• In addition, the cell line can also be used for other hematological disease applications that involve red blood cells or red blood cell precursors. (nih.gov)
  • Adoptive transfer of erythroid precursors could rescue mice from ECM. (bvsalud.org)
  • Erythroid precursors develop in bone marrow at rates usually determined by the requirement for sufficient circulating Hb to oxygenate tissues adequately. (medscape.com)
  • Erythroid precursors differentiate sequentially from stem cells to progenitor cells to erythroblasts to normoblasts in a process requiring growth factors and cytokines. (medscape.com)
  • Normally, erythroid precursors are released into circulation as reticulocytes. (medscape.com)
  • β-thalassaemia is characterised by the reduced synthesis (β+) or absence (β0) of the β-globin chains in the Hb molecule, resulting in accumulation of unbound α-globin chains that precipitate in erythroid precursors in the bone marrow and in the mature erythrocytes, leading to ineffective erythropoiesis and peripheral haemolysis. (ithanet.eu)
  • While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)
  • HLA-G has a restricted distribution and is mainly expressed in trophoblastic cells, thymic epithelium, pancreas, cornea, nail matrix, and erythroid and endothelial precursors under normal physiological condition [12]. (scirp.org)
  • Plasmodium vivax (malaria) is a significant health concern in many parts of Asia, Latin America, North Africa, and the Middle East. (nih.gov)
  • Due to recent evidence that Plasmodium vivax ( P. vivax ) can infect erythroid progenitor cells (reference: YX Ru et al. (nih.gov)
  • Plasmodium replicates within the liver prior to reaching the bloodstream and infecting red blood cells. (bvsalud.org)
  • We conducted a study of patients with uncomplicated Plasmodium falciparum malaria to investigate the clinical, laboratory, and immunohematologic features of hemolysis and anemia during and after antimalarial treatment. (cdc.gov)
  • Late apoptosis of cells of the defence system could be beneficial to the host, clearing excess cells and thereby avoiding the detrimental effects of excessive inflammatory response in the tissue that they would cause (e.g. the deleterious effect of reactive oxygen species or pro-inflammatory cytokines triggered by Plasmodium in the liver) [ 1 ]. (biomedcentral.com)
  • 1 The Duffy-null polymorphism is associated with protection against invasion of RBCs by the Plasmodium vivax malaria. (ashpublications.org)
  • We believe our studies will help elucidate the role of an FLVCR in protecting mosquitoes from heme toxicity and determine whether an FLVCR dysfunction impacts transmission of the malaria parasite at its weakest point, i.e., plasmodium (ookinete) invasion of the mosquito midgut. (sciforschenonline.org)
  • Samples were obtained from Plasmodium falciparum -infected malaria patients from Upazila health complexes (UHC) between 2009 and 2013 in seven endemic districts of Bangladesh. (biomedcentral.com)
  • Due to Plasmodium sequestration in the placenta (placental malaria), and the immunosuppression during pregnancy, malaria represents a substantial risk for both the mother and fetus. (toxys.com)
  • Parvovirus B19 integration into human CD36+ erythroid progenitor cells. (cornell.edu)
  • or as an intrinsic defect arising from impaired proliferation and maturation of myeloid progenitor cells in the BM, which is rare. (ashpublications.org)
  • Hemolysis leads to erythroid hyperplasia and high demands for folate. (medscape.com)
  • Episodes of delayed hemolysis 2-6 weeks after treatment of severe malaria with intravenous artesunate have been described. (cdc.gov)
  • We performed a prospective observational study of patients with uncomplicated malaria to investigate whether posttreatment hemolysis also occurs after oral artemisinin-based combination therapy. (cdc.gov)
  • Eight of 20 patients with uncomplicated malaria who were given oral artemisinin-based combination therapy met the definition of posttreatment hemolysis (low haptoglobin level and increased lactate dehydrogenase level on day 14). (cdc.gov)
  • Given the key role of artemisinins in malaria treatment, WHO calls for prospective clinical studies and further research to improve the understanding of delayed hemolysis after artemisinin therapy ( 10 ). (cdc.gov)
  • We hypothesize that delayed hemolysis occurs not only after intravenous treatment for severe malaria but also in a substantial number of patients given oral ACTs for uncomplicated malaria. (cdc.gov)
