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  • 2017
  • May 23, 2017 · by Aviatior · in Biotechnology industry , iPS Cells , Personalized Therapies , Regenerative Medicine . (wordpress.com)
  • He was also selected as one of the 20 stem cell person of the year 2017 award nominees hosted by THE NICHE site. (wikipedia.org)
  • Dr. Alexey Karpenko was featured in the American documentary "The God Cells: A Fetal Stem Cells Journey" (2017) V. I. Matyushyna (2012). (wikipedia.org)
  • Therapeutic cloning would involve cloning cells from a human for use in medicine and transplants, and is an active area of research, but is not in medical practice anywhere in the world, as of April 2017[update]. (wikipedia.org)
  • multipotent
  • MSCs are mesoderm-derived multipotent stromal cells that have high self-renewal and multi-lineage differentiation potential, anti-inflammatory properties, effects in the innate and adaptive immunity and the ability to repair damaged tissue. (blogspot.com)
  • spinal cord i
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury. (wikipedia.org)
  • Studies dating back to the 1990s have begun researching the olfactory system of mammals, rats in particular, to gain a greater understanding of axonal regeneration and neurogenesis, and the possible implementation of these cells at the site of the spinal cord injury. (wikipedia.org)
  • fetal
  • When Dr. Alexey Karpenko was CEO "EmCell" was granted letters of patent for new methods of treatment with the use of Fetal Stem Cell Transplantations by Ukraine, the USA, Netherlands, Greece and Russia and took part in dozens of international congresses and conferences with contributions regarding clinical use of Fetal Stem Cell Transplantations. (wikipedia.org)
  • At this time, Center "EmCell" in cooperation with six leading research institutes and universities of Ukraine developed legal grounds for practical clinical use of Fetal Stem Cell Transplantation, which were duly approved by Ministry of Health and by Academy of Medical Sciences of Ukraine (1999-2001). (wikipedia.org)
  • adult cells
  • The Chinese team tucked a basket of reprogramming genes inside a virus to infect the adult cells and return them to their naive, versatile state. (medindia.net)
  • Uncovering how adult cells revert back into a primordial, stem cell state is one of the key steps in bringing to fruition the promise of stem cell therapy. (medindia.net)
  • A year later, a team led by Robert Lanza at Advanced Cell Technology reported that they had replicated Mitalipov's results and further demonstrated the effectiveness by cloning adult cells using SCNT. (wikipedia.org)
  • laboratory
  • Possible aspects of using cultured stem cell of laboratory primates in experimental medicine. (springer.com)
  • In healthy adult laboratory animals, progenitor cells migrate within the brain and function primarily to maintain neuron populations for olfaction (the sense of smell). (wikipedia.org)
  • neural
  • Now, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have found a way to stimulate stem cell-derived neurons to direct cognitive function after transplantation to an existing neural network. (medicalxpress.com)
  • We showed for the first time that embryonic stem cells that we've programmed to become neurons can integrate into existing brain circuits and fire patterns of electrical activity that are critical for consciousness and neural network activity," said Stuart A. Lipton, M.D., Ph.D., senior author of the study. (medicalxpress.com)
  • Healthy adult brains contain neural stem cells which divide to maintain general stem-cell numbers, or become progenitor cells. (wikipedia.org)
  • Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder. (wikipedia.org)
  • Two major areas of research include neuroprotection, ways to prevent damage to cells caused by biological processes that take place in the body after the insult, and neuroregeneration, regrowing or replacing damaged neural circuits. (wikipedia.org)
  • Transplantation of OEG into the spinal cord has become a possible therapy for spinal cord damage and other neural diseases in animal models. (wikipedia.org)
  • tissue
  • Myocardial tissue engineering (MTE), a strategy that uses materials or material/cell constructs to prolong patients' life after cardiac damage by supporting or restoring heart function, is continuously improving. (springer.com)
  • Subcutaneous implantation and orthotopic transplantations of tissue engineered constructs were carried out. (springer.com)
