As with all tumors, whether benign or malignant, identification of the cell or cell layer of origin is of the utmost importance. (medscape.com)
The origin of cutaneous tumors can be simplistically divided into three major categories: epidermal, dermal, and adnexal (see image below). (medscape.com)
The higher incidence of SGc in Asian populations may be due to the lower incidence of other eyelid tumors or genetic. (wikipedia.org)
As with all tumors, whether benign or malignant, the paradigm of comprehension depends on identifying the cell or cell layer of origin. (medscape.com)
Most are malignant except the insulin-producing tumors (INSULINOMA). (lookformedical.com)
It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
Salivary gland2
ETV6 FISH testing on cytological smears in cases suspected as SC improves the diagnostic accuracy of FNAC and can help lower the proportion of the Milan categories salivary gland neoplasm of uncertain malignant potential and suspicious for malignancy, maximizing diagnostic information from less invasive samples and aiding in patient management. (bvsalud.org)
Sebaceous carcinoma, also known as sebaceous gland carcinoma (SGc), sebaceous cell carcinoma, and meibomian gland carcinoma is an uncommon malignant cutaneous tumor. (wikipedia.org)
Due to the rarity of this tumor and variability in clinical and histological presentation, SGc is often misdiagnosed as an inflammatory condition or a more common neoplasm. (wikipedia.org)
This entity was first identified and documented by Headington 9 in 1976, who described an epidermal-based tumor composed of atypical clear cells derived from adnexal keratinocytes. (jcadonline.com)
Sebaceous carcinoma is a very rare, aggressive, malignant tumor arising in the adnexal epithelium of the sebaceous gland. (biomedcentral.com)
Syringocystadenoma papilliferum is a benign adnexal tumor of the skin,[2] which can occur either de novo or on some organoid nevus such as nevus sebaceous. (ijcrr.com)
while only two microcystic adnexal carcinoma cases (15%) and one squamous cell carcinoma with ductal differentiation (12%) expressed CK7 in the remaining three tumor categories. (dadospdf.com)
Differentiation6
Tangential shave biopsy of the lesion was performed and the histopathologic report revealed an adnexal neoplasm with trichilemmal differentiation, desmoplastic component, and atypia with margins involved (Figures 2A, 2B, 3A, and 3B). (jcadonline.com)
While the neoplastic cells were negative, luminal staining of ductal structures was noted for CK7, CD15 and CEA in some of the microcystic adnexal carcinoma, desmoplastic trichoepithelioma and squamous cell carcinoma with ductal differentiation cases. (dadospdf.com)
In conclusion, we found CK15 to be a useful marker in distinguishing microcystic adnexal carcinoma from infiltrative basal cell carcinoma and squamous cell carcinoma with ductal differentiation. (dadospdf.com)
The differentiation of microcystic adnexal carcinoma from any of these other entities is not merely semantic but extremely relevant to clinical management. (dadospdf.com)
Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)
A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)
Carcinomas5
HPV-associated SCC may mimic commoner eyelid carcinomas as it lacks overt keratinization. (bvsalud.org)
In basaloid-appearing eyelid carcinomas, p16 immunopositivity should be followed by reflex HR-HPV mRNA ISH, as p16 immunohistochemistry alone has low specificity. (bvsalud.org)
Trichilemmal carcinomas (TCs) are rare, malignant, adnexal neoplasms that differentiate from the outer root sheath (ORS) of the hair follicle. (jcadonline.com)
Primary malignant skin neoplasms most often are carcinomas (either basal cell or squamous cell carcinomas) or melanomas. (nih.gov)
Metastatic malignant neoplasms to the skin include carcinomas and lymphomas. (nih.gov)
Cutaneous neoplasms3
Keratoacanthomas (KAs) are benign cutaneous neoplasms that occur in elderly patients who are frequently exposed to the sun. (medscape.com)
SGc accounts for approximately 0.7% of all skin cancers and 0.2 to 4.6% of all malignant cutaneous neoplasms. (wikipedia.org)
While there are markedly increased rates of cutaneous neoplasms in solid organ transplant recipients, there is evidence to suggest that solid organ transplantation may increase the risk of SGc up to 90 times. (wikipedia.org)
Squamous4
We found that the majority of microcystic adnexal carcinoma (92%) and desmoplastic trichoepithelioma (100%) cases expressed CK15 while the infiltrative basal cell carcinoma and squamous cell carcinoma cases were all negative. (dadospdf.com)
Sixty percent of infiltrative basal cell carcinoma, 31% of microcystic adnexal carcinoma, and 25% of squamous cell carcinoma express CD10. (dadospdf.com)
BerEP4 expression was noted in 38% of microcystic adnexal carcinoma, 57% of desmoplastic trichoepithelioma, 100% of infiltrative basal cell carcinoma, and 38% of squamous cell carcinoma. (dadospdf.com)
In addition, we noticed misdiagnosis of a few cases of microcystic adnexal carcinoma as squamous cell carcinoma at our institution-most likely a consequence of the biopsy technique (superficial shave). (dadospdf.com)