  • Subsequent blood stage parasite loads dictated their cytokine profiles, where low parasite loads preferentially expanded IL-17-producing γδ T cells. (bvsalud.org)
  • Despite this, few studies provide definitive knowledge of parasite-induced host-cell apoptosis. (biomedcentral.com)
  • Here, the focus is on a consideration of host-cell apoptosis as either a pathogenic feature or as a factor enabling parasite survival and development. (biomedcentral.com)
  • In low malaria transmission areas, parasite clearance studies require screening of thousands of febrile individuals to enroll a few patients. (biomedcentral.com)
  • Malabsorption may occur in tropical sprue and other acute or chronic intestinal infections, and may also complicate systemic infections, including acute pneumonias, TB and malaria. (medscape.com)
  • It is a major filter of the blood, which initi-Keywords: spleen, sickle cell disease, hyposplenism, acute ates and links innate and adaptive immune responses againstsplenic sequestration, childhood. (fliphtml5.com)
  • Approximately 100,000 Americans have Sickle Cell Disease (SCD) - a group of inherited red blood cell disorders that can cause acute, chronic pain and serious health complications, including infections, strokes, organ damage, vision problems, and serious fatigue. (cdc.gov)
  • Myeloid malignancies, such as myelodysplastic syndromes and acute myeloid leukemia, are rare, often highly fatal, cancers of the blood cells. (nih.gov)
  • Elucidation of the multiple genetic defects have provided insight into the biology of the cell involving membrane structures, secretory vesicles, mitochondrial metabolism, ribosome biogenesis, transcriptional regulation, and cytoskeletal dynamics, as well as the risk for myelodysplasia and acute myeloid leukemia. (ashpublications.org)
  • They may be due to a peripheral hyperdestruction red blood cells (hyperhemolysis), acute hemorrhage, or repair of a previous deficit of erythrocyte production because the high reticulocyte count shows that the marrow is working. (medical-actu.com)
  • For example, patients with sickle cell anemia who already have chronic anemia may develop additional acute anemia due to bone marrow failure (aplastic crisis). (medscape.com)
  • neutrophils play a central role in acute inflammation, and other white blood cells, such as lymphocytes, play important roles in chronic inflammation. (basicmedicalkey.com)
  • Host cell entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is facilitated via priming of its spike glycoprotein by the human transmembrane protease serine 2 (TMPRSS2). (uni-freiburg.de)
  • Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. (wikipedia.org)
  • As a member of the Physiology Unit, Dr. Ruhl leads clinical research efforts within a translational research team focused on the impact of Alpha thalassemia on human health, including the impact of varying alpha globin gene variants on sickle cell disease and malaria. (nih.gov)
  • The SLC4A1 gene mutations involved in SLC4A1 -associated distal renal tubular acidosis lead to production of altered AE1 proteins that are either stuck inside the cell or trafficked to the wrong side of the cell. (medlineplus.gov)
  • These assays will allow higher identification of GYPB deletions for giant genetic affiliation research and practical experiments to grasp the function of this gene cluster area in susceptibility to malaria and different illnesses. (tbdb.org)
  • According to the U.S. Centers for Disease Control and Prevention (CDC), "Sickle cell trait is not a disease, but having it means that a person has inherited the sickle cell gene from one of his or her parents. (cdc.gov)
  • Haemoglobinopathies are caused by mutations in the two globin gene clusters and are characterised by a reduced or absent synthesis of globin chains in the case of the thalassaemia syndromes, mainly α- and β-thalassaemia, or by defects in the haemoglobin protein structure in the case of structural haemoglobin variants, such as the Hb S that causes sickle-cell disease. (ithanet.eu)
  • Sickle cell disease is caused by one particular mutation on the HBB gene, producing an abnormal version of β-globin known as haemoglobin S (HbS) which can distort red blood cells into a sickle shape. (ithanet.eu)
  • Historically many researchers have centered on understanding the systems managing -globin gene appearance and the results from the thalassemic mutations on crimson cell creation and, subsequently, on physiological procedures suffering from hypoxia and unusual erythropoiesis. (nsdfu.org)
  • Variant Gene Expression and Antigenic Variation by Malaria Parasites. (cornell.edu)
