AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowBone Marrow CellsTransplantation, HomologousGraft vs Host DiseaseHistocompatibilityBone and BonesHematopoietic Stem Cell TransplantationLeukemiaHematologic NeoplasmsTissue DonorsHistocompatibility TestingTransplantation ConditioningWhole-Body IrradiationGraft SurvivalTransplantation ChimeraAnemia, AplasticTransplantation, AutologousHLA AntigensSevere Combined ImmunodeficiencyLymphocyte DepletionCytomegalovirus InfectionsImmunosuppressive AgentsHematopoietic Stem CellsLeukemia, Myeloid, AcuteTreatment OutcomeBone RemodelingHaploidyBone Marrow DiseasesPrecursor Cell Lymphoblastic Leukemia-LymphomaBone Marrow ExaminationRecurrenceGraft RejectionImmunocompromised HostT-LymphocytesBone Marrow PurgingBone Marrow NeoplasmsOpportunistic InfectionsLymphocyte TransfusionImmunosuppressionHaplotypesTime FactorsRetrospective StudiesLeukemia, Myelogenous, Chronic, BCR-ABL PositiveHematopoiesisPeripheral Blood Stem Cell TransplantationMice, Inbred C57BLCyclosporineAcute DiseaseMycosesBone DensityCyclophosphamideAntilymphocyte SerumGraft vs Leukemia EffectKidney TransplantationFetal TherapiesRadiation ChimeraCytomegalovirusFatal OutcomeBusulfanAntigens, CD34Bone ResorptionHematologic DiseasesTransplantation, IsogeneicLiving DonorsColony-Forming Units AssayRemission InductionPneumonia, ViralDisease-Free SurvivalUnrelated DonorsSurvival AnalysisNuclear FamilyCombined Modality TherapyCord Blood Stem Cell TransplantationMyelodysplastic SyndromesStem Cell TransplantationSiblingsSurvival RateGanciclovirLeukemia, MyeloidAspergillosisGraft vs Host ReactionCell DifferentiationBone NeoplasmsLymphoma, Non-HodgkinFollow-Up StudiesPolymerase Chain ReactionGranulocyte Colony-Stimulating FactorHepatic Veno-Occlusive DiseaseCystitisReceptors, KIRBlood Group IncompatibilityMucormycosisTransplantsKiller Cells, NaturalFlow CytometryCells, CulturedMultiple MyelomaBone DevelopmentLeukocyte Count
TransplantationHematologicHematologicalPost-transplant cyclophosphamideOutcomesHematopoietic cell transplantDonors2022Patients with relapsed or refractoryMatched unrelated donor transplantsBlood and marrowPediatricGVHDStem cellsRecipientsClinicalDisordersMyeloidImmune systemBiopsyAplasticCell TherRetrospectiveCytokineHSCTUmbilicalOncologistRefractoryPaediatricCytopeniasVersusRenal FailureBusulfanRelapseHalf matchedLeukemia
Transplantation44
Hematologic5
  • [ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
  • This global trial evaluated omidubicel versus standard cord blood in patients with hematologic malignancies, who needed a bone marrow transplant, but did not have a suitable match donor. (seekingalpha.com)
  • Regimen-related toxicity after fludarabine-melphalan conditioning: a prospective study of 31 patients with hematologic malignancies. (uchicago.edu)
  • Paucity of HLA-identical unrelated donors for African-Americans with hematologic malignancies: the need for new donor options. (uchicago.edu)
  • The treatment of the hematologic malignancy had a good impact solving the enzymatic deficiency and antifungal therapy achieve controlling the infection. (springeropen.com)
Hematological3
  • We offer advanced multimodal integrated care including BMT for pediatric benign hematological disorders like haemoglobinopathies, bone marrow failure syndromes and bleeding disorders, as well as malignancies such as leukemias, lymphomas and solid tumors. (thenationalage.com)
  • Polymorphism of CD44 influences the efficacy of CD34(+) cells mobilization in patients with hematological malignancies. (cdc.gov)
  • Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant. (uchicago.edu)
Post-transplant cyclophosphamide2
  • Low-dose post-transplant cyclophosphamide (PTCy) in conjunction with anti-thymocyte globulin (ATG) appears as a potentially effective graft-versus-host disease (GVHD) prevention strategy in haploidentical hematopoietic cell transplant (haplo-HCT). (biomedcentral.com)
  • In this month's Pharmacy SIG Literature Update: Impact of anti-T-lymphocyte globulin dosing on GVHD in MUD SCT, impact of MRD status before alloHCT on outcomes in secondary AML, low-dose post- transplant cyclophosphamide with low-dose antithymocyte globulin for prevention of GVHD in MUD SCT and more. (astct.org)