It seems that these intraoral sebaceous glands can rarely give rise to a variety of sebaceous neoplasms, such as sebaceous carcinoma [ 7 ]. (biomedcentral.com)
The most common benign and malignant neoplasms arising in this disorder include trichilemmoma, syringocystadenoma papilliferum, keratoacanthoma, apocrine cystadenoma and basal cell carcinoma. (ijcrr.com)
Even though immunohistochemical comparisons of microcystic adnexal carcinoma vs infiltrative basal cell carcinoma and desmoplastic trichoepithelioma exist, they are mostly restricted to the use of a single stain. (dadospdf.com)
First reported in 1982 by Goldstein et al,1 microcystic adnexal carcinoma has been referred to by a variety of names-all of which allude to the clinical behavior and histopathologic features of this lesion. (dadospdf.com)
published online 7 December 2007 histopathologic perspective, the main differential diagnosis for microcystic adnexal carcinoma, a stratified, infiltrating neoplasm characterized by a superficial component of keratinous cysts and a deeper component of smaller nests and strands of cells embedded in a markedly hyalinized stroma, is sclerosing/infiltrative basal cell carcinoma and desmoplastic trichoepithelioma. (dadospdf.com)
Microcystic adnexal carcinoma MP Hoang et al 179 believed to account for its high recurrence rate. (dadospdf.com)
While local recurrence is reported in 50% of cases of microcystic adnexal carcinoma with positive margins, 40-60% of patients experience one or more local recurrences anywhere from 6 months to 30 years after standard wide local excision.4,6,7,9-11 Thus, while the standard of care for microcystic adnexal carcinoma is wide local excision, no further management is mandated for a desmoplastic trichoepithelioma. (dadospdf.com)
Benign1
Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
Lymphomas2
Non-Hodgkin's lymphomas represent the most common ocular adnexa neoplasm [ 1 ]. (biomedcentral.com)
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)
Meibomian glands4
Meibomian glands are a type of sebaceous gland that lines the upper and lower eyelids and do not contain a follicle. (wikipedia.org)
The upper eyelid contains more meibomian glands than the lower eyelid and consequently, SGc is 2-3 times more common in the upper eyelid. (wikipedia.org)
SGc arises from the adnexal epithelium of sebaceous glands, most commonly the Meibomian glands or glands of Zeis. (wikipedia.org)
RESULTS: The two index patients were older adult females, with upper eyelid tumours. (bvsalud.org)
Primary2
A primary or metastatic malignant neoplasm involving the skin. (nih.gov)
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
Malignancies2
While SGc affects Caucasians over 80% of the time, SGc tends to be more prevalent in the Eastern versus Western Hemisphere, contributing to 33% of eyelid malignancies in China versus 1-5.5% in Caucasians. (wikipedia.org)
Regardless of the localization, sebaceous malignancies must be considered aggressive neoplasms with potential for regional and distant metastases. (biomedcentral.com)
Tumours1
Incidence of malignant tumours in patients with a non-functioning pituitary adenoma. (nih.gov)
Mimic1
commonly presents as a painless, red and brown or red and yellow, ulcerated papule on the head or neck and may mimic nonmelanoma skin cancers, molluscum contagiosum, adnexal neoplasms, or pyogenic granuloma. (wikipedia.org)
Metastases1
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
Arises1
The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
Genetic1
The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
Inflammatory1
In fact, clear cell acanthoma possesses a similar staining pattern to inflammatory dermatoses such as psoriasis vulgaris, lichen planus, and discoid lupus erythematosus and might be a localized form of inflammatory eruption rather than a neoplasm. (medscape.com)
METHODS2
METHODS: Two index cases of eyelid HPV-associated SCC are described in detail. (bvsalud.org)
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)
Rare1
The histogenesis of this rare neoplasm is still unclear. (ijcrr.com)
Common3
The periocular region, which includes the meibomian, Zeis, and sebaceous glands of the caruncle and eyelid, is the most common site accounting for up to 75% of SGc. (wikipedia.org)
MTS is an autosomal dominant cancer syndrome characterized by multiple sebaceous and visceral neoplasms, the most common being colorectal adenocarcinoma. (wikipedia.org)
SCC is the second most common eyelid malignancy. (bvsalud.org)
CONCLUSION: The prevalence of HR-HPV in eyelid SCC is low in Indian patients. (bvsalud.org)
Treatment1
Mohs surgery with reconstruction is the optimal treatment for KA on the eyelid. (medscape.com)
Cells2
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
Form1
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. (lookformedical.com)
Found1
The neoplasms may be histologically the same or different, and may be found in the same or different sites. (lookformedical.com)
Multiple1
Multiple KAs should raise suspicion of Muir-Torre syndrome, a genodermatosis with a defect in the MSH mismatch repair gene that is associated with sebaceous neoplasms and gastrointestinal cancers. (medscape.com)