  • Her research focus is to understand the interplay between transcription factors and higher-order chromatin organization in the regulation of gene expression and cell identity. (nih.gov)
  • Additional problems with rAAV vectors include limited tissue dispersion for serotypes that employ heparan sulfate as a receptor (AAV2 and 3), poor infection of non-permissive cell types such as stem cells, challenges with high efficiency targeting of gene delivery to selected cell populations, and a finite transgene carrying capacity. (justia.com)
  • We have reported previously that DHA specifically targets pro-erythroblasts and basophilic erythroblasts, when human CD34+ stem cells are differentiated toward the erythroid lineage, indicating that a window of susceptibility to artemisinins may exist also in human developmental erythropoiesis during pregnancy. (nih.gov)
  • IL-17 drove extra-medullary erythropoiesis and concomitant reticulocytosis, which protected mice from lethal experimental cerebral malaria (ECM). (bvsalud.org)
  • The Birth, Life, and Death of Red Blood Cells: Erythropoiesis, The Mature Red Blood Cell, and Cell Destruction. (sciforschenonline.org)
  • These findings indicate a need for increased vigilance for hemolytic events in malaria patients, particularly those with predisposing factors for anemia. (cdc.gov)
  • The blood cell abnormalities can lead to hemolytic anemia, in which the abnormal red blood cells are prematurely broken down. (medlineplus.gov)
  • breakdown of these abnormal red blood cells may lead to hemolytic anemia. (medlineplus.gov)
  • Hematologic Disorders: Acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia (Diamon-Blackfan anemia), idiopathic thrombocytopenic purpura in adults, pure red cell aplasia, and selected cases of secondary thrombocytopenia. (issapharma.com)
  • Sickle cell disease (SCD) is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia. (nih.gov)
  • Fatalities caused by parasitic infections often occur as a result of tissue injury that results from a form of host-cell death known as apoptosis. (biomedcentral.com)
  • The management of host-cell apoptosis could thus be an adjunctive factor for parasitic disease treatment. (biomedcentral.com)
  • Apoptosis is a form of programmed cell death involved in a wide range of adaptive processes, from embryogenesis to stress injury responses. (biomedcentral.com)
  • During their evolution, parasites have developed mechanisms to induce or avoid host cell apoptosis in order to be able to survive and complete their life cycle. (biomedcentral.com)
  • Pathways involved in apoptosis are highly regulated, demonstrating that this mechanism is finely tuned according to the biological environment of the cell. (biomedcentral.com)
  • Among the factors involved in that balance in infected organisms, the time of apoptosis (early or late occurrence), the cell type and the type of parasitism (intracellular or not) are the major modulators. (biomedcentral.com)
  • Since apoptosis pathways are common to almost all human cells, it could be speculated that protective adjuvant therapy using anti-apoptotic drug would have a beneficial action on damaged cells but, at the same time, it could also induce deleterious effects on tissues where apoptosis was necessary for cell homeostasis. (biomedcentral.com)
  • One other option could be to favour apoptosis of the infected cell. (biomedcentral.com)
  • Treatment devoted to the induction of infected-cell apoptosis, for example to avoid the dissemination of intracellular parasites, could also be responsible for detrimental effects on non-infected cells. (biomedcentral.com)
  • When should cell death be called apoptosis? (biomedcentral.com)
  • None of the single morphological, enzymatic or functional aspects of cell death provide a definitive proof that observed cell death should be considered as apoptosis. (biomedcentral.com)
  • Anemia is strictly defined as a decrease in red blood cell (RBC) mass. (medscape.com)
  • The sickle-shaped red blood cells die prematurely, which can lead to anemia. (ithanet.eu)
  • 19 Some of these disorders are known by fanciful and cryptic names like sickle-cell anemia, thalassaemia, glucose-6-phosphate dehydrogenase deficiency, ovalocytosis, elliptocytosis and loss of the Gerbich antigen and the Duffy antigen. (valerielebrun.be)
  • Cam's work focuses on how oxidative stress disrupts the cell cycle during erythroid development in the context of malarial anemia. (wfu.edu)
