• The differential diagnosis for cysts in the neck includes congenital neck masses, metastatic squamous cell carcinoma , acquired laryngoceles, and cystic schwannomas. (medscape.com)
  • In 1775 , the first breakthrough was made when Sir Percival Pott noted that chimney-sweeping was associated with squamous cell carcinoma of the scrotum. (ivyhospital.com)
  • The objective of this retrospective study was to clarify the potential prognostic significance of pre-therapeutic fibrinogen levels in head and neck squamous cell carcinoma (HNSCC) patients treated with curative intent by primary radiotherapy (RT) or with postoperative radiotherapy (PORT). (springermedizin.at)
  • Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma. (springermedizin.at)
  • Use of imiquimod 5% cream (Aldara™) in cats with multicentric squamous cell carcinoma in situ: 12 cases (2002-2005). (caesegatos.com.br)
  • Tests on human cervical carcinoma cells HeLa, squamous cell carcinoma WHCO5 and normal equine lung cell lines demonstrated that NSC631570 is selectively toxic against cancer cells. (ukrin.com)
  • A retrospective analysis of 330 patients with vulvar cancer treated at the Mayo Clinic between 1955-1990 assessed disease-free interval and sites of failure in patients with squamous cell carcinoma treated with either unilateral or bilateral complete inguinofemoral node dissections. (medscape.com)
  • He demonstrated that the roundworm which he called Spiroptera carcinoma (but correctly named Gongylonema neoplasticum ) could cause stomach cancer ( squamous cell carcinoma ) in rats and mice. (wikipedia.org)
  • Squamous cell carcinoma arising in a second branchial cleft cyst[J]. Am J Clin Oncol, 2004, 27(1): 96-100. (hxkqyxzz.net)
  • Cystic lymph node metastases of head and neck squamous cell carcinoma: pitfalls and controversies[J]. Oral Oncol, 2005, 41(4): 429-434. (hxkqyxzz.net)
  • The clinical importance of cystic squamous cell carcinomas in the neck: a study of 136 cases[J]. Cancer, 1998, 82(5): 944-956. (hxkqyxzz.net)
  • Notably, many lncRNAs dysregulation are associated with Oral squamous cell carcinoma (OSCC) and affect various aspects of cellular homeostasis, including proliferation, survival, migration or genomic stability. (biomedcentral.com)
  • LCMS/MS analyses were applied to identify phytoconstituents of the ethanolic extract of the whole fruits and the aqueous extract of the edible fruit part, in addition to the investigation of their anticancer properties against Ehrlich ascites carcinoma (EAC) in male albino mice. (bvsalud.org)
  • Background: Ehrlich-Lettre ascites carcinoma (EAC) is also known as Ehrlich cell. (apjhs.com)
  • however, there is limited data within hepatocellular carcinoma. (oaepublish.com)
  • Can sorafenib be discontinued in hepatocellular carcinoma patients with a complete response to treatment? (oaepublish.com)
  • These insights, in turn, have prompted novel, testable hypotheses, to be discussed, pertaining to fundamental aspects of cancer biology including the potential stem cell/progenitor cell origins of cancer and the plasticity of gene expression that may underlie tumor heterogeneity and tumor progression. (esmed.org)
  • However it is also involved in the maturation and stabilization of a wide range of oncogenic client proteins which are crucial for oncogenesis and malignant progression. (biomedcentral.com)
  • It has been proved that BaP reduced genome-wide DNA methylation, and activated proto-oncogene by hypomethylation in the promoter region, but silenced tumor suppressor genes by promoter hypermethylation, resulting in cancer initiation and progression. (biomedcentral.com)
  • We hypothesized that a preneoplastic field of inflammation, telomere shortening, and senescence underlies tumor progression in UC progressors. (shengsci.com)
  • Yet, far less attention is paid to the effects of these treatments on tumor progression as reflected by the metastatic process. (biomedcentral.com)
