LncRNA MALAT1KnockdownTumorsOverexpression of MALAT1Cervical cancerGenesInhibitsExpressionMetastasis associatedAntisense oligonucleotideMetastaticStemnessMolecularSignificantly increasedLungCellularLongProgressionCancerInvasionRoleCellsStudiesLncRNAEpithelial-MesenchymaMetastasisDownregulationSiRNATranscriptPrognosticPromotesModulatesNEAT1Positively correlatedInsightsEnhancesTumorigenesisSignificantlyTranscriptsNucleusImplicationResultsHighly expressedMigrationMechanismStudyDiagnosticNetworkCell linesForm
LncRNA MALAT118
- We have found that lncRNA MALAT1 is stress induced through transcription factor NFATc1. (utrgv.edu)
- CRC tissues of different ethnicities were stained using Novel Z Probe based technology (lncRNA MALAT1) and immunohistochemistry (NFATc1). (utrgv.edu)
- and Tripathi, Manish, "Stress induced lncRNA MALAT1 in colorectal cancer health disparity" (2023). (utrgv.edu)
- Our aim was to investigate the role of LncRNA MALAT1 in regulation of Keap1-Nrf2-antioxidant defense in diabetic retinopathy. (figshare.com)
- LncRNA MALAT1 expression (qRT-PCR, immunofluorescence, RNA sequencing), its interactions with Keap1 (FACS), Keap1-Nrf2 interactions and transcription of the antioxidant response genes (immunofluorescence and nuclear RNA sequencing) were investigated in retinal endothelial cells exposed to high glucose. (figshare.com)
- Glucose increased LncRNA MALAT1 levels by increasing Sp1 transcription factor binding at its promoter. (figshare.com)
- Downregulation of LncRNA MALAT1 by its siRNA prevented glucose-induced increase in Keap1, and facilitated Nrf2 nuclear translocation and antioxidant gene transcription. (figshare.com)
- Retinal microvessels from streptozotocin-induced diabetic mice and human donors with diabetic retinopathy also presented similar increase in LncRNA MALAT1 and its interactions with Keap1 , and decrease in Nrf2-mediated antioxidant defense genes. (figshare.com)
- Thus, LncRNA MALAT1 , via Keap1 - Nrf2, regulates antioxidant defense in diabetic retinopathy. (figshare.com)
- Inhibition of LncRNA MALAT1 has potential to protect the retina from oxidative damage, and prevent/slow down diabetic retinopathy. (figshare.com)
- Emerging evidence suggests that lncRNA MALAT1 is abnormally expressed in diabetic nephropathy (DN) and can attenuate renal fibrosis by modulating podocyte epithelial-mesenchymal transition (EMT). (harvard.edu)
- OBJECTIVE: In the present study, we aimed to explore whether QHYS could modulate lncRNA MALAT1 expression and attenuate the podocyte EMT as well as the potential mechanism related to the Wnt/ β -catenin signal pathway. (harvard.edu)
- The expression level of lncRNA MALAT1 was determined by quantitative real-time polymerase chain reaction. (harvard.edu)
- Importantly, QHYS significantly downregulated the expression level of lncRNA MALAT1, upregulated the expression of nephrin, the podocyte marker protein, downregulated the expression of desmin and FSP-1, and mesenchymal cell markers. (harvard.edu)
- CONCLUSION: Conclusively, our study revealed that QHYS significantly reduced proteinuria, alleviated renal fibrosis, and attenuated the podocyte EMT in DN rats, which may be associated with the downregulation of lncRNA MALAT1 expression and inhibition of the Wnt/ β -catenin pathway. (harvard.edu)
- https://pubmed.ncbi.nlm.nih.gov/31025509-epc-derived-exosomes-promote-osteoclastogenesis-through-lncrna-malat1/ [Accessed 25 Feb. 2020]. (bioscience.co.uk)
- MiR-125b participates in the oncogenic role of lncRNA MALAT1 in the phenotypes including cell proliferative and invasive rates in laryngocarcinoma [ 6 ]. (hindawi.com)
- Abstract 1541: LncRNA MALAT1 as a potential therapeutic target in triple negative breast cancer. (flamingotx.com)
Knockdown8
