Male wistar rats. Medical search. Frequent questions

Methods: Pharmacokinetic parameters of riluzole were determined in Wistar rats after single-dose co-administration with ciprofloxacin and grapefruit juice. (researchgate.net)
Materials and Methods: Thirty male Wistar rats were used. (usp.br)

To assess the reproductive toxicity of concoction of Andrographis paniculata in male Wistar albino rats. (ijpsr.com)
18 male Wistar albino rats were divided into 3 groups with 6 animals in each group. (ijpsr.com)
This study shows that concoction of Andrographis paniculata and Nilavembu kudineer in male Wistar albino rats, administered for 30 days, did not produce any significant adverse reproductive effects in terms of sperm count, sperm quality and testicular histology. (ijpsr.com)

Additionally, in adult F1:Fin rats, steatosis was observed in the liver (see Appendix A). (nih.gov)
It seems that treating male adult rats with finasteride causes changes in the carbohydrate metabolism in the liver of their offspring. (nih.gov)
Although HPGL is known for adult rats, information on the influence of age on HPGL is missing. (aspetjournals.org)
Eighteen adult male-specific pathogen-free Wistar rats weighing 250 g to 300 g (Chinese Academy of Medical Sciences Animal Breeding Center) were used in the experiments. (hindawi.com)
A critical defect of 8 mm was performed in 36 Wistar male adult rats that were divided into four groups. (scielo.br)
six adult male Wistar rats were deeply anesthetized (chloral hydrate 400 mg/kg) and placed in a stereotaxic apparatus. (scienceblogs.com)

This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)

The effect of dietary supplementation with garlic, ginger and cabbage at the rate of 10% of the feed on cadmium induced toxicity was investigated in male Wistar rats. (afrithings.net)
The mitigating effect of Ananas comosus (pineapple juice) extract on an aluminum-induced testicular toxicity in male Wistar rats was examined in this study. (springeropen.com)
Adequate design of juvenile toxicity studies in rats, for instance with respect to dose levels per age group, requires an understanding of age-dependent pharmacokinetics. (aspetjournals.org)
This age-dependent HPGL profile will be instrumental for hepatic drug clearance prediction when designing juvenile toxicity studies in Wistar rats. (aspetjournals.org)
Male and female Wistar rats were subjected to test acute oral toxicity. (europa.eu)
RAI rats were subjected to test acute oral toxicity. (europa.eu)
Acute inhalation toxicity of the test item has been investigated in male and female Tif: RAIf (SPF) rats (10 per sex). (europa.eu)
Acute dermal toxicity of the test item was tested in male and female Sprague-Dawley rats. (europa.eu)
Acute toxicity and diuretic studies of the roots of Asparagus racemosus in rats. (raysahelian.com)
The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. (raysahelian.com)

Female Sprague-Dawley rats were starved for 24 h and then given [14C] test substance (0.8 mg/kg) as an aqueous solution by gastric intubation. (europa.eu)
Voss C, Zerban H, Bannasch P, Berger MR. Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats. (who.int)

At the end of four weeks study period, the rats were anaesthetized and the liver and kidneys were removed for histological examination. (njbas-udus.com)

Our aim was to study neuronal transmission in hippocampal slices of male Wistar rats affected with a single dose of TMT (7.5 mg/kg, i.p.) during the first three weeks of its action. (nel.edu)
This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)

IgG and IgM IFAs were performed with wild rats passed the virus to laboratory rats, which then in- HTNV (strain 76-118)- and SEOV (strain L99)-infected fected humans. (cdc.gov)

Two doses (500 and 1000 mg kg -1 ) of the both extracts of Phyllanthus amarus were administered orally to diabetic rats. (scialert.net)
In rats orally exposed for one week to E171 at human relevant levels, titanium was detected in the immune cells of Peyer's patches (PP) as observed with the TiO 2 -NP model NM-105. (nature.com)
The present research aims to examine a periodontal disease model in which specific pathogen-free Wistar rats are orally exposed to Porphyromonas gingivalis associated with Fusobacterium nucleatum . (bvsalud.org)

Chronic unpredictable mild stress paradigm in male Wistar rats: effect on anxiety- and depressive-like behavior. (nel.edu)

