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  • gene
  • Olsen, A.S., O.W. McBride, and D.E. Moore (1981) Number and size of human X chromosome fragments transferred to mouse cells by chromosome-mediated gene transfer. (springer.com)
  • An alternative to generate HPV specific CD4+ and CD8+ T cells is TCR gene transfer. (biomedcentral.com)
  • MicroRNAs (miRNAs) are negative regulators of gene expression that play important role in reprogramming somatic cells. (biomedcentral.com)
  • However, down-regulated pluripotency gene expression and failure to form teratoma indicated that the CRC-iPC cells had only attained partial pluripotency. (biomedcentral.com)
  • Other modalities of therapy such as heat induced ablation of cancer cells by nanoshells and gene therapy are also being developed. (biomedsearch.com)
  • The researchers concluded that the protein does respond to high-cell density and to HMW-HA, which initiates the anti-cancer response of the INK4 gene. (eurekalert.org)
  • We are investigating the functions of this gene using the two hybrid analysis in yeast cells. (unclineberger.org)
  • The first fusion gene was described in cancer cells in the early 1980s. (wikipedia.org)
  • Furthermore, certain consistent chromosomal abnormalities can turn normal cells into a leukemic cell such as the translocation of a gene, resulting in its inappropriate expression. (wikipedia.org)
  • Lymphokine-activated killer T-cell-originated protein kinase is an enzyme that in humans is encoded by the PBK gene. (wikipedia.org)
  • Deletion and reduced expression of Dock8 have been reported in a human lung cancer cell line and Dock8 was also identified as a putative candidate gene associated with progression of gliomas. (wikipedia.org)
  • This gene plays a role in cell cycle regulation. (wikipedia.org)
  • Deletion of an enhancer close to the GADD45G gene is correlated to increased proliferation of neuronal cells, which could account for part of the difference in neural development between humans and other species. (wikipedia.org)
  • GADD45G is expressed in enamel knots, where it regulates gene expression and cell growth. (wikipedia.org)
  • The gene modulates p21-mediated epithelial cell proliferation by activating the p38 MAPK pathway during the development of teeth. (wikipedia.org)
  • In esophageal cancer the expression level and methylation status of the gene are involved in the prognosis of esophageal squamous cell carcinoma. (wikipedia.org)
  • It encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression, mRNA translation, coactivator binding, and cell fate determination during development. (wikipedia.org)
  • Dach1 is similar to the D. melanogaster dac gene, which encodes a nuclear factor essential for determining cell fates in the eye, leg, and nervous system of the fly. (wikipedia.org)
  • Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis. (wikipedia.org)
  • This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. (wikipedia.org)
  • tumour
  • EBV B-lymphoblastoid cell line) with haematological ex vivo or immortalized tumour cells. (le.ac.uk)
  • On co-culture with allogeneic (normal donors) peripheral blood lymphocytes, hybrid cell lines induced elevated levels of T-cell proliferation compared with their relevant tumour cells, which was dependent on expression of co-stimulatory molecules CD80 and CD86, and MHC class I and class II antigens. (le.ac.uk)
  • Moreover, the hybrid cells expressed a range of tumour associated antigens not expressed by HMy2 cells, or by normal PBMC. (le.ac.uk)
  • Tumour- and antigen-specificity of the activated T cells were assessed by IFN-γ releasing ELISpot, MHC class I (HLA-A2)-restricted tumour peptide-specific pentamer staining, and 51Cr-release cytotoxicity assays. (le.ac.uk)
  • Carcinoma
  • As carcinoma cells progress toward high-grade malignancy, they often if not invariably activate the cell-biological program termed the epithelial-mesenchymal transition (EMT). (pnas.org)
  • These findings suggest that the design of future therapeutic approaches will need to consider the various subpopulations of carcinoma cells that reside at various positions along the E-M spectrum. (pnas.org)
  • EBV is a ubiquitous infectious agent that is associated with specific malignancies including Burkitt's lymphoma, Hodgkin's lymphoma and nasopharyngeal carcinoma (NPC), which develop with high incidence in endemic areas. (unclineberger.org)
  • Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and serve as driving mutations for cancers such as medulloblastoma, basal-cell carcinoma, pancreatic cancer, and prostate cancer. (wikipedia.org)
  • Breast cancer and renal cell carcinoma have both been shown to diminish expression of TLR9. (wikipedia.org)
  • melanoma
  • The relationship between the 'spontaneous' frequency of sister-chromatid exchanges (SCE) and tumorigenicity was studied in a series of hybrids between a C57BL melanoma cell line and diploid cells, but no correlation was found between the 2 variables. (biologists.org)
  • Receptor
  • In addition, its intact Fc-part can bind to an Fc receptor on accessory cells like conventional monospecific antibodies. (wikipedia.org)
  • pancreatic
  • While generally considered to be uncommon, with an incidence between 3-5 cases per 100,000, NETs constitute the second most prevalent (35 cases per 100,000) gastrointestinal neoplasm and exceed the number of stomach, pancreatic, esophageal and hepatobilliary malignancies because of their general indolent behavior ( Figure 1 ). (infectiousdiseaseadvisor.com)
  • clones
  • HPV specific CD4+ T cells were generated using either a MHC class I or MHC class II restricted TCR (from clones A9 and 24.101 respectively) directed against HPV16 antigens. (biomedcentral.com)
  • demonstrate
  • We demonstrate that tumorigenicity depends on individual cells residing in this E/M hybrid state and cannot be phenocopied by mixing two cell populations that reside stably at the two ends of the spectrum, i.e., in the E and in the M state. (pnas.org)
  • We demonstrate here that administration of a hybrid peptide antagonist that blocks VIP signaling enhances CD8 T cell responses in a murine model of AML. (jimmunol.org)
  • antigens
  • At first, mouse hybridoma cells whose monoclonal antibodies target one of the desired antigens are produced. (wikipedia.org)
  • Roles
  • Chen J, Miao Z, Xue B, Shan Y, Weng G, Shen B. Long Non-coding RNAs in Urologic Malignancies: Functional Roles and Clinical Translation. (jcancer.org)