-kinase pathway, but not of Ras-mitogen-activated protein (MAP) kinase signaling, was essential to elicit cytotoxic responses. (ashpublications.org)
  • Ewing sarcomas are thought to derive from cells of the neural crest, possibly mesenchymal stem cells, via a pathway that might include postganglionic cholinergic neurons. (medscape.com)
  • Patients with FA gene mutation are hypersensitive to DNA damage and unable to successfully repair damaged DNA when exposed to DNA-crosslinking agents, cytotoxic chemotherapeutics, and ionizing radiation ( 3 , 4 ). (frontiersin.org)
  • however, mechanisms through which these bioactive compounds act on epithelial cells have not been identified. (biorxiv.org)
  • Etoposide (Vepesid, VP-16), an inhibitor of topoisomerase II, is a chemotherapeutic drug commonly used for treatment of different types of malignant diseases. (nel.edu)
  • When administered into the pleural cavity in the treatment of malignant pleural effusion, bleomycin acts as a sclerosing agent. (nih.gov)
  • Thus, we must rely on the elegant mechanisms our cells have developed to repair damage. (the-scientist.com)
  • Single-strand breaks are easily fixed, but double-strand breaks require the complex mechanisms of nonhomologous end-joining and homologous recombination, the latter only being useful in late S, G 2 or M phases of the cell cycle, when homologous chromosomes are present in the cell. (the-scientist.com)
  • 3 Such cellular-suicide mechanisms can eliminate cells that could present problems for the whole organism because of alterations in the DNA or difficulties in dealing with stressful stimuli. (the-scientist.com)
  • In conclusion, prostate cancer cells have resistance mechanisms to overcome cytotoxic therapies such as docetaxel and cabazitaxel. (oncologynurseadvisor.com)
  • Hence, understanding known mechanisms could be a start in coming up with novel therapies to combat resistant prostate cancer cells. (oncologynurseadvisor.com)
  • Many tumor promoters manifest inhibitory effectson antioxidative defence mechanisms, thus increasing the level of oxidative stress in the tumor cell. (iiarjournals.org)
  • However, cancer cells can become multidrug resistant, a phenomenon due to cells expressing mechanisms that cause simultaneous resistance to many different, structurally and functionally, unrelated drugs [6]. (savedelicious.com)
  • Here, we have determined the growth-inhibitory and proapototic mechanisms of 2 small molecule inhibitors of FLT3, AG1295 or PKC412, in hematopoietic progenitor cells, human leukemic cell lines, and primary AML cells expressing FLT3-ITD. (ashpublications.org)
  • Cells use a number of mechanisms to sense and maintain their homeostatic levels. (spandidos-publications.com)
  • In the past view decades the therapy of malignant diseases has improved significantly. (uni-muenchen.de)
  • 2011). A single drug is not very effective in cancer therapy therefore malignant diseases are usually treated with a combination of cytostatic agents. (uni-muenchen.de)
  • Human exposures to asbestiform elongate mineral particles (EMP) may lead to diffuse fibrosis, lung cancer, malignant mesothelioma and autoimmune diseases. (cdc.gov)
  • While it is well understood that doxorubicin activates p53 and induces cell-cycle arrest, we observed that cell-cycle arrest disabled inactivation of anti-apoptotic Bcl-2-family members by vincristine. (uni-muenchen.de)
  • 38 Consistent together with the greater differentiation, G1 arrest also increases when QVD is utilised to inhibit HPK1 cleavage in DCS treated 40AF cells. (cox2-inhibitors.com)
  • For optimal responses, DNA repair must coordinate with other cellular processes, such as cell-cycle progression and programmed cell death. (the-scientist.com)
  • All somatic eukaryotic cells arrest progression through the cell cycle when their DNA is damaged, presumably because optimal repair of the damage would be a mechanistic challenge if the cell continued to replicate DNA or segregate chromosomes. (the-scientist.com)
  • Initiation as the first stage of the "initiation-promotion-progression" model of carcinogenesis ( 9 , 10 ) involves non-lethal DNA mutations in affected cell(s). (iiarjournals.org)
  • Progression as the final stage of carcinogenesis involves irreversible changes from the benign to the malignant cell phenotype by the continuous accumulation of genetic alterations with oxidative stress probably playing a similar role as in the previous stages ( 9 ). (iiarjournals.org)
  • Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
  • The FDA recommends epcoritamab be administered subcutaneously in 28-day cycles until disease progression or unacceptable toxicity. (medscape.com)
  • GSK-3β is particularly important in tumor progression and modulation of oncogenes (including beta-catenin, cyclin D1 and c-Myc), cell cycle regulators (e.g. p27Kip1) and mediators of epithelial-mesenchymal transition (e.g. zinc finger protein SNAI1, Snail). (outcomes4me.com)
  • We applied a range of molecular and cellular techniques to measure cell survival, cell cycle progression, protein expression and DNA damage combined with a transcriptomic micro-array approach in D283-MED cells, for global gene expression analysis in acute and chronic hypoxic conditions. (biomedcentral.com)
  • Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
  • Although several studies revealed the important role of immune cells and related marker genes impact on LUAD prognosis and process, a comprehensive understanding of TIME malignant and metastatic change in LUAD is still limited. (aging-us.com)
  • Streptozotocin-induced diabetic ketoacidosis in a patient with metastatic islet-cell carcinoma. (cancerindex.org)
  • Since the division rate of many cancers cell is very high, in general they are more common in division phase than normal body cells and are therefore more susceptible to the effects of anticancer drugs. (drsymptoms.com)
  • Approximately 80-90% of newly diagnosed lung cancers are classified as NSCLC, primarily consisting of adenocarcinoma, squamous cell carcinoma, or large cell carcinoma histologies. (frontiersin.org)
  • The aim of the study was to investigate the relationship between plasma levels of malondialdehyde (MDA), a routinely used marker of oxidative stress, and squamous cell carcinoma of the oral cavity and oropharynx (OSCC). (iiarjournals.org)
  • SCC: squamous cell carcinoma. (iiarjournals.org)
  • Squamous cell carcinoma (SCC) of the oral cavity and oropharynx (OSCC), the fifth most common cancer worldwide ( 4 ), represents a considerable health problem. (iiarjournals.org)
  • Here, we report a novel molecular target and antimetastatic mechanism of ATO in head and neck squamous cell carcinoma (HNSCC). (nih.gov)
  • ABSTRACT Diet has not been investigated as a potential risk factor for head and neck squamous cell carcinomas in the Syrian Arab Republic. (who.int)
  • Head and neck squamous cell carcino- receive treatment. (who.int)
  • It is not understood, however, whether DNA-dependent protein kinase (DNA-PK), the kinase critical for repairing the majority of radiation-induced DNA double-strand breaks in cancer cells, is immunomodulatory. (bvsalud.org)
  • CD19 is a protein expressed on the surface of B-cell-derived ALLs and non-Hodgkin's lymphomas. (medscape.com)
  • It also binds to the cell cycle control protein, preventing it from polymerizing into its active form. (alexandrosampaio.com)
  • We found that cytoplasmic linker protein 170 (CLIP170) was overexpressed in HNSCC tissues and cells compared to normal controls. (nih.gov)
  • ATO at non-cytotoxic level (1 μM) inhibited the migration and invasion of HNSCC cells by displacing zinc in the zinc finger motif of CLIP170, which is a key protein that controls microtubule dynamics. (nih.gov)
  • The presence of necrostatin-1, an inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK‑1), but not that of Z-VAD-fmk, attenuated the cytotoxic effects of GEF under AAS culture conditions. (spandidos-publications.com)
  • Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
  • We used two MB cell line (D283-MED and MEB-Med8A) and a widely used glioblastoma cell line (U87MG) for comparison. (biomedcentral.com)
  • The drug was recently approved by the US Food and Drug Administration for patients with Philadelphia chromosome-negative precursor B-cell ALL who have relapsed or who were refractory to previous treatment. (medscape.com)
  • The study reported by Dr Topp and colleagues enrolled 189 patients with Philadelphia chromosome-negative, primary refractory or relapsed disease (first relapse within 12 months of first remission, relapse within 12 months after allogeneic hemopoietic stem cell transplantation, or no response to or relapse after first salvage therapy or beyond). (medscape.com)
