Malignant cells germ cell. Medical search. Frequent questions

Some studies have found that size and histology were the major factors determining prognosis for patients with malignant mixed germ cell tumors of the ovary. (kaiserpermanente.org)
If they include aspects of both, they are called mixed germ cell tumors. (dana-farber.org)

Most ovarian germ cell tumors are benign mature teratomas (dermoid cysts). (cigna.com)
Benign germ cell tumors include certain kinds of teratomas. (childrensoncologygroup.org)
Benign extragonadal germ cell tumors are called benign teratomas . (vicc.org)
Teratomas are the most common type of germ cell tumor to develop in extragonadal (not in the ovary or testes) areas. (kidshealth.org)
Benign germ cell tumors include certain kinds of teratomas, a type of tumor that may contain several different types of tissue. (curesearch.org)
There are several sub-types of non-germinomatous germ cell tumors, including teratomas, choriocarcinomas, endodermal sinus tumors (yolk sac tumors), embryonal carcinomas, and mixed tumors. (dana-farber.org)

It begins in the cells that cover the ovary. (medlineplus.gov)
These malignant tumors are also called dysgerminomas when they're in the ovary, or seminomas when they're in the testes. (kidshealth.org)
Germ cell tumors of the ovary are uncommon but aggressive tumors, seen most often in young women and adolescent girls. (kaiserpermanente.org)
Norris HJ, Zirkin HJ, Benson WL: Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases. (kaiserpermanente.org)
Kurman RJ, Norris HJ: Malignant germ cell tumors of the ovary. (kaiserpermanente.org)
Most ovarian cancers are either epithelial carcinomas (cancer that begins in the cells on the surface of the ovary) or malignant germ cell tumors (cancer that begins in egg cells). (cancer.gov)
Malignant ovarian lesions include primary lesions arising from normal structures within the ovary and secondary lesions from cancers arising elsewhere in the body. (medscape.com)
Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
Choriocarcinoma of the ovary is a highly malignant ovarian tumor which is characterized pathologically by the presence of trophoblastic malignant cells, and biochemically by the production of the pregnancy hormone human chorionic gonadotrophin (hCG) in the absence of an ongoing pregnancy. (atlasgeneticsoncology.org)

Although not as difficult to treat as malignant tumors, benign germ cell tumors can cause problems because of their size. (childrensoncologygroup.org)
Children with benign germ cell tumors will have surgery to remove the tumor. (kidshealth.org)

Primordial germ cell (PGC) migration is the process of distribution of primordial germ cells throughout the embryo during embryogenesis. (wikipedia.org)
Primordial germ cells are among the first lineages that are established in development and they are the precursors for gametes. (wikipedia.org)
In vertebrate development, the location where primordial germ cells are specified and the subsequent migratory paths that they take differs among species. (wikipedia.org)
Chicken primordial germ cells are initially specified in the area pellucida (a one-cell thick layer of epiblast lying above the sub-germinal space). (wikipedia.org)
Background: Malignant gonadal (GGCT) and extragonal germ cell tumors [GCT (EGCT)] are thought to originate from primordial germ cells. (uni-luebeck.de)
However, GCTs, including seminomas, can occur in extragonadal sites along the midline of the body, following the embryologic migration route of its precursor cells -- the primordial germ cells. (medscape.com)

The exact cause of germ cell tumors is not completely understood. (childrensoncologygroup.org)
Researchers don't know the cause of germ cell tumors. (dana-farber.org)

In a series of 635 patients with extragonadal germ cell tumors, 17 patients developed hematologic malignancies at a median of 6 months after the extragonadal germ cell tumor was diagnosed. (health.am)