  • Development of a fine connective tissue capsule was found at the site of subcutaneous implantation of the tissue engineered construct. (springer.com)
  • Tests on the cells showed they were capable of differentiating into the three fundamental layers of tissue in an early embryo. (medindia.net)
  • The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood cell production. (wikipedia.org)
  • Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue (the graft). (wikipedia.org)
  • CordLabs licenses its proprietary cord lining stem cell storage technology to cord blood banks, allowing them to also bank cord tissue from which the cord lining stem cells are derived. (wikipedia.org)
  • Organ and Tissue Bioengineering - This is a long term program studying the use of a combination of pluripotent stem cells and decellularized donor hearts to created human hearts for transplantation without the problem of rejection. (wikipedia.org)
  • HRSA oversees the nation's organ and tissue donation and transplantation systems, poison control and vaccine injury compensation programs, and a drug discount program for certain safety-net health care providers. (wikipedia.org)
  • The term is generally used to refer to artificial human cloning, which is the reproduction of human cells and tissue. (wikipedia.org)
  • Yet further treatments using stem cells could potentially be developed due to their ability to repair extensive tissue damage. (wikipedia.org)
  • Adult stem cells are generally limited to differentiating into different cell types of their tissue of origin. (wikipedia.org)
  • Regenerative Medicine
  • Stem cell therapy or regenerative medicine uses undifferentiated cells for the treatment of conditions like leukemias. (medindia.net)
  • He has focused his research interests on improving the translational research and regenerative medicine mainly through the understanding of Stem Cells and Developmental Biology and Biologically inspired Engineering. (wikipedia.org)
  • He is the winner of the 2014 UNESCO-Equatorial Guinea International Prize for Research in the Life Sciences for improving the quality of human life with his stem cell research and its numerous applications in regenerative medicine. (wikipedia.org)
  • differentiate
  • There are no reports on adverse events related to the infusion itself and long-term effects are not available, however in vitro and in vivo studies have shown that MSCs have the potential to differentiate into neoplastic cells and may promote growth of tumor cells. (blogspot.com)
  • Stem cells are cells that can differentiate to become different types of cells. (wikipedia.org)
  • Since pluripotent stem cells have the ability to differentiate into any type of cell, they are used in the development of medical treatments for a wide range of conditions. (wikipedia.org)
  • Scientists
  • Scientists are currently able to make neurons and other brain cells from stem cells, but getting these neurons to properly function when transplanted to the host has proven to be more difficult. (medicalxpress.com)
  • Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. (benthamscience.com)
  • The term cloning is used by scientists to describe many different processes that involve making duplicates of biological material. (aaenvironment.com)
  • Now, cell scientists at the Johns Hopkins University School of Medicine have identified key molecular players responsible for this reversion in fruit fly sperm cells. (medindia.net)
  • Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. (wikipedia.org)
  • In 2006, following "more than two years of intensive ethical and scientific review", two groups of scientists at HSCI were granted permission to explore Somatic Cell Nuclear Transfer techniques to create disease-specific stem cell lines as an approach to various currently incurable conditions. (wikipedia.org)
  • Many nations outlawed it, while a few scientists promised to make a clone within the next few years. (wikipedia.org)
  • In 2013, a group of scientists led by Shoukhrat Mitalipov published the first report of embryonic stem cells created using SCNT. (wikipedia.org)
  • olfactory enshe
  • Olfactory ensheathing glia (OEG), also known as olfactory ensheathing cells (OECs) or olfactory ensheathing glial cells, are a type of macroglia (radial glia) found in the nervous system. (wikipedia.org)
  • immune