In-vitro metabolic inhibition studies using rat and human liver microsomes and intestinal absorption studies of riluzole in a rat everted gut-sac model were conducted to elucidate the mechanism of interaction. (researchgate.net)
A growing body of data indicates that the physiology of the liver is sex-hormone dependent, with some types of liver failure occurring more frequently in males, and some in females. (nih.gov)
In males, in physiological conditions, testosterone acts via androgen receptors (AR) to increase insulin receptor (IR) expression and glycogen synthesis, and to decrease glucose uptake controlled by liver-specific glucose transporter 2 (GLUT-2). (nih.gov)
The study was conducted on the liver (an androgen-dependent organ) from 7, 14, 21, 28, and 90-day old Wistar male rats (F1:Fin) born by females fertilized by finasteride-treated rats. (nih.gov)

Materiais e Métodos: Foram utilizados 30 ratos machos da linhagem Wistar. (usp.br)
Randomização de 32 ratos Wistar machos em quatro grupos: Controle (CG), Exposição à Fumaça (ESG), Antioxidante (AG) e Exposição à Fumaça+Antioxidante (ESAG). (bvsalud.org)

For this, male Wistar rats ( Rattus norvegicus albinus) were randomly divided into 3 groups (n = 10/group) Control ( 0.9% saline solution ), LEV100 (100 mg/kg), and LEV300 (300 mg/kg). (bvsalud.org)
Immunoglobulin (Ig) M or IgG antibodies against the brown Norway rat ( Rattus norvegicus ) ( 4,6 ). (cdc.gov)

In conclusion, the cashew nut oil was responsible for hepatic parenchymal and matrix alteration in wistar rats administered 8.13 mL/kg of cashew nut oil. (njbas-udus.com)

In view of this and on account of the interleukin (IL)-6's role in inflammation and pain induction, this study investigated the effects of Achillea santolina extracts on inflammation which was induced by complete Freund's adjuvant (CFA) in male Wistar rats. (jcimjournal.com)

Conclusions: These results suggest that the eight-arm radial maze is involved in the induction of Trh, Tnxa, S100a9 and Nnat in hippocampus in rats. (umich.edu)
Progressive increase of lysosomal enzyme activities in hippocampus associated with reduction of population spike in a rat model of neurodegeneration. (nel.edu)
This work demonstrates a time-dependent reduction of somatic response in the hippocampus of TMT affected rats during the first three weeks. (nel.edu)
Predator odor evokes sex-independent stress responses in male and female Wistar rats and reduces phosphorylation of cyclic-adenosine monophosphate response element binding protein in the male, but not the female hippocampus. (broadinstitute.org)

Serum IL-6 level was checked by rat standard enzyme-linked immunosorbent assay specific kit. (jcimjournal.com)
The results indicated dose-related effects of methanolic extract on paw edema, hyperalgesia and serum IL-6 level reduction in rats. (jcimjournal.com)
In F1:Fin rats the serum levels of T and DHT negatively correlated with androgen receptor mRNA. (nih.gov)

The objective of the study was to obtain preliminary information on the toxic potential of the test item administered daily to Han-Wistar rats by oral gavage at three dose levels for 14 consecutive days. (europa.eu)
We used 40 male offspring from 14 Wistar rats which received purple grape juice or water by gavage daily for 42 days at a dose of 7 microliters/g. (scirp.org)

Assessment of the toxic effects of levetiracetam on biochemical, functional, and redox parameters of salivary glands in male Wistar rats. (bvsalud.org)
Therefore, the current work investigated the effects of LEV on the biochemical, functional, and redox parameters of the parotid and submandibular glands in rats . (bvsalud.org)
Based on this current study, it was evident that aluminum chloride induced oxidative stress and retarded reproduction in males whereas Ananas comosus mitigated reproduction in males by improving sperm parameters and microarchitecture of the testes. (springeropen.com)
Alshahrani S, Ahmed AF, Gabr AH, Abalhassan M, Ahmad G. The impact of body mass index on semen parameters in infertile men. (medscape.com)

Our research has also shown that the offspring of rats exposed to finasteride have an altered T-DHT ratio and show changes in their testes and epididymides. (nih.gov)
The control group was the offspring (F1:Control) of untreated Wistar parents. (nih.gov)

Male Wistar/DV rats were used in this study to assess our modified 2-week model of CMS as a combination of psychosocial, physical and metabolic stressors and to compare the effect of acute administration of venlafaxine (VFX) and diazepam (DZP), either in stress or no stress conditions. (nel.edu)