Many patients with extragonadal germ cell tumors have histories of infertility, and testicular biopsy in these patients shows various abnormalities, including decreased spermatogenesis, peritubular fibrosis, and interstitial edema. (health.am)
In addition, patients who are successfully treated for extragonadal germ cell tumors have a markedly increased risk of developing a subsequent testicular germ cell tumor. (health.am)
Testicular germ cell tumors are divided into two main types, seminoma and nonseminoma. (cigna.com)
Testicular germ cell tumors usually occur before the age of 4 years or in adolescents and young adults. (cigna.com)
Testicular germ cell tumors in adolescents (11 years and older) and young adults are different from those that form in early childhood. (cigna.com)
Testicular germ cell tumors commonly begin as a painless mass in the scrotum (the skin that holds the testicles). (curesearch.org)
Most germ cell tumors appear in the ovaries ( ovarian tumors ) or testes ( testicular tumors ), but they can also get "trapped" in the brain during the fetal period. (dana-farber.org)

1 Ovarian tumors can be categorized into epithelial and non-epithelial ovarian tumors (NEOTs), according to cell origin. (org.sa)
Nongestational choriocarcinoma arises in women under 40 years old because of germ cell tumor, and the frequency is reported less than 0.6% of all ovarian tumors. (atlasgeneticsoncology.org)
Sex cord stromal tumors account for 7% of all malignant ovarian tumors. (bvsalud.org)
Germ cell tumors make up only 3-7% of malignant ovarian tumors. (bvsalud.org)
Benign ovarian tumors usually grow slowly and rarely become malignant. (msdmanuals.com)

Through directional migration - which requires multiple genes to work, one being the Columbus (clb) gene, which codes for Drosophila HMG CoA reductase - the germ cells move towards the somatic gonadal precursor cells and associate with them. (wikipedia.org)
Childhood extracranial germ cell tumors are grouped as gonadal or extragonadal extracranial tumors. (cigna.com)
Gonadal germ cell tumors form in the gonads (testicles and ovaries). (cigna.com)
At about four weeks, the earliest germ cells in the growing fetus migrate from their point of origin to the gonadal area (the area of the sex organs). (childrensoncologygroup.org)

Some other rarer types of ovarian cancer are malignant germ cell tumors and stromal tumors. (medlineplus.gov)

Hematologic Neoplasia A unique association between mediastinal nonseminomatous germ cell tumors and a variety of hematologic neoplasms is now well described. (health.am)
All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence in this group. (health.am)
Recent evidence indicates that the hematologic neoplasms in this setting are not treatment related, but rather arise from clones of malignant lymphoblasts or myeloblasts contained within the mediastinal germ cell tumor. (health.am)
However, the specific association of leukemias and other hematologic neoplasms with mediastinal nonseminomatous germ cell tumors, rather than with all germ cell tumors, remains unexplained. (health.am)
Overall, 60% of germ cell neoplasms have seminoma in their composition, but pure seminomas are genetically different from those that present as a component of a mixed tumor. (medscape.com)

