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  • Proliferation
  • A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. (cancerindex.org)
  • It is characterized by uncontrolled proliferation of lymphoid lineage cells (typically B cells, rarely non-B lineage) in a context of posttransplant immunosuppression. (medscape.com)
  • Post-transplant lymphoproliferative disorder (PTLD) is the name given to a B-cell proliferation due to therapeutic immunosuppression after organ transplantation. (wikipedia.org)
  • The disease is an uncontrolled proliferation of B cell lymphocytes latently infected with Epstein-Barr virus. (wikipedia.org)
  • However, in immunosuppressed transplant patients, the lack of T-cell immunosurveillance can lead to the proliferation of these EBV-infected of B-lymphocytes. (wikipedia.org)
  • However, calcineurin inhibitors (tacrolimus and ciclosporin), used as immunosuppressants in organ transplantation inhibit T cell function, and can prevent the control of the B cell proliferation. (wikipedia.org)
  • These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
  • numerous tyrosine kinase cell signaling proteins are responsible for the growth and proliferation of eosinophils {see clonal eosinophilia}), methotrexate and Hydroxycarbamide (both are chemotherapy and immunosuppressant drugs), and Alemtuzumab (a antibody that binds to the CD52 antigen on mature lymphocytes thereby marking them for destruction by the body). (wikipedia.org)
  • The fundamental driver of these hypereosinophilic (or uncommonly eosinophilic) disorders is the mutation which increases the proliferation, survival, and further mutation of cells descendant from the originally mutated cell. (wikipedia.org)
  • Smaller cytokine production reduces the T cell proliferation. (wikipedia.org)
  • They affect the proliferation of both T cells and B cells. (wikipedia.org)
  • After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
  • proliferating cell nu
  • Publications] 守内哲也: 'Cloning, sequencing, and chromosomal localization of two tandemly arranged human pseudogenes for the proliferating cell nuclear antigen (PCNA). (nii.ac.jp)
  • cancer
  • An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is increasing in prevalence. (labspaces.net)
  • Despite the emergence of new therapies, such as tyrosine kinase inhibitors, CML and other leukemias remain problematic because some cancer stem cells avoid destruction and eventually regenerate themselves, a stem cell process known as self-renewal that can result in a return and spread (metastasis) of the disease. (labspaces.net)
  • People normally think about DNA instability in cancer, but in this case, it's how the RNA is edited by enzymes that really matters in terms of cancer stem cell generation and resistance to conventional therapy. (labspaces.net)
  • CML is a cancer initiated by a mutant gene called BCR-ABL in blood forming stem cells that leads to an expansion of white blood cells and their precursors. (labspaces.net)
  • Despite tremendous advances in BCR-ABL tyrosine kinase inhibitor therapies, the majority of patients relapse if therapy is discontinued, in part as a result of dormant cancer stem cell resistance. (labspaces.net)
  • This work suggests a novel mechanism for overcoming cancer stem cell resistance to therapy that may prevent relapse and progression. (labspaces.net)
  • Researchers have known for decades that cancer begins when certain key genes in an otherwise healthy cell mutate, and tumor growth depends on continuing, multiple mutations. (innovations-report.com)
  • But only recently have scientists begun to understand the "epigenetic" components of cancer-that is, how other molecules in a cell affect genes without actually altering the sequence of DNA. (innovations-report.com)
  • Principal investigator of the study is Catriona H. M. Jamieson, MD, PhD , associate professor of medicine in the Division of Hematology-Oncology and director of stem cell research at the UC San Diego Moores Cancer Center . (ucsd.edu)
  • Researchers at Mayo Clinic have identified an interaction among proteins that allows cancer cells to grow and metastasize. (medicalxpress.com)
  • Scientists identify two signaling proteins in cancer cells that make them resistant to chemotherapy, and show that blocking the proteins along with chemotherapy eliminate human leukemia in mouse models. (medicalxpress.com)
  • MORIUCHI Tetsuya Cancer Inst.Div.Cell Biol. (nii.ac.jp)
  • OKADA Futoshi Cancer Inst.Div.Cell Biol. (nii.ac.jp)
  • HAMADA Junichi Cancer Inst.Div.Cell Biol. (nii.ac.jp)
  • Adoptive cell transfer: a clinical path to effective cancer immunotherapy. (springermedizin.de)
