• Embryonic stem cells are derived from early embryos and have the ability to differentiate into any cell type. (spiked-online.com)
  • 1] Therapeutic cloning, on the other hand, creates human embryos merely as a source of embryonic stem cells. (reasons.org)
  • Tragically, however, in order to harvest stem cells from human embryos, the embryos must be destroyed. (reasons.org)
  • Crudely put, therapeutic cloning looks to generate human embryos solely for the body parts they can provide. (reasons.org)
  • The Catholic Church has always held that stem-cell research and therapies are morally acceptable, as long as they don't involve the creation and destruction of human embryos. (archstl.org)
  • Johns Hopkins scientists have developed a way to study the earliest steps of human blood development using human embryonic stem cells grown in a lab dish instead of the embryos themselves. (sciencedaily.com)
  • The Johns Hopkins researchers' system involves the study of existing embryonic stem cell lines derived from in vitro fertilization methods, and so doesn't require generation of embryos through cloning, a technique recently reported by South Korean scientists. (sciencedaily.com)
  • In their report on the work in the June issue of the journal Blood, the Johns Hopkins team demonstrated a clear similarity between how human embryonic stem cells specialize into blood cells and how blood cells develop in human embryos. (sciencedaily.com)
  • Historically, scientists have worked on mouse and zebrafish models of embryological blood cell development, but ethical and technical barriers have stood in the way of an in-depth study of blood formation in human embryos. (sciencedaily.com)
  • These colonies can then also form the precursors of blood cells, in a structure similar to the yolk sac of human embryos. (sciencedaily.com)
  • Most importantly, Zambidis says, the stages of blood cell development he and his team found in the stem cell lines correlate with what is already known about early stages of human blood cell development in embryos in the womb. (sciencedaily.com)
  • In humans, a major roadblock in achieving successful SCNT leading to embryonic stem cells has been the fact that human SCNT embryos fail to progress beyond the eight-cell stage. (news-medical.net)
  • They derived several human embryonic stem cell lines from these cloned embryos whose DNA was an exact match to the adult cell that donated the DNA. (news-medical.net)
  • The issue of research involving stem cells derived from human embryos is increasingly the subject of a national debate and dinner table discussions," said President George W. Bush in a 2001 speech announcing his policy on embryonic stem cell research. (erlc.com)
  • Where do the embryos for embryonic stem cells come from? (erlc.com)
  • Oftentimes during the process, more embryos are created than are implanted into a woman's womb. (erlc.com)
  • Currently, all human embryonic stem cell lines in use today were created from embryos generated by IVF. (erlc.com)
  • Researchers reported in Nature on November 22, 2007, that they successfully isolated 2 embryonic stem cell lines from cloned embryos made using cells from the skin of an adult rhesus macaque. (nih.gov)
  • Michigan would join 47 other states in permitting research on human embryos and the creation of new embryonic stem cell lines in Michigan if Proposal 2008-02 is adopted by the voters on November 4. (crcmich.org)
  • It prohibits non-therapeutic research that jeopardizes the life or health of a human embryo, fetus, or neonate, thereby precluding research on embryos to derive human embryonic stem cell lines. (crcmich.org)
  • Stem cells exist both in embryos and adult cells. (articlecity.com)
  • Embryonic stem cells, which must be extracted from embryos three to five days old (known as blastocysts, which contain only about 150 cells at this point of development). (articlecity.com)
  • The cost seems to be small, experimentation with stem cells derived from "spare" embryos that are no longer needed or wanted for in vitro fertilization. (jcrelations.net)
  • The hybrid cells carrying four sets of chromosomes (instead of the usual two) behaved as stem cells when injected into mouse embryos. (i-sis.org.uk)
  • There are two types of stem cell manufacturing: embryonic stem cell production, derived from early-stage embryos, and induced pluripotent stem cell (iPSC) production, which reprograms adult cells to an embryonic-like state. (imarcgroup.com)
  • In her article, Somerville says Canada's Assisted Human Reproduction Act "reflects the view that to create embryos other than by sexual reproduction and other than to help people have children is inherently wrong. (catholicnewsagency.com)
  • Among the real and knotty ethical questions are these: Should human embryos be created expressly to be used for stem cell extraction? (prospect.org)
  • Should women be paid to donate eggs or fertilized embryos to stem cell labs? (prospect.org)
  • He decreed that stem cell colonies produced before Aug. 9, 2001, could continue to receive federal funding for research purposes but no federal money could go to develop new stem cells from embryos. (prospect.org)
  • Scientists and patient advocates were clamoring for studies on the cells, whose vast therapeutic potential was just coming to light, while others were decrying the research as immoral because it necessitated the destruction of days-old human embryos. (americanprogress.org)
  • Researchers hope to use these cells to grow healthy tissue to replace injured or diseased tissues in the human body. (medlineplus.gov)
  • Therapeutic cloning produces embryonic stem cells for experiments aimed at creating tissues to replace injured or diseased tissues. (wisdomanswer.com)
  • For example, 3M's Zeta Plus™ products, used to make life-saving plasma therapies, are manufactured in several locations throughout the globe, strategically located where demand for them is highest. (genengnews.com)
  • If research involving human embryonic stem cells (ESCs) is to achieve its potential for creating breakthrough medical therapies, additional new cell lines should be created, and therapeutic cloning--or somatic cell nuclear transfer (SCNT)--should be employed, according to an expert panel of the National Academy of Sciences. (the-scientist.com)
  • The Church also supports research and therapies using adult stem cells, which are cells that come from any person who has been born - including umbilical cord blood, bone marrow, skin and other organs. (archstl.org)
  • I expected the conversation about stem-cell therapies to be one of those too-difficult conversations as well, one that would also be handled case by case and concession by concession-through litigation rather than legislation. (pharmtech.com)
  • These cells have been sought after as potential therapies for diseases ranging from heart disease to Parkinson's to cancer. (news-medical.net)
  • But SCNT can also be used to clone human cells for transplant or other therapies. (news-medical.net)
  • Geron is halting its development programs for human embryonic stem cell-based therapies, including an ongoing clinical trial in patients with severe spinal cord injuries, the company announced late Monday. (medpagetoday.com)
  • Geron had been one of the most prominent developers of and advocates for therapies based on human embryonic stem cells (ESCs). (medpagetoday.com)