- Genetic loss or systemic knockdown of Malat1 using antisense oligonucleotides (ASO) in the mouse mammary carcinoma model results in slower tumor growth accompanied by significant differentiation into cystic tumors and a reduction in metastasis. (wikipedia.org)
- Malat1 knockdown results in alterations in gene expression and changes in splicing patterns of genes involved in differentiation and protumorigenic signaling pathways. (wikipedia.org)
- MALAT1 knockdown in lung cancer cells resulted in miR-101-3p upregulation and increased cisplatin sensitivity. (oncotarget.com)
- Overexpression of MALAT1 in SW480, and knockdown in SW620 resulted in changes in their oncogenic profiles. (utrgv.edu)
- In addition, knockdown of MALAT1 attenuated the stemness of ESCC cells, as evidenced by a decrease in spheroid formation capacity, stemness marker expression and ALDH1 activity. (moleculardepot.com)
- Moreover, MALAT1 knockdown decreased the migration ability of ESCC cells. (moleculardepot.com)
- Notably, knockdown of MALAT1 enhanced the radiosensitivity and chemosensitivity of ESCC cells. (moleculardepot.com)
- Overexpression of YAP partially rescued the effect of MALAT1 knockdown on stemness and radiosensitivity of ESCC cells. (moleculardepot.com)
Tumors4
- Metastatic tumors have a dependency on Malat1-they can't thrive without it. (wikipedia.org)
- Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. (bmj.com)
- Expression of HOTAIR in OSCC tumors was positively correlated with tumor volume,whereas MALAT1 and H19 negatively correlated with the smoking status of patients. (ias.ac.in)
- Tumors harboring MALAT1-TFEB, ACTB-TFEB, and the novel NEAT1-TFEB translocations constantly express PDL1. (bvsalud.org)
Overexpression of MALAT11
- In contrast, overexpression of Malat1 leads to metastatic reactivation of dormant breast cancer cells. (bmj.com)
Cervical cancer2
- In so far as MALAT1 has been identified to be involved in tumorigenesis of various types of cancer such as lung cancer, pancreatic cancer, cervical cancer Malat1 ASOs represent a potential therapy for inhibiting such cancers progression. (wikipedia.org)
- The HPV-TP53-MALAT1 Axis: Unravelling interactions in cervical cancer development. (cdc.gov)
Genes2
- Similarly, RNA-seq and ChIRP-seq data suggest that KO of Malat1 hampers immune evasion and downregulates metastasis associated genes including Serpins and Wnts. (bmj.com)
- The long non-coding RNA MALAT1 was involved in 97/156 (62%) fusion genes, followed in prevalence by MUC16, FOXP1, WWOX and XIST. (broadinstitute.org)
Inhibits1
- Additionally, Malat1 KO inhibits cancer stemness properties. (bmj.com)
Expression19
- MALAT1 was identified in multiple types of physiological processes, such as alternative splicing, nuclear organization, epigenetic modulating of gene expression, and a number of evidences indicate that MALAT1 also closely relate to various pathological processes, ranging from diabetes complications to cancers. (wikipedia.org)
- This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans. (wikipedia.org)
- Elevated MALAT1 expression is correlated with poor overall survival in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer. (wikipedia.org)
- The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
- Reverse transcription‑quantitative PCR was performed to detect the MALAT1 expression. (spandidos-publications.com)
- Compared with the ox‑LDL group, S/V treatment significantly increased the cell viability, NO concentration and Bcl‑2 expression, decreased the levels of IL‑1β, IL‑6 and TNF‑α and reduced the expressions of MALAT1, ICAM‑1, VCAM‑1, cleaved‑caspase‑3, Bax, TLR4 and p‑p65. (spandidos-publications.com)
- Overall, the findings suggested that S/V could downregulate the expression of MALAT1, inhibit inflammation and apoptosis and improve endothelial function in ox‑LDL‑induced HUVECs via inactivating the TLR4/NF‑κB signaling pathway. (spandidos-publications.com)