  • The US Food and Drug Administration approved epcoritamab (Epkinly, AbbVie and GenMab) today for adults with relapsed/refractory diffuse large B-cell lymphoma following at least two lines of systemic therapy. (medscape.com)
  • The trial's efficacy population included 148 adults with relapsed or refractory CD20+ large B-cell lymphoma who had received at least two prior lines of therapy, including anti-CD20 therapies. (medscape.com)
  • The quest for hostile to cancerous growth compounds from plant sources began vigorously during the 1950s with the disclosure and advancement of the different regular mixtures like vinca alkaloids, vinblastine, vincristine and cytotoxic podophyllotoxins. (researchsquare.com)
  • This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
  • The ethanolic extract of T. camphoratus (TCEE) which contains abundant bioactive compounds including triterpenoids and polysaccharides also has antitumor effects in various human cancer cell lines. (hindawi.com)
  • Both compounds induced up-regulation of proapoptotic BH3-only proteins Bim and Puma, and subsequent cell death. (ashpublications.org)
  • We used four MPM cell lines (MS589, H28, H2052, JMN), a normal mesothelial cell line (HM3), and a lung cancer cell line (H23) in survival studies utilizing bortezomib, cisplatin, and pemetrexed alone and in combination by administering concurrently or by varying the order of administration. (mesothelioma-line.com)
  • Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
  • In terms of tumor treatment, Astragalus polysaccharides (PG2) have been shown to enhance the M1 polarization of macrophages, functional maturation of dendritic cells, and T cell-mediated anticancer immune responses in patients with lung cancer. (baituxiao.com)
  • Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer. (baituxiao.com)
  • In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
  • Using transcriptomic analysis in D283-MED cells, we found a large transcriptional remodelling upon long term hypoxia, in particular the expression of a number of genes involved in detection and repair of double strand breaks (DSB) was altered. (biomedcentral.com)
  • Growth inhibition goes along with cell cycle arrest as a consequence of transcriptional activation of p21WAF1/CIP1 and p27KIP1 and/or inhibition of cyclin A, cyclin D, and thymidylate synthetase (13). (eotp.org)
  • In cancer therapy , there are more than 50 different cell division inflammatory drugs (cytostatics). (drsymptoms.com)
  • The various classes of drugs attack the cancer cells in respectively different phases of the cell cycle. (drsymptoms.com)
  • As so-called "antitumor antibiotics", similar to conventional antibiotics in bacteria, they break apart the genetic material in the cancer cells and it change the cell membrane. (drsymptoms.com)
  • Blinatumomab is the first of a novel class of drugs known as bispecific T-cell engagers and is designed to direct cytotoxic T cells to CD19-expressing cancer cells. (medscape.com)
  • This strategy, along with others, is harnessing our immune system to target cancer cells. (medscape.com)
  • This drug combination has a high rate of failure due to chemoresistance (the ability of cancer cells to dodge treatment) or the presence of advanced disease. (mesotheliomahope.com)
  • The invasive nature of a cancer cell can determine how fast cancer is able to spread throughout the body. (mesotheliomahope.com)
  • A third potential mechanism deals with the limited amount of blood supply and hence, limited cytotoxic drug accessibility to the source of cancer. (oncologynurseadvisor.com)
  • A fourth mechanism suggests that cytotoxic drugs are removed from the source using efflux pumps, and the last mechanism is microtubule alterations that affect cytotoxic drug attachment to cancer cells. (oncologynurseadvisor.com)
  • Inherited resistance is noted in prostate cancer cells that do not express BCL2, indicating that taxanes' mechanism of action relies at least partly on BCL2 inhibition. (oncologynurseadvisor.com)
  • Cycling cells are required for vincristine to kill cancer cells efficiently. (uni-muenchen.de)
  • Increased drug efflux, via these transporters, lowers intracellular drug concentration, allowing cancer cells to escape the toxic effects of the drugs. (savedelicious.com)
  • Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)
  • Cancer is characterized as the uncontrolled multiplication and spread of the body's particular cells. (researchsquare.com)