  • Anemia during pregnancy, as noted in this chapter, is even more likely to be labelled as normal since hemodilution takes place during the first and second trimester as plasma volume increases disproportionately to red cell mass. (glowm.com)
  • Before embarking on the exploration of anemia, it must be ensured that the other lines are normal because the behavior would be different if there was bicytopenia, pancytopenia or anemia with leukocytosis made of lymphocytes, a myelemia or with the presence of abnormal cells in the blood. (medical-actu.com)
  • It is anemia accompanied by a high number of reticulocytes: more than 150 000 cells / mm3. (medical-actu.com)
  • The basic disease process is hematologic (eg, sickle cell disease, HS), and the degree of anemia varies markedly from etiology to etiology and from patient to patient, even with the same etiology. (medscape.com)
  • The discovery of the causes of certain types of anemias (eg, of pernicious anemia [a form of B 12 deficient anemia] and of sickle cell anemia) has been an area where the reciprocal relationship between medicine and biochemistry referred to in Chapter 1 has been extremely beneficial. (basicmedicalkey.com)
  • 2011) with malaria and is the leading global cause of maternal anemia, low birth weight, preterm delivery, stillbirths, and miscarriages (Goldenberg et al. (toxys.com)
  • All artemisinins derivatives, except deoxyartemisinin, inhibited both spontaneous and induced erythroid differentiation, confirming that the peroxide bridge is responsible for the erythro-toxicity. (nih.gov)
  • The substituent at position C-10 is responsible only for the anti-proliferative effect, since 10-deoxoartemisinin did not reduce cell growth but arrested the differentiation of K562 cells. (nih.gov)
  • In 2013, he joined the faculty in the Department of Microbiology and Immunology at UCSF as Assistant Professor in Residence, where his group builds biochemical and single cell genetic tools to dissect mechanisms of the heterochromatin spreading reaction in genome partitioning and directing differentiation. (nih.gov)
  • FIGURE 52-1 Simplified scheme of differentiation of red blood cells and other blood cells from the hematopoietic stem cell. (basicmedicalkey.com)
  • Nevertheless, soluble elements or cytokines that control the locks cell differentiation in the body organ of Corti stay to become elucidated. (immune-source.com)
  • The genome editing technology proved more stable while producing higher and more uniform levels of fetal hemoglobin in human hematopoietic stem cells compared with CRISPR/Cas9-based editing approaches, according to findings published in Nature Genetics. (cdc.gov)
  • Understand the concept of stem cells and their importance. (basicmedicalkey.com)
  • The first solid evidence for the existence of stem cells, and in particular hematopoietic stem cells, was reported from studies done in mice by Ernest McCulloch and James Till in 1963. (basicmedicalkey.com)
  • In recent years, interest in stem cells has grown enormously, and they are now of interest to almost every area of medicine and the health sciences. (basicmedicalkey.com)
  • Stem cells may be totipotent (capable of producing all the cells in an organism), pluripotent (able to differentiate into cells of any of the three germ layers), multipotent (produce only cells of a closely related family) or unipotent (produce only one type of cell). (basicmedicalkey.com)
  • 2017. Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites. . (cornell.edu)
  • An increase of artemisinin-resistant malaria parasites on the Thai-Cambodia and Thai-Myanmar borders is worrisome. (biomedcentral.com)
  • In high-dose females, these liver lesions were especially prominent and included bile duct and oval cell hyperplasia. (nih.gov)
  • They remain in the circulation for approximately 1 day before they mature into erythrocytes, after the digestion of RNA by reticuloendothelial cells. (medscape.com)
  • MS is associated with activated peripheral and CNS-resident immune cells [ 2 ] and it remains to be determined whether erythrocytes play a role in its pathology. (biomedcentral.com)
  • Erythrocytes are anucleate cells responsible primarily for respiratory gas transport [ 4 , 5 ], yet are also thought to play a dynamic role in health and disease [ 6 ]. (biomedcentral.com)
  • Certain of the blood group systems , present on the membranes of erythrocytes and other blood cells, are of extreme importance in relation to blood transfusion and tissue transplantation. (basicmedicalkey.com)
  • However, the altered protein attaches to the normal protein and keeps it from getting to the correct location, leading to a severe reduction or absence of AE1 protein in the correct part of the cell membrane. (medlineplus.gov)