Methods: In a pooling project of nine population-based cancer registries in Germany for the years 1998-2008, 16,883 malignant GCTs and their topographical sites were identified using ICD-O morphology and topography for persons aged 15 years and older. (uni-luebeck.de)
In clinical practice, she concentrates on germ cell tumors, while her epidemiologic research primarily focuses on colorectal cancer screening and prevention. (dana-farber.org)
Extracranial germ cell tumors may be benign (noncancer) or malignant (cancer). (cigna.com)
Cancer is a disease in which abnormal cells in the body grow out of control and form a tumor. (medlineplus.gov)
Malignant germ cell tumors include several types of cancer, such as immature teratoma, yolk sac tumor and choriocarcinoma. (childrensoncologygroup.org)
The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. (vicc.org)
Children's Cancer Hospital offers the most up-to-date and advanced chemotherapy options for childhood germ cell tumors. (mdanderson.org)
Radiation therapy (also called radiotherapy) uses high-energy beams to destroy cancer cells. (mdanderson.org)
New radiation therapy techniques and remarkable skill allow Children's Cancer Hospital doctors to target tumors more precisely, delivering the maximum amount of radiation with the least damage to healthy cells. (mdanderson.org)
Children's Cancer Hospital is committed to providing the most advanced treatments for childhood germ cell tumors with the least impact on your child's body, today and in the future. (mdanderson.org)
Children's Cancer Hospital offers a range of clinical trials for childhood germ cell tumors. (mdanderson.org)
Childhood germ cell tumors are treated in our Children's Cancer Hospital and our Proton Therapy Center. (mdanderson.org)
Information about pediatric CNS Germ Cell Tumors treatment, clinical trials, and research from Texas Children's Cancer Center. (texaschildrens.org)
Texas Children's Cancer Center's Brain Tumor Program and the Neuro-oncology Team treat patients with Intracranial Germ Cell Tumors. (texaschildrens.org)
Germ cell cancer is a rare tumor that affects children, teens, and adults. (curesearch.org)
Surprisingly, many of the genetic changes that occur in cancer cells to make them very aggressive also provide certain vulnerabilities that can be exploited once they are understood. (chop.edu)
We've also been studying diverse small molecule drugs that interfere with those functions of the Bcl2 family that keep cancer cells alive. (chop.edu)
LRI) working on signal transduction in model and lung cancer cells and was awarded his PhD in 1995 (University of London). (imperial.ac.uk)
He has chaired/organised many national and international meetings related to lung cancer, cell signalling and trophoblastic disease. (imperial.ac.uk)
previously demonstrated that native BF-30 may selectively inhibit the proliferation of melanoma cells via in vitro permeabilization of cytoplasmic membrane and DNA-binding, and exerted the outstanding anti-cancer effects in B16F10-bearing mice [ 4 ]. (jcancer.org)

Germ cell brain tumors usually form in the center of the brain, near the pineal gland. (texaschildrens.org)
Germ cell tumors of the brain are rare, accounting for approximately 4 percent of brain tumors in children. (dana-farber.org)
Within the Childhood Brain Tumor Center , our specialists have extensive expertise in treating all types of brain tumors, including germ cell tumors. (dana-farber.org)

This summary is about germ cell tumors that form in parts of the body that are extracranial (outside the brain). (cigna.com)
Malignant extracranial germ cell tumors are tumors that form outside the brain. (cigna.com)

These cells later become sperm in the testicles or eggs in the ovaries. (cigna.com)
Extragonadal extracranial germ cell tumors form in areas of the body other than the brain or gonads (testicles and ovaries). (cigna.com)
When cells that are meant to form sperm in the testicles or eggs in the ovaries travel to other parts of the body, they may grow into extragonadal germ cell tumors . (vicc.org)
These malignant tumors most often develop in the ovaries, testes, or tailbone. (kidshealth.org)
Germ cell tumors most commonly appear in the testes for boys and the ovaries for girls. (curesearch.org)
But ovaries typically contain many 2- to 6-mm follicular cysts and sometimes contain larger cysts that contain atretic cells. (msdmanuals.com)

Conclusions: Our results underline different incidence trends and distinct age-specific incidence patterns of malignant GGCTs and EGCTs, as reported recently by several population-based registries. (uni-luebeck.de)
Ovarian germ cell (GC) tumors are more likely to be found in young women, and the peak tumor incidence occurs at 15 to 19 years of age. (org.sa)
In nongestational choriocarcinoma, no factors have been associated with the etiology of germ cell tumor, apart from an increased incidence associated with dysgenetic gonads. (atlasgeneticsoncology.org)

Extracranial germ cell tumors are most common in adolescents, with rates in this age group lower for females than males. (cigna.com)
In older children, adolescents, and young adults (11 years and older), extragonadal extracranial germ cell tumors are often in the mediastinum. (cigna.com)
Germ cell tumors are rare, about 900 children and adolescents are diagnosed in the United States each year. (childrensoncologygroup.org)
More than 900 children and adolescents are diagnosed with germ cell tumors in the U.S. each year, comprising about 5% of all childhood cancers . (curesearch.org)