  • In 1909, Paul Ehrlich proposes that the immune system usually suppresses tumor formation, a concept that becomes known as the ""immune surveillance"" hypothesis. (ivyhospital.com)
  • Since then, chemotherapy has been one of the main therapeutic strategies in cancer treatment, but, to paraphrase Paul Ehrlich, resistance has followed as a faithful shadow. (nature.com)
  • In 1909, Paul Ehrlich proposed that the immune system can recognise and eliminate tumours (2). (cambridgemedicine.org)
  • Different levels of viable cell inoculum density produced contrasting effects between 255 solid tumors as compared to 72 malignant. (shengsci.com)
  • Some high-grade monomorphic tumours, (such as Ewing's sarcoma), and some other specific tumour types cannot be graded accurately in this way and the tumour grade is defined by the specific histological type or subtype. (biomedcentral.com)
  • Chimeric antigen receptor (CAR) T-cell therapy is a novel therapeutic T-cell engineering option, where T-cells obtained from a patient's blood are engineered ex vivo to express specific tumour antigen receptors. (cambridgemedicine.org)
  • Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. (biomedcentral.com)
  • However, the tumour may evade immune responses through regulatory T-cell-mediated immune suppression in the tumour microenvironment, defective antigen presentation, and production of immunosuppressive cytokines (5). (cambridgemedicine.org)
  • See 10 Patients with Neck Masses: Identifying Malignant versus Benign , a Critical Images slideshow, to help identify several types of masses. (medscape.com)
  • Lipomas are common benign soft tissue tumors, with 15 to 20% of the cases affecting the head and neck region and 1 to 4% involving the oral cavity. (academicjournals.org)
  • This review is intended to provide histopathologists with guidelines for clinical assessment, specimen handling and diagnostic reporting of benign and malignant primary bone tumours. (biomedcentral.com)
  • Primary benign and malignant bone tumours vary widely in their clinical behaviour and pathological features. (biomedcentral.com)
  • Malignant transformation arising in benign lymphoepithelial cysts is a complex and rare occurrence, and related research is limited. (hxkqyxzz.net)
  • Zurück zum Zitat Gay LJ, Felding-Habermann B. Contribution of platelets to tumour metastasis. (springermedizin.at)
  • Cervical metastasis of gingival carcinoma misdiagnosed as branchiogenic carcinoma, a rare entity-report of a case and review of literature[J]. BMC Oral Health, 2017, 17(1): 139. (hxkqyxzz.net)
  • Local invasion and distant metastasis are the cause of death in most malignant tumors. (biomedcentral.com)
  • Malignant tumors consist of cancer cells and tumor-associated host cells, both participating in invasion and distant metastasis. (biomedcentral.com)
  • One of the first molecules implicated in enhancement of distant metastasis after irradiation of the primary tumor was angiostatin, produced by the primary tumor and keeping metastasis dormant. (biomedcentral.com)
  • Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)
  • Cervical small cell carcinoma (SCC) is a rare disease, with a high degree of malignancy and a poor prognosis. (scientificarchives.com)
  • These two important mechanisms of approaching cancer, principally through the clinical application of the P53 tumor suppressor gene and other apoptotic players that for the past 15 years have been included in my cancer strategy as a diagnostic, prognosis, and follow up treatment. (biobran.org)
  • Secondly, the locally hypermethylation of the tumor suppressor gene promoter, and thirdly, 5mC-containing-DNA sequences or direct mutations exposed to ultraviolet light or other carcinogens [ 9 ]. (biomedcentral.com)
  • The impact of plasma Epstein-Barr virus DNA and fibrinogen on nasopharyngeal carcinoma prognosis: an observational study. (springermedizin.at)
  • showed that nigericin could selectively target cancer stem cells in nasopharyngeal carcinoma both in vitro and in vivo. (biomedcentral.com)
