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  • Cancer
  • The occupational risk of cancer occurring in humans from exposure to malignant cells is not well recognized, owing to the few cases reported in the medical literature. (cdc.gov)
  • Although the incidence of cutaneous injuries resulting from sharps contaminated, with viable cancer cells is unknown, it probably represents only a small fraction of the cutaneous injuries incurred by potentially exposed workers. (cdc.gov)
  • In the first two phases of the study, lymphocytes from both normal volunteers and cancer patients were frequently toxic on both tumor cells and fibroblasts. (aacrjournals.org)
  • Cancer patient lymphocytes were more frequently toxic on tumor cells but no more frequently toxic on fibroblasts than were normal lymphocytes. (aacrjournals.org)
  • Results of the last phase of the study raise the possibility that both specific and nonspecific reactions may contribute to the toxicity observed in this laboratory with cancer patient lymphocytes tested against tumor cells. (aacrjournals.org)
  • Guo X, Oshima H, Kitmura T, Taketo MM, Oshima M (2008) Stromal fibroblasts activated by tumor cells promote angiogenesis in mouse gastric cancer. (springer.com)
  • Jones JL, Shaw JA, Pringle JH, Walker RA (2003) Primary breast myoepithelial cells exert an invasion-suppressor effect on breast cancer cells via paracrine down-regulation of MMP expression in fibroblasts and tumour cells. (springer.com)
  • Carotenoids, including β -carotene, lycopene, and derivatives, such as retinoic acid, have been studied for their significant antiproliferative and differentiating activity on cancer cells in experimental models and in clinics. (hindawi.com)
  • Our data suggest the presence of a pool of bioactive compounds in the carotenoid-enriched extract, acting additively, or synergistically, to delay cell growth in cancer cells. (hindawi.com)
  • Scientists have developed a new carbon nanotube device (pictured above) that's capable of detecting single cancer cells . (discovermagazine.com)
  • The researchers' original microfluidic device from four years ago featured tens of thousands of microscopic silicon posts coated with tumor-sticking antibodies: when cancer cells bumped into the posts, they'd stick. (discovermagazine.com)
  • But if cancer cells didn't bump into a silicon post, they'd go undetected. (discovermagazine.com)
  • When cancer cells migrate, there are " usually only several [cancer] cells per 1-milliliter sample of blood" containing billions of other cells, making cancer exceedingly difficult to detect. (discovermagazine.com)
  • This allows the blood to actually flow through the tubes instead of just around them, increasing the likelihood of catching a cancer cell. (discovermagazine.com)
  • So when will they attach these to nano machines that will live in my body and destory cancer cells the moment they are created? (discovermagazine.com)
  • Previous studies have shown that transtubal dissemination of both fluid and malignant cells can occur during sonohysterography in patients with endometrial cancer, but the viability of these cells is unknown. (ovid.com)
  • This prospective study evaluated the occurrence of transtubal spill at laparotomy in patients with endometrial adenocarcinoma during sonohysterography and determined whether the spill volume was critical, and the disseminated cancer cells were viable. (ovid.com)
  • These findings suggest that sonohysterography poses a low risk of transtubal dissemination of viable cancer cells. (ovid.com)
  • A longstanding idea in cancer biology is that during metastasis, cancer cells shed into the circulation from epithelial organs are inherently fragile and are mechanically destroyed by hemodynamic forces. (aacrjournals.org)
  • However, the mechanisms underlying the FSS resistance phenotype and whether these are relevant to cancer cells in tumor tissue or to circulating tumor cells was unknown. (aacrjournals.org)
  • Here we show that cancer cells exposed to FSS exhibit an adaptive response, demonstrating an increased stiffness (Young's modulus) as measured by micropipette aspiration . (aacrjournals.org)
  • Increased stiffness of cancer cells is associated with reduced damage to the plasma membrane upon subsequent challenges with FSS. (aacrjournals.org)
  • Knockdown of RhoA, but not RhoC sensitize prostate cancer cells to FSS. (aacrjournals.org)
  • Pharmacologic inhibition myosin II-based contractility also reduced prostate cancer cell resistance to FSS. (aacrjournals.org)
  • To determine if cancer cells that exist in tumor tissue exhibit resistance to FSS, we isolated cell suspensions from mice bearing prostate-specific PTEN and/or p53 mutations and exposed them to repeated pulses of FSS. (aacrjournals.org)
  • We found that, compared to wild-type control mice, prostate cells from tumor-bearing mice exhibited resistance to FSS characteristic of established human prostate cancer cell lines, indicating that our findings extend beyond established cell lines. (aacrjournals.org)