Outcomes6
  • Currently, there is little information about the effects of MRD on transplant outcomes in haplo-SCT settings. (biomedcentral.com)
  • There may be differences in the anti-leukemia effects of haplo-SCT vs. MSDT [ 21 ], so this study investigated both the asso ciation of MRD status with outcomes in haplo-SCT and MDST settings and also possible differences in the transplant outcomes of patients with positive pre-MRD (as determined by MFC) who underwent haplo-SCT versus MDST. (biomedcentral.com)
  • An important and unanswered question concerns the impact of the number of conventional AML chemotherapy induction cycles to achieve first complete remission on transplant outcomes. (ascopost.com)
  • However, several transplant registry studies in United States and Europe have confirmed comparable survival outcomes between matched unrelated and haploidentical transplants. (mhmedical.com)
  • 12 months = 0) was generated as an approach to classify patients into different risk categories in the purpose to provide guidance to the transplant physician to inform the outcomes to potential patients undergoing 2nd HCT. (biomedcentral.com)
  • This study analyzed the clinical outcomes of 119 pediatric acute leukemia patients who underwent haploidentical HSCT ( n =68) or human leukocyte antigen (HLA)-matched HSCT ( n =51). (blood-genomics.com)
Hematopoietic cell transplant5
  • Immune Reconstitution and Severity of COVID-19 among Hematopoietic Cell Transplant Recipients. (mdanderson.org)
  • Total marrow and lymphoid irradiation may allow a greater dose of radiation to be delivered to the bone marrow as a preparative regimen before hematopoietic cell transplant while causing less side effects to normal organs than standard total body irradiation. (survivornet.com)
  • In a newly reported study, an experimental antibody treatment largely prevented gastrointestinal acute graft versus host disease (GI-aGVHD) in the intestines of mice and non-human primates (NHPs) given a bone marrow transplant-allogeneic hematopoietic cell transplant (allo-HCT)-but without causing broad immune suppression. (genengnews.com)
  • The Hematopoietic Cell Transplant Comorbidity Index predicts survival after allogeneic transplant for nonmalignant diseases. (seattlechildrens.org)
  • Clinicopathologic features of late-onset veno-occlusive disease/sinusoidal obstruction syndrome after high dose intravenous busulfan and hematopoietic cell transplant. (uchicago.edu)
Donors6
  • This may also be complementary to the approach of haploidentical adult stem cell transplants, which involve donors from a close but still mismatched family member. (scitechdaily.com)
  • With rapidly emerging advances in the use of alternative donors, such as mismatched unrelated, cord blood and haploidentical donors, it is now possible to find a potential donor for almost all patients in whom an allograft is indicated. (nih.gov)
  • Donor choice may be further complicated by other important factors, such as urgency of transplant, the presence of alloantibodies, the disease status (homozygosity or heterozygosity) of sibling donors affected by inherited disorders and the cytomegalovirus serostatus of patient and donor. (nih.gov)
  • Younger donors, male donors, fathers rather than mothers, and first-degree to second-degree donors are preferred graft sources for recipients of haploidentical transplants. (mhmedical.com)
  • Donors were HLA-matched related (n = 4), HLA-matched unrelated (n = 16), HLA-haploidentical (n = 2), or HLA-mismatched unrelated (n = 8). (cardiff.ac.uk)
  • For patients lacking matched sibling donors, haploidentical donors are an option. (blood-genomics.com)
20221
  • A 48-year-old Colombian female, Caucasian, without relevant personal or familiar medical history, who had been diagnosed with early T cell precursor ALL, with high-risk criteria due to her age and malignancy subtype who was initially treated with the PETHEMA ALL AR 2011 protocol, and with prophylactic intrathecal chemotherapy, starting in January of 2022. (springeropen.com)
Patients with relapsed or refractory1
  • Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas. (uchicago.edu)
