Major leukocyte disorders. Medical search. Frequent questions

Abnormal expression of major histocompatibility complex class II molecules in the placenta may trigger the initiating immunologic event in this organ, which is followed by cross-reactivity with an antigen present in the skin and the characteristic cutaneous signs of the disease. (medscape.com)
A role for the involvement of major histocompatibility complex class II antigens seems likely because of the association with human leukocyte antigens DR3 and DR4. (medscape.com)
Major histocompatibility complex class III associations have also been observed, as has a high frequency of anti-human leukocyte antigen antibodies. (medscape.com)
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)
We then refined pivotal GWAS-based observation strongly implicating the major histocompatibility complex (MHC) in the development of psychiatric disorders. (inserm.fr)

Major depressive disorder (MDD) has been hypothesized to show characteristics of accelerated biological aging. (biomedcentral.com)
CD300f immunoreceptor is associated with major depressive disorder and decreased microglial metabolic fitness. (nih.gov)
Abstract: The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation forthe variance in this heterogeneous condition. (cam.ac.uk)
There were three groups with major depressive disorder (MDD): treatment-resistant (n = 94), treatment-responsive (n = 47) and untreated (n = 46). (cam.ac.uk)
Parallel to the link between psychiatric symptoms and autoimmunity in autoimmune diseases, neuroimmunological abnormalities occur in classical psychiatric disorders (for example, major depressive, bipolar, schizophrenia, and obsessive-compulsive disorders). (biomedcentral.com)

Understanding the genetic contribution of the human leukocyte antigen system to common major psychiatric disorders in a world pandemic context. (cdc.gov)
We conclude that MDD (and other major psychiatric disorders) should be recognized as vulnerable populations that receive priority for vaccination along with other at-risk groups. (biomedcentral.com)
Major psychiatric disorders (depression, bipolar, schizophrenia, autism…) are all underpinned by immune dysfunctions affecting the vast majority of immune processes ( Berk, Leboyer and Sommer, 2021 ). (inserm.fr)
HLA-G and HLA-E and bipolar disorders and schizophrenia leading to the description of the dual implication of the MHC/HLA in the risk to develop psychiatric disorders. (inserm.fr)
However, epigenetic changes in other candidate genes such as brain-derived neurotrophic factor ( BDNF ) and serotonin transporter are also implicated in early life stress (ELS) and susceptibility to adult psychiatric disorders. (biomedcentral.com)
Further, these epigenetic changes are cell/tissue-specific in regulating expression of genes, providing potential biomarkers for understanding the trajectory of early stress-induced susceptibility to adult psychiatric disorders. (biomedcentral.com)
The impact of early adversity on the susceptibility to psychiatric disorders in later life is influenced by a number of factors. (biomedcentral.com)
We review the link between autoimmunity and neuropsychiatric disorders, and the human and experimental evidence supporting the pathogenic role of neuroinflammation in selected classical psychiatric disorders. (biomedcentral.com)
As biological abnormalities are increasingly identified among patients with psychiatric disorders, the distinction between neurological and psychiatric illness fades. (biomedcentral.com)
Separation of neurological and psychiatric disorders, supported by Descartes's conception of the 'mind' as an ontologically distinct entity and by the reproducibility of neuropathological abnormalities, dominated medicine in the 19th and early 20th centuries [ 8 ]. (biomedcentral.com)
More recently, neuroinflammatory and immunological abnormalities have been documented in patients with classical psychiatric disorders. (biomedcentral.com)

Family history is common, and certain genes and human leukocyte antigens (Cw6, B13, B17) are associated with psoriasis. (merckmanuals.com)
Normally, immune cells can differentiate between healthy "self" and "other" cells by inspecting for the presence or absence of the normal "self" major histocompatibility complexes, also called human leukocyte antigens, present on the surface of every cell that contains a nucleus. (osmosis.org)
Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
HLA antigens are the major determinants used by the body's immune system for recognising and differentiating 'self' from 'non-self' (foreign) substances. (ndtv.com)