- Previous studies have shown that the expression of MALAT1 is increased in endothelial cells induced by ox-LDL and its expression level can reflect the damage degree of endothelial cells ( 11 , 12 ). (spandidos-publications.com)
- Moreover, cisplatin-resistant A549/DDP cells showed higher MALAT1 expression than cisplatin-sensitive lung cancer cells (A549, H460, H1299 and SPC-A1). (oncotarget.com)
- Here, we propose to investigate the association of stress factors with NFATc1 and MALAT1 expression, and the role of these novel molecular drivers in CRC progression and metastasis. (utrgv.edu)
- CRC cell lines were profiled for MALAT1 expression using RT-PCR. (utrgv.edu)
- MALAT1 and NFATc1 expression was scored to be high in underserved population. (utrgv.edu)
- MALAT1 expression was lower in less aggressive SW480 cell line as compared to highly metastatic SW620 cell line. (utrgv.edu)
- In this study, we found that MALAT1 expression was remarkably increased in ESCC cells compared to normal esophageal epithelial cells (HEEC). (moleculardepot.com)
- We also established that MALAT1 binds directly to YAP, thereby enhancing YAP protein expression and increasing YAP transcriptional activity. (moleculardepot.com)
- High expression of MALAT1 was significantly associated with poor outcomes in patients with osteosarcomas. (karger.com)
- MALAT1 expression was positively related to RET and negatively related to miR. (karger.com)
- LncRNA could serve as a biomarkerfor diagnosis and prognosis as well as a molecular target for therapy in oral squamous cell carcinoma (OSCC).Therefore, we have determined the expression profile of 5-lncRNAs namely UCA1, TUG1, HOTAIR,MALAT1, and H19 by quantitative real-time PCR in tumor tissues and adjacent normal tissue of 32 OSCCpatients. (ias.ac.in)
- Importantly, expression of MALAT1 and H19 was down-regulated in tumor tissues of 62.5% and81.25% respectively of OSCC patients. (ias.ac.in)
Metastasis associated4
- The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was initially identified as a tumor-related lncRNA, which can control the proliferation and metastasis of lung adenocarcinoma ( 10 ). (spandidos-publications.com)
- In this study, we investigated the mechanism by which lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) mediates cisplatin resistance in lung cancer. (oncotarget.com)
- LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was first identified as a negative prognostic biomarker in early non-small cell lung cancer [ 8 ]. (oncotarget.com)
- Indeed, an m(6)A site in the lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was recently shown to induce a local change in structure that increases the accessibility of a U5-tract for recognition and binding by heterogeneous nuclear ribonucleoprotein C (HNRNPC). (nih.gov)
Antisense oligonucleotide1
- A new research paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, "Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment. (news-medical.net)
Metastatic8
- Methods Using an in vivo screening platform for the isolation of genetic entities involved in either dormancy or reactivation of breast cancer tumor cells, we have identified Malat1 as a positive mediator of metastatic reactivation. (bmj.com)
- 4 To dissect the functional role of Malat1 in metastatic reactivation, we developed a clean Malat1 knockout (KO) model using paired gRNA CRISPR-Cas9 in metastatic murine syngeneic breast cancer. (bmj.com)
- Results Our data revealed that deletion of Malat1 induces dormancy and attenuated the metastatic colonization resulting in long-term survival of syngeneic mice model. (bmj.com)
- Interestingly, 4T1-Malat1 KO dormant breast cancer cells exhibit metastatic outgrowth in T cells defective mice. (bmj.com)
