• Little and Castle collaborated closely with Abbie Lathrop who was a breeder of fancy mice and rats which she marketed to rodent hobbyists and keepers of exotic pets, and later began selling in large numbers to scientific researchers. (wikipedia.org)
  • Mice or rats of both genders were orally administered distilled water as a control and fGT at 2.0, 1.0, and 0.5 g/kg. (hindawi.com)
  • We developed a method, named Easy-ET, to induce pseudopregnancy in female rats by artificial stimulation using sonic vibration instead of mating with vasectomized males. (nature.com)
  • In mice and rats, females require mating stimulation for the maintenance of pregnancy. (nature.com)
  • The production of female mice with pseudopregnancy induced using sonic vibration was as efficient as rats. (nature.com)
  • Breeding onset occurs at about 50 days of age in both females and males, although females may have their first estrus at 25-40 days. (wikipedia.org)
  • Newborn males are distinguished from newborn females by noting the greater anogenital distance and larger genital papilla in the male. (wikipedia.org)
  • The lyophilized aqueous extract (decoction 70 mg/mL) from the entire plant and administered orally (1 g/kg/day/70 consecutive days) to 12 Hsd:ICR(CD-1) mice, (6 males and 6 females), according to the OECD 407 protocol, as modified by LEBi, caused neither mortality nor evident toxicity signs. (tramil.net)
  • Genome-edited mice were also obtained using frozen-warmed pronuclear embryos with clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated system (Cas) nucleases introduced using the technique for animal knockout system by electroporation (TAKE) method, which were transferred to females with pseudopregnancy induced on the day of embryo transfer. (nature.com)
  • However, this procedure requires a large breeding space, and it is costly to maintain a sufficient number of healthy females and vasectomized males to induce pseudopregnancy. (nature.com)
  • In the control group comprising females with pseudopregnancy induced by mating with vasectomized males, 61.0% of transferred embryos were implanted, and 34.1% developed into offspring. (nature.com)
  • Embryo development using artificially stimulated females was significantly lower than that of the control group in which pseudopregnancy was induced in females by mating with vasectomized males. (nature.com)
  • There were no mortalities or gross abnormalities in the fGT groups for 2 weeks following the single oral dose in mice. (hindawi.com)
  • 97.4% pure) was fed in diet to Crl:CD-1 (ICR)BR mice (50/sex/dose) at 0, 20, 80 and 250 mg/kg/day for 80 weeks. (fluoridealert.org)
  • Daily oral administration of micro calcium carbonate and nano calcium carbonate (Read-across substances) for 28 days to mice did not produce any obvious symptoms of toxicity or mortality even at the highest dose of 1300 mg/kg bw/day administered. (europa.eu)
  • During the mating phase, animals were transferred to polypropylene grid floor cages suspended over trays lined with absorbent paper on a one male: one female basis within each dose group. (europa.eu)
  • RESULTS: In the FST, bupropion reversed TBZ effects in both sexes but fluoxetine was only effective in female mice. (bvsalud.org)
  • The lyophilized aqueous extract (decoction) from the entire frozen plant, administered orally (2 g/kg) to 20 male albino mice every day for 5 consecutive days per week for a total period of 70 days did not cause mortality. (tramil.net)
  • The toxicological studies of a plant extract in mice showed that the LD 50 by intravenous administration is higher than 50 mg/kg and orally at 1 g/kg 7 . (tramil.net)
  • We examined the consequences of CTCF depletion in immortalised human and mouse cells using shRNA knockdown and CRISPR/Cas9 genome editing and examined the growth and development of heterozygous Ctcf ( Ctcf +/- ) mice. (preprints.org)
  • The survival of irradiated mice protected by Vitamin c was significantly increased and statistically higher than that of mice pre-treated with oral administration. (biomedgrid.com)
  • The laboratory mouse genome has been sequenced and many mouse genes have human homologues. (wikipedia.org)
  • The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse Genome Informatics database. (wikipedia.org)
  • Together they generated the DBA (Dilute, Brown and non-Agouti) inbred mouse strain and initiated the systematic generation of inbred strains. (wikipedia.org)
  • The role of mesolimbic dopamine (DA) in regulating behavioral activation has been extensively studied in male rodents, but little is known in female rodents. (bvsalud.org)
  • The mouse has since been used extensively as a model organism and is associated with many important biological discoveries of the 20th and 21st Centuries. (wikipedia.org)