  • Increasing investments in stem cell research, rising chronic disease prevalence, advancements in biotechnology, collaborations between academia and industry, stringent regulations, and expanding awareness of stem cell therapies are stimulating the market growth. (imarcgroup.com)
  • Apart from this, the increasing awareness and acceptance of stem cell-based therapies among patients and healthcare professionals is augmenting the market growth. (imarcgroup.com)
  • This driver is fueled by the promising prospects of stem cell therapies in addressing previously untreatable conditions, such as neurodegenerative diseases and spinal cord injuries. (imarcgroup.com)
  • Stem cell therapies hold immense promise in addressing these ailments by regenerating damaged tissues and organs. (imarcgroup.com)
  • Among the current biomaterial applications, the use of biopolymers as cell scaffolds could aid the development of stem cell-based therapies aimed at replacing tissue loss due to injuries or diseases, such as during myocardial infarction. (jscimedcentral.com)
  • Should expensive therapies derived from stem cell research be covered universally by health insurance? (prospect.org)
  • We have further developed an approach to identify and characterise pluripotent cell lines at the earliest stages of cell fate transformation to cancerous states, which has been an instrumental tool for our program in unlocking new candidate therapies. (bhatiaprogram.com)
  • The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)
  • This brings as oral dopamine therapies with the advantage that with it continued infective risks for the patients the cells can be targeted to the site where dopamine with DBS which is not so for patients with trans- is most needed, namely the striatum. (lu.se)
  • The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)
  • if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
  • The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
  • Given the promise of stem cell research for treating and perhaps curing a variety of debilitating diseases, our committee felt strongly that research not be limited, but include work on both human adult and embryonic stem cells," stated committee chair Bert Vogelstein , professor of oncology and pathology at the Johns Hopkins University School of Medicine, in. (the-scientist.com)
  • SCNT is a method of cloning mammalian cells that can be used to create personalized embryonic stem cells from an adult animal or human. (news-medical.net)
  • Embryonic stem cells are immortal, and have the potential to develop into any type of adult cell, even after months growing in culture dishes. (news-medical.net)
  • By transferring adult cell DNA into an embryonic stem cell, it is possible to create a line of immortal embryonic cells that are able to develop into any type of adult cell, genetically identical to the donor. (news-medical.net)
  • The cloning method is based on the fact that cytoplasmic factors in mature, metaphase II oocytes are able to reset the identity of a transplanted adult cell nucleus to an embryonic state. (news-medical.net)
  • Another successful attempt at human SCNT was made using cells from two adult males. (news-medical.net)
  • The adult cell nuclei were transferred into metaphase-II stage human oocytes, producing a karyotypically normal diploid embryonic stem cell line from each of the adult male donor cells. (news-medical.net)
  • The therapeutic potential of cloned human cells has been demonstrated by another study using human oocytes to reprogram adult cells of a type 1 diabetic. (news-medical.net)
  • however, there are also stem cells in the adult body. (thefutureofthings.com)
  • These adult stem cells are considered multipotent, having the ability to differentiate into different cell types, albeit with a more limited repertoire than embryonic stem cells. (thefutureofthings.com)
  • The ability of our body to regenerate some of its tissues is largely owed to the reserves of adult stem cells. (thefutureofthings.com)
  • Adult stem cells can be used to accelerate bone or tendon healing , and they can induce cartilage progenitor cells to produce a better matrix and repair cartilage damage . (thefutureofthings.com)
  • Adult stem cells can be used to replace damaged heart-muscle cells and are used in practice today . (thefutureofthings.com)
  • The most common application of adult stem cells is probably the restoration of blood cells for patients with leukemia, and there are many more applications currently in practice. (thefutureofthings.com)
  • What are adult stem cells? (erlc.com)
  • The term adult stem cells simply refers to any non-embryonic stem cell, whether taken from a fetus, a child or an adult. (erlc.com)
  • Adult stem cells are sometimes referred to as somatic stem cells to differentiate them from human germ cells, sperm cells and egg cells. (erlc.com)
  • Cloning entails taking the nucleus - the compartment that contains the DNA - from an adult cell and putting it into an egg from which the original nucleus has been removed. (nih.gov)
  • The egg then "reprograms" the adult nucleus so that the cell behaves like an embryo but has the genes of the adult cell. (nih.gov)
  • While some researchers are very enthusiastic about the therapeutic potential of embryonic stem cells, others raise ethical objections and suggest that we focus our energies and funds on researching adult stem cells. (cccb.ca)
  • Researchers may, however, conduct research on embryonic stem cell lines created outside of Michigan and may study adult stem cells. (crcmich.org)
  • They can divide and form all types of differentiated adult cells in the body (neurones, cardiac cells, skin cells, liver cells, etc. (eurekalert.org)
  • Since 2007, a handful of research teams across the world have been capable of reprogramming human adult cells into induced pluripotent cells (iPSC), which have similar characteristics and potential to human embryonic stem cells (hESC). (eurekalert.org)
  • The rejuvenated iPSC cells were again differentiated to adult cells and compared to the original old cells, as well as to those obtained using human embryonic pluripotetent stem cells (hESC). (eurekalert.org)
  • This research paves the way for the therapeutic use of iPS, insofar as an ideal source of adult cells is provided, which are tolerated by the immune system and can repair organs or tissues in elderly patients. (eurekalert.org)
  • Adult stem cells, which are present in small amounts in adult tissue but less adaptable than embryonic stem cells, making their use in medical treatments more challenging. (articlecity.com)
  • This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)
  • Current Clinical Use of Adult Stem Cells to Help Human Patients Proponents of embryonic stem cell research have created a false impression that these cells have a proven therapeutic use. (actionlife.org)
  • Britain s House of Lords final approval of therapeutic human cloning and embryonic stem cells research has intensified the battle for ascendancy between adult and embryonic stem cells. (i-sis.org.uk)
  • In the latest skirmish, two rapid online publications are presented as if they were evidence against the existence of adult stem cells. (i-sis.org.uk)
  • Two reports appeared as advance online publications in the top British journal Nature , accompanied by a news report that begins, "The hyped ability of adult stem cells to sprout replacement tissue types is being called into question. (i-sis.org.uk)
  • This leaves one with the distinct impression that adult stem cells might not exist, and furthermore, they may be a health hazard. (i-sis.org.uk)
