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  • gene
  • Publications] 守内哲也: 'Overexpression of the HOX4A (HOXD3) homerobox gene in human erythroleukemie HEL cells results in altered adhesive properties. (nii.ac.jp)
  • As they are stimulated to become plasma cells, B cells refashion parts of their genome in efforts to create a new gene that encodes a functional antibody. (wikipedia.org)
  • If these gene alterations are successful in coding for a functional antibody (termed Ig for immunoglobulin), the maturing B cells and to a greater extent their plasma cell descendants make and secrete an intact antibody, initially IgM but after class switch recombinations, either IgG, IgA, IgE, or IgD. (wikipedia.org)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • 1981 Beatrice Mintz's laboratory is one of the first to introduce a cloned gene into fertilized mouse eggs and prove that it is retained in animals developing from those eggs, and is transmitted to their progeny. (wikipedia.org)
  • serum
  • Phage display represents a high-throughput technique for screening billions of random fusion antibodies against virtually any target on the surface or inside cancer cells, or even soluble markers found in patient serum. (mdpi.com)
  • genetic
  • The genetic material, in the form of deoxyribonucleic acid (DNA), continues to shorten with each cell division, and cells eventually stop dividing when they sense that their DNA is critically shortened. (wikipedia.org)
  • This allowed the advancement of research on metabolic and genetic features of the clone cell. (wikipedia.org)
  • 1979 Beatrice Mintz shows that a fatal genetic anemia of mice can be prevented in utero by injecting normal blood-forming stem cells into the fetus through a placental blood vessel. (wikipedia.org)
  • proliferation
  • The fundamental driver of these hypereosinophilic (or uncommonly eosinophilic) disorders is the mutation which increases the proliferation, survival, and further mutation of cells descendant from the originally mutated cell. (wikipedia.org)
  • plasma cells
  • Plasma cells are key effector elements of the adaptive immune system. (wikipedia.org)
  • Plasma cells develop from B lymphocytes which are stimulated to undergo this maturational development by T lymphocytes during the latter cells' processing of these antigens. (wikipedia.org)
  • For instance, two plasma cells belonging to the same clone could be derived from different memory cells (in turn with shared clonality) and could be residing in quite distant locations, such as the cervical (in the neck) and inguinal (in the groin) lymph nodes. (wikipedia.org)
  • Blood
  • The World Health Organization classifies these disorders into a) Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 (i.e. high eosinophil blood counts caused by mutations in the eosinophil cell line of one of these three genes), 'b) Chronic eosinophilic leukemia, and c) the Idiopathic hypereosinophiic syndrome. (wikipedia.org)
  • However
  • However, during course of cell division, one of the cells can get mutated further and acquire new characteristics to diverge as a new clone. (wikipedia.org)
  • In many clinical settings, however, studies on the T cell receptor and IL-5 are not available and therefore not routine parts of the diagnostic work-up or criteria for the disease. (wikipedia.org)
  • markers
  • Selection directed to tumoral cells' surfaces lead to the identification of unknown tumoral markers. (mdpi.com)
  • single
  • When ultimately many cells are produced by a single cell, clonal expansion is said to have taken place. (wikipedia.org)
  • Single cells separated out required the support of other cells in order to function and proliferate. (wikipedia.org)
  • Sanford developed micropipettes where single cells could be picked up and isolated from under the microscope and placed in a detailed microenvironment, where diffusion of cellular products was restricted to inside a small closed culture. (wikipedia.org)
  • mouse
  • Her first success in duplicating an identical copy of a cell was with a mouse fibroblast. (wikipedia.org)
  • 1993 Beatrice Mintz produces the first mouse model of human malignant melanoma, in which the disease resembles the human malignancy. (wikipedia.org)
  • human
  • Publications] 守内哲也: 'Cloning, sequencing, and chromosomal localization of two tandemly arranged human pseudogenes for the proliferating cell nuclear antigen (PCNA). (nii.ac.jp)
  • found
  • Activation of GSH-Px promoter was found in both cell llines expressing wild-type p53 and mutant p53, indicating that GSH-Px promoter is activated by N-terminal activation domain of p53. (nii.ac.jp)
  • growth
  • Publications] 浜田淳一: 'Differing distribution of hepatocyte growth factor-positive cells in the liver of LEC rats with acute hepatitis and hepatoma. (nii.ac.jp)
  • section
  • In 1974 Sanford was appointed head of the cell physiology and oncogenesis section of the NCI's Laboratory of Biochemistry. (wikipedia.org)
  • Possible
  • Publications] 守内哲也: 'Possible roles of an adult T cell leukemia-derived factor (ADF)/thioredoxin in drug resistance of adult T cell leukemia (ATL) to Adriamycin. (nii.ac.jp)
  • methods
  • Also the improvement of methods that require smaller amounts of cells has opened the possibility to use this approach on patient samples. (mdpi.com)
  • shown
  • A karyotype is typically presented as an image of the chromosomes from a single cell arranged from largest (chromosome 1) to smallest (chromosome 22), with the sex chromosomes (X and Y) shown last. (wikipedia.org)
  • high
  • Despite the diversity of platforms, ultimately they all use genomic DNA from disrupted cells to recreate a high resolution karyotype in silico. (wikipedia.org)
  • active
  • There are an array of clinical variants of the disease, ranging from the asymptomatic monoclonal gammopathy of undetermined significance (MGUS) and smouldering MM, to the more aggressive active MM and plasma cell leukaemia. (biomedcentral.com)