Cisplatin-based chemotherapy for ovarian germ cell malignancies: the Australian experience. (kaiserpermanente.org)
We also are studying the process by which neuroblastoma cells become resistant to the body's protective mechanisms to prevent them from becoming cancerous, and ultimately how these cells become resistant to the chemotherapy and radiation therapy used to kill them. (chop.edu)
These studies are designed to both improve the initial response of these tumors to chemotherapy, and also to restore therapy responses in tumors cells that have become resistant and relapsed. (chop.edu)

Seminoma is the most common pure germ cell tumor (GCT) of the testis, accounting for up to 50% of cases. (medscape.com)
These are pure germ cell tumors. (dana-farber.org)

Germ cells get their name because they normally produce the specialized cells that create life: sperm and egg cells - the sex cells needed for reproduction. (childrensoncologygroup.org)
Extragonadal germ cell tumors form from developing sperm or egg cells that travel from the gonads to other parts of the body. (vicc.org)
Childhood Central Nervous System (CNS) germ cell tumors form in germ cells, which are cells that develop into sperm or ova (eggs). (texaschildrens.org)
In boys , the cells make sperm and in girls , they make eggs. (kidshealth.org)
In humans, germ cells produce specialized cells needed for reproduction: sperm cells in boys and egg cells in girls. (curesearch.org)

Genetic changes have also been studied in the past few decades, with documentation of aneuploid DNA content in seminomas and intratubular germ cell neoplasia of the unclassified type (IGCNU), the precursor lesion. (medscape.com)

The two main types of germ cell tumors of the brain are germinomas and non-germinomatous tumors. (dana-farber.org)

PGCs interact with a wide range of cell types as they move from the epiblast to the gonads. (wikipedia.org)
Germ cell tumors most commonly appear in the gonads (sex organs). (childrensoncologygroup.org)
Usually, germ cells migrate to the gonads during fetal development. (dana-farber.org)

A procedure in which a sample of blood is examined to measure the amounts of certain substances released into the blood by organs, tissues , or tumor cells in the body. (vicc.org)
Treatment for germ cell tumors depends upon the child's age and overall health, the types of tissues in the tumor, the tumor's location, the child's tolerance for specific types of procedures and the overall prognosis. (mdanderson.org)
Neuroblasts are the immature cells that will eventually develop into the adrenal glands and peripheral nerve tissues of a child. (chop.edu)

not cancerous) or malignant (cancerous). (kidshealth.org)
When these cells fail to mature properly, they may instead become cancerous -- giving rise to neuroblastoma. (chop.edu)
They can be benign (noncancerous) or malignant (cancerous). (dana-farber.org)

they are also called dermoid cysts because although derived from all 3 germ cell layers, they consist mainly of ectodermal tissue. (msdmanuals.com)

The mediastinum is the site for a variety of lesions, both benign and malignant. (allenpress.com)
Candida may play a role in the etiopathogenesis of premalignant and malignant lesions. (bvsalud.org)

The PGCs move passively (without the need for energy) with underlying somatic cells, cross epithelial barriers, and respond to cues from their environment during active migration. (wikipedia.org)
This is followed by more passive movement, due to the invagination of the posterior midgut primordium, which leads to the PGCs in the centre of the embryo, surrounded by epithelial cells that have been folded back on themselves. (wikipedia.org)

The association of Klinefelter syndrome and mediastinal nonseminomatous germ cell tumors is now well recognized. (health.am)
Four of 22 consecutive patients (18%) treated at Indiana University for primary mediastinal germ cell tumors had karyotypic confirmation of Klinefelter syndrome, and an additional patient had clinical features. (health.am)
therefore, the association with mediastinal germ cell tumor seems specific. (health.am)
Foci of malignant lymphoblasts have been recognized histologically in several mediastinal germ cell tumors. (health.am)
More importantly, several patients have had an identical chromosomal abnormality (an isochromosome of the short arm of chromosome 12) in the neoplastic cells from the mediastinal germ cell tumor and the hematologic neoplasm, providing strong evidence for a common origin. (health.am)
In addition to hematologic neoplasia, several cases of idiopathic thrombocytopenia in association with mediastinal nonseminomatous germ cell tumors have been reported. (health.am)