- Interestingly, rescue experiments suggest that Malat1 or Serpinb6b protects T cell-induced cell death and induces dormancy re-awakening thereby rescue the metastatic potential of 4T1 Malat1 KO cells. (bmj.com)
- Combination of Malat1 ASO with double immune checkpoint inhibitors greatly affects the metastatic outgrowth in breast cancer. (bmj.com)
- Conclusions Taken together, our studies demonstrate that tumor intrinsic Malat1 regulates Serpinb6b that eventually controls immune evasion and promote dormancy metastatic reactivation. (bmj.com)
- Biomarkers in Patients with Metastatic Breast Cancer and the PRAEGNANT Study Network vat recente ontwikkelingen samen en beschrijft hoe het Preagnant netwerk een professionele infrastructuur creeërt voor patiënten en professionals, artsen en onderzoekers. (kanker-actueel.nl)
Stemness1
- Long noncoding RNA MALAT1 promotes the stemness of esophageal squamous cell carcinoma by enhancing YAP transcriptional activity. (moleculardepot.com)
Molecular1
- At the molecular level, the ASO-Malat1 hybrid stimulates a naturally occurring cellular enzyme that degrades the Malat1 lncRNA. (wikipedia.org)
Significantly increased1
- Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. (wikipedia.org)
Lung3
- Lung cancer patients with high MALAT1 levels were associated with cisplatin resistance and low overall survival. (oncotarget.com)
- These results demonstrate that MALAT1/miR-101-3p/MCL1 signaling underlies cisplatin resistance in lung cancer. (oncotarget.com)
- Additionally, our data strongly suggests that Malat1 KO cells persists as non-proliferative dormant cells in lung due to CD8+ T cell-umpired immune activity. (bmj.com)
Cellular2
- To further characterize this first example of an m(6)A-switch in a cellular RNA, we used nuclear magnetic resonance and Förster resonance energy transfer to demonstrate the effect of m(6)A on a 32-nucleotide RNA hairpin derived from the m(6)A-switch in MALAT1. (nih.gov)
- The m(6)A-induced structural changes in the MALAT1 hairpin can serve as a model for a large family of m(6)A-switches that mediate the influence of m(6)A on cellular processes. (nih.gov)
Long1
- The Long non-coding RNA MALAT1 functions as a competing endogenous RNA to regulate vascular remodeling by sponging miR-145-5p/HK2 in hypertension. (amedeo.com)
Progression1
- Malat1 is one of the most abundant and highly conserved nuclear lncRNAs and have shown the associated with metastasis and serving as a predictive marker for various tumor progression. (bmj.com)
Cancer1
- Levering the breadth and depth of our team's expertise in RNA therapeutics and cancer drug development, we have a promising pipeline with programs against "undruggable" targets STAT 3 and MALAT1. (flamingotx.com)
Invasion1
- Recently, MALAT1 has been implicated in metastasis and invasion of liver, bladder, breast and cervical cancers [ 11 - 14 ]. (oncotarget.com)
Role2
- MALAT1 may play a role in temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta). (wikipedia.org)
- This indicates a critical role of immune microenvironment via Malat1-dependent immune evasion. (bmj.com)
Cells1
- Our single-cell RNA-seq and multicolor flowcytometry evaluation reveal enhanced T cells and reduced neutrophils proportions in mice with Malat1 KO cells. (bmj.com)
Studies3
- Deels door te weinig bewijs uit goed gekwalificeerde studies, deels door onwetendheid bij de behandelend artsen, vooral in de niet-academische ziekenhuizen, deels ook door te grote ego's van de behandelend artsen, maar vooral door de onderliggende financiële belangen van de farmaceutische bedrijven en ziekenhuizen. (kanker-actueel.nl)
- De screening en registratie van al die afwijkingen in een algemene databank is daarom heel belangrijk om toekomstige klinische studies succesvol en bepalend te laten zijn voor de behandelingen. (kanker-actueel.nl)
