Major cold shock protein. Medical search. Frequent questions

cspA mRNA 5' UTR is the untranslated region of the cspA gene, which is important in the cold shock response in Enterobacteriales such as E. coli. (wikipedia.org)
By regulating temperature, cspA proteins carry out the vital function of homeostasis. (wikipedia.org)
cspA protein is then produced in significantly higher quantities, making up over 2% of the cell's proteome during cold shock. (wikipedia.org)
cspA protein binds Hfq, which upregulates production of sigma factors which mediate a stress response. (wikipedia.org)

The peroxidation of lipids (16, 17), protein oxidation, and the formation of peroxinitrites frequently occur after liver ischemia and reperfusion. (ectrx.org)
Plastid lipid-associated proteins (PAPs) and Carotenoid Associated Proteins (CAP) are general terms conferred to two classes of proteins accumulated at high levels in chromoplasts of plant cells [ 1 , 2 ] that are involved in the sequestration of hydrophobic compounds including lipids and carotenoids. (openbiochemistryjournal.com)
Peroxide and malondialdehyde levels are often increased by freezing and thawing stress suggesting peroxidation of lipids [ 2 ] that result in structural and functional membrane and membrane protein changes [ 3 ]. (biomedcentral.com)

The mechanisms of injury caused by low temperatures are classified into three types (freezing, cold shock, and indirect chilling), and our study. (escabelcosmetic.com)
Most women suffer a hormone imbalance in the fall or winter because of colder temperatures. (shared.com)
It has been shown that mitochondria are one of the major sources of superoxide, which is a powerful oxidant radical, in chilling-sensitive plant tissues at low temperatures [ 4 ]. (biomedcentral.com)
And they found that these species of microorganisms"huddled" together in colder temperatures to form a chemically linkedunit called a biofilm. (space.com)
The cold temperatures of spacecould result in very slow growth, with generation times possibly longer thanthe average humanlifespan , DasSarma said, and this forces a reconsideration of the durationof astrobiology laboratory experiments. (space.com)
Abiotic stress conditions, such as shortage or excess of solar energy, water and nutrients, extremes of hot and cold temperatures, pollution (e.g. heavy-metal pollution) can all have a major impact on plant growth and can significantly reduce plant yield and growth. (allindianpatents.com)

Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function. (escabelcosmetic.com)
Cold acclimation and freezing stress tolerance role of protein metabolism. (escabelcosmetic.com)
Burn victims experience major changes in energy and protein metabolism, with basal energy expenditure increasing by more than 100 percent (Williams et al . (veterinary-practice.com)

Nineteen national-level public health laboratories performed routine dengue diagnostic assays on a proficiency testing panel consisting of two modules: one containing commercial serum samples spiked with cultured dengue viruses for the detection of nucleic acid and non-structural protein 1 (NS1) (Module A) and one containing human serum samples for the detection of anti-dengue virus antibodies (Module B). A review of logistics arrangements was also conducted. (who.int)

That entry was the first to discuss the roles of heat shock and chaperone proteins in hormesis. (anti-agingfirewalls.com)
Initial trials in the expression vector without protein chaperone failed to obtain soluble MCP. (utep.edu)
By fusing trigger factor (TF), a bacterial cold shock chaperone, to the N-terminal of the CroV MCP, we obtained soluble TF-MCP. (utep.edu)
As explained by Paul Workman, president of The Institute of Cancer Research (ICR) - one of the main cancer drug research centres in the world - cancer cells present specific types of damage due to their very nature, and chaperone proteins are precisely what enable them to survive that damage. (cnio.es)
In other words, a tumour cell needs chaperone proteins to survive and proliferate. (cnio.es)
Therefore, a possible strategy to combat cancer would be to block the chaperone proteins. (cnio.es)
More basic issues will also be addressed, such as our understanding of exactly how chaperone proteins carry out their functions in cells and what their role in cancer and other ageing processes are. (cnio.es)
Chaperone proteins play an essential role in protein folding, stability, and activity in healthy and pathological cells, including cancer cells", explains Djouder. (cnio.es)

Protein synthesis during cold shock in barley tissues. (escabelcosmetic.com)

Anti-Cold shock domain-containing protein E1, Anti-N-ras upstream gene protein, Anti-UNR protein. (escabelcosmetic.com)
Here, high mobility group box-1 (HMGB-1) protein was explored as a potential mediator of stress-induced microglial priming and whether HMGB-1 does so via the nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome. (jneurosci.org)

If the observation-to-parameter ratio is small, for example when diffraction data only extend to low resolution, the Bayesian framework implemented in REFMAC 5 uses external restraints to inject additional information extracted from structures of homologous proteins, prior knowledge about secondary-structure formation and even data obtained using different experimental methods, for example NMR. (iucr.org)