Matched unrelated donor transplants1
Blood and marrow1
  • This work represents a path forward by demonstrating the ability to reliably expand adult stem cells from umbilical cord blood in the laboratory without terminally differentiating the cells into more mature and relatively short-lived blood cells," says Joseph McGuirk, MD, professor of medicine and medical director of blood and marrow transplant at the University of Kansas Health System, who was not directly involved with the study. (scitechdaily.com)
Pediatric4
  • Maillard, together with co-senior and co-corresponding author Leslie S. Kean, MD, PhD, a professor of pediatrics at Harvard Medical School and director of pediatric stem cell transplant at Dana-Farber/Boston Children's Cancer and Blood Disorders Center, and lead author Victor Tkachev PhD, an assistant professor of surgery at Mass General Brigham, have long sought to prevent this fatal complication. (genengnews.com)
  • We are one of the few teams in the country to have completed more than 100 Pediatric bone marrow transplants. (thenationalage.com)
  • Dr. Monica Thakar is a pediatric bone marrow transplant physician with expertise in treating children and young adults with leukemia, lymphoma, and a wide variety of non-malignant diseases with particular focus on primary immune deficiencies. (seattlechildrens.org)
  • The study suggests that haploidentical HSCT shows comparable OS, LFS, and GRFS to HLA-matched HSCT in pediatric patients with acceptable complications, and can therefore be recommended as an effective alternative for this population. (blood-genomics.com)
GVHD7
  • Describe and characterize cytokine release syndrome (CRS) post-haploidentical HCT with TMLI as conditioning regimen and PTCy as GvHD prophylaxis as assessed by incidence, frequency and severity. (survivornet.com)
  • The study, headed by researchers at Penn Medicine and Dana-Farber/Boston Children's Cancer and Blood Disorders Center, demonstrated that antibody blockade of the Notch signaling pathway improved post-transplant survival and protected against gastrointestinal GVHD in particular. (genengnews.com)
  • We found that just a single dose of antibodies to block the Notch signaling pathway, given immediately before the transplant, was able to prevent gastrointestinal GVHD, without impairing immune function in the rest of the body," said Ivan Maillard, MD, PhD, a professor of Medicine and vice chief for research in hematology-oncology at the Perelman School of Medicine at the University of Pennsylvania. (genengnews.com)
  • And even when a bone marrow transplant is curative for leukemia or lymphoma, GVHD-in which T cells in the donor graft attack the recipient's own tissues-can still be fatal. (genengnews.com)
  • The donor's cells are not as well matched to the patient's cells as in a standard allogeneic transplant, which increases the risk of complications such as graft-versus-host disease (GVHD) and graft rejection. (vanyahealth.com)
  • Patterns and kinetics of T-cell chimerism after allo transplant with alemtuzumab-based conditioning: mixed chimerism protects from GVHD, but does not portend disease recurrence. (uchicago.edu)
  • The 3-year probability of total chronic graft-versus-host disease (GVHD) was 21.4% and 34.1% in the haploidentical and HLA-matched HSCT groups, respectively ( P =0.526). (blood-genomics.com)
Stem cells12
  • The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
  • The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
  • Total body irradiation is a form of radiotherapy that involves irradiating the patient's entire body in an attempt to suppress the immune system, prevent rejection of the transplanted bone marrow and/or stem cells and to wipe out any remaining cancer cells. (survivornet.com)
  • Adult stem cells from umbilical cords are more likely to be a match for more people because there are fewer compatibility requirements than for a bone marrow transplant. (scitechdaily.com)
  • In this type of transplant, the patient's own stem cells are collected before the high-dose chemotherapy and/or radiation therapy is given. (vanyahealth.com)
  • In this type of transplant, stem cells are taken from a donor (usually a close relative or sibling) and given to the patient. (vanyahealth.com)