  • Infusion of autologous OTQ923 into three participants with severe sickle cell disease resulted in sustained induction of red-cell fetal hemoglobin and clinical improvement in disease severity. (cdc.gov)
  • A decrease in body fluid can come from medications, fluid loss, lack of fluid intake, or illnesses such as diabetes.A decrease in body fat can … In West Africa an HLA class I antigen (HLA Bw53) and an HLA class II haplotype (DRB1*13OZ-DQB1*0501) are independently associated with protection against severe malaria. (valerielebrun.be)
  • Human leucocyte antigen-matched related haematopoietic stem cell transplantation using low-dose cyclophosphamide, fludarabine and thymoglobulin in children with severe aplastic anaemia. (amedeo.com)
  • It is the first potentially major consequences, such as vascular complica-organ injured in sickle cell anaemia (SCA) with evidence of tions and immune dysfunction, in addition to the long iden-hyposplenism present before 12 months in the majority of tified susceptibility to encapsulated bacteria. (fliphtml5.com)
  • Hyposple- in sickle cell disease (SCD) are discussed.nism increases the susceptibility of SCA children to infectionwith encapsulated bacteria, which is notably reduced by peni- Functions of the spleencillin prophylaxis and immunization. (fliphtml5.com)
  • Therefore, folate is required for normal cell division and, e.g. bone marrow and gastrointestinal mucosa have the highest requirements. (medscape.com)
  • Vertebral fractures and low lean mass in young men with sickle cell disease: Lack of association with bone mineral density and clinical characteristics. (amedeo.com)
  • There is a balance between red cell production by the bone marrow and destruction of old red blood cells by the spleen. (enetmd.com)
  • A bone marrow sample or biopsy (removal of a small sample of bone marrow for analysis) may be needed to decide if red blood cell production is defective. (enetmd.com)
  • Especially in the drug discovery field, knowledge of how small molecules associate with proteins plays a fundamental role in understanding how drugs or metabolites can affect cells, tissues, and human metabolism. (uni-freiburg.de)
  • Haemoglobin is a molecule made up of iron and protein, which carries oxygen in the red blood cells in the blood around the body from the lungs to the tissues (e.g. muscles or brain) where this oxygen is essential to the functioning of the tissues. (enetmd.com)
  • Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. (wikipedia.org)
  • It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. (wikipedia.org)
  • Studies suggest that with the help of glycophorin A, the altered AE1 protein can often get to the cell membrane in red blood cells, which explains why most people with SLC4A1 -associated distal renal tubular acidosis do not have blood cell abnormalities. (medlineplus.gov)
  • Guidelines and Measures provides users a place to find information about AHRQ's legacy guidelines and measures clearinghouses, National Guideline Clearinghouse (NGC) and National Quality Measures Clearinghouse (NQMC) These qualitative defects create a red blood cell membrane that is less tolerant of shear stress and more susceptible to permanent deformation. (valerielebrun.be)
  • 23], Protection also derives from the instability of sickle hemoglobin, which clusters the predominant integral red cell membrane protein (called band 3) and triggers accelerated removal by phagocytic cells. (valerielebrun.be)
  • Discuss the general structure of the red blood cell membrane. (basicmedicalkey.com)
  • Because clinical manifestations of malaria only arise during the blood stage of infection, a perception exists that liver infection does not impact disease pathology. (bvsalud.org)
  • Sickle cell disease (SCD) is associated with chronic haemolysis, immuno-suppression and suscepti- bility to infections, which may trigger infection-associated haemolysis (IAH). (bvsalud.org)
  • Tryphena's work focuses on the gut biology, particularly the gut microbiome and gut barrier integrity following a malaria infection and its influence on disease severity. (wfu.edu)
  • Included, were patients infected with HIV and followed in the service whose clinical and laboratory diagnosis of malaria had been performed and/or patients with whom the diagnosis of co-infection was done with the regression of a medical consultation following the consent of the legal representative. (longdom.org)
