Major cause of acute renal ischemia reperfusion. Medical search. Frequent questions

In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using pioglitazone. (frontiersin.org)
In patients with progressive CKD there is histological evidence of inflammation in the interstitium and strategies that reduce inflammation reduce renal injury in pre-clinical models of CKD. (wjgnet.com)
In this review we discuss current evidence that complement activation contributes to progression of CKD, how complement could cause renal inflammation and whether complement inhibition would slow progression of renal disease. (wjgnet.com)
It is therefore possible that inhibiting complement activation would reduce inflammation, lead to reduced fibrosis and preservation of renal function. (wjgnet.com)
In this pre-clinical study, scientists demonstrated the mechanism by which DPEP-1 regulates the recruitment of leukocytes (i.e. inflammation) to the kidney following ischemia reperfusion injury, which is injury that occurs after a reduction in blood flow to the kidney. (archbiopartners.com)
The publication, entitled "Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury" by Lau et al. (archbiopartners.com)
Inflammation is known to contribute to AKI related to ischemia-reperfusion and other insults to the kidney that may occur in the course of cardiac surgery. (archbiopartners.com)
Their findings identified DPEP-1 as a novel therapeutic target for diseases of these organs where inflammation plays a major role. (archbiopartners.com)
Arch also has patent protection to re-purpose the small molecule cilastatin, a known DPEP-1 inhibitor, for the prevention of acute kidney injury caused by inflammation in several different indications. (archbiopartners.com)
N-acetylcysteine is known to impair hemostasis when used for the prevention of perioperative inflammation and ischemia-reperfusion injury. (medscape.com)
Studies of renal transplant recipients and patients undergoing cardiac surgery suggest that damage and inflammation caused by IRI and CPB is amplified by complement activation 4 . (nature.com)

One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
A recent study demonstrated that SA prevented oxidative stress in l-arginine-induced acute pancreatitis ( 9 ). (spandidos-publications.com)
The mechanism of cisplatin-induced acute kidney injury includes oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum stress, which result in apoptosis, necrosis and ferroptosis of renal tubular epithelial cells, causing rapid loss of kidney function [ 8 - 11 ]. (ijbs.com)

ABSTRACT: While acute blood pressure elevations are commonly seen in the ED, not all require emergency treatment. (nursingcenter.com)

The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
Restoration of blood supply, termed reperfusion, has been used to treat ischemic myocardium and prevent further tissue damage. (spandidos-publications.com)
Most intrinsic ARF cases are associated with ATN from prolonged ischemia or toxic injury, and the terms ischemic and nephrotoxic ATN are frequently used synonymously with ischemic or nephrotoxic ARF. (medscape.com)
Apoptotic pathways in ischemic acute renal failure. (bmj.com)
5) Previous reports have described the utility of "visceral branch-first techniques" in reducing visceral ischemic time with minimal reperfusion injury. (authorea.com)

Nitric oxide production (by iNOS) may play several roles in renal pathophysiology, including induction of tubular damage. (biomedcentral.com)
Pathologically, ATN is characterized by varying degrees of tubule cell damage (see Pathophysiology) and by cell death that usually results from prolonged renal ischemia, nephrotoxins, or sepsis. (medscape.com)
The current understanding of the pathophysiology of acute tubular necrosis (ATN) is the result of intensive scientific studies performed over many decades. (medscape.com)
The term cardiorenal syndrome (CRS) is often used to describe this condition and represents an important model for exploring the pathophysiology of cardiac and renal dysfunction. (biomedcentral.com)

It is considered as a major cause of acute renal failure and the main factor in early recovery of renal graft function and long-term survival post renal transplantation. (frontiersin.org)
One of the primary causes of ARF is I/R which is a drop in blood flow leading to inadequate supply of oxygen and nutrients to renal tissue which can be caused by, amongst others, surgery, organ transplantation and shock [ 1 ]. (biomedcentral.com)
Kidney transplantation results in superior life expectancy and better quality of life if compared to dialysis treatment for patients with end-stage renal failure. (intechopen.com)
The ultimate goal for any renal transplantation patient is to have an optimally functioning graft as early as possible after completion of surgery. (intechopen.com)
One of the reasons for graft failure after renal transplantation is inadequate graft perfusion caused by mis-management of perioperative hydration policy. (intechopen.com)
Ischemia reperfusion injury is a common cause of AKI in humans undergoing cardiac surgery or kidney transplantation. (archbiopartners.com)
Nevertheless, in most countries, priority is given to transplantation over other types of renal replacement therapies, since patients with a functioning transplant leave longer, with a better quality of life and less comorbidities. (mdmsignaling.com)