  • The donor's stem cells will engraft in the patient's bone marrow and start producing new blood cells. (vanyahealth.com)
  • Cord blood transplant is a type of allogeneic transplant that uses stem cells from the umbilical cord of a newborn baby. (vanyahealth.com)
  • Cord blood transplants are an alternative to using stem cells from a matched adult donor. (vanyahealth.com)
  • The main advantage is that cord blood cells are less mature than adult stem cells, which makes it less likely for the patient's immune system to reject the transplant. (vanyahealth.com)
  • However, cord blood units often have fewer stem cells than a bone marrow or peripheral blood transplant, which can increase the time it takes for the patient's blood counts to recover. (vanyahealth.com)
  • The immune system cells come from the bone marrow where they grow from special cells called stem cells. (zhihuiya.com)
Recipients4
  • Interleukin-10 gene polymorphism in bone marrow transplant recipients. (cdc.gov)
  • Influence of ABCB1, CYP3A4*18B and CYP3A5*3 polymorphisms on cyclosporine A pharmacokinetics in bone marrow transplant recipients. (cdc.gov)
  • BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants. (uchicago.edu)
  • Pilot study of comprehensive geriatric assessment (CGA) in allogeneic transplant: CGA captures a high prevalence of vulnerabilities in older transplant recipients. (uchicago.edu)
Clinical4
  • The results of the large phase 3 randomized Bone and Marrow Transplant Clinical Trials Network multicenter clinical trials were reported recently confirming superiority of haploidentical transplant over double cord transplant in terms of improved overall survival and decreased NRM. (mhmedical.com)
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
  • Duncan is a laboratory and clinical haematologist and medical director of the Bone Marrow Transplant Laboratory at Fiona Stanley Hospital in Perth. (anztct.org.au)
  • Duncan has been a principle investigator on numerous allogeneic transplant clinical trials and is immediate past co-chair of the ALLG bone marrow transplant and cellular therapies group. (anztct.org.au)
Disorders1
  • This development could make these cells available to more people, and be more readily accepted in those who undergo adult stem cell treatments for conditions such as leukemia, blood disorders, immune system diseases, and other types of cancers, but who do not have an appropriate available bone marrow match. (scitechdaily.com)
Myeloid2
  • Clonal hematopoiesis is frequently present, and there is a risk of progression to a myeloid malignancy. (merckmanuals.com)
  • Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant. (uchicago.edu)
Immune system1
  • Patients who have had a bone marrow transplant are at an increased risk of infections due to the suppression of their immune system. (vanyahealth.com)
Biopsy3
Aplastic6
  • Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (merckmanuals.com)
  • The term aplastic anemia commonly implies a panhypoplasia of the bone marrow with cytopenias in at least two hematopoietic lineages. (merckmanuals.com)
  • Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). (medscape.com)
  • Paul Ehrlich introduced the concept of aplastic anemia in 1888 when he reported the case of a pregnant woman who died of bone marrow failure. (medscape.com)
  • Aplastic anemia is diagnosed with blood and bone marrow studies. (medscape.com)
  • These findings are observed in aplastic anemia and in other marrow-failure states and are often proportional to the macrocytosis. (medscape.com)
Cell Ther1
Retrospective1
  • The role of allogeneic transplant for adult Ph+ ALL in CR1 with complete molecular remission: a retrospective analysis. (wustl.edu)
Cytokine2
  • Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
  • The treatment options for disease relapse after HCT include withdrawal of immune suppression, chemotherapy, second allogeneic transplant, cytokine and adoptive cell therapy and donor lymphocyte infusion [ 1 ]. (biomedcentral.com)
HSCT2
  • Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