  • Targeting of cancer neoantigens with donor-derived T cell receptor repertoires. (springermedizin.de)
  • Over the last few years, both synchrotron-based FTIR (S-FTIR) and Raman microspectroscopies have helped to better understand the effects of drugs on cancer cells. (rsc.org)
  • However, cancer is a mixture of cells with different sensitivity/resistance to drugs. (rsc.org)
  • Phage display represents a high-throughput technique for screening billions of random fusion antibodies against virtually any target on the surface or inside cancer cells, or even soluble markers found in patient serum. (mdpi.com)
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • The expansion of a particular clone of immune B cells is usually interpreted by clinicians as evidence of unrestricted cell growth, the hallmark of cancer. (wikipedia.org)
  • A transmissible cancer is a cancer cell or cluster of cancer cells that can be transferred between individuals without the involvement of an infectious agent, such as an oncovirus. (wikipedia.org)
  • Clonally transmissible cancer, caused by a clone of malignant cells rather than a virus, is an extremely rare disease modality, with few transmissible cancers being known Animals that have undergone population bottlenecks may be at greater risks of contracting transmissible cancers. (wikipedia.org)
  • It did not take her long to make an impact, as almost immediately after joining she made her largest discovery involving a method of cloning mammalian cancer cells in vitro. (wikipedia.org)
  • However, it is reduced or absent from most cancer cells. (wikipedia.org)
  • Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. (wikipedia.org)
  • gene
  • Chronic myeloid leukemia develops when a gene mutates and causes an enzyme to become hyperactive, causing blood-forming stem cells in the bone marrow to grow rapidly into abnormal cells. (medicalxpress.com)
  • Publications] 守内哲也: 'Overexpression of the HOX4A (HOXD3) homerobox gene in human erythroleukemie HEL cells results in altered adhesive properties. (nii.ac.jp)
  • It is widely accepted that HCV drives the expansion of few B-cell clones expressing a restricted pool of selected immunoglobulin variable (IgV) gene subfamilies frequently endowed with rheumatoid factor (RF) activity. (hindawi.com)
  • Moreover, we identi-fied recurrent mutation of the epigenetic modifier genes EZH2, TET2, and BCOR and recurrent chromoso-mal imbalances which correlate with changes in gene expression as compared to normal B cells. (uni-ulm.de)
  • As they are stimulated to become plasma cells, B cells refashion parts of their genome in efforts to create a new gene that encodes a functional antibody. (wikipedia.org)
  • If these gene alterations are successful in coding for a functional antibody (termed Ig for immunoglobulin), the maturing B cells and to a greater extent their plasma cell descendants make and secrete an intact antibody, initially IgM but after class switch recombinations, either IgG, IgA, IgE, or IgD. (wikipedia.org)
  • Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. (wikipedia.org)
  • Clonal hypereosinophilia is hypereosinophilia caused by a pre-malignant or malignant clone of eosinophils that bear mutations in genes for PDGFRA, PDGFRB, or FGFR1 or, alternatively, a chromosome translocation that creates the PCM1-JAK2 fusion gene. (wikipedia.org)
  • 1981 Beatrice Mintz's laboratory is one of the first to introduce a cloned gene into fertilized mouse eggs and prove that it is retained in animals developing from those eggs, and is transmitted to their progeny. (wikipedia.org)
  • molecular
  • The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
  • They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
  • 1991 Timothy Yen discovers that a molecular motor controls the way human cells sort their chromosomes when cells divide during mitosis. (wikipedia.org)
  • progenitor
  • They are classified as either totipotent (iTC), pluripotent (iPSC) or progenitor (multipotent-iMSC, also called an induced multipotent progenitor cell-iMPC) or unipotent-(iUSC) according to their developmental potential and degree of dedifferentiation. (wikipedia.org)
  • mutations
  • The World Health Organization classifies these disorders into a) Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 (i.e. high eosinophil blood counts caused by mutations in the eosinophil cell line of one of these three genes), 'b) Chronic eosinophilic leukemia, and c) the Idiopathic hypereosinophiic syndrome. (wikipedia.org)
  • 1991
  • 1991 Philip Tsichlis, Alfonso Bellacosa, and Joseph Testa clone the AKT1 and AKT2 genes - the first viral oncogenes described that inhibit programmed cell death. (wikipedia.org)
  • genes
