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  • generate
  • Dr. Mitalipov said the technique was efficient enough that one donation - which can include multiple eggs - would probably be enough to generate a stem cell line, even accounting for failures. (nytimes.com)
  • Chris Mason, chair of regenerative medicine bioprocessing at University College London, who was not involved in the work, said its approach was "the most simple, lowest-cost and quickest method" to generate so-called pluripotent cells - able to develop into many different cell types - from mature cells. (lfpress.com)
  • ES cells with mutations in aprt, fyn, and myc were utilized to generate monochromosomal hybrids with neomycin phosphotransferase-marked murine Chr 8, 10, or 15 respectively in a hamster or rat background. (deepdyve.com)
  • The company Geron was granted approval to treat patients with spinal cord injury using embryonic stem cell derived oligodendrocytes, the cells that generate the myelin that lines the nerves. (cellmedicine.com)
  • cardiomyocytes
  • Differentiated cells bear cell surface and morphologic markers characteristic of cardiomyocytes, and a proportion of them undergo spontaneous periodic contraction. (google.com)
  • In particular, he noted that the study authors failed to show creation of cells called cardiomyocytes, which cause heart muscle to beat. (bio-medicine.org)
  • laboratory
  • The Newcastle University team have developed a method for establishing early stage sperm from human embryonic stem cells in the laboratory. (biologynews.net)
  • Dr. Iacovitti, who is also professor of neurology at Jefferson Medical College of Thomas Jefferson University, and her co-workers devised a technique using only a few additives, "all chemically defined and of human origin" to get embryonic stem cells to become dopamine-producing in the laboratory dish in only three weeks, compared to the five-to-eight week period it usually takes. (biologynews.net)
  • The likely most immediate benefit is cells that can be used for safety screening of new drugs, says study leader Igor Slukvin , an assistant professor in the university's Department of Pathology and Laboratory Medicine. (blogspot.com)
  • donor
  • The trachea structure came from a donor trachea that was seeded with stem cells from the patient. (reddit.com)
  • The DNA of the donor cell undergoes 'reprogramming' by the egg to its embryonic state and division ensues the early 8-celled blastocyst stage is reached. (biotecharticles.com)
  • A stable cell line can be created to genetically match the donor through various harvesting and culturing and can become potentially all types of cell of the human body. (biotecharticles.com)
  • Inactivated Sendai virus, which is known to cause cell-fusion, was used in the union of egg and donor cell. (biotecharticles.com)
  • The initial cell lines used fetal skin cells which subsequently moved on to donor cells from a 8-month-old Leigh Syndrome patient substantiating the efficacy of adult mature cells as donor cells. (biotecharticles.com)
  • Melton and Eggan's first nuclear transfer experiments will attempt to create diabetes specific stem cells by removing the nuclei from skin cells taken from diabetic volunteers at the Naomi Berrie Diabetes Center at Columbia University Medical Center and inserting them into donor eggs from which the nuclei have been removed. (rxpgnews.com)
  • Complete panels of donor cell lines, each containing a different human chromosome, have been developed. (deepdyve.com)
  • engraftment
  • An essential concern in converting a come cell-derived pancreatic progenitor therapy to medical practice is definitely the variability that will become experienced within the individual environment during the period of cell engraftment and growth in?vivo. (healthandwellnesssource.org)
  • The goal of this project will be to promote the engraftment of stem cell derived pancreatic progenitors and their maturation toward mono-hormonal insulin producing Beta cells in order to treat Type 1 Diabetes. (umich.edu)
  • Development
  • While clinical use is some years away, the new technique could produce cells with enormous potential for studying the development and treatment of disease. (blogspot.com)
  • The development of stem cells into mature, specialized cells is governed by trace amounts of biological signalling molecules, so Slukvin and colleagues Kyung-Dal Choi and Maxim Vodyanik exposed two types of highly versatile stem cells to various compounds. (blogspot.com)
  • 2003) and decreasing beta cell function during the development from pre-diabetes to overt diabetes (Weyer et?al. (healthandwellnesssource.org)
  • produce
  • Bone marrow stem cells are already used to screen drugs, but the new technique promises to produce large quantities of cells in a dish that can be more exactly tailored to the task at hand, without requiring a constant supply of bone marrow cells from donors. (blogspot.com)
  • In the interim, Slukvin expects the new technique to produce cells that model a variety of medical conditions. (blogspot.com)
  • Mouse
  • According to Theunissen, the disparities between mouse and human ESCs are attributable not to species-specific differences but rather to differences of cell state. (labmanager.com)
  • We then use microporous scaffolds consisting of different biomaterials including polymers and hydrogels to deliver the derived cells into a clinically translatable, extrahepatic site of a Diabetic mouse model. (umich.edu)
  • pancreatic
  • Despite apparent variations in the pathogenesis of type 1 and 2 diabetes, both illnesses are characterized by reduced blood sugar homeostasis producing from inadequate insulin creation by pancreatic beta cells. (healthandwellnesssource.org)