  • There is a need in the art for improved AAV vectors that can infect cells that are non-permissive for AAV. (justia.com)
  • Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity. (cornell.edu)
  • 66] These differences reflect the intensity of transmission of P. falciparum malaria from locality to locality and season to season, so fitness calculations will also vary. (valerielebrun.be)
  • Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. (nih.gov)
  • This study seeks a better understanding of the clinical profile of coinfected biological and therapeutic HIV-Malaria in Children's Hospital Pediatrique du jour Day Centre Hospital Universitaire Souro Sanou (CHUSS) Bobo-Dioulasso. (longdom.org)
  • He received his ScB in Biology from Brown University and MD/PhD from the University of Pennsylvania where his graduate work in the lab of Craig Thompson focused on the role of glucose metabolism and lipid biosynthesis in the growth of normal and malignant hematopoietic cells. (nih.gov)
  • 17. Angelucci E. Hematopoietic stem cell transplantation in thalassemia. (medrech.com)
  • intramuscular administration is contraindicated), pure red cell aplasia, select cases of secondary thrombocytopenia. (nih.gov)
  • Haemoglobinopathies are the most common monogenic diseases in the world and are prevalent in former malaria regions in the Mediterranean, the Middle-East, South-East Africa and Sub-Saharan Africa. (ithanet.eu)
  • Do we know of diseases in which there are very specific targets-in which certain cell types are damaged or destroyed while neighboring cells are left intact? (blogspot.com)
  • An important issue will be to predict the beneficial or deleterious effects of controlling human cell death by apoptotic-like mechanisms during parasitic diseases. (biomedcentral.com)
  • AD is one of the most common neurodegenerative diseases, characterized by the progressive loss of neuronal cells in the central nervous system which eventually contributes to memory impairment. (biomedcentral.com)
  • 25] Targeting the stimuli that lead to endothelial activation will constitute a promising therapeutic strategy to inhibit sickle red cell adhesion and vaso-occlusion. (valerielebrun.be)
  • His research program integrates genetic, epigenetic, and functional genomic methodologies to understand the determinants of blood cell development and develop innovative therapeutic strategies for blood disorders. (nih.gov)
  • Cell death by apoptotic-like mechanisms could be described as a ride to death with a return ticket, as initiation of the pathway may be reversed, with the potential that it could be manipulated for therapeutic purposes. (biomedcentral.com)
  • Extended publicity to therapeutic hyperoxia can induce extreme unwanted effects on intestinal epithelial cells. (iisinai.org)
  • However, if the net effect of protection against malaria outweighs the other detrimental effects, the protective mutation will tend to be retained and propagated from generation to generation. (valerielebrun.be)
  • Improper location or absence of AE1 in kidney cell membranes disrupts bicarbonate exchange, and as a result, acid cannot be released into the urine. (medlineplus.gov)
  • On the contrary, cell growth was markedly reduced by DHA, artemisone and artesunate but not by artemisinin, 10-deoxoartemisinin or deoxy-artemisinin. (nih.gov)
  • Modeling of γδ T cell dynamics suggests that this protective mechanism may be key for the establishment of naturally acquired malaria immunity among frequently exposed individuals. (bvsalud.org)
  • For her postdoctoral studies, she joined Konrad Hochedlinger's lab at the Massachussetts General Hospital and Harvard Stem Cell Institute, Boston, where she focused on dissecting epigenetic and chromatin organization changes during somatic cell reprogramming and their effect on pluripotency. (nih.gov)
  • these cells can be potentially used for culturing P. vivax and other species of malaria. (nih.gov)
  • 5600 Fishers Lane [56] Because of these several reports from different parts of the world it is clear that some variants of P. vivax are being transmitted to humans who are not expressing DARC on their red cells. (valerielebrun.be)
  • To better investigate the toxicity of artemisinin derivatives, the structure-activity relationship was evaluated against the K562 leukaemia cell line, used as a model for differentiating early human erythroblasts. (nih.gov)
  • Human genetic resistance to malaria refers to inherited changes in the DNA of humans which increase resistance to malaria and result in increased survival of individuals with those genetic changes. (valerielebrun.be)