- De Netwerk groep Preagnant is zo'n groep van ziekenhuizen en onderzoekers die gegevens verzamelen en daaruit weer nieuwe studies ontwerpen en laat zien aan oncologen en behandelaars welke behandelingen en medicijnen verder ontwikkeld zouden moeten worden voor een juiste personalised medicine aanpak. (kanker-actueel.nl)
LncRNA12
- At the molecular level, the ASO-Malat1 hybrid stimulates a naturally occurring cellular enzyme that degrades the Malat1 lncRNA. (wikipedia.org)
- Emerging evidence suggests that lncRNA MALAT1 is abnormally expressed in diabetic nephropathy (DN) and can attenuate renal fibrosis by modulating podocyte epithelial-mesenchymal transition (EMT). (harvard.edu)
- OBJECTIVE: In the present study, we aimed to explore whether QHYS could modulate lncRNA MALAT1 expression and attenuate the podocyte EMT as well as the potential mechanism related to the Wnt/ β -catenin signal pathway. (harvard.edu)
- The expression level of lncRNA MALAT1 was determined by quantitative real-time polymerase chain reaction. (harvard.edu)
- Importantly, QHYS significantly downregulated the expression level of lncRNA MALAT1, upregulated the expression of nephrin, the podocyte marker protein, downregulated the expression of desmin and FSP-1, and mesenchymal cell markers. (harvard.edu)
- CONCLUSION: Conclusively, our study revealed that QHYS significantly reduced proteinuria, alleviated renal fibrosis, and attenuated the podocyte EMT in DN rats, which may be associated with the downregulation of lncRNA MALAT1 expression and inhibition of the Wnt/ β -catenin pathway. (harvard.edu)
- LncRNA-metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) influences numerous cellular processes, including EMT. (mdpi.com)
- Recently, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a lncRNA, has been discovered to be closely related to OS progression and hypoxia responses which are associated with angiogenesis. (ijbs.com)
- 8. Aberrant expression of lncRNA malat1 modulates radioresistance in colorectal cancer in vitro via miR-101-3p sponging. (nih.gov)
- IL-6 induced lncRNA MALAT1 enhances TNF-α expression in LPS-induced septic cardiomyocytes via activation of SAA3. (antibodies-online.com)
- PNPO was positively correlated with lncRNA MALAT1 which was negatively correlated with miR-216b-5p. (aging-us.com)
- Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a well-studied lncRNA that plays an important role in tumorigenesis [ 9 , 10 ]. (aging-us.com)
Epithelial-Mesenchyma2
- Retraction Note: YAP1-induced MALAT1 promotes epithelial-mesenchymal transition and angiogenesis by sponging miR-126-5p in colorectal cancer. (bvsalud.org)
- 10. Chronic oxymatrine treatment induces resistance and epithelial‑mesenchymal transition through targeting the long non-coding RNA malat1 in colorectal cancer cells. (nih.gov)
Metastasis13
- Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a nuclear enriched long non-coding RNA that is generally overexpressed in patient tumors and metastases. (nih.gov)
- Overexpression of MALAT1 has been shown to be positively correlated with tumor progression and metastasis in a large number of tumor types including breast tumors. (nih.gov)
- Surprisingly, a recent report by Kim et al shows a metastasis suppressive role for Malat1. (nih.gov)
- Long noncoding RNA MALAT1 suppresses breast cancer metastasis. (nih.gov)
- Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a highly abundant nuclear long noncoding RNA that promotes malignancy. (nih.gov)
- Methods: We found that metastasis associated lung adenocarcinoma transcript-1 (MALAT1) is upregulated in gastric cancer tissue compared to adjacent normal tissue, as determined by microarray and subsequent qRT-PCR, then investigated the impact of MALAT1 on apoptosis, cell proliferation, and the cell cycle to dissect the carcinogenesis of gastric cancer, and examined mechanisms of invasion and metastasis. (elsevierpure.com)
