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  • Prostate Cancer
  • Prostate cancer (PCa) is the most commonly diagnosed male cancer and the second leading cause of cancer-related death for men in the United States. (cuny.edu)
  • These regulatory changes collectively result in decreased prostate size and function, which can be beneficial to men suffering from benign prostatic hyperplasia (BPH) and could play a role in prostate cancer. (jove.com)
  • New therapies for two common prostate diseases, prostate cancer (PrCa) and benign prostatic hyperplasia (BPH), depend critically on experiments evaluating their hormonal regulation. (jove.com)
  • Progress in prostate cancer research is severely limited by the availability of human-derived and hormone-na├»ve model systems, which limit our ability to understand genetic and molecular events underlying prostate disease initiation. (jove.com)
  • Diagnosis
  • These studies have resulted in major advances in the understanding of the microbiology of the causative organisms, the methods of diagnosis, the clinical course of disease, and the complexities of treatment. (unlv.edu)
  • Benign Prostatic
  • The purpose of this project is to evaluate the safety, efficacy, and feasibility of performing prostatic artery embolization (PAE) using endovascular techniques and particle embolics in men suffering from lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). (clinicaltrials.gov)
  • Bacterial
  • Here, we describe our protocols for standardizing the bacterial inoculum 7 as well as the procedure for catheterizing anesthetized male mice for instillation of bacteria. (jove.com)
  • Processes
  • Migration is a key property of live cells and critical for normal development, immune response, and disease processes such as cancer metastasis and inflammation. (jove.com)
  • Injury
  • In order to study human acute lung injury and pneumonia, it is important to develop animal models to mimic various pathological features of this disease. (jove.com)
  • This clinically relevant animal model is suitable for studying pathology, mechanism of repair, following acute lung injury, and also can be used to test potential therapeutic agents for this disease. (jove.com)
  • hereditary
  • The acropnym men also stands for multiple endocrine neoplasia, a hereditary condition that involves benign and malignant tumors of various glands. (healthtap.com)
  • Cancer
  • Surgical resection is an essential treatment for most cancer patients, but surgery induces dysfunction in the immune system and this has been linked to the development of metastatic disease in animal models and in cancer patients. (jove.com)
  • The current challenge is to identify safe and promising immunotherapies in preclinical mouse models and to translate them into viable perioperative therapies to be given to cancer surgery patients to prevent the recurrence of metastatic disease. (jove.com)
  • Orthotopic mouse models of colorectal cancer, which feature cancer cells growing in their natural location, replicate human disease with high fidelity. (jove.com)
  • The majority of cancer-related deaths occur subsequent to the development of metastatic disease. (jove.com)
  • Type
  • The discoveries in the late 1960s that two types of herpes simplex virus infected humans, and that type 1 caused the majority of oral infections and type 2 the majority of genital infections (2, 3), were landmarks that catalyzed subsequent epidemiologic studies and confirmed the belief that genital herpes was a sexually transmitted disease. (unlv.edu)
  • rats
  • Furthermore, surgery has been carried out almost exclusively in male rats of different strains and ages. (jove.com)
  • There are two distinct isoforms of 5aR in male humans and rats, and thus developing a 5aR inhibitor is a challenging pursuit. (jove.com)
  • sexually
  • Herpes simplex virus infection of the human genital tract is a sexually transmitted disease which in the past 25 years has received a great deal of careful scientific study (1). (unlv.edu)
  • Screening for sexually transmitted diseases in short-term correctional institutions: summary of evidence reviewed for the 2010 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines. (umassmed.edu)
  • Sexually Transmitted Diseases, 6 (2 Suppl), 103-111. (unlv.edu)
  • antioxidants
  • The purpose of this study is to determine whether antioxidants (vitamin E, selenium and lycopene)can change(reduce)prostate tumor size or blood flow to the prostate as determined by MRI imaging among men on Active Surveillance. (clinicaltrials.gov)
  • Human
  • Toward developing better model systems for studying human prostate carcinogenesis, we and others have taken advantage of the unique pro-prostatic inductive potential of embryonic rodent prostate stroma, termed urogenital sinus mesenchyme (UGSM). (jove.com)