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  • Pancreas
  • Gastrointestinal cancer refers to malignant conditions of the gastrointestinal tract (GI tract) and accessory organs of digestion, including the esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. (wikipedia.org)
  • melanoma
  • Microscopic characteristics of rhabdoid cells include: Oval to polygonal cell shape Eosinophilic, hyaline-like perinuclear agglomerations of intermediate filaments Compressed, eccentric nuclei Prominent central macronucleoli (one or two) Abundant eosinophilic cytoplasm Reticular chromatin pattern The differential diagnosis of LCLC-RP includes secondary metastatic lesions, melignant melanoma of the lung with rhabdoid phenotype, mucinous adenocarcinomas (particularly those featuring signet-ring cells), rhabdomyosarcoma, epitheloid angiosarcoma, pleural mesothelioma, and plasmacytoma. (wikipedia.org)
  • Expression
  • Yet neither the spectrum of tissue expression nor the signalling pathways of OPN in MM and pulmonary adenocarcinoma have been characterized, although in vitro evidence links OPN to the epidermal growth factor receptor (EGFR) pathway. (mesothelioma-line.com)
  • OPN expression was investigated immunohistochemically in 104 adenocarcinomas and 38 MM and correlated with histological features, including tumour type, grade and proliferation and with expression of activated intermediary EGFR signalling pathway molecules p65, p-AKT, p-ERK, p-STAT-3, and of metalloproteinase (MMP)-1, MMP-2 and MMP-9. (mesothelioma-line.com)
  • In adenocarcinoma, high OPN expression was correlated with expression of p65, p-ERK and MMP-9. (mesothelioma-line.com)
  • Frequent OPN expression is typical of, but not specific for MM, whereas it appears to select adenocarcinoma cases with p65 and MMP-9 expression, suggesting a link with EGFR signalling pathways. (mesothelioma-line.com)
  • common
  • Worldwide, the incidence of each type is about the same, but in developed countries like North America and Europe adenocarcinoma is the more common. (wikipedia.org)
  • typically
  • Highly differentiated adenocarcinomas form SRCCs via a loss of adherens and tight junctions that typically separate MUC4, a mucin protein, and ErbB2, an oncogenic receptor. (wikipedia.org)
  • treatment
  • High-grade dysplasia and early stages of adenocarcinoma can be treated by endoscopic resection and new endoscopic therapies such as radiofrequency ablation, whereas advanced stages (submucosal) are generally advised to undergo surgical treatment. (wikipedia.org)
  • mucin
  • Highly differentiated adenocarcinomas form SRCCs via a loss of adherens and tight junctions that typically separate MUC4, a mucin protein, and ErbB2, an oncogenic receptor. (wikipedia.org)
  • Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelatinous ascites. (wikipedia.org)
  • Lung
  • For example, one group found a positive correlation between persistently activated tyrosine-phosphorylated STAT3 (pSTAT3), found in 50% of lung adenocarcinomas, and IL-6. (wikipedia.org)
  • Cancer
  • Low-grade mucinous adenocarcinoma is used by the American Joint Committee on Cancer and World Health Organization and is nearly or completely synonymous with the DPAM designation. (wikipedia.org)
  • growth
  • Modern views on the mechanisms of malignant growth. (ssmj.ru)
  • The infiltration and active destruction of tissue below the basement membrane , a characteristic of a malignant growth. (in.gov)