Male and female Harlan Sprague-Dawley rats and B6C3F1 mice were administered TCAB (at least 97.8% pure) in corn oil:acetone (99:1) by gavage for 3 months (rats only) or 2 years. (nih.gov)
For the adh-dependent oxidation of racemic butenediol in liver cytosol of male b6c3f1 mice, male sprague-dawley rats and three humans, saturation kinetics were found. (dakne.co)
Mice7
We investigated the toxicokinetics and bioavailability of bisphenol AF (BPAF) in male and female Harlan Sprague Dawley rats and B6C3F1/N mice following a single gavage administration of 34, 110, or 340 mg/kg. (rti.org)
The ECFP transgenic mouse strain was maintained by mating homozygous ECFP male and female mice. (bakingandbakingscience.com)
Male and female Sprague Dawley rats and B6C3F1/N mice were exposed from gestation day 5 or postnatal day 35, respectively, to code division multiple access (CDMA) or global system for mobile (GSM) modulations semi-continuously for 18 h/day in 10 min intervals in reverberation chambers at specific absorption rates (SAR) of 1.5, 3, or 6 W/kg (rats) or 2.5, 5, or 10 W/kg (mice). (saferemr.com)
DNA damage was significantly increased in the frontal cortex of male mice (both modulations), peripheral leukocytes of female mice (CDMA only), and hippocampus of male rats (CDMA only). (saferemr.com)
The IFNAR1KO rescues spatial memory and ameliorates loss of presynaptic terminals preferentially in female HIVgp120tg mice. (biomedcentral.com)
In this paper, we report the beneficial effects of CLA and EX on bone, in four different groups of Balb-C young, male mice. (biomedcentral.com)
In conclusion, CLA increases bone mass in both cancellous and cortical bones, and the effects of CLA on bone is not further improved by EX in pure cortical bone of young male mice. (biomedcentral.com)
Oral toxicity study1
In an acute oral toxicity study performed according to OECD Guideline 423 and in compliance with GLP, groups of Sprague Dawley rats were given a single oral (gavage) dose of the test substance at 2000 mg/kg bw (3 females) followed by 300 mg/kg bw (6 females). (europa.eu)
Strain2
The EGFP transgenic mouse strain was maintained by mating a male hemizygous carrier with a female C57BL/6J mouse. (bakingandbakingscience.com)
According to further acute oral toxicity supporting studies in Sprague-Dawley strain rats according to OECD401 conducted by Safepharm in 1992 and 1994, the LD50 was found to be greater than 2000 mg/kg bw. (europa.eu)
Acute oral toxicity1
In the acute oral toxicity key study in female Crl:WI (SPF) rats, following the acute toxic class method in accordance with the OECD Guideline 423, the LD50 was established to be 500 mg/kg bw on basis of LD50 cut off mg/kg bw, because three animals died in 2000 mg/kg bw at first step (Toxicoop, 2017). (europa.eu)
Toxicity1
Because it is expected that more in vivo dose-response curves for developmental toxicity of than 20% of the laboratory animals needed for REACH will be the parent glycol ethers in rat and man. (cdc.gov)
Oxon1
Diet: A pelleted diet (Rodent 2018C Teklad Global Certified Diet, Harlan Laboratories U.K. Ltd., Oxon, UK) was used and was available ad libitum. (europa.eu)
Increasing dose1
EROD activities in the lung generally increased with increasing dose and were significantly greater in all treated groups of males and females compared to their respective vehicle controls. (nih.gov)
LD501
Under the test conditions, the oral LD50 for ZnDMA was 500 mg/kg bw in female rats. (europa.eu)
Liver4
There were no statistically significant differences in the BrdU labeling indices in the liver of males or females exposed to TCAB compared to their respective vehicle controls. (nih.gov)
At the end of the 3-month study, absolute and relative liver weights were significantly greater than those of the vehicle controls in all dosed groups of males and in females administered 10 mg/kg or greater. (nih.gov)
Significant dose-dependent changes were found in alkaline phosphatase and cholesterol for the male and female rats, indicating that exposure to more than 125 mg/kg of silver nanoparticles may result in slight liver damage. (biomedcentral.com)
The target organ for the silver nanoparticles was found to be the liver in both the male and female rats. (biomedcentral.com)
Study6
All male and female rats survived to the end of the study. (nih.gov)
A number of females that died during the study were partially cannibalised. (europa.eu)
Sixteen rats (eight male, eight female) were euthanized at the termination of the study and necropsied. (europa.eu)
The purpose of this study was, therefore, to evaluate the effects of a long term treatment with orntide, a GnRH antagonist, on testosterone levels and fertility in male rats. (biomedcentral.com)
This study demonstrates detrimental mitochondrial and muscular outcomes in the adult male rat exposed to postnatal hyperoxia. (frontiersin.org)
0.05) in the body weight of male rats after 4 weeks of exposure, although there were no significant changes in food or water consumption during the study period. (biomedcentral.com)
Mortality1
There was a decreased level of mortality in the females at 1310 mg/kg bw compared to the two lower doses and to males at the same dose. (europa.eu)
Mated females were housed individually during gestation and lactation, in solid floor polypropylene cages with stainless steel mesh lids and softwood flakes. (europa.eu)
Last year, the fiscal year 2018 NDAA reported by the Senate Committee on Armed Services and ultimately approved by the Senate included provisions that would have individually and collectively restricted, if not outright prohibited, medical research on diseases and disorders that affect our nation's men and women who serve or have served in the U.S. Armed Services. (veteransforcommonsense.org)