Using the American College of Surgeons National Surgical Quality Improvement Program, Dr. Kim‚Äôs work has explored variations in acute kidney injury risk among different types of general surgery procedures and the interaction effects among major surgical complications with respect to postoperative mortality. (columbia.edu)
ST-elevation myocardial infarction (STEMI) following successful primary percutaneous coronary intervention (pPCI) is the leading cause of mortality and morbidity worldwide in major adverse coronary events (MACEs) due to mechanical complications, acute heart failure and cardiac shock after successful procedure. (bmj.com)
ABI patients undergoing renal replacement therapy (RRT) are more susceptible to neurological complications. (beds.ac.uk)
Acute kidney injury and early allograft dysfunction are 2 common complications after liver transplant. (ectrx.org)
Clinical evidence suggests that tissue injury such as acute kidney injury (AKI) is not an isolated event and it has become apparent that much of the increased risk of death is derived from distant complications [ 5 , 6 ]. (biomedcentral.com)
Due to the reduced renal reserve in these patients, the consequences are particularly poor and may include longer hospital stays with complications, increased need for acute dialysis, and further progression to end-stage kidney disease (ESKD) 3 . (nature.com)
Cardiac complications constitute a major cause of postoperative morbidity and mortality in surgical patients. (medscape.com)
REBOA procedures carrying life-threatening risks such as arterial access complications, organ ischemia, vascular trauma, and time loss ( 2 ) should be critically evaluated in addition to resuscitative laparotomy, thoracotomy with aortic cross-clamping, or manual aortic compression. (frontiersin.org)
Poor enhancement severity of acute pyelonephritis and its of renal parenchyma, absent excretion of contrast complications. (egyptianjournal.xyz)

At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
Thus, pioglitazone ameliorates renal IRI by inhibiting the NF-κB signaling pathway and inflammatory response in rats. (frontiersin.org)
Therefore, in this study, we aimed to investigate the molecular mechanisms underlying pioglitazone hydrochloride-mediated amelioration of renal IRI with respect to the nuclear factor-kappaB (NF-κB) signaling pathway and inflammatory response using a rat model. (frontiersin.org)
HMGB1 is a major mediator of endotoxin shock and is recognized as a DAMP by certain immune cells, triggering an inflammatory response. (wikipedia.org)
Clinical evidence suggests that tissue injury in both acute kidney injury and heart failure has immune-mediated inflammatory consequences that can initiate remote organ dysfunction. (biomedcentral.com)
IL-22 is reported to play a key role in several inflammatory diseases, such as drug-induced acute hepatitis, inflammatory bowel diseases, pneumonia, asthma, and renal ischemia-reperfusion injury [ 12 ]. (biomedcentral.com)
Calcium oxalate (CaOx), the major constituent of most kidney stones, induces inflammatory infiltration and injures renal tubular cells. (biomedcentral.com)
Renal inflammatory diseases range from mild to severe, acute to chronic and may be associated with predisposing risk factors like diabetes mellitus, human immunodeficiency virus (HIV), leukemia, vesico- ureteric reflux and staghorn calculi. (egyptianjournal.xyz)
The study aim to highlight the value of multidetecter C.T imaging in assessment of renal inflammatory diseases. (egyptianjournal.xyz)
Acute infections include acute pyelonephritis, The study aim to highlight the value of renal and perirenal abscesses, pyonephrosis, multidetecter C.T imaging in assessment of renal emphysematous pyelonephritis and emphysematous inflammatory diseases. (egyptianjournal.xyz)
Conclusions Our results demonstrate that VPA sustains early prosurvival cell signaling, reduces the inflammatory response, and improves renal function in a hemorrhage with prolonged ischemia and reperfusion model. (bmj.com)

have compared 3,769 to 13,598 matched patients treated or not treated with renal replacement therapy (RRT) in ICU and observed a higher incidence of end-stage renal disease with RRT (2.63 vs. 0.91/100 patient-years, hazard ratio = 3.23 [2.70-3.86]) [ 20 ]. (springeropen.com)