  • To examine whether FSS impacts circulating tumor cells, we treated prostate cancer cell line acutely with blebbistatin, a myosin II inhibitor, and vehicle control and injected these differentially fluorescently-labeled cells along with 15 micron fluorescent beads. (aacrjournals.org)
  • 60% of vehicle treated cancer cells survive intact in the lungs whereas only ~40% of blebbistatin-treated cells survive. (aacrjournals.org)
  • We examined the site-specific implantation of cancer cells in peritoneal tissues after an i.p. inoculation of 10 5 P388 leukemia cells. (aacrjournals.org)
  • Twenty-four h after the inoculation, the number of viable cancer cells infiltrating into specific tissue sites of the peritoneum was estimated by an i.p. transfer method. (aacrjournals.org)
  • A significant correlation was established between the logarithm of the number of infiltrating cancer cells and the logarithm of the number of milky spots. (aacrjournals.org)
  • These cancer cells were found microscopically to be infiltrating only the milky spots, whereas none were seen at the other sites. (aacrjournals.org)
  • These results suggest that cancer cells seeded i.p. specifically infiltrate the milky spots in the early stage of peritoneal metastases. (aacrjournals.org)
  • Researchers have known for decades that cancer begins when certain key genes in an otherwise healthy cell mutate, and tumor growth depends on continuing, multiple mutations. (innovations-report.com)
  • But only recently have scientists begun to understand the "epigenetic" components of cancer-that is, how other molecules in a cell affect genes without actually altering the sequence of DNA. (innovations-report.com)
  • However, when the group exposed metastatic tumor cells to the microenvironment of hESCs containing Lefty, they witnessed dramatically reduced Nodal expression (production) in these cancer cells together with decreased tumor cell growth and invasiveness and an increase in apoptosis, or programmed cell suicide. (innovations-report.com)
  • Although exposure to a hESC microenvironment inhibited Nodal expression and tumor growth in both metastatic melanoma and breast cancer cells, the breast cancer cells underwent more complex reprogramming. (innovations-report.com)
  • Melanoma cells responded to the hESC-derived factors within three days, but breast cancer cells required two additional days to achieve the most significant reduction in Nodal. (innovations-report.com)
  • Yet, despite the inherent differences between melanoma cells and breast cancer cells, these divergent tumor types both underwent cell suicide following exposure to the hESC microenvironment. (innovations-report.com)
  • The remarkable similarity of the responses of the two tumor types is likely attributable to the commonality of plasticity (for example, the aberrant and unregulated expression of Nodal) that indiscriminately unifies highly aggressive cancer cells, regardless of their tissue of origin," Hendrix said. (innovations-report.com)
  • Further, the tumor suppressive effects of the hECs microenvironment, by neutralizing the expression of Nodal in aggressive tumor cells, provide previously unexplored novel therapeutic modalities for cancer treatment," Hendrix said. (innovations-report.com)
  • So, simultaneous down-regulation of Nrf2 and induction of ROS in cancer cells can lead to more apoptosis. (biomedcentral.com)
  • During the PDT process, protoporphyrin IX (PpIX), an effective photosensitizer, can selectively kill cancer cells by activating a special light source. (dovepress.com)
  • Results of some studies have showed that cancer cells can be effectively killed by using either a light source or an individual treatment due to the generation of reactive oxygen species and electrons from a wide range of wavelengths, which suggest that CAP can act as a potential light source for anticancer applications compared with UV light sources. (dovepress.com)
  • In summary, these results indicated for the first time that PpIX-loaded polymersomes together with CAP posttreatment could be a promising tool for skin cancer drug delivery with selective toxicity toward melanoma cells sparing healthy fibroblasts. (dovepress.com)
  • Squeezing" stops malignant breast cancer cells from spreading and turns them back into healthy cells, according to new research revealing, for the first time, that simple mechanical forces alone can revert and stop out-of-control growth of cancer cells. (medicaldaily.com)
  • An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is increasing in prevalence. (labspaces.net)
  • Despite the emergence of new therapies, such as tyrosine kinase inhibitors, CML and other leukemias remain problematic because some cancer stem cells avoid destruction and eventually regenerate themselves, a stem cell process known as self-renewal that can result in a return and spread (metastasis) of the disease. (labspaces.net)
  • People normally think about DNA instability in cancer, but in this case, it's how the RNA is edited by enzymes that really matters in terms of cancer stem cell generation and resistance to conventional therapy. (labspaces.net)