  • To investigate regulation of the expression of the human cell-surface heme transporter (FLVCR). (sciforschenonline.org)
  • Conclusions/Significance Local conformation of ACE is definitely significantly modified in tumor lung cells and may become recognized by conformational fingerprinting of human being ACE. (immune-source.com)
  • Determination of serum folate and red cell folate which are decreased in folate deficiency, are not readily available in hospitals in developing countries. (medscape.com)
  • Scientists have found that sickle cell trait originated as an evolutionary response to malaria, one of the deadliest illnesses in tropical regions. (cdc.gov)
  • Dr. Ruhl serves on the NIH Pulmonary Consult Service and routinely sees patients in the NIH Sickle Cell Program. (nih.gov)
  • Genomic alteration using adenine base editors demonstrated the most potency in restarting fetal hemoglobin expression in cells of patients with sickle cell disease, study results showed. (cdc.gov)
  • Enhanced IgG immune response to COVID-19 vaccination in patients with sickle cell disease. (amedeo.com)
  • Haematopoietic stem cell mobilisation followed by high-dose chemotherapy and autologous stem cell transplantation for patients with sickle cell disease and myeloma. (amedeo.com)
  • Blood samples had been screened by an automatic blood typing system (PK7300) utilizing bromelain-treated purple blood cells (RBCs) and murine monoclonal anti-M. The M-positive RBC samples had been analysed by immunoblotting utilizing anti-M as the first antibody. (tbdb.org)
  • The present invention provides mutant adeno-associated virus (AAV) that exhibit altered capsid properties, e.g., reduced binding to neutralizing antibodies in serum and/or altered heparin binding and/or altered infectivity of particular cell types. (justia.com)
  • This is about 1000 times greater than mutation rates measured in Drosophila and other organisms and much higher than recorded for the sickle-cell locus in Africans. (valerielebrun.be)
  • In children, the spleen can become engorged with blood cells in a "splenic sequestration. (nih.gov)
  • Neurofilament light chain: A potential biomarker for cerebrovascular disease in children with sickle cell anaemia. (amedeo.com)
  • A novel promoter of endothelial dysfunction in African Americans: Relevance to sickle cell anaemia. (amedeo.com)
  • Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis. (cdc.gov)
  • From the abstract: ' What genetic modifiers of sickle cell disease (SCD) are currently defined, and what are potential approaches to improve future studies? (cdc.gov)
  • Genetic counseling in sickle cell disease: Insights from the Indian tribal population. (cdc.gov)
  • In type-I diabetes, it seems likely that Coxsackie virus infections (in people with a genetic predisposition, in which HLA type plays a major role) trigger an autoimmune disease that gradually (over a year or so) destroys the islet cells which produce insulin. (blogspot.com)
  • Finally, we showed that infected mice treated with NL-CVX1 developed both anti-SARS-CoV-2 antibodies and memory T cells and were protected against reinfection a month after treatment. (bvsalud.org)
  • The present invention further provides nucleic acids comprising nucleotide sequences that encode mutant capsid proteins, and host cells comprising the nucleic acids. (justia.com)
  • The mature erythrocyte remains in circulation for about 120 days before being engulfed and destroyed by phagocytic cells of the reticuloendothelial system. (medscape.com)
  • Changes in the intestinal tract are glossitis, angular cheilosis, mild malabsorption and delayed regeneration of liver cells. (medscape.com)
  • This dichotomy relied on liver stage-dependent activation of Vγ4+ γδ T cells. (bvsalud.org)
  • The mutations involved in hereditary spherocytosis lead to a reduction of AE1 protein, which results in abnormal red blood cells that are round and spherical rather than a flattened disk shape and are more fragile than usual. (medlineplus.gov)
  • However, cell death is a very complex phenomenon and descriptions were, in many cases, based on methods available in a particular laboratory rather than standardized methods. (biomedcentral.com)
  • In some cases, a pathogen targets a particular cell type and has little effect on anything else. (blogspot.com)
  • This protein transports negatively charged atoms (anions) across cell membranes. (medlineplus.gov)
  • However, some altered AE1 proteins cannot be helped by glycophorin A and are not trafficked to red blood cell membranes. (medlineplus.gov)