For information on intracranial (inside the brain) germ cell tumors, see Childhood Central Nervous System Germ Cell Tumors Treatment. (cigna.com)

These two associated cell types then migrate together anteriorly, until they coalesce into the embryonic gonad at the future site of the mature gonad. (wikipedia.org)
Unlike most model organisms where germ cell migration is predominantly via the gut epithelium, chicken PGCs migrate through the embryonic vascular epithelium. (wikipedia.org)

and (3) treatment of germ cell tumors in pediatric patients. (dana-farber.org)
In clinical care, Dr. Frazier is the national expert on germ cell tumors in pediatric patients and oversees the care of these patients referred to DFCI. (dana-farber.org)
In addition, she is cochair of two national protocols that opened in 1999 for the treatment of low-risk and high-risk pediatric germ cell tumors and chair of the COG Germ Cell subcommittee in COG Rare Tumors. (dana-farber.org)

Germ cell tumors are growths that occur in children, teens and adults. (childrensoncologygroup.org)
In addition, younger women and teens tend to have certain ovarian growths, such as germ cell tumors. (momjunction.com)

Before they settle into the reproductive organs, germ cells develop along the baby's "midline. (kidshealth.org)
Because the germ cells travel along the midline to reach the reproductive organs as a fetus grows, they can sometimes settle in other places. (kidshealth.org)

In the NHS, he is Director of the Charing Cross/ Imperial College Trophoblastic Disease and Malignant Ovarian Germ Cell Tumour (MOGCT) Centre and supraregional tumour marker assay service. (imperial.ac.uk)
To evaluate anti-tumour effects and mechanism of novel BF-30 derivative via cell-based assays and melanoma-bearing model mice. (jcancer.org)

Successfully treating your child's germ cell tumor depends on identifying the tumor type and location. (dana-farber.org)

An extragonadal non-seminomatous malignant germ cell tumor that arises from the mediastinum. (nih.gov)

Signs and symptoms of extragonadal germ cell tumors include breathing problems and chest pain. (vicc.org)
Malignant extragonadal germ cell tumors may cause signs and symptoms as they grow into nearby areas. (vicc.org)

What Are the Signs & Symptoms of Germ Cell Tumors? (kidshealth.org)
Early on, a child with a benign or malignant germ cell tumor might have few symptoms or none at all. (kidshealth.org)

Elevated serum human chorionic gonadotropin (hCG) levels can occur in seminomas and correlate with syncytiotrophoblastic giant cells seen histologically. (medscape.com)

Alpha fetoprotein (AFP) is not produced by seminoma cells, and its serum detection usually indicates a nonseminomatous component. (medscape.com)

These may require taking samples for blood chemistry, blood cell count, genetics and certain proteins called tumor markers such as AFP and bhCG that are produced by some germ cell tumors. (childrensoncologygroup.org)

The average age of patients with Klinefelter syndrome who develop extragonadal germ cell tumors is approximately 18 years, 10 years younger than the median age of those developing this tumor in the absence of Klinefelter syndrome. (health.am)
On the clinical side, I have developed expertise in the management of patients with neuroblastoma, germ cell tumors, and histiocytic diseases (such as Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, or LCH and HLH). (chop.edu)
This cross-sectional study was performed using data from all female patients diagnosed with NEOT (germ cell [GC], sex cord-stromal cells [SCSC], sarcoma, and small cell carcinoma) from 2002 to 2017 at Princess Noorah Oncology Center, National Guard Hospital Jeddah, Saudi Arabia. (org.sa)
Germ cell tumors were more common in younger patients, while SCSC tumors were more frequent in the older age group. (org.sa)