  • After stem cell reinfusion, patients need to avoid crowds and sources of bacteria to prevent life-threatening infection at a time when the immune system is not fully functional. (aota.org)
  • ATIR™ is administered as an adjunctive treatment on top of a haploidentical stem cell transplantation enhancing early immune reconstitution without causing GvHD. (fiercebiotech.com)
  • We could use embryonic stem cells or induced stem cells to modify the immune-related genes in the pig to make the pig organ compatible to the human immune system," he said in a press release. (medindia.net)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • Hematopoietic stem cell transplantation has cured the immune abnormalities in one TRIANGLE patient, although the neurodevelopmental delay would likely remain. (wikipedia.org)
  • therapeutic
  • Kevin Eggan (born 1974 in Normal, Illinois) is a Professor of Stem Cell and Regenerative Biology at Harvard University, known for his work in stem cell research (also known as "therapeutic cloning"), and as a spokesperson for stem cell research in the United States. (wikipedia.org)
  • It owns 39 patents worldwide with intellectual property for the isolation of stem cells from the umbilical-cord lining membrane of all mammals, which also includes the banking and cultivation of these cells, as well as the therapeutic applications of these cells. (wikipedia.org)
  • In 1998, James Thomson and Jeffrey Jones derived the first human embryonic stem cells, with even greater potential for drug discovery and therapeutic transplantation. (wikipedia.org)
  • potentially
  • At the time, stem cell research in the United States was threatened by political pressure due to concerns over the ethics of human embryo research, and research such as this was at risk of potentially being made illegal. (wikipedia.org)
  • 2016
  • As of today (March, 2016), to my knowledge, there are 13 registered trials of MSCs in kidney transplantation that are currently recruiting patients or have been completed on the clinicaltrials .gov website. (blogspot.com)
  • therapy
  • The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE. (springer.com)
  • Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. (benthamscience.com)
  • Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. (benthamscience.com)
  • Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. (benthamscience.com)
  • The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. (benthamscience.com)
  • Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. (benthamscience.com)
  • Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. (benthamscience.com)
  • Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. (wikipedia.org)
  • this is the only form of stem-cell therapy that is widely practiced. (wikipedia.org)
  • Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)
  • Among several clinical trials that have reported that adult stem-cell therapy is safe and effective, powerful effects have been reported from only a few laboratories, infarcts as well as heart failure not arising from myocardial infarction. (wikipedia.org)
  • Adult stem cell therapy for treating heart disease was commercially available in at least five continents as of 2007. (wikipedia.org)
  • researchers
  • Researchers at Weill Cornell Medicine have discovered an innovative method to make an unlimited supply of healthy blood cells from the readily available cells that line blood vessels. (amsny.org)
  • Medical Xpress)-Researchers and patients look forward to the day when stem cells might be used to replace dying brain cells in Alzheimer's disease and other neurodegenerative conditions. (medicalxpress.com)
  • Researchers allowed the cloned embryo to develop for 12 days utilizing technology used in stem cell research before halting the experiment. (aaenvironment.com)
  • Chinese researchers said on Wednesday they had created versatile stem cells from pigs, a ground-breaking achievement that could open up new paths for combatting human disease. (medindia.net)
  • Reporting online this week in Cell Stem Cell , researchers show that two proteins are responsible redirecting cells on the way to becoming sperm back to stem cells. (medindia.net)
  • To figure out how this was happening, the researchers first suspected two proteins Jak and STAT known to act together to help stem cells maintain their stem cell-ness. (medindia.net)
  • In the 1990s MMRL researchers discovered the M cell, confirming that the heart is made of several different cell types. (wikipedia.org)