She has also shown the presence in bipolar and schizophrenic patients of human endogenous retrovirus activation (HERV-W) in psychotic and bipolar disorders. (wikipedia.org)
Individuals possessing human leukocyte antigen (HLA)-B12 are 3 times more likely to develop this disorder. (medscape.com)
An association between Human Leukocyte Histocompatibility Antigen B-27 (HLA-B27) and major arthritis syndromes such as Ankylosing Spondylitis and Reactive Arthritis is well documented (Khan et al. (cdc.gov)
In particular, we are interested in applying quantitative experimental and computational techniques to discover new mechanisms that control the cell adhesion properties of blood leukocytes and platelets during human inflammatory and thrombotic disorders. (buffalo.edu)
In this regard, while glycosylation is a major post-translational modification (PTM) that alters the structure of most human proteins, relatively little is known about the functional diversity imparted by this modification. (buffalo.edu)
Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 during E-selectin mediated cell adhesion. (buffalo.edu)
We reported correlations between classical Human Leukocyte Antigen (HLA) haplotypes and bipolar disorders, schizophrenia and autism spectrum disorders ( rev in Tamouza et al, 2021 ). (inserm.fr)
Among the consequences of the low grade inflammation following persistent infections, we demonstrated the reactivation of Human Endogenous Retroviral W elements (HERV-W) reflected both at DNA, RNA and protein levels, both in schizophrenia and bipolar disorders ( Tamouza et al, 2021 ). (inserm.fr)
The process begins by identifying an appropriate donor by doing a test called tissue typing or human leukocyte antigen (HLA) histocompatability typing of immediate family members initially using serologic techniques. (ndtv.com)
Next-generation-based human leucocyte antigen (HLA) typing showed all patients carried HLA-C*15:02, and modelling studies showed that afatinib and erlotinib bound well within the E/F binding pockets of HLA-C*15:02. (bvsalud.org)
In a recent meta-analysis using greater than 100 000 subjects, the 100 RA risk loci outside the human leukocyte antigen region explained only 5.5% and 4.7% of heritability in Europeans and Asians, respectively. (nature.com)
Typing for human leukocyte antigen-B27 is appropriate for patients with recurrent anterior uveitis. (aafp.org)
Genetic susceptibility to CBD is associated with alleles of the major histocompatibility gene, human leukocyte antigen DP (HLA-DP) containing glutamic acid at the 69th position of the beta chain (HLA-DPbeta-E69). (cdc.gov)

During the last one and half years, blood samples were collected in the heparinized blood collecting tubes from 570 dairy bulls including 11 HF and 81 HF crossbred bulls for investigation of heterozygous/carrier animals for various genetic disorders, including Bovine Leukocyte Adhesion Deficiency Syndrome. (jabonline.in)
Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle. (jabonline.in)
Incidence of hereditary citrullinaemia and bovine leukocyte adhesion deficiency syndrome in Indain dairy cattle (Bos Taurus, Bos indicus) and buffalo (Bubalus bubalis) population. (jabonline.in)
Low incidence of Bovine Leukocyte Adhesion Deficiency (BLAD) carriers in Indian dairy cattle and buffalo breeds. (jabonline.in)
PCR based identification of bovine leukocyte adhesion deficiency syndrome (BLAD) carriers in Karan Fries bulls. (jabonline.in)
9. Roy A, Kotikalapudi R, Patel RK, Anantaneni R, Katragadda S. New cases of Bovine Leukocyte Adhesion Deficiency (BLAD) carriers in Indian Holstein cattle. (jabonline.in)
Detection of new silent mutation at 348bp position in a CD18 gene in Holstein cattle normal and heterozygous for Bovine Leukocyte Adhesion Deficiency syndrome. (jabonline.in)
11. Kriegesmann B, Jansen S, Baumgartner BG, Brenig B. Partial genomic structure of the bovine CD 18 gene and the refinement of test for bovine leukocyte adhesion deficiency. (jabonline.in)
Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. (medscape.com)
Thus the infections in patients with leukocyte adhesion deficiency act similarly as those observed in patients with neutropenia. (medscape.com)
Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
However, IgM and IgG serum levels are within the reference range in patients with leukocyte adhesion deficiency II. (medscape.com)
Leukocyte adhesion deficiency II may be classified as one of the congenital disorders of glycosylation (CDG), a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. (medscape.com)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)
Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)
Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. (ox.ac.uk)
Subjects with leukocyte adhesion deficiency-1 (LAD-I) do not express beta2 integrins because of mutations in the gene specifying the beta2 subunit, and they suffer recurrent bacterial infections. (ox.ac.uk)

