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  • grafts
  • While peripheral blood grafts may seem to be logistically easier to collect, as a bone marrow harvest requires multiple needle puncture in the pelvic bone in an operating room under anesthesia, it requires five days of growth factor injections and 6-12 hours on an apheresis machine. (oncologynurseadvisor.com)
  • Infection
  • IL-7 as an immunotherapy agent has been examined in many pre-clinical animal studies and more recently in human clinical trials for various malignancies and during HIV infection. (wikipedia.org)
  • cells
  • 1989) Structure of the gene of tum-transplantation antigen P91 A: the mutated exon encodes a peptide recognized with Ld by cytolytic T cells. (springer.com)
  • At Mary Imogene Bassett, he began to study rodents that received lethal doses of radiation who were then saved by an infusion of marrow cells. (wikipedia.org)
  • IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. (wikipedia.org)
  • Acute erythroid leukemias can be classified as follows: 50% or more of all nucleated bone marrow cells are erythroblasts, dyserythropoiesis is prominent and 20% or more of the remaining cells (non- erythroid) are myeloblasts. (wikipedia.org)
  • These cells may constitute 90% or more of the marrow elements. (wikipedia.org)
  • Remissions were brief, but the principle was clear - antifolates could suppress proliferation of malignant cells, and could thereby re-establish normal bone-marrow function. (wikipedia.org)
  • Several years later at the National Cancer Institute, Roy Hertz and Min Chiu Li then demonstrated complete remission in women with choriocarcinoma and chorioadenoma in 1956, discovering that methotrexate alone could cure choriocarcinoma (1958), a germ-cell malignancy that originates in trophoblastic cells of the placenta. (wikipedia.org)
  • cancer
  • Fanconi anemia (FA) is an inherited bone marrow failure syndrome characterized by chromosomal fragility, progressive marrow failure, and cancer predisposition. (bloodjournal.org)
  • Wright's group were the first to demonstrate use of the drug in solid tumors, as opposed to leukemias, which are a cancer of the marrow. (wikipedia.org)
  • study
  • The goal of this study is to determine what causes some children to have different drug concentrations of fludarabine in their bodies and if drug levels are related to whether or not a child experiences severe side-effects during their bone marrow transplant. (ucsf.edu)
  • clinical
  • BPDCN are characterized by co-expression of CD4 and CD56 antigens in the absence of any specific myeloid or lymphoid lineage or markers, primary skin infiltrations followed by bone marrow involvement, and aggressive clinical course. (czytelniamedyczna.pl)
  • In this paper we report two cases of BPDCN diagnosed in our center with objective to increase clinical awareness for these rare and aggressive malignancies that seem to be underdiagnosed in Poland. (czytelniamedyczna.pl)
  • The center is staffed by nationally and internationally recognized experts who have made major clinical and research advances in the treatment of childhood malignancies. (wikipedia.org)
  • clonal
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • Cancer
  • However, the cited gene changes can go awry in plasma cells by, for example, placing a gene that ordinarily controls cell growth adjacent to the normally highly active antibody gene promotor thereby creating a cancer-causing oncogene or, more commonly, by forming extra chromosomes (see trisomy) or chromosomes that have deleted or repetitive sections, any of which such changes may promote malignancy in more complex and less well understood ways. (wikipedia.org)
  • Current research programs include molecular oncology, tumor cell biology, developmental therapeutics, cancer genetics and genomics, cell and gene therapy, transplantation biology, tumor immunology and neuro-oncology. (wikipedia.org)
  • lesions
  • Clinically, the typical initial presentation of BPDCN is presence of asymptomatic cutaneous lesions that are subsequently followed by bone marrow involvement and leukemic dissemination (5, 10). (czytelniamedyczna.pl)
  • cell
  • Experimental chimeras have been used to study a number of biological questions, including the origin and fate of cell lineages during embryonic development, immunological self-tolerance, tumor susceptibility, and the nature of malignancy. (thefreedictionary.com)
  • This is in contrast to Shwachman-Bodian-Diamond syndrome, in which the bone marrow defect results primarily in neutropenia, and Fanconi anemia, where all cell lines are affected resulting in pancytopenia. (wikipedia.org)
  • function
  • Regular and frequent laboratory evaluations are required to monitor kidney function, avoid drug-induced bladder complications and screen for bone marrow toxicity. (wikipedia.org)
  • Usually
  • Usually occurs in of affected organs, malignancy screening tests, in buy viagra amsterdam and serum electrolytes, creatinine, bun. (bac.edu)
  • evidence
  • 2400 U/ml (or per local reference laboratory) In addition, in the case of familial HLH, no evidence of malignancy should be apparent. (wikipedia.org)