2013. Green asparagus (Asparagus officinalis) prevented hypertension by an inhibitory effect on angiotensin-converting enzyme activity in the kidney of spontaneously hypertensive rats. (raysahelian.com)

Exosomes were isolated from rat and human blood plasma by various UC and SEC conditions. (nih.gov)
Furthermore, with this method only a minor fraction of total exosomes could be isolated from blood as deduced from the constant amount of exosomal markers CD63 and TSG101 detected after serial UC of rat blood plasma samples. (nih.gov)
Muramtsu K. Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats. (sci-rep.com)
Aiming to elucidate the association between them, plasma albumin redox state was investigated in rats fed various kinds of AIN-93G-based low protein diets. (frontiersin.org)
Plasma albumin redox state was shifted to a more oxidized state in rats fed 3% casein (CN) diet than those fed 3% whey protein or 3% wheat gluten diet, while supplementing 3% CN diet with cystine reversed it to a more reduced state, indicating that cystine would complement the shortage of cysteine in CN, thereby increasing albumin synthesis rate. (frontiersin.org)
We have consecutively reported that the redox state of plasma albumin (the balance of reduced and oxidized forms of plasma albumin) is influenced by the amount of protein intake in rats ( 13 - 15 ), and the ratio of MA to total albumin correlates with the albumin fractional synthesis rate, which is also stimulated by dietary proteins ( 14 ). (frontiersin.org)
Furthermore, we have recently shown that the shift of plasma albumin redox state to an oxidized state in growing rats, induced by ingestion of a casein (CN)-based low protein (LP) diet, was ameliorated when cystine (Cyss) was added to the CN-based LP diet ( 16 ). (frontiersin.org)
Pb-intoxication increased oxidative stress in rats, while treatment with NaHS blunted increases in plasmatic MDA levels and increased antioxidant status of plasma. (hindawi.com)
In the first experiment no differences in the ChE activity in plasma (pChE) and erythrocytes (rbcChE) were found between the shocked and control rats. (aaem.pl)

Ethanolic leaf extract of Psidiumguajava: Phytochemical and trypanocidal activity in rats infected with Trypanosomabruceibrucei. (sci-rep.com)

Although the data in this field are not decisive and there are some confounding factors in human studies, it can be inferred that the use of any illicit drug with an effect on male sexual health reduces fertility potency. (magiran.com)

Zaringhalam J, Manaheji H, Mghsoodi N, Farokhi B, Mirzaiee V . Spinal mu-opioid receptor expression and hyperalgesia with dexamethasone in chronic adjuvant- induced arthritis in rats. (jcimjournal.com)

Spatial memory performance of Wistar rats exposed to mobile phone med. (emf-portal.org)

[ 2 , 3 ] In male Wistar rats injected with cocaine to produce left ventricular dysfunction, Isabelle et al prevented cocaine-related cardiomyopathy with administration of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and xanthine oxidoreductase inhibitors, thereby preventing excess production of reactive oxygen species. (medscape.com)

Introduction Prostate cancer is the most common cancer in men. (researchgate.net)

Male and female Han-Wistar rats (8-9 weeks old animals) were treated in the study for 14 consecutive days as shown below. (europa.eu)
Throughout the mating period, each female animal was paired with a predetermined male animal from the same test group. (europa.eu)
Male and female Tif. (europa.eu)
Single application of different dose levels ( up to 10 g/kg bw) of the test substance did not cause lethality in male and female Tif. (europa.eu)
To this end we tested the effect of 1.25 and 2.5 mg/kg olanzapine and 0.25 and 0.4 mg/kg risperidone using female and male Wistar rats in the CAR test. (lu.se)
Whereas there were no significant differences between the female and male. (lu.se)
Whereas there were no significant differences between the female and male rats in response to either dose of olanzapine administration, an injection of 0.4 mg/kg risperidone significantly suppressed avoidance more in female rats than in male rats. (lu.se)
In addition, we found that the estrous cycle of the female rats did not have a significant effect on the avoidance response. (lu.se)
In conclusion, we show that there are sex-specific differences as well as similarities between female and male rats in the CAR test and novel APDs should be tested on female and male rats in the future. (lu.se)
Operant conditioning of response variability in male and female Wistar rats. (bvsalud.org)

Eighteen male Wistar rats were randomly divided into sham, shock, and drainage groups. (hindawi.com)