  • Surgery can either be performed in cancer patients to make a tissue diagnosis of cancer, where a small portion of the tumour is removed, or a complete excision of the malignant tumour is done when the diagnosis is unequivocal. (fagoniacreticaforcancer.com)
  • The main goals of such forms of therapy vary from cure achieved by killing all tumour cells, controlling the growth of cancer cells, thereby causing remission, or palliative care to reduce symptoms and making the patient more comfortable. (fagoniacreticaforcancer.com)
  • This allows the tumour to rapidly take up the drug, resulting in quick action against the cancer cells which can be present anywhere in the body-be it the site of origin of the tumour or on tumour cells that have spread to distant sites. (fagoniacreticaforcancer.com)
  • Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)
  • Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
  • This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
  • This is because cancer cells maintain high basal level of ROS, thus they are vulnerable to any further increase in ROS (Fig. 1 ). (degruyter.com)
  • ROS-modulation in normal vs. cancer cell. (degruyter.com)
  • NF-κB is constitutively active in cancer cells and promotes anti-apoptotic molecule expression. (outcomes4me.com)
  • NF-κB activation is particularly important in cancer cells that have become chemo- and/or radio-resistant. (outcomes4me.com)
  • By inhibiting the topoisomerase II enzyme activity in cancer cells, this drug leads to DNA damage and subsequently to cell death. (nel.edu)
  • Differential regulation by melatonin of cell growth and androgen receptor binding to the androgen response element in prostate cancer cells. (nel.edu)
  • Although the LAT family plays important roles in the development and function of normal tissues, they are frequently increased in cancer cells ( 3 ). (spandidos-publications.com)
  • LAT-1 is most commonly upregulated in multiple types of cancer and has also been used as a biomarker for malignant cancer ( 4 , 5 ). (spandidos-publications.com)
  • Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
  • A subpopulation of cells within a cancer has the properties of stem cells. (msdmanuals.com)
  • A cancer may release cells into the circulation at a very early stage of development. (msdmanuals.com)
  • Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
  • Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
  • Experiments suggest that the abilities to invade, migrate, and successfully implant and stimulate new blood vessel growth are all important properties of the cells that cause metastases, which are likely a subpopulation of the primary cancer. (msdmanuals.com)
  • Cancer cells often present neoantigens on their cell surface that can be detected as "non-self" by the immune system, resulting in an attack by the immune system. (msdmanuals.com)
  • Destruction of cancer cells may be complete, in which case the cancer never appears. (msdmanuals.com)
  • Dans une étude cas-témoins non appariés en milieu hospitalier, 108 personnes atteintes d'un cancer et 105 témoins ont été interrogés sur leurs apports alimentaires en recourant à la version en langue arabe d'un questionnaire validé sur la fréquence de consommation alimentaire. (who.int)
  • Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
  • Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. (bvsalud.org)
  • Angiosarcoma is a rare malignant vascular neoplasm which constitutes less than 1% of all sarcomas. (bvsalud.org)
  • While IR alone was associated with a trend towards decreased tumor volume compared with untreated, only the M3814 + IR treatment arm was associated with consistent and significant reduction in tumor burden, which correlated with higher levels of γ-H2AX in tumor cells, a marker of double-strand DNA breaks. (bvsalud.org)
  • KG 1a cells with innate resistance to 1,25D also express HPK1 C fragments, that are diminished by treatment method DCS. (cox2-inhibitors.com)
  • Vitamin D resistance of KG 1a, AML M1 type cells,39 may also be attenuated by treatment with DCS, and, as in adaptively resistant 40AF cells, this is certainly associated with all the disappearance of your cleaved fragment and concurrent improve inside the level of your FL HPK1. (cox2-inhibitors.com)
  • Treatment of SH-SY5Y cells with the MAC complex reduced cell growth in concentration dependent manner. (biomedcentral.com)
  • New treatment strategies for malignant gliomas. (ukrbiochemjournal.org)