The functional response of MDMs to hSAA-1 and/or tubercle bacilli was also evaluated for selected cytokines at the protein level by applying the Milliplex system. (bvsalud.org)
The systemic inflammatory response to severe burns negatively impacts a number of organ systems, even affecting gastrointestinal barrier function with subsequent translocation of gut bacteria, endotoxin and cytokines, leading to septic shock (Gosain and Gamelli, 2005). (veterinary-practice.com)

As described in the petition, an introduced gene called cold shock protein B, derived from the bacterium Bacillus subtilis, appears to help. (escabelcosmetic.com)
CroV MCP gene was codon optimized, synthesized, and amplified by PCR followed by cloning into a bacterial expression system in order to obtain purified protein of high homogeneity. (utep.edu)
Delivering a Ribonucleoprotein (RNP) like the protein Cas9 complexed to an RNA molecule to intact plant cells could be a very innovative solution for accepting the gene-editing technology for many crops. (oregonstate.edu)
More specifically, the present invention concerns altering tolerance in plants to various environmental stresses and to increasing seed yield by modifying plant haemoglobin gene expression and/or by modifying plant haemoglobin protein levels. (allindianpatents.com)
A gene conferring tolerance to, for example, osmotic stress may therefore also confer tolerance to cold and drought stresses. (allindianpatents.com)

Heat shock protein 90 inhibitors in the treatment of cancer: current. (escabelcosmetic.com)
Different factors may be operating for the formation of this effect, such as the mobilization of transposable elements, effect of inbreeding and alteration of the heat-shock proteins functions. (scielo.br)
Diferentes fatores podem estar atuando para a formação deste panorama observado, tais como mobilização de elementos transponíveis, seleção por endocruzamento e alteração na função de proteínas de choque térmico (heat-shock proteins). (scielo.br)
One important heat shock protein is discussed further in the blog entry HSP70 to the rescue The relatively recent blog entries Mitohormesis and Radiation hormesis define hormesis in more detail and discuss it as it relates to mitochondrial oxidative stress and stress induced by radiation. (anti-agingfirewalls.com)
Molecular chaperones belong to a family of evolutionary highly preserved proteins known as heat shock proteins (HSP). (cnio.es)
Heat shock proteins make it possible for cells to survive under conditions of stress. (cnio.es)
They were discovered in the 1960s when a researcher heated fruit flies ( Drosophila melanogaster, a regular model organism used in laboratories) and noticed that, within a few minutes, these animals synthesised large amounts of what we now call heat shock proteins. (cnio.es)
They prevent heat loss in extreme cold weather and protect organs against shock. (alainnclinic.com)
Small Heat Shock Proteins (sHSPs) were the most abundant proteins identified in the CPC. (openbiochemistryjournal.com)
A current significant focus is to identify grapevine material resistant or tolerant to extreme environmental conditions like drought, cold, and heat. (oregonstate.edu)

The protein was expressed in Rosetta2 Escherichia coli cells. (escabelcosmetic.com)

A cold shock protein promotes high-temperature microbial growth through binding to diverse RNA species. (escabelcosmetic.com)
TF facilitates the proper folding of proteins at low temperature in bacteria. (utep.edu)
Each plant species has its own optimal temperature for growth, and its geographical distribution is determined to a major extent by the temperature zone in which it can survive. (allindianpatents.com)

LIN28 inhibitor LI71 directly binds the cold shock domain (CSD) to suppress LIN28's activity against let-7 in leukemia cells and embryonic stem cells. (escabelcosmetic.com)

The cell environment and intercellular connections have major impact in cellular stress response. (unizg.hr)
One of the researchers who will focus on the role of chaperones in the correct folding of cellular proteins is Johannes Buchner, from the Technical University of Munich, Germany. (cnio.es)
It performs many essential functions, including, but not limited to, the shape and strength of cells, the protection against physical shocks, the control of cell expansion, the transport of substances between and across the cell, and a barrier between the interior cellular components and the external environment. (oregonstate.edu)

March 13, 2013, my body went into septic shock. (cdc.gov)
What my family learned from the ICU team was that my body was in septic shock. (cdc.gov)

Cold shock treatment was found to increase the number of TNTs and TMs, while the treatment with sHSP27 inhibitor J2 reduced the number of structures. (unizg.hr)
Also, localization of protein sHSP27 and membrane structures that refer to the transport is noted. (unizg.hr)
rium properties, completely determined by the interactions within crystal structures of 38 nonhomologous proteins, we find that it the system. (lu.se)

The only exception is water ( H 2 0 ) since water is void of carbohydrate, protein and fat. (alainnclinic.com)