Significantly7
Terminal mean body weights of males were not significantly different from vehicle controls in any group. (nih.gov)
Terminal mean body weights of females administered 10 mg/kg or greater were significantly less than those of the vehicle controls. (nih.gov)
Mean body weight gains of all dosed groups of females were significantly less than those of the vehicle controls. (nih.gov)
Absolute and relative lung weights were significantly greater in 100 mg/kg males and 3 mg/kg or greater females. (nih.gov)
Absolute and relative right kidney and spleen weights were generally significantly greater for all dosed groups of males. (nih.gov)
Absolute thymus weights of 10 mg/kg or greater males and absolute and relative thymus weights of 1 mg/kg or greater females were significantly less than those of the vehicle controls. (nih.gov)
Sixty download, techniqueFwu-Hsing, Harlan Sprague-Dawley participants( Rattus norvegicus) introduced continuously and significantly programmed into 4 abuse days( ie, DFDBA at 1 involvement, 2 preservation, and 3 system to 6 computation $'000 calcium grants and FDBA at 23 provision subject t) and a department program( no threshold). (mcephotography.com)
ANIMALS3
After recovery of normal serum testosterone levels in the treated animals, each rat was housed with two proven breeder, but drug-naive, females. (biomedcentral.com)
Irrespective of the actual and their embryotoxic alkoxyacetic acid metabolites in rat and number of laboratory animals required for REACH, the man. (cdc.gov)
During the mating phase, animals were transferred to polypropylene grid floor cages suspended over trays lined with absorbent paper on a one male: one female basis within each dose group. (europa.eu)
Cages1
Following evidence of successful mating, the males were returned to their original cages. (europa.eu)
Groups5
groups of 10 male and 10 female rats received the corn oil:acetone vehicle alone. (nih.gov)
Significant induction of hepatic 7-ethoxyresorufin-O-deethylase (EROD) and 7-pentoxyresorufin-O-deethylase activities was observed in all dosed groups of males and females. (nih.gov)
Significant induction of hepatic acetanilide-4-hydroxylase activity was observed in males exposed to 3 mg/kg or greater and all treated groups of females. (nih.gov)
Two groups of male rats received either 120-day orntide microspheres (8.8 mg orntide/kg/120 days) or vehicle alone (control group). (biomedcentral.com)
Five-week-old rats, weighing about 99 g for the males and 92 g for the females, were divided into four 4 groups (10 rats in each group): vehicle control, low-dose (30 mg/kg), middle-dose (125 mg/kg), and high-dose (500 mg/kg). (biomedcentral.com)
Adult male1
It is measured in a laboratory using an artificial model of a large adult male with different fluids to simulate human tissue. (saferemr.com)
Exposure1
These differences were not present in female rats with the same postnatal hyperoxia exposure. (frontiersin.org)
Test material3
For the induction phase, 0.3 mL of the undiluted test material was applied to the shaved backs of 10 male and 10 female Hartley-derived albino guinea pigs under occlusion for 6 hours once each week for 3 weeks. (epa.gov)
A naive control group consisting of 5 male and 5 female guinea pigs was treated with 0.3 mL of the undiluted test material at challenge only. (epa.gov)
The stability and homogeneity of the test material formulations were previously determined by Harlan Laboratories Ltd. (Harlan Laboratories Ltd. Project Number: 2974-0011). (europa.eu)
Lungs1
Five of the males had lesions observed in the lungs which varied from red or white, pinpoint foci to a dark red, firm lobe. (europa.eu)
Approximately2
females approximately 1-2 hours post dose, males approximately 3 hours post dose. (europa.eu)
Hunched posture in all females from Day 1(from approximately 3 hours post dose). (europa.eu)
Deaths2
Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer deaths in men today. (hindawi.com)
Prostate cancer is the most frequently diagnosed malignancy and the second leading cause of cancer deaths in American men today with an estimated 241,740 new cases of prostate cancer and 28,170 deaths estimated in year 2012 [ 1 ]. (hindawi.com)
Control2
All mates of treated rats achieved pregnancy as rapidly as the mates of control rats although two of the control rats did not sire a litter with either female and one sired only one litter. (biomedcentral.com)
Compared to control rats, male rats exposed to 14 days of postnatal hyperoxia then aged to 1 year demonstrated higher skeletal muscle fatigability, lower muscle mitochondrial oxidative capacity, more mitochondrial damage, and higher glycolytic enzyme expression. (frontiersin.org)
Weight1
Increase in body weight increases bone mass but aging is associated with bone loss in both men and women [ 18 ]. (biomedcentral.com)
Results1
The hematology results indicate that TCAB induced a microcytic normochromic responsive anemia in male Sprague-Dawley rats. (nih.gov)
Model1
The first model used a cross of females expressing human Agt with males expressing human renin, resulting in upregulation of the circulating and uteroplacental RAS. (jci.org)
Evidence1
In the last decade, more evidence has suggested that males also lose almost the same amount of bone as women [ 20 ]. (biomedcentral.com)
Controls1
Treated male rats which recovered from chemical castration and untreated controls were mated with breeder females. (biomedcentral.com)