This disease is classified two types in origin, gestational choriocarcinoma and nongestational germ cell tumor. (atlasgeneticsoncology.org)
The nongestational type is as a component of a mixed germ cell tumor and a pure ovarian choriocarcinoma is a very rare malignant tumor. (atlasgeneticsoncology.org)
Microscopically, hemorrheage and necrosis are found, and tumor cells resemble placental trophoblastic cells: cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST). The CT and IT tend to grow in clusters and sheets separated by ST. The typical pattern of choriocarcinoma has been called two cell pattern, biphasic-terms that reflect the relatively regular, alternating arrangement of CT and ST in the tumor interspread with intermediate trophoblast. (atlasgeneticsoncology.org)

Pak1 Knockout (KO) clones in HNSCC cells showed that they were more sensitive to IR as compared to wild type (wt) cells. (bvsalud.org)

Most extragonadal extracranial germ cell tumors form along the midline of the body. (cigna.com)

A sample of tissue is removed and examined under a microscope to evaluate cell types, the extent of disease and other factors. (childrensoncologygroup.org)
What are the types of CNS Germ Cell Tumors? (texaschildrens.org)
A mixed germ cell tumor has two types of germ cells in it. (texaschildrens.org)
There are two types of germ cell tumors: malignant (life-threatening) or benign (not life-threatening). (curesearch.org)

Germ cell tumors can spread to other parts of the brain and spinal cord. (texaschildrens.org)
Germ cell tumors that develop in the brain or spinal cord are also called CNS (central nervous system) germ cell tumors. (dana-farber.org)

Seckl MJ , Malholland P, Bishop AE, Teale JD, Hales CN, Glaser M, Watkins S, Seckl JR (1999) Hypoglycaemic coma due to an insulin secreting small cell carcinoma of the cervix. (imperial.ac.uk)

Treatment for childhood Germ Cell Tumors often includes surgery. (mdanderson.org)
Malignant ovarian germ cell tumors: identification of novel prognostic markers and long-term outcome after multimodality treatment. (kaiserpermanente.org)
Participation within a different trial for treatment of germ cell tumours and/or concurrent treatment within any other clinical trial. (gpoh.de)
Qi J, Wang W, Lu W, Chen W, Sun H, Shang A. Design and biological evaluation of novel BF-30 analogs for the treatment of malignant melanoma. (jcancer.org)
Furthermore, results of H&E staining prove that chronic treatment of LBF-30 effectively suppressed metastasis and invasion of B16F10 cells. (jcancer.org)
LBF-14 holds potential to be developed as a promising once-weekly candidate for the treatment of malignant melanoma. (jcancer.org)

Our results show that PAK1 is highly expressed in HNSCC cell lines, as compared to normal buccal mucosa cells and when HNSCC cells were exposed to IR, they show activated PAK1 and an aggressive phenotype as determined by in vitro functional assays. (bvsalud.org)

Adjuvant therapy of ovarian germ cell tumors with cisplatin, etoposide, and bleomycin: a trial of the Gynecologic Oncology Group. (kaiserpermanente.org)

2 Sex cord-stromal cell (SCSC) tumors are more likely to affect adult women between the ages of 30 to 59 years. (org.sa)

Anatomy44

Organisms19

Diseases51

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Psychiatry and Psychology1

Phenomena and Processes55

Disciplines and Occupations2

Technology, Industry, Agriculture1

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Mixed germ cell t2

Teratomas6

Ovary9

Benign germ cell t2

Primordial germ6

Cause of germ cell t2

Extragonadal germ cell1

Testicular7

Ovarian tumors5

Gonadal4

Stromal tumors1

Neoplasms5

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Tumors that form2

Ovaries6

Incidence3

Adolescents4

Chemotherapy3

Pure germ2

Sperm5

Intratubular1

Germinomas1

Gonads3

Tissues3

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Lesions2

Epithelial2

Mediastinal6

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Migrate2

Pediatric3

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Patients4

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Types4

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Treatment6

Assays1

Cisplatin1

Cord-stromal1