One week later, the left renal artery was clamped for 30 min to cause ischemia-reperfusion injury, and mice were injected with iohexol using a retro-orbital injection method. (asn-online.org)
8) A bifurcated graft of the neo-graft was anastomosed to the common iliac arteries first, followed by reattachments of the left renal artery, superior mesenteric artery and celiac axis without aortic cross-clamp. (authorea.com)

Currently, his research focus is to better characterize the epidemiology of adverse perioperative outcomes such as acute kidney injury. (columbia.edu)
Approximately 20% of patients with acute brain injury (ABI) also experience acute kidney injury (AKI), which worsens their outcomes. (beds.ac.uk)
This article summarizes the epidemiology and outcomes of AKI in neurocritically ill adults admitted to the ICU, focusing on prevalent ABI conditions like traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), and acute stroke. (beds.ac.uk)
Kidney disease: improving global outcomes (KDIGO) Acute Kidney Injury Work Group. (bmj.com)
Incidence and outcomes in acute kidney injury: a comprehensive population-based study. (bmj.com)
Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. (bmj.com)
Acute kidney injury (AKI) is a major concern following cardiac surgery and has the potential to significantly impact patient outcomes. (nature.com)

Dr. Kim's early research involved the study of the molecular mechanisms underlying volatile anesthetic mediated protection from renal ischemia-reperfusion injury in pre-clinical models. (columbia.edu)

In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
Sprague-Dawley (SD) rats were subjected to bilateral renal artery clamping for 45 min followed by perfusion restoration for establishing a simulated renal IRI model. (frontiersin.org)
6. Hariri AT, Moallem SA, Mahmoudi M, Memar B, Hosseinzadeh H. Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal. (ac.ir)
14. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A. Protective effect of aqueous saffron extract ( Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. (ac.ir)
Methods The ischemia-reperfusion model in anesthetized rats was established using hemorrhage and a 3-hour tourniquet application. (bmj.com)

Contrast-induced nephropathy (CIN) is a major clinical problem associated with acute kidney injury during hospitalization, however therapeutic methods for CIN have made little progress. (asn-online.org)
Moreover, the transitivity of exRNA information between cells suggests their functional and probably therapeutic roles in renal diseases. (biomedcentral.com)
VPA as a therapeutic for focal ischemia associated with prolonged tourniquet application was investigated in this study. (bmj.com)

A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
C.T has the ability to diagnose and assess renal infection site and extension of infection to pararenal fascia, renal infection unilateral or bilateral and infection focal or diffused. (egyptianjournal.xyz)

Knowledge of the pathophysiologic consequences of chronic renal failure is too important for anesthesiologists, because many of these patients have at least one of these sequences, most commonly hypertension, coronary artery diseases, diabetes mellitus and pulmonary dysfunction. (intechopen.com)
Since the right renal artery is located on the bottom of the aneurysm, the reconstruction was performed after initiating a left heart bypass (LHB). (authorea.com)
During these reattachments, antegrade pulsatile blood flow to the spinal cord was guaranteed not only via the Adamkiewicz artery but also the collateral network, which ultimately minimizes spinal cord ischemia. (authorea.com)

Membrane attack complexes (MACs) formed following complement activation ultimately injure the kidney due to epithelial renal tubular cell apoptosis. (nature.com)
Thus, the present study elucidated a novel mechanism by which both BNIP3-mediated and PINK1-PARK2-mediated mitophagy protects against cisplatin-induced renal tubular epithelial cell ferroptosis through the ROS/HO1/GPX4 axis. (ijbs.com)
This phase involves the restitution of cell polarity and tight junction integrity in sublethally injured cells, removal of dead cells by apoptosis, removal of intratubular casts by reestablishment of tubular fluid flow, and regeneration of lost renal epithelial cells. (medscape.com)