- As a type of new targets for prognosis of malignancies, long non-coding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcription 1) is associated with proliferation and metastatic abilities of several malignancies. (oncotarget.com)
- Our previously findings indicate that the long non-coding RNA MALAT1 promotes colorectal cancer (CRC) cell proliferation invasion and metastasis and by increasing expression of AKAP-9. (mdm2-inhibitors.com)
- Outcomes MALAT1 SRPK1 and SRSF1 type a complicated We previously discovered that MALAT1 marketed CRC development and metastasis by regulating AKAP-9 gene appearance [9]. (mdm2-inhibitors.com)
- The long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) is described as a potential biomarker for NSCLC (non-small cell lung cancer). (biomedcentral.com)
- 3. Early-stage colon cancer with high malat1 expression is associated with the 5-Fluorouracil resistance and future metastasis. (nih.gov)
- 4. Long non-coding RNA metastasis-related lung adenocarcinoma transcript 1 ( malat1 ) forms a negative feedback loop with long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) in sepsis to regulate lung cell apoptosis. (nih.gov)
- 15. Resveratrol inhibits invasion and metastasis of colorectal cancer cells via malat1 mediated Wnt/β-catenin signal pathway. (nih.gov)
Downregulation2
- Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. (nih.gov)
- Downregulation of MALAT1 was accomplished with two different siRNAs. (elsevierpure.com)
SiRNA1
- The Wnt/β-catenin related genes were significantly decreased by transfection of siRNA MALAT1. (elsevierpure.com)
Transcript1
- Through the bioinformatics analyses, a microRNA response element (MRE) for miR-216b-5p is found in the 3′-untranslated region (3′-UTR) of PNPO and MALAT1 transcript. (aging-us.com)
Prognostic3
- Elevated MALAT1 expression is correlated with poor overall survival in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer. (wikipedia.org)
- The statistical analysis was performed to unveil the potential relationships between the expression of MALAT1 and prognostic factors of breast cancer such as OS (overall survival), RFS (relapse-free survival), number of metastatic lymph nodes and pTNM staging in patients with TNBC or Her-2 positive breast cancer. (oncotarget.com)
- MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker. (cas.cz)
Promotes5
- MALAT1 is involved in gastric carcinogenesis via inhibition of apoptosis and promotes invasiveness via the epithelial-to-mesenchymal transition. (elsevierpure.com)
- MALAT1 promotes proliferation and invasion abilities of breast cancer cells through XBP1 (X-box binding protein 1)-HIF (hypoxia-inducible factor)-1α pathway in MDA-MB-231 and through Her-2 pathway in MDA-MD-435. (oncotarget.com)
- Olanzapine MALAT1 promotes SRSF1 phosphorylation by regulating SRPK1 appearance and Olanzapine activity To determine whether a MALAT1-SRPK1-SRSF1 complicated features within SW80 CRC cells we evaluated the degrees of SRSF1 appearance and phosphorylation in Scramble-SW480 RNAa-MALAT1-SW480 and RNAi-MALAT1-SW480 cells. (mdm2-inhibitors.com)
- 7. Long Noncoding RNA malat1 Promotes colorectal cancer Progression by Acting as a ceRNA of miR-508-5p to Regulate RAB14 Expression. (nih.gov)
- 11. malat1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in colorectal cancer Patients and Promotes Chemoresistance through EZH2. (nih.gov)
Modulates1
- This prompted us to check the theory that MALAT1 modulates AKAP-9 appearance and function by marketing SRPK1-catalyzed SRSF1 phosphorylation in CRC cells. (mdm2-inhibitors.com)
NEAT11
- determining the relative expression of lncRNAs (NEAT1 and MALAT1) in healthy and diseased periodontal tissue. (who.int)