  • Fusion could also be obtained between ES cells and cells isolated from adult brain. (i-sis.org.uk)
  • These researchers pointed out that the spontaneous fusion rate (without interleukin-3) was extremely low, between 2-11 per million bone marrow cells, and is unlikely to account for all the findings with adult stem cells. (i-sis.org.uk)
  • In fact, the senior authors in both reports admit that some adult stem cells may genuinely revert to an earlier stage of development or switch fates [1]. (i-sis.org.uk)
  • Neither report cited a paper published last year in the journal Blood [4], where a group from the Stem Cell Institute, Department of Medicine, and Cancer Center, University of Minnesota Medical School, Minneapolis, reported the most comprehensive experiments proving that a single adult stem cell can differentiate into all cell types in culture. (i-sis.org.uk)
  • The finding that adult cells can fuse with ES cells is therefore irrelevant to the debate, and the fact that it was used in an attempt to discredit adult stem cells is itself revealing, particularly in view of other recent findings on ES cells. (i-sis.org.uk)
  • This latest anti-publicity on adult stem cells comes on the heels of a paper announcing success in embryonic stem (ES) cell transplant in a Parkinson rat model published in the house journal of the United States National Academy of Sciences [5]. (i-sis.org.uk)
  • They found that the spontaneous mutation frequency in ES cells is 100-fold lower than that in mouse embryonic fibroblasts (a somatic cell line), which is similar to adult cells in vivo . (i-sis.org.uk)
  • Within a few years, unless the religious right manages to stop it, specialized cells developed from either embryonic or adult cells will be used therapeutically to treat everything from Parkinson's, Alzheimer's, diabetes, spinal injuries, heriditary impairments, and even the regeneration of diseased organs. (prospect.org)
  • As a consequence, clones created from a cell taken from an adult might have chromosomes that are already shorter than normal, which may condemn the clones' cells to a shorter life span. (wisdomanswer.com)
  • Similarly, cancerous adult stem cells and cancerous pluripotent stem cells share many properties that are distinct from other cancer cells that make up a tumour. (bhatiaprogram.com)
  • Uniquely, our approach is to study both adult and pluripotent cells in their normal and cancerous states. (bhatiaprogram.com)
  • These cells are obtained using Nobel Prize winning "cell reprogramming" technology to reverse cell fate decisions in adult cells. (bhatiaprogram.com)
  • Cloning describes the processes used to create an exact genetic replica of another cell, tissue or organism. (medlineplus.gov)
  • A renewable, tissue culture source of human cells capable of differentiating into a wide variety of cell types would have broad applications in basic research and therapeutic techniques. (spiked-online.com)
  • Current screening of potential new drugs is done using cell lines derived from animals or 'abnormal' human tissue such as tumor cells. (spiked-online.com)
  • The resulting tissue will be an almost exact genetic match to the patient and will therefore not face rejection and transplantation can be made much safer without the need for immune suppression. (spiked-online.com)
  • The exact process of differentiation is not yet understood and although embryonic stem cells can, in principle, provide for all human tissue, scientists are some way from controlling the process. (spiked-online.com)
  • Without any chemical manipulation or stimulation, the clusters of human stem cells first became colonies of cells that can produce endothelium, or the tissue that makes up the circulatory system. (sciencedaily.com)
  • XI - embryonic stem cells: embryonic cells that are capable of modifying the cells of any organism tissue. (hinxtongroup.org)
  • In addition to their ability to supply cells at the turnover rate of their respective tissues, they can be stimulated to repair injured tissue caused by liver damage, skin abrasions and blood loss. (thefutureofthings.com)
  • If there are intact cells in this tissue they have been 'stored' frozen. (wikiquote.org)
  • It is also our view that there are no sound reasons for treating the early-stage human embryo or cloned human embryo as anything special, or as having moral status greater than human somatic cells in tissue culture. (wikiquote.org)
  • With this raw material, biomedical firms can create stem cell lines that, among other things, aid recuperation via the regeneration of tissue that has been lost or damaged. (articlecity.com)
  • Current research is focused on growing a wide range of new tissue from stem cells, including muscle, blood, brain, and cartilage cells. (articlecity.com)
  • They have many of the positive characteristics of embryonic stem cells while sourcing material is far less challenging, since postpartum tissue can be used. (articlecity.com)
  • Similarly, the transplantation of other tissue-specific stem cells, such as stem cells isolated from epithelial and neural tissues, can treat mouse disease models and human patients in which epithelial and neural cells are damaged. (articlecity.com)
  • The meeting, organized by Elisa Martí (IBMB-CSIC, Barcelona, Spain), Jonas Muhr (Karolinska Institutet, Stockholm, Sweden) and Kate Storey (University of Dundee, UK), brought together international researchers interested in spinal cord development and those who are developing strategies to restore the function of the spinal cord in pathological situations using regeneration of the damaged tissue, including controlled cell replacement. (biologists.com)
  • Embryonic stem cells (ESC) provide a great therapeutic potential for cardiac tissue. (jscimedcentral.com)
  • He explained that the early embryonic cells that his laboratory tries to turn into specialized tissue for therapeutic purposes hadn't even ''individuated'' yet. (prospect.org)
  • The technique of plant tissue culture involves micropropagation and plant cell culture. (wisdomanswer.com)
  • Plant tissue culture Totipotency is the ability of plant cells, where a cell can change to a meristematic state and can be differentiated into a whole plant. (wisdomanswer.com)
  • This property of plant cells has an advantage over Animal cell tissue culture. (wisdomanswer.com)
  • By using the plant tissue culture process, these clones can be produced in quick succession and with uniformity - making it simpler for producers to supply consistent quality products on-demand. (wisdomanswer.com)
  • Most recently, to unlock the complex heterogeneous system of healthy tissue and cancerous tumour, we are using and developing novel approaches of multi-cytomics (single cell RNAseq, flow and image-based cytometry, clonal tracking). (bhatiaprogram.com)
  • Our research focuses currently on tissue restricted bone marrow blood stem cells and previously on embryonic stem cell lines. (bhatiaprogram.com)
  • Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
  • However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
  • The resulting cells were pluripotent and could be differentiated into insulin-producing beta cells to restore the function of the pancreas in the donor. (news-medical.net)
  • These cells are considered pluripotent . (thefutureofthings.com)
  • These old cells were reprogrammed in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated and human embryonic stem cells (hESC): cells of all types can again be differentiated after this genuine "rejuvenation" therapy. (eurekalert.org)