  • In various aspects, T-PLL can be regarded as T-cell counterpart of B-CLL with what it shares morphologic features, the mature lymphocyte phenotype, the pathogenetic im-portance of TCL1 activation and ATM inactivation and a mutational landscape dominated by recurrent chromosomal imbalances rather than recurrently mutated genes. (uni-ulm.de)
  • They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
  • successfully
  • Here, we successfully cloned sensitive and resistant leukaemia cells to nilotinib, a drug used in the management of leukaemia. (rsc.org)
  • In the 1940s she became the first person to successfully clone a mammalian cell in vitro, which allowed for more efficient means of creating pure strains of cells for study. (wikipedia.org)
  • differentiation
  • The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. (cancerindex.org)
  • This differentiation and activation of the B cell occurs most rapidly after exposure to antigen by antigen-presenting cells in the reticuloendothelial system, and under modulation by T cells, and is closely intertwined with affinity maturation. (wikipedia.org)
  • The finding of T cells bearing abnormal immunophenotype cluster of differentiation markers is critical to making the diagnosis. (wikipedia.org)
  • They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. (wikipedia.org)
  • Progenitors are obtained by so-called direct reprogramming or directed differentiation and are also called induced somatic stem cells. (wikipedia.org)
  • This meant that the cells can change their differentiation pathway. (wikipedia.org)
  • In Drosophila imaginal discs, cells have to choose from a limited number of standard discrete differentiation states. (wikipedia.org)
  • The fact that transdetermination (change of the path of differentiation) often occurs for a group of cells rather than single cells shows that it is induced rather than part of maturation. (wikipedia.org)
  • chronic
  • This shows chronic myeloid leukemia blood cells. (labspaces.net)
  • The antibiotic tigecycline, when used in combination with current treatment, may hold the key to eradicating chronic myeloid leukaemia (CML) cells, according to new research. (medicalxpress.com)
  • hypereosinophilia
  • The symptom of episodic angioedema in lymphocyte-variant hypereosinophilia resembles that occurring in Gleich's syndrome, a rare disease that is accompanied by secondary hypereosinophilia plus a sub-population of CD3(-), CD4(+) T cells and therefore proposed, at least in many patients, a subtype of lymphocyte-variant hypereosiophilia. (wikipedia.org)
  • receptor
  • In many clinical settings, however, studies on the T cell receptor and IL-5 are not available and therefore not routine parts of the diagnostic work-up or criteria for the disease. (wikipedia.org)
  • It also acts as a cell surface receptor, in particular for laminin, and is involved in several pathogenic processes. (wikipedia.org)
  • Wimmer is co-discoverer of the poliovirus receptor CD155, a cell-adhesion molecule and tumor antigen, whose expression is regulated by the sonic hedgehog pathway. (wikipedia.org)
  • dendritic
  • It is also a potent chemoattractant and activator of dendritic cells, is implicated in homing of these cells, and can stimulate the migration of activated NK cells. (wikipedia.org)
  • BRAK/CXCL14 is a potent inhibitor of angiogenesis and a chemotactic factor for immature dendritic cells. (wikipedia.org)
  • Methods
  • Also the improvement of methods that require smaller amounts of cells has opened the possibility to use this approach on patient samples. (mdpi.com)
  • lymphocytes
  • Plasma cells develop from B lymphocytes which are stimulated to undergo this maturational development by T lymphocytes during the latter cells' processing of these antigens. (wikipedia.org)
  • By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both the cell and the humoral immunity. (wikipedia.org)
  • enzyme
  • Most other cells cannot divide indefinitely as after a few cycles of cell division the cells stop expressing an enzyme telomerase. (wikipedia.org)
  • However, this enzyme in "youthful" cells replaces these lost bits (nucleotides) of DNA, thus making almost unlimited cycles of cell division possible. (wikipedia.org)
  • receptors
  • Many of the effects of laminin are mediated through interactions with cell surface receptors. (wikipedia.org)
  • Glucocorticoids also suppress the humoral immunity, causing B cells to express smaller amounts of IL-2 and IL-2 receptors. (wikipedia.org)
  • findings
  • Our unpublished findings show a massive DNA hypomethylation in T-PLL at enhancer sites in normal T-cells. (uni-ulm.de)
  • normal