Lay Summary The JAK/STAT inhibitor tofacitinib, recently approved for the treatment of ulcerative colitis, is found to modulate the intestinal endothelial barrier functions in directing the leukocyte adhesion and transmigration in ulcerative colitis patients displaying high levels of endothelial STAT3/STAT6 phosphorylation. (sciencegate.app)
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is associated with enhanced leukocyte infiltration to the gut, which is directly linked to the clinical aspects of these disorders. (ucc.ie)

Some of the most enriched biological processes were lymphocyte activation and proliferation, leukocyte adhesion and migration, antigen processing and presentation and cellular response to IFN-γ. (sciencegate.app)

MYH9 -related disorder is caused by mutations in the MYH9 gene. (medlineplus.gov)
Batten disease is a group of mostly pediatric neurodegenerative lysosomal storage disorders caused by mutations in the CLN1-14 genes. (bvsalud.org)

She has also published numerous studies showing the association of bipolar disorders with genetic variants of genes involved in the synthesis of monoamines (serotonin, dopamine in particular), but also of clock genes, or more recently of genes involved in the immune response against inflammation. (wikipedia.org)
Our studies of inflammation biology examine the contribution of cell surface carbohydrate structures or glycans to white blood cell (leukocyte) activation and adhesion. (buffalo.edu)
The end goal is to apply systems level understanding of glycosylation processes in order to uncover new pathways and small molecule inhibitors that can control leukocyte migration during inflammation. (buffalo.edu)
Serum leukocyte detection is a common, inexpensive and simple indicator of inflammation in clinical work, including neutrophils, monocytes and other sub-cells. (fortunejournals.com)
Rheumatoid arthritis (RA) is a multifactorial and systemic autoimmune disease and characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage and bone destruction and systemic features including cardiovascular, pulmonary, psychological and skeletal disorders. (nature.com)
Uveitis, or inflammation of the uveal tract (i.e., iris, ciliary body, and choroid), results from a heterogeneous collection of disorders of varying etiologies and pathogenic mechanisms. (aafp.org)
Many acute and chronic lung disorders with variable degrees of pulmonary inflammation and fibrosis are collectively referred to as interstitial lung diseases (ILDs) or diffuse parenchymal lung diseases. (atsjournals.org)

The complex vertebral malformation (CVM) syndrome is a congenital autosomal recessively inherited disorder first observed in Danish Holsteins. (researchgate.net)
MYH9 -related disorder was previously thought to be four separate disorders: May-Hegglin anomaly, Epstein syndrome, Fechtner syndrome, and Sebastian syndrome. (medlineplus.gov)
Disorders like the seronegative spondyloarthropathies and juvenile idiopathic uveitis usually involve the anterior segment of the eye, but other conditions like Behçet syndrome, syphilis, and sarcoidosis can affect any location. (aafp.org)

1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
The incidence of PIDs varies greatly from about 1:500 births with selective IgA deficiency to only a few known cases for the rarest disorders. (lu.se)
In certain metabolic disorders ( ADA and PNP deficiency) enzyme substitution therapy can be applied. (lu.se)

We will first highlight some of the major neoplasia-associated infections of clinical relevance in the context of neoplasia and immune response modulation. (frontiersin.org)
Although overt inflammatory responses play a major role in malignant transformation of host cells following an infection, it is a disbalanced immune responses, which contribute to drive malignant transformation. (frontiersin.org)
We also detected changes in energy utilization and immune responses in leukocytes from older cows. (biomedcentral.com)
Beta1 and beta2 integrin function on leukocytes is crucial for a successful immune response and the platelet integrin alpha(IIb)beta3 initiates the process of blood clotting through binding fibrinogen. (ox.ac.uk)
These patients are often erroneously diagnosed with refractory primary psychotic disorders, delaying initiation of effective immune therapy (Table 1 ). (biomedcentral.com)