  • S.W. Goldberg and Efim London used radium to treat 2 patients with basal cell carcinoma of the skin. (ivyhospital.com)
  • Horrifying giant basal cell carcinoma of the face--a case report. (uchicago.edu)
  • It is highly malignant with fulminant clinical course, bizarre histologic appearance and poor prognosis. (uchicago.edu)
  • An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (bvsalud.org)
  • Wilms tumor , or nephroblastoma, is the most common solid renal mass and abdominal malignancy of childhood, with a prevalence of 1 case per 10,000 population. (medscape.com)
  • Most children with Wilms tumor will present with signs of a renal condition, including abdominal swelling or a suspicious mass. (medscape.com)
  • A CT scan of the abdomen confirms the renal origin of the tumor and determines the presence of bilateral tumors. (medscape.com)
  • About 5% of renal masses that are initially thought to be Wilms tumor are subsequently diagnosed as another condition. (medscape.com)
  • The tumors may be large, and their size may make it difficult to identify its renal origin on sonograms. (medscape.com)
  • Therefore, CT and MRI may be useful for distinguishing between renal tumors and adrenal tumors. (medscape.com)
  • 2012. "Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas. (esmed.org)
  • In vitro tests showed that after incubation with NSC631570 normal liver cells and Ehrilch tumour ascitic cells demonstrate different oxygen consumption: after initial increase, oxygen consumption in cancer cells falls to zero whereas oxygen consumption in normal cells returns to normal and the cells remain undamaged (38). (ukrin.com)
  • This means that NSC631570 can differentiate between healthy and malignant cells, a feature not yet managed by other anti-cancer drugs. (ukrin.com)
  • Surgical staging of vulvar cancer has changed dramatically since en bloc dissections were performed in the 1970s, which included resection of the vulva, mons pubis, and bilateral inguinofemoral and pelvic nodes in one large specimen. (medscape.com)
  • Although mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). (biomedcentral.com)
  • An analysis of extensive cancer datasets confirmed fundamental differences of tumor mutational burden in HCC and malignant melanoma, challenging the notion that exome-derived mutations contribute relevantly to the expectable neoepitope pool in malignancies with only few mutations. (biomedcentral.com)
  • In addition, the novel cancer stem cell paradigm raises the prospect of cell-targeted therapies instead of treatment directed against the whole tumour. (nature.com)
  • Conjugation of glucose with metabolic agents to selectively target cancer cells was inspired by the widespread use of radiolabeled glucose analog to visualize tumors and their metastases. (oncotarget.com)
  • Consistency in diagnostic evaluation with respect to both terminology and report content facilitates liaison at multidisciplinary bone tumour meetings and collaboration between cancer units and networks, as well as providing a common database for audit of the clinical, radiological and pathological aspects of bone tumours. (biomedcentral.com)
  • Primary branchiogenic carcinoma: malignant degeneration of a branchial cyst, a case report[J]. Cancer Rep (Hoboken), 2021, 4(2): e1315. (hxkqyxzz.net)
  • Martin H, Morfit HM, Ehrlich H. The case for branchiogenic cancer (malignant branchioma)[J]. Ann Surg, 1950, 132(5): 867-887. (hxkqyxzz.net)
  • Carcinoma arising in a branchial cleft cyst[J]. Cancer, 1976, 37(5): 2417-2422. (hxkqyxzz.net)
  • Cancer patients and tumor-bearing animals excrete high levels of modified purines and pyrimidines some of which, e.g. (shengsci.com)
  • Metastatic cancer cells are released from the primary tumor or from other metastases, at an undefined moment of its development, to arrive in the circulation and home at distant sites, where the ecosystem permits them to survive and either remain dormant as micro-metastases or grow to form macro-metastases (Mareel et al. (biomedcentral.com)