Elucidating the precise molecular mechanisms underlying cisplatin-induced acute kidney injury will provide evidence for future treatment. (ijbs.com)
We aimed to determine the ameliorative impact of diacerein on renal ischemia/reperfusion injury (I/R) condition, exploring the underlying mechanisms. (bvsalud.org)

Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. (biomedcentral.com)
Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. (radcliffecardiology.com)

Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. (rndsystems.com)

Go to Acute Tubular Necrosis for more complete information on this topic. (medscape.com)
Although the majority of data describing the role of HA originate from animal and cell studies, the available data from humans demonstrate that an upregulation of HA also occurs in diabetic kidneys, in transplant-rejected kidneys, and during acute tubular necrosis. (diva-portal.org)
Acute tubular necrosis (ATN) is clinically characterized by acute renal failure (ARF), which is defined as a rapid (hours to days) decline in the glomerular filtration rate (GFR) that leads to retention of waste products such as BUN and creatinine. (medscape.com)

The current definition has been expanded into five subtypes whose etymology reflects the primary and secondary pathology, the time frame, as well as cardiac and renal co-dysfunction secondary to systemic disease [ 1 ] (Table 1 ). (biomedcentral.com)

Myocardial infarction (MI) is a major cause of mortality and disability worldwide ( 1 ). (spandidos-publications.com)
40-55%) are higher than the mortality rates due to ICU-related myocardial infarction (20%), sepsis without AKI (15-25%), or acute respiratory distress syndrome requiring mechanical ventilation (30-40%) [ 1 ]. (beds.ac.uk)

Intrinsic ARF (40% of ARF cases) is the result of structural damage to the renal tubules, glomeruli, interstitium, or renal vasculature. (medscape.com)
The specific physico-chemical properties of HA enable a unique hydration capacity, and in the last decade it was revealed that in the interstitium of the renal medulla, where the HA content is very high, it changes rapidly depending on the body hydration status while the HA content of the cortex remains unchanged at very low amounts. (diva-portal.org)

The prognosis value of apelin-12 in predicting short-term (during hospitalisation) and long-term (2.5 years) major adverse cardiovascular events, respectively, was analysed among patients with estimated glomerular filtration rate exceeding and below 90 mL/min×1.73m 2 . (bmj.com)
REBOA enabled cardiovascular stabilization after 90 min of CPR and laparotomy with vascular reconstruction and contributed to the survival of the patient without major clinical deficits. (frontiersin.org)
A hypertensive emergency is a sharp rise in blood pressure to a level above 180/120 mmHg that is associated with target organ damage, often involving exigent neurologic, cardiovascular, or renal manifestations. (nursingcenter.com)
The trial had to exhibit at least one of the following results: major adverse cardiovascular events (MACE), cardiovascular death or hospitalization for heart failure, cardiovascular death, hospitalization for heart failure, renal or cardiovascular adverse events, or non-cardiovascular death. (bvsalud.org)

Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)
Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
The development of gastrointestinal angiodysplasia in VWD is a major clinical problem, since these dysplasias may bleed, which is aggravated in patients with a bleeding disorder, and therefore has a major impact on medical outcome, quality of life and health care costs. (einthovenlaboratory.com)
KDIGO clinical practice guideline for acute kidney injury. (bmj.com)
KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. (bmj.com)

This interim analysis seems to indicate the superiority of tonsillectomy with pulse methylprednisolone in terms of improving renal prognosis for the treatment of IgA nephropathy as a whole. (mdmsignaling.com)

Cisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. (ijbs.com)
Kaplan-Meier survival curves showed tonsillectomy with pulse methylprednisolone were associated with lower incidence of renal outcome compared with conservative therapy and steroids therapy (log-rank test, P (mdmsignaling.com)

In performing noncardiac surgery on patients on anticoagulation, the major concern is when it is safe to perform surgery without increasing the risk of hemorrhage or increasing the risk of thromboembolism (eg, venous, arterial) after discontinuing treatment. (medscape.com)

This may minimize the risk or degree of ischemia-reperfusion injury even if no selective organ perfusion was applied. (authorea.com)

Complement activation is known to occur in many diverse renal diseases, including glomerulonephritis, thrombotic microangiopathies and transplant rejection. (wjgnet.com)

Wijeysundera et al sought to determine whether N-acetylcysteine is associated with increased blood loss and blood product transfusion in 89 patients with preexisting moderate renal insufficiency undergoing cardiac surgery. (medscape.com)