  • METHODS: Male and female CD1 mice received Tetrabenazine (TBZ), a VMAT-2 blocker that depletes DA and induces depressive symptoms in humans. (bvsalud.org)
  • Mice belong to the Euarchontoglires clade, which includes humans. (wikipedia.org)
  • This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. (wikipedia.org)
  • Mice are mammals of the clade (a group consisting of an ancestor and all its descendants) Euarchontoglires, which means they are amongst the closest non-primate relatives of humans along with lagomorphs, treeshrews, and flying lemurs. (wikipedia.org)
  • In 1902 Lucien CuĂ©not published the results of his experiments using mice which showed that Mendel's laws of inheritance were also valid for animals - results that were soon confirmed and extended to other species. (wikipedia.org)
  • Laboratory mice are usually of the species Mus musculus. (wikipedia.org)
  • Other mouse species sometimes used in laboratory research include two American species, the white-footed mouse (Peromyscus leucopus) and the North American deer mouse (Peromyscus maniculatus). (wikipedia.org)
  • In this context, the aim of this study was to evaluate the influence of exposure to EE on mice behavior in the open field test (OFT) and forced swimming tests (FST), as well as the response to antidepressant drugs (fluoxetine 30 mg/kg and bupropion 30 mg/kg, p.o. (bvsalud.org)
  • During the 18th century Joseph Priestley and Antoine Lavoisier both used mice to study respiration. (wikipedia.org)
  • This study examined the application of this method for the induction of pseudopregnancy in mice. (nature.com)
  • This study demonstrated that induction of pseudopregnancy by sonic vibration was also possible in mice. (nature.com)
  • This study examined the application of sonic vibration to induce pseudopregnancy in mice. (nature.com)
  • The effect was intermittent in males throughout the study. (fluoridealert.org)
  • In the present study, we first evaluated the effect of sex and age on the main parameters of the mouse retinal clock. (molvis.org)
  • All abovementioned results were similar to those in mice protected by Vitamin c , but the protecting actions of Vitamin c on promoting recovery of nucleated cells and leukocyte counts were significantly higher than those of Vitamin c . (biomedgrid.com)
  • The main conclusion is that mice behavior in the OFT is sensitive to alterations in the housing environment and depends on the developmental stage of exposure. (bvsalud.org)
  • After administration of Vitamin c , enhanced CD4 and CD8 cells, numbers of NK cells and CD4 and CD8 cells in mice were found and lymphocytes numbers was higher than in irradiated control group. (biomedgrid.com)
  • 035 - 181177 'XDE-795: Potential Tumorigenic Effects in Prolonged Dietary Administration to CD-1 Mice,' (Bellringer, M.E. (fluoridealert.org)
  • The vehicle control was distilled and de-ionized water (0.5 mL) on 12 mice of similar characteristics. (tramil.net)
  • Mice exposed to perinatal enrichment remained longer in the peripheral zone of the OFT and performed fewer grooming than mice housed under standard condition, and these effects were independent of drug treatment. (bvsalud.org)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • Stimulated recovery of leukocyte, lymphocytes, and NK cells counts were observed in mice pre-treated with Vitamin c . (biomedgrid.com)
  • Following evidence of successful mating, the males were returned to their original cages. (europa.eu)
  • As a general rule, inbred mice tend to have longer gestation periods and smaller litters than outbred and hybrid mice. (wikipedia.org)
  • Mice have been used in biomedical research since the 17th century (from May 30, 1678) when William Harvey used them for his studies on reproduction and blood circulation and Robert Hooke used them to investigate the biological consequences of an increase in air pressure. (wikipedia.org)
  • In the early part of the 20th century, Harvard undergraduate Clarence Cook Little was conducting studies on mouse genetics in the laboratory of William Ernest Castle. (wikipedia.org)
  • Therefore, application to the skin of nude mice prior to radiation exposure may provide protection against UV and radiation [17]. (biomedgrid.com)
  • Mice were tested on the Forced Swim Test, (FST), the Dark-Light box (DL), the elevated plus maze (EPM), Social Interaction (SI) test, and sucrose preference and consumption using the two bottles test. (bvsalud.org)
  • Vitamin c also reduced the frequency of micronucleated reticulocytes and provided cell protection in the reproductive system, thus increasing the survival rate of subletically irradiated mice [18,19]. (biomedgrid.com)