  • There is good evidence that cancer cells disseminate from the primary site early during tumor development (Hosseini et al. (biomedcentral.com)
  • Data set for reporting of carcinoma of the adrenal cortex: explanations and recommendations of the guidelines from the International Collaboration on Cancer Reporting. (ukw.de)
  • Following this, in 1971, Sir Frank Mac Farlane Burnet hypothesised that tumour cell antigens induced immunological reaction against cancer and postulated the "immune surveillance theory" (4). (cambridgemedicine.org)
  • Kirrander P, Sherif A, Friedrich B, Lambe M, Hakansson U, steering committee of the Swedish National Penile Cancer R. The Swedish National Penile Cancer Register: Incidence, Tumour Characteristics, Management and Survival. (cancercentrum.se)
  • The synergistic effect of pemetrexed + cSBL is not mediated by changes in caspase-3 activity To investigate whether the synergistic anti-tumor effect Schizandrin A of pemetrexed + cSBL was mediated by apoptosis, we analyzed activated caspase-3 levels. (bios-mep.info)
  • Mucoepidermoid carcinoma in a cervical cyst: a case of branchiogenic carcinoma[J]. Laryngoscope, 1984, 94(1): 107-112. (hxkqyxzz.net)
  • Zimmermann CE, von Domarus H, Moubayed P. Carcinoma in situ in a lateral cervical cyst[J]. Head Neck, 2002, 24(10): 965-969. (hxkqyxzz.net)
  • The molecular mechanisms underlying such resistance have been investigated in a range of tumour types, including the adult brain tumours glioblastoma, yet little is known for paediatric brain tumours. (biomedcentral.com)
  • This review expounds the up- or down-regulation of lncRNAs in OSCC and the molecular mechanisms by which lncRNAs perform their function in the malignant cell. (biomedcentral.com)
  • The immune system interacts closely with tumour cells via complex mechanisms and can result in either eradication of the tumour or immune evasion by the tumour (5). (cambridgemedicine.org)
  • Induction with EAC cells resulted in abnormalities in the gene expression of pro-apoptotic genes (Bax and caspase-3) and anti-apoptotic gene (Bcl-2) in the tumor mass. (bvsalud.org)
  • Moreover, microscopic, histopathological, and immune-histochemical examinations of the tumor mass and liver tissues exhibited extensive growth of malignant Ehrlich carcinoma cells and marked hydropic degeneration of hepatocytes and infiltration by tumor cells to liver tissue with marked inflammatory reaction. (bvsalud.org)
  • In 1902, a German scientist, Theodor Boveri proposed that cancerous tumors arise from single cells that have experienced chromosome damage, causing the cells to divide uncontrollably. (ivyhospital.com)
  • Treatment of tumor-bearing mice (transplanted with sarcoma 180 cells, Ehrlich, or Mep 2 ascites cells) with cSBL at a nontoxic dose prolonged success [16]. (bios-mep.info)
  • RESULTS cSBL exhibits higher tumor cell selectivity than pemetrexed and cisplatin We evaluated the effects of cSBL, pemetrexed, and cisplatin within the viability of epithelioid mesothelioma cells (NCI-H2452 [H2452], MESO-1, and MESO-4), biphasic mesothelioma cells MSTO-211H (MSTO) and sarcomatoid mesothelioma cells (H28), and non-malignant mesothelial cells (MeT5A) using WST-8 assays. (bios-mep.info)
  • Investigators have studied DNA methylation in tumor cells for nearly 50 years. (esmed.org)
  • Researchers at the University of Natural Resources and Life Sciences, Vienna compared NSC631570's inhibitive effect on the reproduction of malignant and normal cells. (ukrin.com)
  • Laser scanning microscopy showed a high capacity to absorb NSC631570 in malignant cells while absorption in normal cells was considerable lower under the same experimental conditions (36). (ukrin.com)
  • At lower NSC631570 concentrations malignant cells die as a result of apoptosis, at higher concentrations the formation of microtubules is prevented und polyploidy occurs (62). (ukrin.com)