  • Friedman HS, Kerby T, Calvert H. Temozolomide and treatment of malignant glioma. (ukrbiochemjournal.org)
  • The effect of such combined treatment can be explained by measuring the cell cycle distribution, which shows that both etoposide and VPA change the cell cycle phase distribution. (nel.edu)
  • The results found here warrant further studies of combined treatment of neuroblastoma cells with etoposide with HDAC inhibitors and may help in the design of new protocols geared to the treatment of high risk neuroblastomas. (nel.edu)
  • Here we report a severe life-threatening complication of treatment with streptozotocin in a patient with pancreatic island-cell carcinoma. (cancerindex.org)
  • In the present study, the TCEE treatment induced cell cycle arrest and suppressed cell growth on both Hep3B and HepJ5 cells. (hindawi.com)
  • Accordingly, pre-treatment with 350 nM LSD1 inhibitor for 3 days followed by exposure to serial dilutions of ruxolitinib led to synergistic growth inhibition in non-DS-AMKL and ML-DS cell lines (Supplementary Fig. 4 ), as well as in all ML-DS patient samples (Fig. 1A ). (nature.com)
  • The antifolate action specifically targets the fast-dividing cells, and tend to have adverse effects on the bone marrow, skin, and hair. (wikipedia.org)
  • 36 This indicates that the previously documented non apoptotic func tions of caspases37 may possibly contribute towards the effects of QVD on AML cells, similar to the antitumor results of other protease inhibi tors. (cox2-inhibitors.com)
  • The effects of etoposide and VPA on UKF-NB-4 cells were tested under the normoxic and also the hypoxic (1% O2) cultivation conditions. (nel.edu)
  • The aims of this preclinical study are to evaluate the capability of TCEE to suppress human hepatocellular carcinoma cells and clarify the related antitumor effects. (hindawi.com)
  • Several inhibitors have been described, such as AG1295, CEP701, PKC412, and SU-11 248, with cytotoxic effects to cell lines and primary AML cells in vitro expressing mutant FLT3. (ashpublications.org)
  • The combination of LSD1 inhibition and ruxolitinib proved to be very effective in non-DS-AMKL blasts, however, with only additive cytotoxic effects in one of the two patient samples (Fig. 1A ). (nature.com)
  • 5 Conversely, p53 induction by oxidative damage may help reduce the development of atherosclerosis, perhaps by suppressing the growth or enhancing the death of cells involved in causing atherosclerotic lesions. (the-scientist.com)
  • In our work we discovered that the influence of p53 status on extrinsic cell death induction was much more multifaceted. (uni-muenchen.de)
  • However, excessive levels of ROS are cytotoxic and lead to the induction of programmed cell death ( 11 ). (iiarjournals.org)
  • Acute myeloid leukemia (AML) is a disease with diverse genetic features of the leukemic cells and with variable outcome. (cancercentrum.se)
  • AuNPL exerted their cytotoxic activity against HeLa cells through accumulation of the cells in the subG1 phase of the cell cycle, inducing the apoptotic cell death mediated by the activation of caspase-3 − 8, and − 9. (ac.rs)
  • The administered as tablets, injections or infusion drugs distributed in the various organs and can be achieved and destroy potentially scattered tumor cells. (drsymptoms.com)
  • A single drug, or more frequently, combinations of several drugs that act differently are used to destroy the malignant tumour. (fagoniacreticaforcancer.com)
  • Some drugs work better when given continuously, while others require three weekly cycles. (fagoniacreticaforcancer.com)
  • Etoposide and VPA were found as cycle phase specific drugs that are cytotoxic to human UKF-NB-4 neuroblastoma cells used either as single drugs or both together. (nel.edu)
  • Many antineoplastic drugs, such as antimetabolites, are most effective when cells are actively dividing. (msdmanuals.com)
  • Some drugs work only during a specific phase of the cell cycle, requiring prolonged administration to catch dividing cells during the phase of maximal sensitivity. (msdmanuals.com)
  • The disease is usually characterized by the accumulation of monoclonal CD5+ B lymphocytes arrested in the G0/G1 phases of the cell cycle. (eotp.org)
  • Alkylating agents, such as temozolomide (TMZ), are among the most effective cytotoxic agents used for malignant gliomas, however, the responses still remain poor. (ukrbiochemjournal.org)
  • Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. (cdc.gov)
  • Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. (medscape.com)
  • Although many plasma cell disorders have been reported in patients with POEMS syndrome, most patients are seen with osteosclerotic myeloma or monoclonal gammopathy of unknown significance. (medscape.com)
  • As reported with other monoclonal antibodies, life-threatening reactions can potentially result from massive release of cytokines, and blinatumomab also causes B-cell depletion, leading to further decreases in immunoglobulin levels, and thus increasing the risk for infections, he writes. (medscape.com)
  • We aimed to elucidate the impact of hypoxia on the sensitivity of MB cells to chemo- and radiotherapy. (biomedcentral.com)
  • The biologic simultaneously binds CD3 on cytotoxic T cells to CD20 on lymphomic B cells, inducing T-cell mediated destruction. (medscape.com)
  • Novel luteolin capped gold nanoparticles (AuNPL) were synthesized and their anticancer effect towards human cervical adenocarcinoma HeLa cells was investigated in vitro. (ac.rs)
  • Onconase dosage is being investigated through in vitro studies using cells that are grown in a lab and studies using mice cells. (mesotheliomahope.com)
  • In in vitro and in vivo experiments, bleomycin has been shown to cause cell cycle arrest in G2 and in mitosis. (nih.gov)
  • While macrophages were reported to act as one of the cells in LUAD, enrichment analysis of macrophage marker genes revealed the important role of macrophages in the activation of neutrophils. (aging-us.com)
  • Cytoprotective properties of AuNPL towards HaCaT cells were examined by measuring the physiological and H2O2 induced intracellular reactive oxygen species (ROS) levels using flow cytometry. (ac.rs)
  • respiratory burst (the rapid release of Reactions of oxygen radicals with Mitochondrial oxidative phosphor- reactive oxygen species from cells) cel ular components can deplete an- ylation is a major source of oxy- that involves nicotinamide adenine tioxidants, can cause direct oxidative gen radicals of endogenous origin. (who.int)
  • Exogenous agents are also impli- aldehyde) to form various pro-mu- tion, resisting cell death, enabling cated in the generation of reactive tagenic exocyclic adduct s (Bartsch replicative immortality, inducing oxygen. (who.int)
  • FLT3-ITD expression causes malignant transformation and factor-independent growth when expressed in factor-dependent cell lines. (ashpublications.org)
  • These data suggest that topotecan needs to be administered in high concentrations, such as an intratumoral polymer, to limit glioma cell growth in synergy with CD95L in vivo . (aspetjournals.org)
  • In this study, we investigated the effect of VPA on CLL cells ex vivo. (eotp.org)
  • It is a broad-spectrum antihelminthic drug, whose mechanism of action involves inhibiting microtubule formation in the cell. (alexandrosampaio.com)
  • The presence of p53 in tumor cell lines and xenograft tumor cells resulted in augmented, unaffected or decreased cell death. (uni-muenchen.de)
  • Under AAS culture conditions, the cell killing effect of GEF was synergistically pronounced in the EGFR-expressing cell lines, namely, CAL 27, Detroit 562, A549 and PANC-1 cells compared with those treated with either GEF or AAS alone. (spandidos-publications.com)
  • 1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)
  • Chinese hamster ovary) cell suspension culture and purified by chromatography including specific viral inactivation and removal procedures. (who.int)
  • Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress ( 2 - 6 ). (iiarjournals.org)
  • In contrast SMIP004 to most other hematological malignancies, CLL cells have a negligibly low fraction of growing cells. (eotp.org)
  • In addition, ozone oxidizes the outer lipid layer of malignant cells and destroys them through cell lysis (break- down). (silvermedicine.org)
  • Consequently, when cell cycle arrest was deactivated by adding caffeine, the antitumor activity of TRAIL was decreased. (uni-muenchen.de)
  • Macroautophagy (thereafter designated as autophagy) is a self-digestive system conserved in all eukaryotic cells. (spandidos-publications.com)
  • In this report, we determine the biological and molecular response of cultured MPM cells to bortezomib alone and in combination with cisplatin or pemetrexed. (mesothelioma-line.com)