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  • Sequestration
  • High levels of inflammatory cytokines are associated with endothelial cell activation and increased expression of adhesion molecules that contribute to the sequestration of parasitized erythrocytes and leukocytes in the cerebral vascular bed and the resultant CM syndrome ( 10 , 13 - 15 ). (rupress.org)
  • A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain," American Journal of Pathology , vol. 155, no. 2, pp. 395-410, 1999. (hindawi.com)
  • An immunohistochemical study of the pathology of fatal malaria: evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration," American Journal of Pathology , vol. 145, no. 5, pp. 1057-1069, 1994. (hindawi.com)
  • It is caused by the sequestration of malaria-infected erythrocytes onto brain endothelia, followed by blood-brain barrier (BBB) damage and neurological deficit. (kuleuven.be)
  • World Health Organ
  • This observational prospective cohort study will enroll 512 Tanzanian children, 6 months to 6 years old, admitted to the hospital with CM (Group 1) as defined by World Health Organization criteria and uncomplicated malaria (UM-Group 2). (clinicaltrials.gov)
  • Of 348 children admitted with cerebral malaria (as defined by the World Health Organization), 168 met the inclusion criteria, underwent all investigations, and were included in the analysis. (nih.gov)
  • occurs
  • This suggests that in most cases P. falciparum avoids targeting the brain and that cerebral malaria only occurs when red blood cells express a subset of PfEMP1 proteins with particular adhesion phenotypes which allow for efficient binding to the cerebral blood vessels. (sciencecodex.com)
  • syndrome
  • Recent data also show that ADHD can be linked to CM. Post malaria syndrome can also include psychotic or acute confusional episodes and tremor. (omicsonline.org)
  • brain
  • Malaria parasites live in red blood cells and make them stick to the inside of small blood vessels, particularly in the brain and also the eye. (rxpgnews.com)
  • In cerebral malaria, the eye acts as a window onto the brain, providing valuable information for the doctors caring for the patients," says Dr Beare. (rxpgnews.com)
  • This has been suggested as the reason we only see cerebral malaria in some infected individuals, and if the infected red blood cells do not bind in the brain cerebral malaria cannot occur. (sciencecodex.com)
  • Knowing that binding in the brain is a key feature of cerebral malaria allows researchers to focus their attention on developing new interventions for severe disease based on the interaction between infected red blood cells and the host cells lining the blood vessels in the brain. (sciencecodex.com)
  • We hypothesized that localized cerebral microvascular thrombosis in CM is caused by a decreased expression of the anticoagulant and protective receptors thrombomodulin (TM) and endothelial protein C receptor (EPCR) and that low constitutive expression of these regulatory molecules in the brain make it particularly vulnerable. (nih.gov)
  • We tested the hypothesis that cerebral malaria is caused by blood-brain barrier inflammation and cerebral edema. (ajtmh.org)
  • 1997
  • A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya," Human Molecular Genetics , vol. 6, no. 8, pp. 1357-1360, 1997. (hindawi.com)
  • quinine
  • Chemotherapy for cerebral malaria mainly involves the use of quinine (a bitter alkaloid extracted from the Cinchona tree bark), in case the patient exhibits chloroquine resistance. (buzzle.com)
  • Even though chloroquine is the common anti-malarial drug but in the cases of cerebral malaria quinine (a bitter alkaloid from chinchona) is use. (onlymyhealth.com)
  • Comparison of combinations of parenteral artemisinin derivatives plus oral mefloquine with intravenous quinine plus oral tetracycline for treating cerebral malaria. (who.int)
  • rodent
  • To understand the microcirculatory events during cerebral malaria, we have studied the lethal strain of rodent Plasmodia, Plasmodium yoelii 17XL, originally described by Yoeli and Hargreaves in 1974. (ajtmh.org)