An early revascularization strategy with either PCI or CABG, in collaboration between cardiologists and surgeons, is recommended for appropriate patients with suspected cardiogenic shock related to acute coronary syndrome (eg, those with uncertain neurologic status, those who received previous fibrinolysis), regardless of the time delay from MI onset. (medscape.com)
5 In addition, elevated cTns identify patients with acute coronary syndrome at high risk because of adverse anatomy and pro-coagulant activity. (radcliffecardiology.com)
CABG may be performed as an emergency procedure in the context of an ST-segment elevation MI (STEMI) in cases where it has not been possible to perform percutaneous coronary intervention (PCI) or where PCI has failed and there is persistent pain and ischemia threatening a significant area of myocardium despite medical therapy. (medscape.com)

The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
True hypertensive emergencies are characterized by a rapid elevation in blood pressure to a level above 180/120 mmHg and are associated with acute target organ damage, which requires immediate hospitalization for close hemodynamic monitoring and IV pharmacotherapy. (nursingcenter.com)
In the United States, although 18% of ED patients have severely elevated blood pressure at or above 180/110 mmHg upon presentation, 3 far fewer have hypertensive emergency, as previously defined, which occurs in conjunction with acute or impending target organ damage. (nursingcenter.com)

Additionally, disturbance in acid-base, electrolytes and fluid balance are usually related to a marked decline in the glomerular filtration rate (GFR) caused by a variety of systemic diseases such as diabetes mellitus or hypertension, and renal disorders as chronic glomerulonephritis,cystic kidney disorder,interstitial nephritis, obstructive uropathy, and lupus nephritis. (intechopen.com)
One major producer of HA in the kidney is the renomedullary interstitial cell, which displays receptors and/or synthesis enzymes for the hormones mentioned above. (diva-portal.org)

Acute kidney injury (AKI) represents an additional challenge for patients recovering from cardiac surgery. (archbiopartners.com)
Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in ≥50% of patients with chronic kidney disease (CKD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) 2 . (nature.com)

The various etiologies of ARF can be grouped into 3 broad categories: prerenal, intrinsic renal, and postrenal. (medscape.com)

However, reperfusion following a period of prolonged ischemia can often cause myocardial ischemia-reperfusion (I/R) injury, leading to damage of cardiac tissues ( 5 ). (spandidos-publications.com)
The flow cytometry analysis demonstrated an elevated expression of innate and mature dendritic cells in I/R renal tissues. (bvsalud.org)

Administration of recombinant human superoxide dismutase (rh-SOD) in recipients of cadaveric renal allografts demonstrated prolonged patient and graft survival with improvement in both acute and chronic rejection events. (wikipedia.org)

SUMMARY: One of the reasons for acute kidney damage is renal ischemia. (bvsalud.org)

The histopathological evaluation of renal tissue was also conducted. (frontiersin.org)
Ischemia/ reperfusion was found to affect renal function and induce histopathological alterations. (bvsalud.org)

However, most current studies on exRNA in renal diseases were derived from limited numbers of patients or in vitro data. (biomedcentral.com)
Acute kidney injury and mortality in hospitalized patients. (bmj.com)
Predicting one-year mortality of critically ill patients with early acute kidney injury: data from the prospective multicenter FINNAKI study. (bmj.com)
In the organ crosstalk, the combination of AKI with acute lung injury remains a formidable challenge for clinicians treating critically ill patients. (biomedcentral.com)
Any AKI, even if resolved by hospital discharge, can affect the already diminished renal reserve in patients with preexisting CKD 3 . (nature.com)
Drug-induced acute kidney injury is the second most common cause of acute kidney injury in hospitalized patients, especially in the intensive care unit[ 1 , 2 ]. (ijbs.com)
During cisplatin treatment, approximately 20%-30% of patients develop acute kidney injury [ 7 ]. (ijbs.com)
The recommended phases of CT scan for Imaging is not routinely indicated in urinary tract evaluating renal infections are a non-contrast scan, infections, however with severe symptoms, high nephrographic phase at 50-90 s and excretory phase risk immunocompromised state, diabetic patients at 2 min if there is obstruction ( 4) . (egyptianjournal.xyz)
Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. (springeropen.com)
Patients with altered renal function at hospital discharge (never reversed or relapse no recovery) had the worst outcome. (springeropen.com)
In this period, 114 patients reached the renal outcome. (mdmsignaling.com)
[ 12 ] Consider placing an IABP in patients with cardiogenic shock who have acute mitral regurgitation or a ventricular septal defect, as well as select patients with severe cardiogenic shock when other MCS devices are unavailable. (medscape.com)
only 20├óÔé¼ÔÇ£30%, however, are eventually proven to have acute ischaemic heart disease due to AMI in half of these patients. (radcliffecardiology.com)
1 Crowding in emergency departments, in part due to delays in evaluating this large number of patients, is a major problem. (radcliffecardiology.com)