Ischemic stroke (IS) is a common neurological disease in the elderly, but the relationship between neutrophil/albumin ratio (NAR) and leukocyte count/albumin ratio (LAR) and the severity of neurological function injury and early neurological deterioration (END) occurrence remain elusive in acute IS. (fortunejournals.com)
According to the NIHSS score at admission, the disease group was divided into three groups (mild, moderate and severe IS), and the differences in five indexes NAR, LAR, neutrophil count, leukocyte count and albumin among the four groups were analyzed. (fortunejournals.com)
The results showed that higher NAR, LAR, neutrophil count, leukocyte count levels and lower albumin levels were associated with acute IS, and the levels of NAR and LAR increased gradually in three groups of IS. (fortunejournals.com)

In December 2021, Prof. Leboyer received the Inserm Grand Prix for the innovative character of her research work, especially on bipolar disorders, schizophrenia and autism spectrum disorders. (wikipedia.org)

To this end, we have counted the number of leukocytes, monocytes, lymphocytes and granulocytes (neutrophils, eosinophils, basophils) in 22 healthy controls and in 109 depressed inpatients. (nih.gov)

Literature survey indicated the origin of the miR from liver cells and not of platelet, leukocyte, smooth muscle or endothelial (EC) origin. (biomedcentral.com)

The incidence of MYH9 -related disorder is unknown. (medlineplus.gov)

Stressor exposure during early life has the potential to increase an individual's susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. (biomedcentral.com)

Her research focuses on bipolar disorder, schizophrenia and autism. (wikipedia.org)
She contributed with Josselin Houenou to the description of the neuroanatomical bases of psychiatric diseases, such as the abnormalities of the cortico-limbic loops underlying the abnormalities of emotion regulation in bipolar disorder or the abnormalities of the cerebellum in schizophrenia. (wikipedia.org)

Past and emerging techniques to study leukocyte trafficking both in vitro and in vivo have expanded our knowledge of the leukocyte migration process and the role of inhibitors. (ucc.ie)
Various strategies have been employed to target chemokine- and integrin-ligand interactions within the multistep adhesion cascade and the S1P/S1PR1 axis in leukocyte migration. (ucc.ie)

There are numerous major biological and social factors which have been distinctly linked with their spread. (fourwinds10.com)
They have a wide cellular and tissue distribution, and play a major role in the mediation of biological responses. (medscape.com)

While systemic autoimmune diseases are well-documented causes of neuropsychiatric disorders, synaptic autoimmune encephalitides with psychotic symptoms often go under-recognized. (biomedcentral.com)

Comparative review of recessive genetic disorders occurrence in Indian Cattle. (jabonline.in)
LC-FAOD is a group of six rare and ultra-rare life-threatening genetic disorders in which the body is unable to convert dietary fatty acids into energy. (nihr.ac.uk)

Though there is an abundance of preclinical data demonstrating efficacy of leukocyte trafficking inhibitors, many have yet to be confirmed in clinical studies. (ucc.ie)

Exploration of RNA-seq signatures in other leukocyte populations and single cell RNA sequencing may help uncover more subtle differences. (cam.ac.uk)

[ 1 , 2 ] The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection. (medscape.com)
A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major blood cells. (elifesciences.org)
Table 1 lists the main systemic disorders associated with uveitis, typical clinical findings, and suggested diagnostic studies. (aafp.org)
IPF is now recognized as a distinct clinical disorder. (atsjournals.org)

Leukemias are a group of hematologic disorders characterized by the dysfunctional proliferation and development of leukocytes. (origene.com)

The major focus of this review is the recent research on the cellular and molecular basis of beryllium sensitization and disease, using a multidisciplinary approach of bioinorganic chemistry and immunology. (cdc.gov)

The platelets in people with MYH9 -related disorder are larger than normal. (medlineplus.gov)
All individuals with MYH9 -related disorder have thrombocytopenia and enlarged platelets. (medlineplus.gov)
All of these disorders involved thrombocytopenia and enlarged platelets and were distinguished by some combination of hearing loss, renal disease, and cataracts. (medlineplus.gov)
While some cells use more than one type of myosin II, certain blood cells such as platelets and white blood cells (leukocytes) use only myosin IIA. (medlineplus.gov)
Platelets and leukocytes, which only use myosin IIA, are most affected by a lack of functional myosin-9. (medlineplus.gov)
Integrins are the major adhesion receptors of leukocytes and platelets. (ox.ac.uk)