  • Using this new "cocktail" of six factors, the senescent cells, programmed into functional iPSC cells, re-acquired the characteristics of embryonic pluripotent stem cells. (eurekalert.org)
  • Induced pluripotent stem cells, which harness the power of genetic reprogramming - basically, the altering of a cell's DNA - to change the course of cellular development. (articlecity.com)
  • ReCyte Therapeutics, Inc. is developing applications of BioTime's proprietary induced pluripotent stem cell technology to reverse the developmental aging of human cells to treat cardiovascular and blood cell diseases. (aol.com)
  • Human somatic (such as blood stem cells) and pluripotent stem cells (such as embryonic stem cell lines) share common distinct pathways. (bhatiaprogram.com)
  • Our human cancer stem cell and pluripotent stem cell screening platform represents an important and proprietary component of our program being developed over the last decade. (bhatiaprogram.com)
  • Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
  • Alternatively, transgenesis and gene targeting techniques can be used to introduce the patient's genes into the stem cell line. (spiked-online.com)
  • Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
  • More and more we're learning that the genes that turn on in the embryo to make blood stem cells are the same genes that go wrong in cancer," he says. (sciencedaily.com)
  • This was believed to be due to an inability to activate certain embryonic genes. (news-medical.net)
  • Two separate research teams have figured out how to "reprogram" cells with just a handful of genes to give them the characteristics of embryonic stem cells. (nih.gov)
  • Found within Wharton's jelly - which is easily harvested from what would otherwise be post-natal medical waste - are several distinct stem cell genes. (articlecity.com)
  • Cells become cancerous by accumulating, stepwise, a series of several mutations that alter the function of genes important for cell growth. (agemed.org)
  • But, although the mutation frequency of genes was much lower in ES cells, mutant ES cells accumulated with time in culture. (i-sis.org.uk)
  • We've captured these phases of stem cell specialization, or differentiation, in a dish," says Zambidis. (sciencedaily.com)
  • These observations will facilitate molecular characterization of PSC-derived RGCs during differentiation, critical knowledge for establishing the veracity of these in vitro produced cells. (caltech.edu)
  • The term stem cell can be defined by two very important qualities: the cell has the ability to self-renew and, in a more general sense, the cell has not completed differentiation into its final state. (thefutureofthings.com)
  • This general definition includes a wide variety of cells with varying degrees of differentiation potential. (thefutureofthings.com)
  • Stem cells are defined by their capacity for self-renewal and multilineage differentiation, making them uniquely situated to treat a broad spectrum of human diseases. (articlecity.com)
  • The latest advances in the field of spinal cord development and its regeneration following damage were discussed at a recent EMBO workshop 'Spinal cord development and regeneration' in Sitges, Spain (October, 2014), highlighting the use of direct visualization of cellular processes, genome-wide molecular techniques and the development of methods for directed stem cell differentiation and regeneration. (biologists.com)
  • mEScell growth and differentiation on PLDLA-co-TMC membrane, demonstrated the cyto compatibility of this polymer, and provided evidence of minimal to no toxicity on the cells, allowing adhesion and cell proliferation, as well as differentiation into cardiomyocytes. (jscimedcentral.com)
  • These beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion, effectively maintaining axonal integrity in vitro. (bvsalud.org)
  • First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
  • Accordingly, researchers at this institution were quick to appreciate the enormous promise of human embryonic stem cells (hESCs) as research tools for understanding how the body normally works, thus laying the groundwork to identify disease-related aberrations. (ca.gov)
  • Our work is important because the researchers who use our laboratory are studying the causes of major human diseases that occur as the result of trauma (e.g., paralysis), cell death (e.g. (ca.gov)
  • With the advent of hESCs, researchers are envisioning new therapeutic approaches. (ca.gov)
  • The researchers then used these cells as the source of genetic material to clone pigs with organs that lacked the sugar groups responsible for HAR. (reasons.org)
  • Knowing the steps by which stem cells develop into blood cells are likely to help medical researchers figure out how to treat cancers of the blood, such as leukemia and lymphoma, Zambidis notes. (sciencedaily.com)
  • Finally, some of the cells in the colonies form blood cells similar to those found in the liver and bone marrow of a developing fetus, making it simple for the researchers to pick out the blood cells for further investigation. (sciencedaily.com)
  • Researchers have been hoping to harness the therapeutic potential of cloning ever since the cloning of Dolly the sheep in 1997. (nih.gov)
  • Before this new study was published, Nature asked another group of researchers to confirm that the stem cells were genetically identical to the donor skin cells. (nih.gov)
  • The stem cells, the researchers showed, could turn into heart or nerve cells in the laboratory, and had other characteristics of established embryonic stem cell lines. (nih.gov)
  • The researchers have successfully rejuvenated cells from elderly donors, some over 100 years old, thus demonstrating the reversibility of the cellular aging process. (eurekalert.org)
  • The researchers proved that the iPSC cells thus obtained then had the capacity to reform all types of human cells. (eurekalert.org)
  • Researchers first multiplied skin cells (fibroblasts) from a 74 year-old donor to obtain the senescence characterized by the end of cellular proliferation. (eurekalert.org)
  • To check the "rejuvenated" characteristics of these cells, the researchers tested the reverse process. (eurekalert.org)
  • This programme was created in 2001 by Inserm and provides a platform for young researchers, who have obtained their PhD in science, to set up and coordinate a team within an existing research structure. (eurekalert.org)
  • Since the initial discovery of the self-renewing properties of stem cells in the early 1960s - pioneered by a small team of researchers at the Ontario Cancer Institute [3] - the understanding of the power and diversity of stem cells has increased rapidly. (articlecity.com)
  • In the first report [2], researchers from Edinburgh and Oxford took cells from the mouse brain marked with transgene 1, and cultured them together with ES cells marked with a second transgene, 2. (i-sis.org.uk)
  • Two distinct neurodevelopmental abnormalities that arise just weeks after the start of brain development have been associated with the emergence of autism spectrum disorder, according to a new Yale-led study in which researchers developed brain organoids from the stem cells of boys diagnosed with the disorder. (lifeboat.com)
  • Now, researchers from MIT, the MIT-IBM Watson AI Lab, and Harvard Medical School have produced a hypothesis that may explain how a transformer could be built using biological elements in the brain. (lifeboat.com)
