BiotransformationChromatography, High Pressure LiquidGas Chromatography-Mass SpectrometryMicrosomes, LiverGlucuronatesHydroxylationGlucuronidesMass SpectrometryCytochrome P-450 Enzyme SystemBileMagnetic Resonance SpectroscopyNordazepamChromatography, LiquidCytochrome P-450 CYP3AAdministration, OralHalf-LifeCunninghamellaSubstance Abuse DetectionTandem Mass SpectrometrySpectrometry, Mass, Electrospray IonizationStereoisomerismCarbon RadioisotopesNorfenfluramineDrug InteractionsCanrenoneDealkylationMetabolic Detoxication, Phase IRats, Sprague-DawleyReference StandardsArea Under CurveLiverChromatography, Thin LayerAryl Hydrocarbon HydroxylasesMetabolic Detoxication, DrugDose-Response Relationship, DrugTissue DistributionOxidation-ReductionMetabolic Clearance RateEthylene ChlorohydrinKynuramineMetabolomicsMetabolomeKineticsKetoconazoleSpectrophotometry, UltravioletFecesPhthalic AcidsChrysenesCatecholsGingerChromatography, GasFlunitrazepamCytochrome P-450 CYP2D6Biological AvailabilityMixed Function OxygenasesCotinineDeoxyepinephrineMolecular StructureHairSpecies SpecificitySulfadimethoxineOxidoreductases, N-DemethylatingFoods, SpecializedDogsMicrosomesCacodylic AcidCarcinogensNitrosaminesTroleandomycinMucoralesDichloroethylenesDibenzothiepinsPhenylacetatesProadifen3,4-MethylenedioxyamphetamineReproducibility of ResultsGlycolsInjections, IntravenousMethoxyhydroxyphenylglycolPhenytoinHydroxyeicosatetraenoic AcidsBiperidenMorphine DerivativesHippuratesDoxepinOxazepamCalibrationFluoroacetatesTrifluoroacetic AcidPropafenoneDrug StabilityFatty AlcoholsTime FactorsRats, Inbred F344DiazepamPlasticizersProdrugsBuspironeGlucuronosyltransferaseHydroxyindoleacetic Acid