  • Together our results demonstrate a new mechanism explaining hypoxia-induced resistance involving the alteration of the response to DSB in D283-MED cells, but also highlight the cell type to cell type diversity and the necessity to take into account the differing tumour genetic make-up when considering re-sensitisation therapeutic protocols. (biomedcentral.com)
  • Medulloblastoma (MB) is a malignant embryonal brain tumour originating from neural stem cells or granule-cell progenitors of the cerebellum, due to a deregulation of signalling pathways involved in neuronal development such as Wnt or Sonic Hedgehog (SHH) [ 1 ]. (biomedcentral.com)
  • cell count of ascetic fluid and morphological changes of tumor cells after treatment with drugs and to study the percentage viability of the cells. (apjhs.com)
  • Materials & Methods: A mouse bearing the tumor strain was taken from our laboratory in the Department of Pathology, IPGMER, Kolkata, where the strain was being maintained serially by inoculation of malignant cells into healthy mice every 8-10 days. (apjhs.com)
  • Actinomycin D alone produced a moderate effect on tumor cells. (apjhs.com)
  • Formation of active Hsp90/Cdc37 complex is one of the essential steps for facilitation of chaperone client interaction, non-assembly of which can lead to prevention of the chaperone-client association resulting in apoptosis of tumor cells. (biomedcentral.com)
  • this is usually evidenced by the type of connective tissue matrix formed by tumour cells. (biomedcentral.com)
  • The increase of interleukin-4 (IL-4) level in tumor environment and the up-regulation of IL-4 receptor (IL-4R) on tumor cells have been long observed. (shengsci.com)
  • Such cells are described as disseminated tumor cells (DTC) (Sosa et al. (biomedcentral.com)
  • 2014 ) or sometimes as circulating tumor cells (CTC) (Kim et al. (biomedcentral.com)
  • In 1959, Lewis Thomas suggested that the human immune system can recognise tumour-specific antigens on the surface of newly developing tumour cells as 'foreign' and eliminate them (3). (cambridgemedicine.org)
  • Consequently, immune cells fail to recognise and kill tumour cells. (cambridgemedicine.org)
  • CAR T-cells are T-cells that have been engineered to express receptors that specifically target tumour-associated antigens (8). (cambridgemedicine.org)
  • The second-generation CAR T-cells consist of one additional co-stimulatory component (mainly CD28, CD137 or CD134) in the intracellular domain, which amplifies anti-tumour responses in vivo (8). (cambridgemedicine.org)
  • Independent risk factors for inguinal lymph node metastases include clinical lymph node status, tumor grade, lymph vascular space invasion, depth of invasion, and age. (medscape.com)
  • Gilman and co-workers were the first to introduce chemotherapy into clinical practice at the end of the Second World War when they used nitrogen mustard to treat a patient with advanced malignant lymphoma. (nature.com)
  • Cardio-Metabolic Indices and Metabolic Syndrome as Predictors of Clinical Severity of Gastroenteropancreatic Neuroendocrine Tumors. (ukw.de)
  • ENSAT registry-based randomized clinical trials for adrenocortical carcinoma. (ukw.de)
  • Therapy is primarily guided by histopathological criteria as the depth of tumor penetration in the submucosa directly correlates with the probability of lymph node metastases. (researchgate.net)
  • Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)
  • Endogenous interleukin-4 promotes tumor development by increasing tumor cell resistance to apoptosis. (shengsci.com)
  • WOLCHOK, J.D. Of Mice and Men (and Dogs): development of a xenogeneic DNA vaccine for canine oral malignant melanoma. (caesegatos.com.br)
  • The approach was successfully validated in a state-of-the-art dataset from malignant melanoma, and despite multi-omics evidence for somatic mutations, mutated naturally presented HLA ligands remained elusive in HCCs. (biomedcentral.com)
  • This study suggests that exome-derived mutated HLA ligands appear to be rarely presented in HCCs, inter alia resulting from a low mutational burden as compared to other malignancies such as malignant melanoma. (biomedcentral.com)