  • Those two factors make attempts to clone humans for reproductive purposes ethically troubling. (reasons.org)
  • Otherwise, such a treaty would not recognize the inherent human nature of the early human embryo or fetus until after birth , and thus cloning them and using them for research - both "therapeutic" and "reproductive" -- would not be banned, and women undergoing "infertility treatments" could surely be put in danger. (lifeissues.net)
  • Organism cloning (also called reproductive cloning) refers to the procedure of creating a new multicellular organism, genetically identical to another. (wisdomanswer.com)
  • What's the difference between therapeutic cloning and reproductive cloning? (wisdomanswer.com)
  • Gene cloning, also known as DNA cloning, is a very different process from reproductive and therapeutic cloning. (wisdomanswer.com)
  • 2. Over the years, the international community has tried without success to build a consensus on an international convention against the reproductive cloning of human beings. (who.int)
  • 3. Creating awareness among ministries of health in the African Region will provide them with critical and relevant information on the reproductive cloning of human beings and its implications to the health status of the general population. (who.int)
  • 5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
  • The reader benefits from the scholar's clear explanation about embryonic stem-cell research and therapeutic cloning. (catholicnewsagency.com)
  • … "embryo" means a human organism during the first 56 days of its development following fertilization or creation, excluding any time during which its development has been suspended, and includes any cell derived from such an organism that is used for the purpose of creating a human being. (hinxtongroup.org)
  • At the top of the list comes the zygote-a fertilized egg, which of course has the ability to divide and differentiate into all cell types in the body and create a new organism. (thefutureofthings.com)
  • The first three divisions of the zygote give birth to eight totipotent cells, each of which also has the ability to become an entire organism. (thefutureofthings.com)
  • They are able to differentiate into any cell of an organism and have the ability of self-renewal. (articlecity.com)
  • Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes. (agemed.org)
  • This investment in manufacturing represents a significant step forward based on our expectation that our treatment has the potential to impact the tumor micro-environment and break immune tolerance in solid tumors. (genengnews.com)
  • What deserves greater attention, however, is therapeutic cloning, a (potential) cloning application considered far more important to the biomedical and scientific communities and one far more ethically challenging. (reasons.org)
  • It is the potential use of embryonic stem cells that makes a national conversation difficult, because, like the still-unresolved abortion debate, it pits technology against notions of personhood. (pharmtech.com)
  • DESCRIPTION (provided by applicant): The capacity to evaluate the teratoma forming potential of differentiated embryonic stem cell populations represents an urgent need before widespread therapeutic application of these cells is possible. (sbir.gov)
  • Cloning of human cells is a technology that holds the potential to cure many diseases and provide a source of exactly matched transplant tissues and organs. (news-medical.net)
  • in other words, it has the potential to become any type of cell. (thefutureofthings.com)
  • Stem cells have two unique characteristics: (1) an almost unlimited capacity for self-renewal (they can theoretically divide without limit to replenish other cells for as long as the person is alive) and (2) they retain the potential to produce differentiated and specialized cell types. (erlc.com)
  • Exploring the potential of human-derived cell lines and glial cell line-derived neurotrophic factor for network inhibition. (lu.se)
  • The advantages of stem cell manufacturing are manifold, as it offers a renewable source of cells for research, drug testing, and potential therapeutic applications. (imarcgroup.com)
  • Additionally, innovations in genetic editing techniques, like CRISPR-Cas9, offer precise control over stem cell characteristics, further expanding their therapeutic potential. (imarcgroup.com)
  • They instead refer to the embryo as a "clump of cells" or as "potential human life," Somerville says, "despite the fact that they are, given the right conditions, human life with the potential to go on living for years and years, just like all of us. (catholicnewsagency.com)
  • The potential of stem cell research to enhance human life is extraordinary. (prospect.org)
  • The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)
  • Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
  • Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)
  • Since UCSF contributed two hESC lines to the federal registry, our team members participated in the government's program to distribute these cells, which entailed teaching scientists how to use them. (ca.gov)
  • To characterize RGCs in human embryonic stem cell (hESC) derived retinal organoids we examined RGC markers and surface antigen expression and made comparisons to human fetal retina. (caltech.edu)
  • Human embryonic stem cells (hESC) are undifferentiated multiple-function cells. (eurekalert.org)
  • These data represent a proof‐of‐concept that hESC‐derived GABAergic neurons can exert a therapeutic effect on epileptic animals presumably through establishing inhibitory synapses with host neurons. (lu.se)
  • The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
  • Finally, there are major shortages of cells and organs for use in transplantation procedures. (ca.gov)
  • One such approach, called "xenotransplantation" (the transplantation of living cells, tissues, and organs from one species to another species), turns to pigs as a source of organs for human transplants. (reasons.org)
  • For example, because hematopoietic stem cells can reconstitute the entire blood system, bone marrow transplantation has long been used in the clinic to treat various diseases. (articlecity.com)
  • Some in vivo transplantation studies have reported robust (35-50%) levels of transdifferentiation, which makes it unlikely that the results are due to cell fusion events. (i-sis.org.uk)
  • Transplantation of cells releasing γ‐aminobutyric acid (GABA) could be used to counteract the imbalance between ex-citation and inhibition within epileptic neuronal networks. (lu.se)
  • 1999). Majority of the organs for transplantation are donated from patients in whom brain-stem death has been diagnosed and who are then ventilated to maintain adequate oxygenation and circulation-the so called non-heart-beating donors (NHBDs) (D Allessandro et al . (scialert.net)
  • Transplantation of midbrain dopaminergic progenitor cells is a promising treatment for Parkinson's disease. (bvsalud.org)
  • However, transplanted cells can be injured by mechanical damage during handling and by changes in the transplantation niche. (bvsalud.org)
  • Overall, our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation. (bvsalud.org)
  • For example, human cells carry unique identifiers-molecular "bar codes"-that must be closely matched or the transplant will be rejected. (ca.gov)
  • Although attempts have not yet been made to create a therapeutic transplant from embryonic stem cells, the methods have been developed to allow the creation of functional, mature cells using human cell cloning technology. (news-medical.net)