Positively correlated1
- The expression of MALAT1 in triple negative and Her-2 positive breast cancers was positively correlated to the number of metastatic lymph nodes in patients with breast cancer. (oncotarget.com)
Insights1
- Here, we discuss these results in the context of a large body of published literature that support a pro-tumorigenic role for MALAT1 in order to gain potential insights into the basis of these observed differences. (nih.gov)
Enhances2
- Because prior research demonstrated that SRPK1 interacts with SRSF1 Olanzapine and enhances SRSF1 phosphorylation [15] we also utilized RNA-IP assays to check whether SRPK1 interacts with MALAT1 in SW480 cells. (mdm2-inhibitors.com)
- Body 2 MALAT1 enhances AKAP-9 appearance by marketing SRPK1-mediated SRSF1 proteins phospholation To verify that adjustments in MALAT1-mediated SRSF1 phosphorylation was because of SRPK1 enzyme activity RNAa-MALAT1-SW480 cells had been treated using the SRPK1. (mdm2-inhibitors.com)
Tumorigenesis1
- Conclusions: In our study, we found that deregulation of MALAT1 could be involved in both tumorigenesis and invasiveness in gastric cancer cells. (elsevierpure.com)
Significantly2
- Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. (wikipedia.org)
- siR-MALAT1 significantly decreased AGS cell invasiveness and migration. (elsevierpure.com)
Transcripts1
- A microRNA response element was found in both PNPO and MALAT1 transcripts for miR-216b-5p and the dual-luciferase reporter assay confirmed the binding of these transcripts. (aging-us.com)
Nucleus1
- nucleus and activation of MALAT1 elevated nuclear degrees of phospho-SRSF1. (mdm2-inhibitors.com)
Implication1
- The implication of MALAT1 RNA in the pathology of various cancers has been documented. (wikipedia.org)
Results2
- No impact of tumor stage, age, gender, and smoking status on MALAT1 levels could be observed, but results based on small numbers. (biomedcentral.com)
- Taken together, these results reveal the biological function and a regulatory mechanism of PNPO, in which the MALAT1/miR-216b-5p/PNPO axis may be important in IDC development. (aging-us.com)
Highly expressed1
- Transcriptome sequencing analysis showed that MALAT1 was lowly expressed and miR-382-3p was highly expressed in serum-Exos samples of T2DM mice. (biomedcentral.com)
Migration1
- Our study suggested that MALAT1 is a core signaling molecule for promoting development and migration of triple negative and Her-2 positive breast cancers. (oncotarget.com)
Mechanism1
- In this study, we confirm that MALAT1 induces pro-angiogenic effects, and demonstrate that the underlying mechanism involves a MALAT1/mechanistic target of rapamycin (mTOR)/hypoxia inducible factor-1α (HIF-1α) loop. (ijbs.com)
Study3
- The objective of the current study is to explore the role of MALAT1 in hyperglycemia (HG)-induced EMT. (mdpi.com)
- In today's study we utilized traditional western blot and RT-PCR analyses to confirmed once again that MALAT1 governed Olanzapine AKAP-9 gene appearance in SW480 CRC cells (Supplementary Body 1A-1C). (mdm2-inhibitors.com)
- The aim of this study was to evaluate the performance of MALAT1 as a blood based biomarker for NSCLC. (biomedcentral.com)
Diagnostic1
- Alternatively, MALAT1 might be applicable as a complementary biomarker within a panel in order to improve the entire diagnostic performance. (biomedcentral.com)
Network1
- 2. malat1 -miRNAs network regulate thymidylate synthase and affect 5FU-based chemotherapy. (nih.gov)
Cell lines1
- Moreover, MALAT1 could possibly be involved in regulation of MYC gene and CD47 (an immune checkpoint gene) in both cell lines. (oncotarget.com)
Form1
- We discovered that SRPK1 particularly interacts with SRSF1 (Body 1C-1D) which signifies that MALAT1 SRPK1 and SRSF1 most likely form a complicated. (mdm2-inhibitors.com)