CroV derived its name from its host, a unicellular marine zooplankton Cafeteria roenbergensis (Cro) that is the major microbial grazer in the ocean. (utep.edu)
The lab-grown archaea alsoadapted to the cold by aggregating to form biofilms or microbial mats, like theslimy plaque that accumulates on your teeth. (space.com)

ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)

Researchers at the University of Colorado School of Medicine have found a drug that boosts memory function in those with Down syndrome, a major milestone in the treatment of this genetic disorder that could significantly improve quality of life. (freedomsphoenix.com)

Amino acids are building blocks of proteins. (medlineplus.gov)

Scientists with the Maryland Astrobiology Consortium focusedon two species of cold-adapted microbes. (space.com)
Both microbes are types of Archaea,one of the three major types of life along with Bacteria (another class ofmicrobes) and Eukaryotes (a group that includes animals, plants, fungi and Protists,e.g. paramecium, algae, protozoa and slime molds). (space.com)
Their full sequenceswill soon be available, allowing scientists to learn which genes generateproteins, such as cold-shock proteins, that help the microbes adapt to extremecold. (space.com)

Chakroborty, Sayan, "Expression and characterization of major capsid protein (MCP) of a giant marine virus: Cafeteria roenbergensis virus (CroV)" (2013). (utep.edu)

After large-scale expression in bacteria, ultra-high purity TF-MCP fusion protein was obtained by affinity chromatography and size exclusion chromatography. (utep.edu)

Reexamination of the effect of osmotic and cold shock on phosphate uptake and some attempts to restore uptake with phosphate binding protein. (escabelcosmetic.com)

Content of mammalian spermatozoa on susceptibility to cold-shock. (escabelcosmetic.com)

Nanoparticles were shown to deliver different molecules (DNA, RNA, and protein) in mammalian cells. (oregonstate.edu)

A major problem that plants have faced since they colonized earth's surface is the exposure to a high atmospheric demand of water. (frontiersin.org)
The research, while encouraging, is at an early stage and focuses on the hibernation ability that all mammals retain, which is prompted by exposure to cold. (parkertrustlaw.com)
Exposure to 100 inescapable tail shocks (ISs) increased HMGB-1 and NLRP3 protein in the hippocampus and led isolated microglia to release HMGB-1 ex vivo . (jneurosci.org)

Shock is a complex clinical syndrome caused by an acute failure of circulatory function. (medscape.com)
A peculiar family of proteins that could become the target of a new generation of cancer drugs, some of which are already undergoing clinical trials, are molecular chaperones. (cnio.es)

Yet, the local yield a set of mean atomic positions r 0 density, averaged over volume elements of 0.1-1 nm3, varies k r k that define the ``ground-state'' protein structure, or, if resolution permits, a small substantially within a protein (14, 17, 18). (lu.se)

A major part of research is therefore geared towards finding compounds that act against orphan proteins, whose active ingredients must, consequently, be innovative. (cnio.es)

Structure in solution of the major cold-shock protein from Bacillus subtilis. (cathdb.info)
After cold shock, the Bacillus subtilis desaturase Des introduces double. (escabelcosmetic.com)

Shortly after SARS-CoV emerged at the turn of the 21st century, the spike (S) protein (particularly in its native conformation) was identified as the immunodominant antigen of the virus3. (who.int)

Recent evidence has shown that in cases of generalized ischemia after hemorrhagic shock, the effectiveness of melatonin in improving liver function depends on the melatonin receptor (40). (ectrx.org)

They can help deliver large cargo molecules like protein, DNA, and RNA (Numata et al. (oregonstate.edu)
On aver- comprising some 1015 protein molecules. (lu.se)

Replication protein A 70 kDa DNA-binding subunit C OS=Oryza sativa subsp. (uu.nl)

All the plant cell systems that caused an uncoupling of oxidation and phosphorylation in plant mitochondria can participate in plant defence from oxidative damage during cold stress. (biomedcentral.com)
This study involves precisely defining by molecular techniques the individual signaling proteins expressed in the acinar cell and then subsequently assessing if individual agonists utilize discrete and different elements of the PI-signaling pathway. (rochester.edu)
Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)
protein patterns of subjects with leish- Cell culture maniasis [17]. (who.int)

Cold Spring Harbor Protocols 2018:prot097055. (escabelcosmetic.com)

Burn severity can be described as a percentage of total body surface area (TBSA), with major burns affecting greater than 10 percent TBSA, and severe burns affecting greater than 20 percent TBSA, leading to life-threatening systemic complications (Pavletic and Trout, 2006). (veterinary-practice.com)
The majority (~75%) of infections in humans are asymptomatic, but a small proportion of symptomatic patients develops severe dengue characterized by rapid progression into shock, severe bleeding and/or multiorgan impairment, which leads to death if unattended or mismanaged. (who.int)