  • Neither the title of the paper, nor the abstract mentioned that in the experiment, five out of 25 rats receiving the transplant died with "teratoma-like tumors" in their brains, a well-known hazard of ES cells. (i-sis.org.uk)
  • On January 10, 2020, he wrote a piece in The Boston Pilot titled "The Foxes and the Henhouse" in which he discusses the production of two gene-edited human babies in China, and the apparent inability of the scientific establishment to provide adequate ethical regulation and oversight of research involving embryonic humans. (wikipedia.org)
  • In rodents, and even in some preliminary trials in humans, human embryonic stem cells have been shown to bridge gaps in spinal cord injuries , allowing restoration of motor functions. (thefutureofthings.com)
  • They have the physiological characteristics of "young" cells, both from the perspective of their proliferative capacity and their cellular metabolisms. (eurekalert.org)
  • They then completed the in vitro reprogramming of the cells. (eurekalert.org)
  • In December 2001, Pacholczyk testified before the Massachusetts Senate that "embryonic human life is inviolable and deserving of unconditional respect. (wikipedia.org)
  • This BBC piece quotes Obama as saying, "I will lift the current administration's ban on federal funding of research on embryonic stem cell lines created after 9 August 2001. (cbc-network.org)
  • With In a response to the proposal made by the the foundation of the faculty of Medicine president of the Islamic Republic of Iran in in Tehran University in 1934, education in September 1998, the United Nations Ge- medical ethics comprised a part of medical neral Assembly declared 2001 as the year of student education courses [ 8 ]. (who.int)
  • Blastocytes obtained through nuclear transfers would be used to generate the embryonic stem cells that could be differentiated to specific tissues or organs for transfer to the nuclear donor. (spiked-online.com)
  • The ICM continues to differentiate into three germ layers-ectoderm, mesoderm and endoderm, each of which follows a specific developmental destiny that takes them along an ever-specifying path at which end the daughter cells will make up the different organs of the human body. (thefutureofthings.com)
  • Morphogenetic cell movements along the rostro-caudal and dorso-ventral axes (medio-lateral in fish) are responsible for the formation of the elongated tube that will connect the brain to organs and body muscles. (biologists.com)
  • However, there are a number of factors limiting the procurement of organs and accordingly, therapeutic cloning that perhaps can yield still better results needs to be considered as an alternative. (scialert.net)
  • And yet, all of us would be appalled at the idea of terminating their lives so we could harvest their tissues or organs in order to save others," she says, in reference to the common utilitarian argument that embryonic stem-cell research is valid in an effort to find cures that could save people's lives. (catholicnewsagency.com)
  • Would we abide by these unprecedented restrictions, which meant that research would be limited to first-generation cells, or could we find ways to develop second-generation, higher-quality hESCs? (ca.gov)
  • By voting in favor of Proposition 71, which funds research involving human embryonic stem cells (hESCs) that is not supported by the federal government, the citizens of California sent a clear message that they want scientists in our state to play an important role in research that could revolutionize medical treatments and render significant economic benefits. (ca.gov)
  • We generated GABAergic interneuron precursors from human embryonic stem cells (hESCs) and grafted them in the hippocampi of rats developing chronic SRSs after kainic acid‐induced status epilepticus. (lu.se)
  • Zambidis says that if blood stem cells are to be used for therapeutic purposes, they would likely come from this next stage of development. (sciencedaily.com)
  • How do blood stem cells look in the microscope? (lu.se)
  • Father Tad Pacholczyk is convinced that embryonic stem cells will someday cure diseases. (archstl.org)
  • Since embryonic stem cells have the ability to form virtually any cell type in the body, those taken from a cloned embryo could potentially be used to treat many diseases. (nih.gov)
  • Another vital driver propelling the global stem cell manufacturing market is the escalating prevalence of chronic diseases. (imarcgroup.com)
  • BioTime's therapeutic product development strategy is pursued through subsidiaries that focus on specific organ systems and related diseases for which there is a high unmet medical need. (aol.com)
  • BioTime's majority owned subsidiary Cell Cure Neurosciences Ltd. is developing therapeutic products derived from stem cells for the treatment of retinal and neural degenerative diseases. (aol.com)
  • BioTime's subsidiary OrthoCyte Corporation is developing therapeutic applications of stem cells to treat orthopedic diseases and injuries. (aol.com)
  • As the embryonic cells divide and the daughter cells differentiate, they become increasingly specific. (thefutureofthings.com)
  • A particular field encouraged by the foundation is stem-cell research, with the great hope that it will result in the ability to get cells to differentiate into neurons and support cells to bridge the gap of a spinal cord injury. (thefutureofthings.com)
  • As stem cells within a developing human embryo differentiate within the cell, their capacity to diversify generally becomes more limited and their ability to generate many differentiated cell types also becomes more restricted. (erlc.com)
  • By learning how stem cells differentiate and become specialized, scientists hope to gain a better understanding of how cells in general work and what can go wrong. (erlc.com)
  • The cells could be made to differentiate into bone forming cells, cartilage forming cells, fat cells, skeletal muscle cells and endothelial cells. (i-sis.org.uk)
  • These cells are multipotent, meaning they can give rise to several other differentiated and specialized cells of the body (for example, liver cells, kidney cells, brain cells). (erlc.com)
  • The frequency of fusion is between one in 10 000 to one in 100 000 brain cells, which is rather low. (i-sis.org.uk)
  • Using whole‐cell patch‐clamp recordings, we characterised the maturation of the grafted cells into functional GABAergic inter-neurons in the host brain, and we confirmed the presence of functional inhibitory synaptic connections from grafted cells onto the host neurons. (lu.se)
  • While incredibly effective, transformers are also mysterious: Unlike with other brain -inspired neural network models, it hasn't been clear how to build them using biological components. (lifeboat.com)
  • They suggest that a biological network composed of neurons and other brain cells called astrocytes could perform the same core computation as a transformer. (lifeboat.com)
  • Creating brain-like computers with minimal energy requirements would revolutionize nearly every aspect of modern life. (lifeboat.com)
  • Together, their teams were successful in finding ways to create or mimic the properties of a single brain element (such as a neuron or synapse) in a quantum material. (lifeboat.com)
  • This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)