  • In this experiment, the researchers developed a protocol for using SCNT in human cells, which differs slightly from the one used in other organisms. (wikipedia.org)
  • Some stem cell researchers are working to develop techniques of isolating stem cells that are as potent as embryonic stem cells, but do not require a human embryo. (wikipedia.org)
  • somatic cells
  • It is a technical exploit because until now, no-one has been able to achieve reprogramming using somatic cells, cells that do not come from sperm or eggs, from a hooved animal. (medindia.net)
  • prolong
  • In the last few years the transplantation field has struggled to find how to prolong graft survival by inducing tolerance, minimize immunosuppression, inhibit fibrosis and treat rejection episodes. (blogspot.com)
  • regarding stem cell res
  • Eggan's work as of 2007[update] has succeeded in developing a technique of merging stem and skin cells that has obtained considerable public attention as a possible avenue to avoid moral objections regarding stem cell research in the context of serious illness. (wikipedia.org)
  • individual's
  • Once a diagnosis is made, the treatment is based on an individual's clinical condition and may include standard management for autoimmunity and immunodeficiency. (wikipedia.org)
  • 2002
  • He is the founder of Department of Stem Cells in 2002 as well as Royan institute for Stem Cell Biology and Technology in 2010. (wikipedia.org)
  • The firm was founded in 2002 by Phan Toan Thang, Ivor Lim and Gavin Tan and originally sold skin cell samples for research. (wikipedia.org)
  • Biology
  • We knew from our previous work that cells destined to be sperm could revert back to being stem cells, but we didn't know how," says Erika Matunis, Ph.D., an associate professor of cell biology at the Johns Hopkins University School of Medicine. (medindia.net)
  • Hossein Baharvand is an Iranian stem cell and developmental biologist and director of Royan Institute for Stem Cell Biology and Technology. (wikipedia.org)
  • He then obtained his Ph.D. in Cell and Developmental Biology from Khwarizmi University (former Tarbiat Moallem University) in 2004. (wikipedia.org)
  • and germ cell biology. (wikipedia.org)
  • In addition, he has been investigating the biologically inspiring engineering on stem cells and developmental biology. (wikipedia.org)
  • In August 2004, Eggan moved to Harvard University in Cambridge, Massachusetts, as a junior fellow, becoming an assistant professor of Molecular & Cellular Biology at their Stem Cell Institute ("HSCI") in 2005. (wikipedia.org)
  • neurons
  • Lipton and his team-including Juan Piña-Crespo, Ph.D., Maria Talantova, Ph.D., and other colleagues at Sanford-Burnham and Stanford University-transplanted human stem cell-derived neurons into a rodent hippocampus, the brain's information-processing center. (medicalxpress.com)
  • Stroke and traumatic brain injury lead to cell death, characterized by a loss of neurons and oligodendrocytes within the brain. (wikipedia.org)
  • They are also known as olfactory Schwann cells because they ensheath the non-myelinated axons of olfactory neurons in a similar way to which Schwann cells ensheath non-myelinated peripheral neurons. (wikipedia.org)
  • Olfactory receptor neurons have an average lifespan of 6-8 weeks and therefore must be replaced by cells differentiated from the stem cells that are within a layer at the nearby epithelium's base. (wikipedia.org)
  • OEG are thought to be in part responsible for the neurogenesis of primary olfactory neurons through the processes of fasciculation, cell sorting, and axonal targeting. (wikipedia.org)
  • MSCs
  • But what exactly makes MSCs attractive to transplantation? (blogspot.com)
  • MSCs inhibit T cell proliferation via several mechanisms including indoleamine 2,3 -dioxygenase (IDO) activity, production of prostaglandin E2 and transforming growth factor (TGF-β), expression of low levels of major histocompatibility complex (MHC) class II and costimulatory molecules including B7-1 (CD80), B7-2 (CD86) and CD40. (blogspot.com)
  • In experiments, MSCs affect the ability of DCs to prime T cells in vivo . (blogspot.com)
  • The available data on B cells has not been studied extensively but some experiments report that MSCs increase CD4+, CD25+ and FoxP3+ regulatory T cell function (Treg) which may cause arrest of B lymphocytes in the Go-G1 phase of the cell cycle. (blogspot.com)