Shock Shock is a life-threatening condition in which blood flow to the organs is low, decreasing delivery of oxygen and thus causing organ damage and sometimes death. (msdmanuals.com)

Introduction: In the course of tuberculosis (TB), the level of major acute phase protein, namely serum amyloid A (hSAA-1), increases up to a hundredfold in the pleural fluids of infected individuals. (bvsalud.org)

Mass spectrum (MS) and dynamic light scattering (DLS) were performed to analyze the molecular weight and hydrodynamic diameter of the fusion protein. (utep.edu)
This showed that only CSP 310 (cold shock protein with molecular weight 310 kD) caused a significant increase of non-phosphorylative respiration. (biomedcentral.com)

Its major functions include building, repairing and maintaining healthy body tissues. (alainnclinic.com)

1998). Intense pain stimulates a massive sympathetic response, which promotes the cardiovascular effects of shock. (veterinary-practice.com)

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)

Food (or fluid) we consume can be divided into 3 major nutrient categories. (alainnclinic.com)
In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. (rochester.edu)
Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile , and surgical evaluation should be instituted as clinically indicated. (nih.gov)

Ribonucleoprotein сomplexes consist of ribonucleic acid s and RNA-binding protein s. (mdpi.com)
The study of an influence of infiltration by different plant uncoupling system activators (pyruvate, which activates AOX, and linoleic acid which is a substrate and activator for PUMP and CSP 310) showed that all of these decreased lipid peroxidation during cold stress. (biomedcentral.com)

Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

Mitochondria are one of the major sources of reactive oxygen species during cold stress. (biomedcentral.com)
We studied the effects of CSP 310-like native cytoplasmic proteins from a number of cereal species (winter rye, winter wheat, Elymus and maize) on the energetic activity of winter wheat mitochondria. (biomedcentral.com)
It has also been shown that cold stress causes an increase in antioxidant levels in many plant species. (biomedcentral.com)

Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts. (msdmanuals.com)
proteins could carry out their biological functions. (lu.se)

This was a major breakthrough in dementia research, and their findings were published in the scientific journal Nature . (parkertrustlaw.com)

The spike protein of SARS-CoV--a target for vaccine and therapeutic development. (who.int)

When researching this treatment in mice, scientists found that levels of a "cold-shock" protein called RBM3 soared in the ordinary mice, but not in the others. (parkertrustlaw.com)
Three studies presented Thursday at a major world conference on AIDS show new ways that scientists are striving toward a cure for the three-decade-old disease. (freedomsphoenix.com)

MULLER CH, RAVNIK SE: Lipid transfer protein: a natural stimulator of the sperm. (escabelcosmetic.com)

HPS occurs primarily in the fall, when small rodents (eg, field mice) inhabit human dwellings to protect themselves from the cold weather. (medscape.com)

Furthermore, it has been found that different isoenzymes of glutathione reductase are expressed during cold acclimation of red spruce ( Picea rubens ) needles. (biomedcentral.com)

We now know that the cold, UV radiation, changes in pressure, and other types of damage also enable stressed cells to produce these proteins. (cnio.es)

Cold water swimming may protect the brain from degenerative diseases like dementia, researchers from Cambridge University have discovered. (parkertrustlaw.com)
Its transparent body allows researchers to easily detect expression of various fluorescent proteins, including green fluorescence protein, in live animals. (molcells.org)

Carbs are a major source of energy of our body, and they come mainly from grains, such as rice and noodles. (alainnclinic.com)
Cold beverages or food sends a shock through the body. (shared.com)
Major burns cause a hypermetabolic state characterised by hyperglycemia and catabolism of body protein stores. (veterinary-practice.com)

Chinese medicine also agrees with the theory, saying anything cold that you consume can cause bloating, mood disorders, skin irritation, and digestive problems. (shared.com)

Another research avenue is to generate new material resistant to major pests and diseases like Powdery and Downy Mildew and Botrytis. (oregonstate.edu)
The study shows the usefulness of proteomics in identifying proteins that may express differences between sensitive and resistant L. tropica isolates. (who.int)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)
Sample preparation (protein and drug-resistant L. tropica parasites extraction) niasis, early diagnosis and appropriate [8]. (who.int)

The benefits of red clover to farming include nitrogen fixation, soil improvement and high nutritive value in terms of protein-rich feed for livestock. (biomedcentral.com)
The nutritional benefits are attributable to easy digestibility, high voluntary intake by livestock and high protein content during ensiling [ 3 ]. (biomedcentral.com)
High mobility group box-1 protein (HMGB-1) is perhaps the most studied alarmin. (jneurosci.org)

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