  • Moreover, we have generated his-tone modification maps of reference epigenomes from T-PLL samples and integrated them with those of normal T-cell subsets. (uni-ulm.de)
  • Various types of ChIP-Seq and reverse ChIP experiments shall be performed in normal T-cells, T-PLL cells, and the newly to establish models (or conventional transfection models as back-up if necessary) to identify the factors driving the epigenetic switch. (uni-ulm.de)
  • 1979 Beatrice Mintz shows that a fatal genetic anemia of mice can be prevented in utero by injecting normal blood-forming stem cells into the fetus through a placental blood vessel. (wikipedia.org)
  • human
  • A British scientist who won this year's Nobel prize for medicine has predicted that human clones will be allowed and accepted within 50 years. (medindia.net)
  • As prerequisite, we plan to develop yet missing human T-PLL models using Cas9 technologies in human T-cells and precursor cells as well as mouse xeno-grafts. (uni-ulm.de)
  • For instance, multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant adult human stem cells that can self-renew. (wikipedia.org)
  • hESCs can be generated by SCNT using dermal fibroblasts nuclei from both a middle-aged 35-year-old male and an elderly, 75-year-old male, suggesting that age-associated changes are not necessarily an impediment to SCNT-based nuclear reprogramming of human cells. (wikipedia.org)
  • Protein Synthesis
  • IRES elements allow initiation of protein synthesis in a cap-independent manner, which violates a long-standing dogma in protein synthesis of eukaryotic cells. (wikipedia.org)
  • inflammatory
  • This chemokine is chemotactic for monocytes and can activate these cells in the presence of an inflammatory mediator called prostaglandin-E2 (PGE2). (wikipedia.org)
  • single
  • When ultimately many cells are produced by a single cell, clonal expansion is said to have taken place. (wikipedia.org)
  • A single malignant clone of CTVT cells has colonized dogs worldwide, representing the oldest known malignant cell line in continuous propagation. (wikipedia.org)
  • Single cells separated out required the support of other cells in order to function and proliferate. (wikipedia.org)
  • Sanford developed micropipettes where single cells could be picked up and isolated from under the microscope and placed in a detailed microenvironment, where diffusion of cellular products was restricted to inside a small closed culture. (wikipedia.org)
  • latter
  • Furthermore, the effects of drugs on cells produce both chemical and morphological changes, the latter could affect the spectra of cells incubated with drugs. (rsc.org)
  • The latter would confirm that the spectral differences between the so-called resistant clonal cells prior to and after adding a drug might reside on those more or less sensitive cells that have been able to remain alive when they were collected to be studied with S-FTIR or Raman microspectroscopies. (rsc.org)
  • blood
  • The primary efficacy endpoint is 8-week RBC-TI rate, which is defined as the proportion of patients achieving red blood cell transfusion independence during any consecutive eight weeks since entry into the trial. (globenewswire.com)
  • cDNA
  • The probe types used for non-polymorphic arrays include cDNA, BAC clones (e.g. (wikipedia.org)
  • overexpressed a human cDNA library in S. cerevisiae, and screened for genes that simultaneously affected cell cycle and cell polarity controls, inducing a filamentous yeast budding phenotype, and thus identified the HEF1 protein (Human Enhancer of Filamentation 1). (wikipedia.org)
  • tumor
  • Exogenous PUFA and a TRPC3 antagonist regularly attenuated breasts cancer tumor cell proliferation and migration, recommending a mechanism where PUFA restrains the breasts cancer partially via its inhibition of TRPC stations. (cancercurehere.com)
  • Additionally, our outcomes also claim that TRPC3 shows up as a fresh mediator of breasts cancer tumor cell migration/invasion and represents a potential focus on for a fresh course of anticancer agent. (cancercurehere.com)
  • Furthermore, high cellular degrees of COX are generally used being a marker for malignant breasts cancer tumor (6,10,12). (cancercurehere.com)
  • Within this research, we discovered the functional appearance of TRPC3 in individual MCF-7 breasts cancer tumor cell-mediated Ca2+ entrance. (cancercurehere.com)
  • Ca2+ entrance via turned on TRPC was improved when PUFA had been absent, recommending a double-gating system for Danshensu TRPC which may be involved with MCF breasts cancer tumor cell proliferation and invasion. (cancercurehere.com)
  • We all know enough to fear the name, just as we do the words tumor and malignant. (americorpshealth.biz)