  • CML is a cancer initiated by a mutant gene called BCR-ABL in blood forming stem cells that leads to an expansion of white blood cells and their precursors. (labspaces.net)
  • Despite tremendous advances in BCR-ABL tyrosine kinase inhibitor therapies, the majority of patients relapse if therapy is discontinued, in part as a result of dormant cancer stem cell resistance. (labspaces.net)
  • Detection of hyperdiploid in malignant cells in fine-needle aspirates from lung cancer by fluorescence in situ hybridization]. (openrepository.com)
  • Identifying whether a potential drug is having an effect on cancer cells is not always obvious. (medgadget.com)
  • findings
  • Further, the findings illuminate the remarkable plasticity of melanoma cells and the utility of the developing zebrafish as a model for studying the epigenetic modulation of tumor cells. (medindia.net)
  • These findings support an inside-out model of T cell triggering driven by small-molecule induction of BTN3A1. (jimmunol.org)
  • Scientists presenting the latest findings Dec. 17 at the annual meeting of the American Society for Cell Biology in San Francisco said that "tissue organization is sensitive to mechanical inputs from the environment" during the beginning stages of a cell's growth and development. (medicaldaily.com)
  • leukemic cells
  • We therefore studied the biotransformation of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine ([3H]ET18-OMe) labeled in position 9-10 of the 1-alkyl chain, in rat plasma and erythrocytes, HL60 and K562 leukemic cells, HT29 adenocarcinoma cells, and cultured hepatocytes at 37 degrees C, and in a system of isolated and perfused rat liver. (aspetjournals.org)
  • colonies
  • Hendrix and co-researchers previously demonstrated that a three-dimensional matrix conditioned by hESCs induced metastatic melanoma cells to revert to a normal, skin cell-like type with the ability to form colonies in the manner of hESCs (Postovit and Seftor et al, Stem Cells 24:501-505, 2006). (innovations-report.com)
  • promotes
  • This suggests that a single pass through the right mouse heart damages circulating tumor cells, but that a mechanism that depends on myosin II promotes survival of these cells. (aacrjournals.org)
  • The team has already been studying whether Taxol, a chemo agent, promotes the epithelial-mesenchymal transition in cells it does not kill. (medgadget.com)
  • Malignancy
  • Finally we report our results from the investigation of 66 cases of T-cell malignancy and of 111 cases of B and non-B, non T cell malignancies. (springer.com)
  • mice
  • We studied 23 nude mice, in which 7 × 10 6 rhabdomyosarcoma cells (RH-30 cell line) were injected in the dorsal subcutaneous tissues. (springer.com)
  • It s important to note," says Blelloch, "that the stem cells from the cloned melanoma were incorporated into most, if not all, tissues of adult mice, showing that they can develop into normal, healthy cells," such as those for skin pigmentation, immunity, and connective tissue. (innovations-report.com)
  • experiments were also performed to demonstrate the anticancer efficacy of DS/Cu in Raji cells xenografted nude mice. (biomedcentral.com)
  • The results of our animal experiments also showed that the mean tumor volume in DS/Cu-treated mice was significantly smaller than that in DS or control group, indicating that DS/Cu inhibits the proliferation of Raji cells in vivo . (biomedcentral.com)
  • Normal
  • We examined the effects of algae extracts on normal hematopoietic cells and leukemia cells. (hindawi.com)
  • These data suggest that algae extracts may inhibit AML cell lines and leukemia blasts, but they may also have potential inhibitory effects on normal hematopoiesis. (hindawi.com)
  • Strikingly, nodal inhibition promoted the reversion of these cells toward a normal skin cell type. (medindia.net)
  • In the last phase of the study, normal lymphocytes were less frequently toxic on both types of target cells. (aacrjournals.org)
  • Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. (google.com)
  • 3. A method according to claim 2 , wherein the normal cells in the spleen are normal B cells. (google.com)
  • Fate of 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET18-OME) in malignant cells, normal cells, and isolated and perfused rat liver. (aspetjournals.org)
  • Expressed during embryogenesis to help blood cell development, ADAR1 subsequently turns off and is triggered by viral infections where it protects normal hematopoietic stem cells from attack. (labspaces.net)
  • tissues
  • The significance of the research team's finding is profound in that it implies that through secretion of Nodal, aggressive melanoma cells maintain their plasticity and modulate the microenvironment, as exemplified by their ability to direct the formation of zebrafish tissues. (medindia.net)
  • differentiation
  • This effect was associated with the activation of a "nonprotective" form of autophagy and, in SAOs cells, to the induction of cell differentiation via a mechanism that involved AMPK activation. (hindawi.com)