  • Direct neuronal conversion of resident glial cells is advantageous since they are ubiquitously distributed brain cells able to self-renew and replenish their number, making them ideal candidates for endogenous repair. (lu.se)
  • The use of stem cell-derived dopamine neurons or deep brain stimulation (DBS) represents two alternative approaches to treat Parkinson's Disease. (lu.se)
  • This could offer comfort to proponents of ES cells. (i-sis.org.uk)
  • His writings and comments have addressed issues such as the rationing of medical care (such as ventilators), whether and when prisoners should be given priority to receive vaccinations for COVID-19, whether public health officials can make it mandatory for people to receive a vaccine, and whether medical treatments and vaccines derived from cell lines derived from aborted fetuses are ethical. (wikipedia.org)
  • Scientists anticipate that in the future stem cell lines will provide a virtually unending supply of pancreatic cells for diabetic patients, neuronal cells for patients with neural disorders such as Parkinson's or Alzheimer's disease, and a host of heart cells that may treat a variety of cardiac problems. (spiked-online.com)
  • Banking of multiple cell lines with varying genetic spectrum that can be matched to patients is one possibility. (spiked-online.com)
  • It might be expected that the richest nation on Earth would encourage its top scientists to pursue this work with vigor rather than limiting funding opportunities, creating legal barriers and fencing off any newly developed cell lines. (spiked-online.com)
  • The team that isolated the embryonic stem cell lines was led by Dr. Shoukhrat Mitalipov at Oregon Health and Science University in Portland. (nih.gov)
  • This was confirmed by examining the cells chromosomes and identifying the distinctive chromosomes from both mouse lines. (i-sis.org.uk)
  • This statement shows that, from a Roman Catholic point of view, the starting point for reflection on the ethics of embryonic stem cell research does not begin with stem cell research in itself nor even with the social good that comes about from the possible results of such research. (jcrelations.net)
  • Margaret Somerville, founding director of the McGill Centre for Medicine, Ethics and Law at McGill University in Montreal, makes her case from a purely academic and secular perspective in a comment published in the National Post last week, called "The ethics of stem cells. (catholicnewsagency.com)
  • I recently participated in a debate at the Harvard Medical School on the ethics of stem cell cloning. (prospect.org)
  • In recent decades, great strides have been made in biomedi- cal ethics, especially in the fields of education, research and legislation. (who.int)
  • Great Iranian Muslim scholars netics, stem cell research, and organ trans- laid huge emphasis on teaching and practis- plantation are some of the medical issues ing ethics. (who.int)
  • Zambidis and colleagues are currently using their model to study the next stage in blood cell development, which in a growing embryo involves blood cell precursors moving from the yolk sac into the liver, bone marrow and thymus. (sciencedaily.com)
  • This will allow the establishment of the appropriate neuronal connections to build functional circuits for motor and sensory processing. (biologists.com)
  • Dr Thomas Okarma, who heads up the Geron Corporation, claims to have heart cells that 'beat' in laboratory dishes developed from stem cells (2). (spiked-online.com)
  • In this fashion, mice or other laboratory animals that exhibit particular traits can be created for specialized studies, or herds of farm animals (such as goats, sheep or cows) can be created that produce pharmaceutically useful proteins in their milk. (who.int)
  • In the new work, Hopkins scientists and colleagues from the University of Pittsburgh School of Medicine used laboratory-grown dishes of human stem cells, in clumps called human embryoid bodies, and observed three distinct steps taken by stem cells on their way to becoming blood cells. (sciencedaily.com)
  • A stem cell line is a family of constantly dividing cells, the product of a single group of stem cells, which can be grown indefinitely in the laboratory. (erlc.com)
  • Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
  • One cloning technology that has been developed for mammalian and human cells is somatic cell nuclear transfer (SCNT). (news-medical.net)
  • The early mammalian embryo consists of the extra-embryonic cell layers-the trophoblast and a body of cells called the inner cell mass (ICM), which eventually become the embryo proper. (thefutureofthings.com)
  • Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson's disease. (bvsalud.org)
  • Making Sense of Bioethics: Must Catholics Refuse a COVID-19 Vaccine Made With a Cell Line from an Abortion? (wikipedia.org)
  • Lieberman told the paper he thinks about the issue a lot and if elected president he would follow a policy that makes abortion safe, rare and legal. (ontheissues.org)
  • When the Republicans in South Dakota passed a draconian abortion ban, making all abortions illegal except those that would save the life of the mother, McCain said he "would take appropriate steps under state law to ensure that the exceptions of rape, incest of life of the mother were included. (issues2000.org)
  • For the official Roman Catholic Church, as for Cardinal Bernardin, the fetus - even (one may say especially) at the earliest stage of embryonic life - is an example of "the weakest among us. (jcrelations.net)
  • This collaboration highlights the strength of AGC Biologics' viral vector services, our scientific expertise, and the decades of scientific GMP manufacturing knowledge we have here in Milan. (genengnews.com)
  • See Declaration on the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells. (wikipedia.org)
  • There are two main reasons stem cells are of interest to both scientific and medical research. (erlc.com)
  • But it is perhaps not auspicious to quote him for purposes of the scientific debates on human cloning, because Ramsey agreed with and supported the scientific myth of the "pre-embryo" 47 made famous by Jesuit Richard McCormick and frog embryologist Clifford Grobstein. (lifeissues.net)
  • This piece will focus on the medical technology being developed using Wharton's jelly as a source material for stem cells, but will also delve into broader aspects of stem cell research, one of the most fascinating current areas of scientific study. (articlecity.com)
  • On the issue of stem cell research, the gap between the scientific and religious cultures has never been wider. (prospect.org)
  • Yet the president's decision allows private entrepreneurs to make the major scientific and ethical decisions, which leads to inconsistent public policy and fragments the science. (prospect.org)
  • This allows us to ask scientific questions and explore novel therapeutic approaches that are unique to our program and expertise. (bhatiaprogram.com)
  • The University of California, San Francisco (UCSF) has a long history of making innovative discoveries that change the way scientists and clinicians think about disease processes and their approaches to finding cures. (ca.gov)
  • A number of scientists are trying to create life in the lab, specifically artificial cells. (reasons.org)
  • While regarded by many top scientists as the Holy Grail of medicine, others consider embryonic stem-cell research sacrilegious. (thefutureofthings.com)
  • A number of large biotech companies and scientists are looking toward stem cells as the basis for a therapeutic solution to cure such illnesses as blindness, diabetes and spinal cord injuries. (thefutureofthings.com)