  • Analysis of the 3-year cumulative recurrence rate suggested no significant difference between the haploidentical HSCT group and HLA-matched HSCT group (cumulative incidence, 32.7% vs. 31.2%, P =0.801). (blood-genomics.com)
Umbilical2
  • Therefore, for any specific patient, the transplant physician may be faced with a myriad of potential choices, including decisions concerning which donor to prioritize where there is more than one, the optimal selection of specific umbilical cord blood units and which conditioning and graft-versus-host disease prophylactic schedule to use. (nih.gov)
  • 1999). First identified and isolated from the bone marrow (BM), MSCs can now be expanded from a variety of other tissues including adipose tissue (AT), umbilical cord blood (UCB), skin, tendon, muscle, and dental pulp (Im et al. (pdffox.com)
Oncologist1
  • With the opening of such ultramodern clinic, the residents of Ahmadabad and nearby areas will benefit from best paediatric services for Bone Marrow transplant expertise consultations for the children.Dr. Rishab Bharadwaj is a consultant Paediatric Haemato - Oncologist and Bone Marrow transplant physician. (thenationalage.com)
Refractory1
  • Feasibility of clofarabine cytoreduction before allogeneic transplant conditioning for refractory AML. (uchicago.edu)
Paediatric2
  • RIMC is the largest hospital having dedicated liver intensive care units in the country, world's 2nd largest liver transplant Centre, Now have come together for launching the Paediatric Bone Marrow Transplant clinic, which is no less than a boon to the Ahmadabad City. (thenationalage.com)
  • Our Liver transplant team and Bone Marrow transplant team headed by Prof. Rela, who has over 30 years of experience & has personally done more than 5000 paediatric liver transplants. (thenationalage.com)
Cytopenias1
  • Purpose Deficiency of adenosine deaminase 2 (DADA2) is an inherited inborn error of immunity, characterized by autoinflammation (recurrent fever), vasculopathy (livedo racemosa, polyarteritis nodosa, lacunar ischemic strokes, and intracranial hemorrhages), immunodeficiency, lymphoproliferation, immune cytopenias, and bone marrow failure (BMF). (cardiff.ac.uk)
Versus1
  • 0.5 x 109 cells/kg and being transplanted in CR1 versus CR/PR from second-line therapy were identified as independent predictors for OS and PFS. (astct.org)
Renal Failure1
  • Allogeneic stem cell transplant in renal failure: engraftment and prolonged survival, but high incidence of neurologic toxicity. (uchicago.edu)
Busulfan3
  • Adding venetoclax to fludarabine/busulfan RIC transplant for high risk MDS and AML is feasible, safe, and active. (harvard.edu)
  • Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive disease. (uchicago.edu)
  • To create space in the bone marrow, patients are given two drugs, Campath-1H and busulfan. (zhihuiya.com)
Relapse5
  • I. Estimate overall survival (OS), cumulative incidences of relapse/disease progression, and non-relapse mortality (NRM) in each arm at 100 days, and 1 year post-transplant. (survivornet.com)
  • Estimate rate of relapse and non-relapse mortality (NRM) at 1 year post-transplant. (survivornet.com)
  • V. Cellular and molecular assessment of TMLI effect on bone marrow environment and TMLI effect on the engraftment and disease relapse. (survivornet.com)
  • Predictors for survival after transplant relapse. (uchicago.edu)
  • Second allogeneic hematopoietic stem cell transplant (HCT) remains as an option for disease relapse after initial HCT. (biomedcentral.com)
Half matched2
  • Dr Deenadayalan, said "We believe all patients should be offered a stem cell donor, which is why we are pioneering haploidentical (half matched) transplants. (thenationalage.com)
  • Haploidentical transplant, also known as half-matched transplant, is a type of allogeneic transplant where the donor and the recipient are not a perfect match but share one haplotype (half of the genetic material) in common. (vanyahealth.com)
Leukemia1
  • We present a case of 48-year-old female patient with acute lymphoblastic leukemia, stem cell transplant candidate, who developed a fever with lymphadenopathy and lung nodules, consistent with paracoccidioidomycosis infection, in whom a myeloperoxidase deficiency was later discovered. (springeropen.com)