  • In addition, MSCs by mediating T cells, inhibit the maturation, migration, proliferation and antibody production of B cells . (blogspot.com)
  • In regards to dosing and frequency, the MSCs proposed dose is 0.4 - 10 x 10 6 cells per kilogram of body weight in humans but using a high dose has also been reported. (blogspot.com)
  • MSCs may have a very important role in kidney transplantation given their immunosuppressive, reparative properties and potential to induce tolerance, however there are several technical aspects that are complex such as isolation, culture, amplification and cost, plus long-term outcomes are unclear at the moment and large clinical trials are needed. (blogspot.com)
  • human
  • The basic human fear behind stem cell research is misanthropy, which is a hatred or distrust of mankind. (aaenvironment.com)
  • Advanced Cell Technologies ACT has reported the successful cloning of a human embryo by removing DNA from the skin of a man's leg and inserting it into a cow's egg, which previously had its nucleus removed. (aaenvironment.com)
  • Another possibility would be to modify genes in lines of pig stem cells so that they replicate flaws in human genes that cause diabetes and other diseases, he suggested. (medindia.net)
  • Work on similar lines is being carried out on human cells, first achieved in 2007 by Shinya Yamanaka of Kyoto University. (medindia.net)
  • For the first time, he generated the mouse and human embryonic stem cells (2003) and induced pluripotent stem cells (2008) in Iran. (wikipedia.org)
  • Stem Cell Research - This program is focused on generating induced pluripotent stem cells to be used in testing the safety and efficacy of new drugs, and also for the creation of human models of heart disease to improve understanding of arrhythmic syndromes and to custom design treatments and cures. (wikipedia.org)
  • With the cloning of a sheep known as Dolly in 1996 by somatic cell nuclear transfer (SCNT), the idea of human cloning became a hot debate topic. (wikipedia.org)
  • In 2004 and 2005, Hwang Woo-suk, a professor at Seoul National University, published two separate articles in the journal Science claiming to have successfully harvested pluripotent, embryonic stem cells from a cloned human blastocyst using somatic-cell nuclear transfer techniques. (wikipedia.org)
  • In this case, each embryo was created by taking a nucleus from a skin cell (donated by Wood and a colleague) and inserting it into a human egg from which the nucleus had been removed. (wikipedia.org)
  • This paved the way for Mario Capecchi, Martin Evans, and Oliver Smithies to create the first knockout mouse, ushering in a whole new era of research on human disease. (wikipedia.org)
  • In early 2009, the FDA approved the first human clinical trials using embryonic stem cells. (wikipedia.org)
  • Many of the debates surrounding human embryonic stem cells concern issues such as what restrictions should be made on studies using these types of cells. (wikipedia.org)
  • Much of the criticism has been a result of religious beliefs, and in the most high-profile case, US President George W Bush signed an executive order banning the use of federal funding for any cell lines other than those already in existence, stating at the time, "My position on these issues is shaped by deeply held beliefs," and "I also believe human life is a sacred gift from our creator. (wikipedia.org)
  • genes
  • In most cases, isolated genes or cells are duplicated for scientific study, and no new animal results. (aaenvironment.com)
  • Eggan's research goals at Harvard were to understand how nuclear transplantation works, and to make stem cells that carry genes for specific diseases such as Parkinson's disease, amyotrophic lateral sclerosis (Lou Gehrig's disease), and Alzheimer's. (wikipedia.org)
  • umbilical cord
  • In 2004, Phan found two unique kinds of stem cells from the outer lining membrane of the umbilical cord. (wikipedia.org)
  • The firm also developed the skin care product CALECIM made from red deer umbilical cord lining extract which comprises secreted cell proteins integrated into a cream and a serum cosmetic product. (wikipedia.org)
  • Congress
  • These discoveries sparked extensive debate in the United States Congress, with opponents of the use of embryonic stem cells from fetuses arguing that these or similar methods of creating stem cells from skin might be eventually used instead to satisfy the conflicting demands of medical research and morals. (wikipedia.org)