Therefore, H 2 S pathway may be involved in Pb-induced hypertension and treatment with NaHS exerts antihypertensive effect, promotes non-NO-mediated relaxation, and decreases oxidative stress in rats with Pb-induced hypertension. (hindawi.com)
While one showed that honey increases the sperm count of male rats, the other showed that too much honey can have a negative effect on fertility in rats. (healthline.com)
Our findings evidenced the cardioprotective effect of trans- resveratrol in rats exposed to cigarette smoke. (bvsalud.org)

The total of 21 male Wistar rats aged 37 d old were divided into three groups, namely ethanol, ethanol-curcumin, and control groups. (jcimjournal.com)
Twenty male wistar rats weighing between 70g and 90g were purchased and randomly allocated into four treatment groups with graded levels of Corchorus olitorius ( 2.5%, 5% and 10%) while the control had no Corchorus olitorius . (sci-rep.com)
Twelve male Wistar rats were randomly assigned to four groups labeled I, II, III and IV (3 rats per group). (njbas-udus.com)
The maze experimental groups of rats performed the eight-arm radial maze one time per day since 7 weeks of age for 14 consecutive days, and number of the errors was counted. (umich.edu)
In order to expand our findings, male Wistar rats were divided into four groups: Saline, Pb, NaHS, and Pb + NaHS. (hindawi.com)
Male Wistar rats were randomized into four groups: Control Group (CG), Exposure to Smoke Group (ESG), Antioxidant Group (AG) and Exposure to Smoke plus Antioxidant Group (ESAG). (bvsalud.org)

men present a decrease in sperm quality, testicular cancer and reproductive tract anomalies (Jégou et al. (ivis.org)

Dosimetry models for the lower respiratory tract (LRT) of humans and rats are used to calculate deposition and retention using the principle of particle mass balance in the lower respiratory tract. (cdc.gov)
Realistic asymmetric lung geometries using detailed morphomet- ric measurements of the tracheobronchial (TB) airways in rats and humans are employed in model calculations. (cdc.gov)
Dose metrics based on the deposited mass per unit area in small and large airways of the TB region indicate HECs of 1 to 5 times those of rats: that is, an equivalent exposure to humans which would achieve the same internal dose as in the rat would be 1 to 5 times greater. (cdc.gov)
Transmission of hantaviruses among rodents and from also identifi ed in laboratory rats, which were used by these rodents to humans generally occurs through inhalation of students for their scientifi c research. (cdc.gov)
HFRS outbreaks have occurred showed that partial small segment sequences recovered among farmers and workers during close contact with in- from humans, laboratory rats, and local wild rats belonged fected rodents in disease-endemic areas. (cdc.gov)
Hantavirus sequences recovered from humans tions have also occurred among technicians and researchers and laboratory rats clustered within 1 of 3 lineages of SEOV after handling laboratory rodents. (cdc.gov)

Our study showed that four weeks following infection with Porphyromonas gingivalis and Fusobacterium nucleatum bone loss in Wistar rats could be identified. (bvsalud.org)

however, revealed some hepatocyte morphological lesions including mild microvesicular steatosis, kupffer cell hyperplasia, shrinkage of glomeruli, glomerular distortion, necrotic renal tubules, severe congestion and atrophy of renal tubules in rats fed 8.13mL/kg of the nut oil. (njbas-udus.com)

Effects of stress pretreatment on the dynamics of blood cholinesterase activity after exposure to an organophosphorus pesticide in the rat. (aaem.pl)
Surprisingly, in rats subjected to a single series of inescapable electric footshocks (60 10 msec triplets of 3.0 mA, 2 msec, square pulses during 20 min - IF ) two weeks prior to the CVP exposure, these effects are not observed. (aaem.pl)

Fourteen days after the beginning of treatment, males and females from the same test group were mated for a maximum of 2 weeks. (europa.eu)
The duration of treatment covered a 2-week pre-mating and mating period in both sexes, approximately 1 week post-mating in males, and the entire gestation period as well as 4 days of lactation in females followed by an additional treatment until one day before sacrifice. (europa.eu)

0.001) for rat pups until 3 weeks of age compared with adults. (aspetjournals.org)

The control group was given rat pellets and distilled water. (springeropen.com)

The feed intakes as well as weight change of the experimental rats were monitored for eight weeks. (sci-rep.com)