Erythema multiforme major is a more severe, potentially life-threatening disorder. (medscape.com)
TEN is a severe, life-threatening disorder. (rarediseases.org)
It is also important to note that these disorders represent a spectrum of disease ranging from mild cases to those with severe, life-threatening complications. (rarediseases.org)
However, spermatozoa's lipids are the main substrates for peroxidation, which may provoke severe functional disorder of sperm. (scialert.net)
To date, there has been a small number of reports that severe depression is accompanied by disturbances in total white blood cell (i.e. leukocytosis) and leukocyte subset (i.e. neutrophilia, monocytosis, lymphopenia) counts. (nih.gov)

The mechanisms of leukocyte sub-cells in the process of acute IS are different. (fortunejournals.com)

In particular, she has shown that patients with bipolar disorders have a particular immunogenetic terrain, predisposing them to a poorer anti-infectious response, explaining the persistence of inflammatory responses. (wikipedia.org)
However, patients with primary immunodeficiency might shed vaccine-derived polioviruses (VDPVs) for an extended period, which could pose a major threat to polio eradication programs. (cdc.gov)
Une corrélation significative positive a été trouvée entre la vitamine C plasmatique et l'apport alimentaire en vitamine C. Le taux de vitamine C plasmatique et leucocytaire était significativement moins élevé dans le groupe des patients asthmatiques. (who.int)
LIMITATION: Patients with chronic inflammatory disorders, elevated levels of leukocytes or cardiac protein markers, or diabetes were excluded. (duke.edu)
We noted leukocytosis in major depressed patients compared with normal subjects, whilst minor depressives manifested intermediate findings. (nih.gov)
Despite major accomplishments in our understanding of the pathogenesis of lung fibrosis ( 1 ), the diagnosis and management of patients with IPF continues to pose significant challenges ( 2-4 ). (atsjournals.org)
Calcium folinate rescue has to be performed by parenteral administration in patients with malabsorption syndromes or other gastrointestinal disorders where enteral absorption is not assured. (janusinfo.se)

These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
CR1/CD35 and CR2/CD21 are major receptors for activated fragments of C3. (medscape.com)

Fabry disease, or Anderson-Fabry disease, is a rare X-linked hereditary lysosomal storage disorder characterized by deficient enzyme activity of alpha-galactosidase A. This enzyme is a lysosomal hydroxylase that when deficient causes an abnormal systemic accumulation of the glycosphingolipid ceramide trihexoside in various tissue and organs. (hcplive.com)

Senescent cells are involved in exacerbating various kinds of age-related disorders such as diabetes, obesity, cardiovascular diseases, neurodegenerative diseases, etc . (ijpsr.com)
This review is focused on the major factors responsible for cell senescence, its related pathways, and the role of cell senescence in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. (ijpsr.com)

In this review, we are trying to find the link between cellular senescence and age-related neurological disorders 3 . (ijpsr.com)

Endothelial and microvascular dysfunction are pivotal causes of major adverse cardiac events predicted by coronary flow reserve (CFR). (biomedcentral.com)

Asthma is a chronic relapsing inflammatory study in Tehran with the hypothesis that disorder of the airways and a major health plasma and leukocyte vitamin C level are problem worldwide [ 1 ]. (who.int)
Our results might point to the existence of an inflammatory process in major depressed subjects, particularly in males. (nih.gov)

There are basically two entities divided into the following: (1) erythema multiforme consisting of erythema minor and major and (2) SJS/TEN. (medscape.com)
A major cause of erythema multiforme is the herpes virus (HSV). (medscape.com)
In the past, erythema multiforme (EM) was considered part of this disease spectrum, but is now considered a distinct disorder. (rarediseases.org)

OSA is a risk factor for cardiovascular disorders including hypertension, congestive heart failure (CHF), myocardial ischemia, arrhythmias and infarction, and cerebrovascular conditions including stroke [ 3 ]. (hindawi.com)