  • We have previously reported the TCR inhibitory molecule CD5 impairs reactivity of tumor-specific PBL-derived T-cell clones against the cognate target and controls their susceptibility to activation-induced cell death (AICD) triggered by tumor cells. (jimmunol.org)
  • Our data also indicate that tumor suppression in CD5-deficient mice is transient and that tumor flare up correlates with increase in AICD of tumor-infiltrating CD8+ T cells. (jimmunol.org)
  • Our data suggest that tumor T lymphocyte infiltration occurs at early stages of cancer development and that tumor-mediated AICD is most likely involved in the induction of T-cell tolerance to malignant cells. (jimmunol.org)
  • B. Voss, S. Wilop, S. Jonas, M. H. M. El-Komy, J. Schaller, V. von Felbert, M. Megahed: Tumor Volume as a Prognostic Factor in Resectable Malignant Melanoma. (wikipedia.org)
  • murine
  • Additionally, we investigated the effect of short hairpin ribonucleic acid (shRNA)-mediated PTTG1 knockdown on the proliferation of the murine myeloma plasma cell line 5TGM1 in vitro and in vivo. (biomedcentral.com)
  • citation needed] CD34 is expressed in roughly 20% of murine hematopoietic stem cells, and can be stimulated and reversed. (wikipedia.org)
  • antigen
  • After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which are taken up by the B cell through receptor-mediated endocytosis and processed. (wikipedia.org)
  • Pieces of the antigen (which are now known as antigenic peptides ) are loaded onto MHC II molecules, and presented on its extracellular surface to CD4+ T cells (sometimes called T helper cells ). (wikipedia.org)
  • These T cells bind to the MHC II-antigen molecule and cause activation of the B cell. (wikipedia.org)
  • First, the B cells have to encounter a foreign antigen, and are then required to be activated by T helper cells before they differentiate to specific cells. (wikipedia.org)
  • This process favors, by selection for the ability to bind antigen with higher affinity, the activation and growth of B cell clones able to secrete antibodies of higher affinity for the antigen. (wikipedia.org)
  • Differentiation through a T cell-independent antigen stimulation (stimulation of a B cell that does not require the involvement of a T cell) can happen anywhere in the body and results in short-lived cells that secrete IgM antibodies. (wikipedia.org)
  • Since B cell maturation also involves somatic hypermutation (a process completed before differentiation into a plasma cell), these antibodies frequently have a very high affinity for their antigen. (wikipedia.org)
  • renal cell carc
  • NEDD9-binding regions in the miR-145 locus would allow the direct binding of the NEDD9 3'UTR to the genomic region of miR-145, and some studies suggests this miR regulates NEDD9 in glioblastoma prostate cancer, and renal cell carcinoma cells. (wikipedia.org)
  • precursor
  • Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell, eosinophil and dendritic cell precursor adhesion, and to facilitate opening of vascular lumina. (wikipedia.org)
  • first described a sequence tag corresponding to the NEDD9 3′ untranslated region based on the cloning of a group of genes predominantly expressed in the brain of embryonic, but not adult mice, a group of genes designated neural precursor cell expressed, developmentally down-regulated. (wikipedia.org)
  • somatic
  • Beyond unicellular organisms) Telomerase is active in normal stem cells and most cancer cells, but is normally absent from, or at very low levels in, most somatic cells. (wikipedia.org)
  • In adults, telomerase is highly expressed only in cells that need to divide regularly especially in male sperm cells[citation needed] but also in epidermal cells, in activated T cell and B cell lymphocytes, as well as in certain adult stem cells, but in the great majority of cases somatic cells do not express telomerase. (wikipedia.org)
  • factor
  • in a cell surface glycoprotein and functions as a cell-cell adhesion factor. (wikipedia.org)
  • ERβ also plays a role in regulating APOE, a risk factor for AD that redistributes lipids across cells. (wikipedia.org)
  • When bound by its proper ligand, Platelet-derived growth factor (PDGF), it [tyrosine kinase]] becomes active in phosphorylating proteins that, among other functions, promote cell growth and proliferation. (wikipedia.org)
  • NEDD9 is induced by Wnt signaling in colon cancer, based on binding to T-cell factor (TCF) factors in the promoter region. (wikipedia.org)
  • chromosomal
  • Karyotypes have been used for several decades to identify chromosomal abnormalities in both germline and cancer cells. (wikipedia.org)
  • replication