  • This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. (biomedcentral.com)
  • 2001 ). Molecular communication between ecosystems is also witnessed by the vasculogenic and pro-metastatic tumor bed effect as discussed by Kuonen et al. (biomedcentral.com)
  • Radiofrequency, microwave, and laser ablation of liver tumors: time to move toward a tailored ablation technique? (oaepublish.com)
  • If a Wilms tumor is suspected or if the primary tumor is histologically confirmed, it should be staged by using CT or MRI. (medscape.com)
  • All primary malignant bone tumour cases should be discussed at a properly constituted sarcoma multidisciplinary team (MDT) meeting. (biomedcentral.com)
  • Since these mutated HLA ligands were unacquainted to the immune system before carcinogenesis, they have been proposed as ideal tumor-specific targets [ 10 , 11 ]. (biomedcentral.com)
  • This study presents a case of the malignant degeneration of lymphoepithelial cyst in parapharyngeal space. (hxkqyxzz.net)
  • Malignant degeneration of a branchial cyst: a case report[J]. J Stomatol Oral Maxillofac Surg, 2018, 119(5): 440-443. (hxkqyxzz.net)
  • It was originally established as an ascites tumor in mice. (apjhs.com)
  • Carcinoma within a lymphoepithelial cyst: a case report[J]. West China Journal of Stomatology, 2023, 41(2): 237-242. (hxkqyxzz.net)
  • The tumor (see the images below) occurs in both hereditary and sporadic forms, and approximately 6% are bilateral. (medscape.com)
  • In most cases, there will be a solitary tumor in one kidney, but 5-13% of children have bilateral tumors and 10% have multifocal tumors in a single kidney. (medscape.com)
  • CHADE, D. C.. Avaliação do bacilo de Calmette-Guérin recombinante expressando o antígeno S1PT no tratamento do carcinoma urotelial de bexiga em modelo experimental . (caesegatos.com.br)
  • Glycine N-methyltransferase tumor susceptibility gene in the benzo(a)pyrene-detoxification pathway. (shengsci.com)
  • Carcinoma, Giant Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • MRI diffusion studies have been shown to help differentiate Wilms tumor from neuroblastoma, with the apparent diffusion coefficient (ADC) being substantially higher for Wilms tumor. (medscape.com)
  • One probable mode of action for ICP inhibitors is the induction and/or restoration of T cell effector functions against individual somatic tumor mutations presented by HLA molecules (i.e., mutated neoepitopes) [ 9 ]. (biomedcentral.com)
  • Effects of tumor cell viability and inoculum density on growth parameters in the human tumor, soft-agar clonogenic assay. (shengsci.com)
  • This graph shows the total number of publications written about "Carcinoma, Giant Cell" by people in this website by year, and whether "Carcinoma, Giant Cell" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Carcinoma, Giant Cell" by people in Profiles. (uchicago.edu)
  • Recurrent giant cell carcinoma of the bladder. (uchicago.edu)
  • What Is the Optimal Duration of Adjuvant Mitotane Therapy in Adrenocortical Carcinoma? (ukw.de)
  • First German Guideline on Diagnostics and Therapy of Clinically Non-Functioning Pituitary Tumors. (ukw.de)
  • In a study of ultrasound and laboratory findings in Wilms tumor survivors with a solitary kidney, signs of kidney damage were seen in 22 of 53 patients (41.5%) on ultrasonography. (medscape.com)
  • The discovery of the X-ray in 1895 by Wilhelm Roentgen paved the way for imaging and treatment of various tumors. (ivyhospital.com)
  • We investigated whether cSBL exhibited higher tumor selectivity than pemetrexed and cisplatin, and whether combination treatment with cSBL + pemetrexed was similar or superior to combination treatment with pemetrexed + cisplatin. (bios-mep.info)
  • This study was conducted to evaluate the response of chemotherapy in the treatment of Ehrlich's ascetic carcinoma. (apjhs.com)
  • Our findings argue that senescence acts as a tumor suppressor mechanism that is abrogated during the transition from LGD to HGD in UC. (shengsci.com)