There are many different major histocompatibility (HLA) proteins and individuals possess only a small, relatively unique set that is inherited from their parents. (ndtv.com)

There are major alterations in the metabolic profiles associated with the start of lactation [ 11 ]. (biomedcentral.com)
11]. metabolic disorders including dyslipid This was a crosssectional study. (who.int)

Major Adverse Cardiac Events (MACE) is used as a composite endpoint to assess the morbidity as well as mortality of survivors [ 7 ]. (biomedcentral.com)
4 The deposition of ceramide trihexoside in lysosomes is found predominantly in vascular endothelial cells, smooth muscle cells, cardiac myocytes, leukocytes, fibroblasts, and epithelial cells of ganglion, corneal, and renal origins. (hcplive.com)
Up to 20% of women will experience major cerebrovascular, cardiac, or renal events, at a median age of 46 years. (hcplive.com)

Astrocytes and Gliotransmitters: New Players in the Treatment of Major Depression? (benthamscience.com)
Major depression related leukocytosis appears to be characterized by neutrophilia and monocytosis. (nih.gov)

We have contributed to the demonstration of an immuno-genetically determined inefficient anti-infectious responses by showing several associations between functionally relevant polymorphisms located in genes encoding major innate sensors and the risk to develop bipolar disorders ( Oliveira et al, 2017 ). (inserm.fr)

This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)

20 µg/108 leukocytes) was deficient in 92.0% of asthmatics versus 8.0% of controls. (who.int)

Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML), Chronic Lymphocytic Leukemia (CLL) and Chronic Myelogenous Leukemia (CML) are the 4 major subtypes of leukemia. (origene.com)

Posttransplant lymphoproliferative disorders , or PTLDs , are uncontrolled growths of cells called lymphocytes that may occur in transplant recipients after receiving a solid organ, such as a kidney or a lung, or stem cells. (osmosis.org)
Post-transplant lymphoproliferative disorders ( PTLDs ) are a group of lymphoid neoplasms characterized by uncontrolled growths of lymphocytes. (osmosis.org)

Cancer is the major burden of disease worldwide. (academicjournals.org)
Pemphigoid gestationis is a rare autoimmune vesiculobullous skin disease closely related to the pemphigoid group of blistering disorders. (medscape.com)
MYH9 -related disorder is a condition that can have many signs and symptoms, including bleeding problems, hearing loss, kidney (renal) disease, and clouding of the lens of the eyes ( cataracts ). (medlineplus.gov)
The first sign of renal disease in MYH9 -related disorder is typically protein or blood in the urine. (medlineplus.gov)
In a drop of blood we can identify all major blood cells and characterize their pathological changes in several disease conditions in vitro and in patient samples. (elifesciences.org)
Our study demonstrates that drinking water is a major environmental factor that can alter disease phenotypes and disease progression in rodent disease models. (bvsalud.org)

A U.S. national-level HLA-B27 prevalence estimate is required for public health planning purposes because of the recent significant improvements in the medical therapy for HLA-B27 related disorders. (cdc.gov)

In the next step, four SNVs from three genes related to the mitochondrial respiratory chain were selected, which is a major source of ROS, and conducted a case-control study. (nature.com)

Anatomy1

Diseases1

Psychiatry and Psychology1

Phenomena and Processes1

Histocompatibility complex5

Depressive5

Psychiatric disorders11

Antigens4

Human13

Adhesion deficiency24

Ulcerative colitis2

Lymphocyte activation1

Caused by mutations2

Inflammation7

Syndrome3

Deficiency3

Immune5

Albumin3

20211

Monocytes1

Platelet1

Incidence1

Adulthood1

Schizophrenia2

Migration2

Biological2

Neuropsychiatric disorders1

Genetic disorders2

Inhibitors1

Populations1

Clinical4

Proliferation1

Immunology1

Platelets6

Severe5

Mechanisms1

Patients7

Receptors2

Systemic1

Neurodegenerative2

Neurological disorders1

Dysfunction1

Inflammatory2

Erythema multiforme3

Myocardial1

Individuals1

Metabolic2

Cardiac3

Depression2

Responses1

Endothelial cells1

Deficient1

Chronic1

Lymphocytes2

Disease6

Prevalence1

Respiratory1