  • FU is thought to kill cells via the inhibition of thymidylate synthase and also deprive cells of TTP during DNA replication, which leads to the introduction of uracil in DNA causing the fragmentation of newly synthesized DNA. (wikipedia.org)
  • lymphoid
  • Upon stimulation by a T cell, which usually occurs in germinal centers of secondary lymphoid organs like the spleen and lymph nodes , the activated B cell begins to differentiate into more specialized cells. (wikipedia.org)
  • fully differentiated
  • A cell may stay in this state for several days, and then either die or irrevocably differentiate into a mature, fully differentiated plasma cell. (wikipedia.org)
  • In baboon skeletal muscle, which consists of fully differentiated post-mitotic cells, less than 3% of myonuclei contain damaged telomeres and this percentage does not increase with age. (wikipedia.org)
  • stain
  • Cells were washed, stained with LIVE/DEAD® Fixable Near-IR dead cell stain, washed, and fixed with FIX & PERM® Reagent A. Cells were then washed, permeabilized with FIX & PERM® Reagent B, stained with MPO-FITC conjugate, and washed. (antikoerper-online.de)
  • secrete
  • Plasma cells , also called plasma B cells , plasmocytes , plasmacytes , or effector B cells , are white blood cells that secrete large volumes of antibodies . (wikipedia.org)
  • Plasmablasts secrete more antibodies than B cells, but less than plasma cells. (wikipedia.org)
  • They secrete high levels of antibodies, ranging from hundreds to thousands of antibodies per second per cell. (wikipedia.org)
  • For example, plasma cells will likely secrete IgG3 antibodies if they matured in the presence of the cytokine interferon-gamma . (wikipedia.org)
  • growth
  • Conclusions/Significance: The lipid kinase SphK1 plays a positive and essential role in the growth and development of malignant mesothelioma and is therefore a likely therapeutic target. (docplayer.net)
  • Additionally, KaLwRij mice exhibit an inherent ability to support the growth of exogenous malignant plasma cells. (biomedcentral.com)
  • This proto-oncogene may play a role in the regulation of embryonic development and cell growth. (wikipedia.org)
  • mice
  • cells in diabetic mice, and that the anti-hyperglycemic efficacy of this combination was better than that of 1-deoxynojirimycin (DNJ) or polysachharide alone. (jove.com)
  • In this report, we compared the antitumor T-cell response developed against the B16F10 melanoma engrafted in CD5-deficient and wild-type (wt) C57BL/6 mice. (jimmunol.org)
  • In vivo, the CD79a ITAM tyrosines synergize with the CD79b ITAM tyrosines to mediate the transition from the pro to the pre B cell stage as suggested by the analysis of mice with targeted mutations of the CD79a and CD79b ITAM. (wikipedia.org)
  • immunoglobulin
  • The CD79a/b heterodimer associates non-covalently with the immunoglobulin heavy chain through its transmembrane region, thus forming the BCR along with the immunoglobulin light chain and the pre-BCR when associated with the surrogate light chain in developing B cells. (wikipedia.org)
  • Human
  • Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) after a long latent period. (biomedcentral.com)
  • The role of telomeres and telomerase in cell aging and cancer was established by scientists at biotechnology company Geron with the cloning of the RNA and catalytic components of human telomerase and the development of a polymerase chain reaction (PCR) based assay for telomerase activity called the TRAP assay, which surveys telomerase activity in multiple types of cancer. (wikipedia.org)
  • The CD79a cytoplasmic domain further contains a non-ITAM tyrosine distal of the CD79a ITAM (human CD79a Tyr210, mouse CD79a Tyr204) that can bind BLNK and Nck once phosphorylated, and is critical for BCR mediated B cell proliferation and B1 cell development. (wikipedia.org)
  • dependent
  • Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (wikipedia.org)
  • resistant
  • Bisphosphonates are resistant clones as anxiety is often quoted by the topoisomerase iI-DNA Retrobulbar. (interracialmarriageandfamily.com)
  • Since the periplasmic gap is more prone to environmental variation than the inner cell, alkaline phosphatase is suitably resistant to inactivation, denaturation, or degradation. (wikipedia.org)
  • Morphology
  • No abnormalities were observed on the cellular morphology of these cell lines both at low and high densities of cultures by microscopy according to the guideline from ATCC ( 15 ). (aacrjournals.org)
  • We monitored the cell morphology of these cell lines by microscopy, and confirmed to maintain their morphologic images in comparison with the original morphologic images from the above affiliation. (aacrjournals.org)