  • Cytotoxicity
  • In combination with a low concentration (1 μM) of Cu 2+ , DS induced cytotoxicity in Raji cells with an IC 50 of 0.085 ± 0.015 μM and in Molt4 cells with an IC 50 of 0.435 ± 0.109 μM. (biomedcentral.com)
  • migrate
  • The Hendrix lab has long hypothesized that the plastic nature of malignant melanoma cells serves as an advantage by enhancing the cells' ability to migrate, invade and metastasize virtually undetected by the immune system. (medindia.net)
  • Groundbreaking work by Hendrix and colleagues is elucidating how, by becoming more like unspecialized stem cells, aggressive melanoma cells gain enhanced abilities to migrate, invade and metastasize while remaining virtually undetected by the immune system. (innovations-report.com)
  • inhibition
  • Inhibition of cell contractility- and proteolysis-mediated matrix reorganization prevented leader-follower behavior and malignant cell-induced epithelial cell invasion. (springer.com)
  • CD27 + /CD45RA − Th1-like effector cells killed K562 target cells through a mechanism that could be enhanced by either compound or TCR Ab and blocked by Src inhibition or butyrophilin 3 isoform A1 (BTN3A1) disruption. (jimmunol.org)
  • tissue
  • To study heterotypic cell-cell interactions and elucidate the biological consequences of intratumor heterogeneity, we developed a tissue-engineered multicellular spheroid (MCS) co-culture model that recapitulates the cellular diversity and fully three-dimensional cell-cell and cell-matrix interactions that characterize human carcinomas. (springer.com)
  • The method comprises parenterally injecting a mammalian subject, at a locus and by a route providing access to said tissue or organ, with an composition comprising antibody/fragment which specifically binds to targeted organ, tissue or cell. (google.com)
  • human
  • We are presenting here data on the mechanism of action of a carotenoid-enriched extract obtained from the pumpkin Cucurbita moschata , variety "long of Naples," on two malignant human cell lines, Caco-2 and SAOs, derived from a colon adenocarcinoma and an osteosarcoma, respectively. (hindawi.com)
  • We examined lysis mediated by human Vγ9Vδ2 effector T cells in response to the naturally occurring ( E )-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) or a synthetic cell-permeable prodrug, bis (pivaloyloxymethyl) ( E )-4-hydroxy-3-methyl-but-2-enyl phosphonate. (jimmunol.org)
  • The human Vγ9Vδ2 T cells are unique in that they respond to pathogen-associated small molecules in a way that appears dependent on TCR signaling ( 1 ). (jimmunol.org)
  • Though epithelial and mesenchymal cells can look different, sometimes they're nearly identical to the human eye. (medgadget.com)
  • In response to primary stimulation with the imidazoquinoline, S28690, human mononuclear cells produced tumor necrosis factor-α, but were unable to do so upon restimulation with S28690. (aacrjournals.org)
  • Accordingly, the effects of repeated activation through TLR7 in primary human cells were studied in this paper. (aacrjournals.org)
  • back on th
  • An early signal, in the form of compression, appears to get these malignant cells back on the right track," researcher Daniel Fletcher, professor of bioengineering at UC Berkeley said in a statement. (medicaldaily.com)
  • If we can block the capacity of leukemia stem cells to use ADAR1, if we can knock down that pathway, maybe we can put stem cells back on the right track and stop malignant cloning. (labspaces.net)
  • patterns
  • In contrast, innate cells can use pattern-recognition receptors such as the TLRs to detect foreign small molecules known as pathogen-associated molecular patterns. (jimmunol.org)
  • TLR7, expressed by B cells and some dendritic cells, recognizes molecular patterns associated with viruses that can be mimicked by synthetic imidazoquinolines. (aacrjournals.org)
  • study
  • The different results obtained in the last phase of the study cannot be attributed solely to the different method of lymphocyte separation, since other factors, such as better growth status of the target cells and greater facility in performing the assays, might also be responsible. (aacrjournals.org)
  • In this study, we investigated the cytotoxic effect of this propolis sample on A375 melanoma cells. (mdpi.com)
  • found
  • Using chronic lymphocytic leukemia B cells as a model to facilitate biochemical analysis, the tolerized state was found to be associated with altered receptor components, including down-regulated expression of TLR7 mRNA and decreased levels of interleukin-1 receptor-associated kinase 1. (aacrjournals.org)
  • stem cell
  • Importantly, Lefty is secreted only in hESCs, and not in any other stem cell type tested - including stem cells isolated from amniotic fluid, cord blood or adult bone marrow - or placental cells. (innovations-report.com)
  • Although treatments including chemotherapy and stem cell transplantation are developing very fast, patients still suffer from relapse and treatment related complications. (biomedcentral.com)