  • Scientists, many of whom are sold on utilitarian-based ethical analysis, try to downplay the issue of human life in stem-cell research. (catholicnewsagency.com)
  • Bringing together Universities and high school students, UniStem Day is an opportunity to foster learning, discovery and debate in the field of stem cell research - inspiring the scientists of tomorrow. (lu.se)
  • These and many more questions will be answered by PhD students, postdoctoral fellows, and senior scientists from Lund Stem Cell Center during UniStem Day 2024. (lu.se)
  • Genenta Science, which is engaged in the development of hematopoietic stem progenitor cell immuno-gene therapy for cancer, signed a development and manufacturing service agreement with AGC Biologics to manufacture cell therapy lentivirus-based product for Genenta's ongoing clinical programs. (genengnews.com)
  • Importantly, midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts. (bvsalud.org)
  • However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)
  • In the second report [3], mouse bone marrow cells marked with green fluorescent protein were found to fuse with ES cells in culture in the presence of the cytokine, interleukin-3, which is known to encourage cell fusion. (i-sis.org.uk)
  • Another subsidiary, OncoCyte Corporation, focuses on the diagnostic and therapeutic applications of stem cell technology in cancer, including the diagnostic product PanC-Dx™ currently being developed for the detection of cancer in blood samples. (aol.com)
  • Nucleic acid aptamers are of great potentials in diagnostic and therapeutic applications because of their unique molecular recognition capabilities. (bvsalud.org)
  • Based on results from Phase I of the ongoing Phase I/II clinical trial, we are scaling up the manufacturing process to be ready for Phase II of the trial," said Pierluigi Paracchi, CEO of Genenta. (genengnews.com)
  • There are major obstacles to overcome before a stem cell line is liable to reach clinical trials. (spiked-online.com)
  • The decision to narrow Geron's technology and therapeutic focus was made after a strategic review of the costs, value inflection timelines, and clinical, manufacturing, and regulatory complexities," the company said. (medpagetoday.com)
  • These investments support cutting-edge research, the development of advanced manufacturing techniques, and the expansion of clinical trials. (imarcgroup.com)
  • BioTime is developing Renevia™ (formerly known as HyStem®-Rx), a biocompatible, implantable hyaluronan and collagen-based matrix for cell delivery in human clinical applications. (aol.com)
  • Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)
  • DBS is a widely used FDA-approved treatment and stem cell-derived dopamine neuron replacement has now evolved to the first in-human clinical trials. (lu.se)
  • In another strategy, called therapeutic cloning, the embryo can instead be used to create stem cells that are genetically identical to a patient. (nih.gov)
  • Pacholczyk writes a nationally-syndicated column, titled "Making Sense of Bioethics," that appears in numerous Catholic diocesan newspapers in the United States and has been reprinted in newspapers in Canada, England, Poland, and Australia. (wikipedia.org)
  • That's why Father Pacholczyk, director of education at the National Catholic Bioethics Center in Philadelphia, said that the efforts to help people understand the immorality of embryo reserch, including human cloning, must focus on humanizing the issue and appreciating our own embryonic origins, not just on the desired results of embryonic or other types of stem-cell research. (archstl.org)
  • The life-enhancing promise of stem cell research is just too potent and the ethical questions too tricky to leave the issue in the hands either of private entrepreneurs or religious fundamentalists, much less both. (prospect.org)
  • In sexual reproduction, clones are created when a fertilized egg splits to produce identical (monozygous) twins with identical genomes. (who.int)
  • Only days after the world's leading embryonic stem cell researcher began receiving thousands of applications from sick patients who want him to make therapeutic clones. (bioedge.org)
  • Clones are cells that have come from asexual reproduction or a parent cell. (wisdomanswer.com)
  • It is likely that human stem cells will have similar properties. (spiked-online.com)
  • We hypothesize that the ESC ovarian tumor model, with human vascular cells, will provide an ideal microenvironment to support human stem cell growth. (nih.gov)
  • Until now, research results demonstrated that senescence (the final stage of cellular aging) was an obstacle blocking the use of this technique for therapeutic applications in elderly patients. (eurekalert.org)
  • At the same time, there are indeed myriad ethical questions raised by the effort to develop therapeutic applications of stem cell cloning. (prospect.org)
  • Should some applications be considered therapeutic and others cosmetic? (prospect.org)
  • Here, we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells. (bvsalud.org)
  • Because embryonic stem cells are capable of becoming virtually every type of cell in the human body, understanding how they do so might provide the chance to harness that process to make a limitless supply of specific cells for therapeutic purposes. (sciencedaily.com)
  • The breakthrough may eventually put to rest the ethical controversy surrounding stem cells. (nih.gov)
  • The goal of this case is "to expose students to the basic of embryonic stem cells, their therapeutic uses, and the controversy surrounding embryonic stem cells through the story of a college student, Jim Allison, who becomes paralyzed after a car accident. (wisc.edu)
  • Inserm's AVENIR "Genomic plasticity and aging" team, directed by Jean-Marc Lemaitre, Inserm researcher at the Functional Genomics Institute (Inserm/CNRS/Université de Montpellier 1 and 2), has recently succeeded in rejuvenating cells from elderly donors (aged over 100). (eurekalert.org)
  • Cancer A clonal growth (cells all descended from one ancestral cell) that undergo continuing mitotic divisions and are not inhibited in their growth when they come in contact with neighboring cells (contact inhibition). (agemed.org)
  • Cancer cells often spread (or metastasize ) throughout the body by way of the bloodstream or lymphatic vessels to form tumors in new locations beyond the primary site of origin. (agemed.org)
  • We hypothesize that ovarian cancer cells will induce human ovarian TVM expression. (nih.gov)
  • We therefore propose (3) to isolate ovarian tumor stem cells and grow them in vivo using the ESC ovarian cancer model. (nih.gov)
  • We have revealed the influences on cancer stem cells from the microenvironment or "niche" in patients, and we have created a suite of tools from human assays to high content screens for chemical genomics and lead target/drug discovery, which we have moved into Phase I trials. (bhatiaprogram.com)
  • Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
  • Here, the stem cell line is created using the genetic properties of the prospective recipient via somatic cell nuclear transfer. (spiked-online.com)
  • To achieve this, they used an adapted strategy that consisted of reprogramming cells using a specific "cocktail" of six genetic factors, while erasing signs of aging. (eurekalert.org)
  • 2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)