The purpose of this review was to collect as much literature as possible about the impact of illicit drugs on male fertility and summarize their valuable data. (magiran.com)
Honey has been lauded for its potential to boost fertility in both men and women, but the evidence is mixed. (healthline.com)

TMT administration to rats, we found a time-dependent reduction of postsynaptic neuronal firing, expressed by diminished population spike (PoS) amplitude recorded in the stratum pyramidale accompanied with marked increase in specific activity of NAGA to respective 111%, 163% and 252% in the 1st, 2nd and 3rd week compared to unaffected rats. (nel.edu)

Therefore, it can be concluded that leaves of Corchorus olitorius are palatable and highly nutritious and can improve growth performance of rats when fed for eight weeks. (sci-rep.com)

The treatment was carried out daily for one month, after which the motor coordination performance of the rats was examined using revolving drum apparatus at test days 1, 8, and 15. (jcimjournal.com)

Two separate studies using rats, conducted in Nigeria in 2013, give very different results. (healthline.com)
Our results indicated that rat BMSC produce BDNF, at least until passage number 12. (sld.cu)
Infertility as a proxy of general male health: results of a cross-sectional survey. (medscape.com)
These results that contact with hantavirus-infected laboratory rats caused suggest that the HFRS outbreak in Shenyang was caused a HFRS outbreak among 13 doctors and 1 veterinarian at by SEOV that was circulating among local wild rats and had medical research institutions in Japan ( 8 ). (cdc.gov)

Almost all studies suggested that taking all kinds of illicit drugs with the effects on different parts of the male reproductive system can result in subfertility or complete infertility in the consumers. (magiran.com)
Petersen PM, Skakkebaek NE, Vistisen K, Rørth M, Giwercman A. Semen quality and reproductive hormones before orchiectomy in men with testicular cancer. (medscape.com)
Association Between Use of Marijuana and Male Reproductive Hormones and Semen Quality: A Study Among 1,215 Healthy Young Men. (medscape.com)

The rat studies referenced for the MRL derivation are well described. (cdc.gov)
Prior studies have shown that it is necessary to place ligatures around molars to study periodontal destruction in rats. (bvsalud.org)

In the present study, pharmacokinetics of CIP following IN and IV administration to rats was investigated and compared. (researchgate.net)
Although, in clinical practice, IV administration of CIP is not recommended for routine use in the management of CRS, this route was herein chosen because oral bioavailability of CIP is only around 20% in rats (Hwang et al. (researchgate.net)
A well characterized animal model of Parkinson's disease is the unilateral destruction of the dopaminergic pathway in rats by administration of 6-hydroxydopamine (6-OHDA) ( Ungerstedt and Arbuthnott, 1970 ). (jneurosci.org)
In the stratum radiatum, reduction of the slope of excitatory postsynaptic potential was not time-dependent but almost constantly reduced from the 1st to 3rd week after TMT administration (55-60%) compared to control rats. (nel.edu)

The aim of this study was to evaluate the biosafety of Anacardium occidentale (cashew) nut oil using male Wistar rats as model. (njbas-udus.com)
The PBPK rat model by Chan (2006) is helpful and provides a very good description of the processes although these are no species extrapolation and no risk assessment tools applied to this model. (cdc.gov)
In the 6-hydroxydopamine model of Parkinson's disease in the rat, there is a significant reduction in the number of dendritic spines on the principal projection neurons in the neostriatum, presumably attributable to loss of the nigrostriatal dopamine input. (jneurosci.org)

Anatomy35

Organisms11

Diseases36

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Psychiatry and Psychology10

Phenomena and Processes39

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture3

Health Care4

Methods2

Albino3

Adult6

Oxidative stress in rats exposed1

Toxicity10

Sprague-Dawley2

Histological1

Hippocampal2

Strain1

Orally3

Behavior1

Liver4

Machos2

Rattus2

Hepatic1

Inflammation1

Hippocampus4

Serum3

Gavage2

Parameters4

Offspring2

Acute1

Kidney1

Plasma9

Leaf extract1

Reduces1

Chronic1

Spatial memory1

Cocaine1

Prostate1

Female10

Randomly divided1

Effect3

Groups6

Sperm1

Humans6

Bone1

Lesions1

Exposure2

Females2

Pups1

Control group1

Experimental1

Fertility2

Neuronal1

Weeks1

Apparatus1

Results4

Reproductive3

Studies2

Administration4

Model3