In the publication, the enzyme DPEP-1 was identified for the first time as a major neutrophil adhesion receptor on the lung, liver and kidney endothelium. (archbiopartners.com)

Ischemia due to early hypoperfusion followed by ischemia reperfusion injury (IRI) results in renal tissue damage 4 . (nature.com)

2022 United States Renal Data System (USRDS) annual data report: epidemiology of kidney disease in the United States. (bmj.com)
Epidemiology of acute kidney injury in the intensive care unit. (bmj.com)
14. Liaño F, Pascual J. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. (bmj.com)

Antidiuretic hormone, nitric oxide, angiotensin II, and prostaglandins are classical hormones/compounds involved in renal fluid handling and are important regulators of HA turnover during variations in hydration status. (diva-portal.org)

In rat renal tissue, pioglitazone treatment decreased the serum levels of post-renal IRI creatinine and urea nitrogen, as well as necrosis. (frontiersin.org)
The differential diagnosis of a small amount of cardiomyocyte necrosis and, therefore, mild elevation of cTn, is broad and includes acute and chronic disorders. (radcliffecardiology.com)
Results We found that VPA sustained Protein kinase B (Akt) phosphorylation and Insulin-like growth factor signaling and modulated the systemic release of interleukin (IL)-1β, tumor necrosis factor alpha, and IL-6 after 2 hours of limb reperfusion. (bmj.com)

They speculated that the effect was related to SOD's antioxidant action on the initial ischemia/reperfusion injury of the renal allograft, thereby reducing the immunogenicity of the allograft. (wikipedia.org)
This study showed that octreotide infusion in the first 3 days after liver transplant could improve renal and allograft function and reduce infection and length of hospital stay. (ectrx.org)

Renal tubule cell damage begins to evolve (but is not yet established) during this phase. (medscape.com)

Thanks to the evolving techniques, exRNAs, particularly those detected from urine have gained great interest in renal diseases. (biomedcentral.com)
This review will provide insights into the roles of exRNA in pathogenesis, diagnosis and therapy of renal diseases. (biomedcentral.com)
In this review, we will overview of the characterization of exRNA, summarize the current cognition about the role of exRNAs in renal diseases and compare the isolation and detection techniques. (biomedcentral.com)

Acute cardiorenal syndrome (CRS type 1) and acute renocardiac syndrome (CRS type 3) are particularly relevant in high-acuity medical units. (biomedcentral.com)

Danger-associated molecular patterns (DAMPs) are endogenous ligands released from renal tubular cells following ischemia/reperfusion injury that activate the complement system through the classical, lectin and alternative pathways. (nature.com)

In the context of neurocritical care, AKI diagnosis holds significance for acute brain injury (ABI) management. (beds.ac.uk)

Anatomy26

Organisms11

Diseases31

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes33

Disciplines and Occupations1

Health Care2

Inflammation11

Oxidative Stress3

Abstract1

Ischemic5

Pathophysiology4

Transplantation7

Complications9

Inflammatory11

Treated with renal replace1

Left renal artery2

Outcomes7

Injury in pre-clinical models1

Rats5

Therapeutic3

Bilateral2

Artery3

Epithelial3

Mechanisms2

Morbidity2

Cytokines1

Tubular necrosis3

Dysfunction1

Myocardial infarction2

Interstitium2

Cardiovascular4

Clinical5

Nephropathy1

Incidence2

Hemorrhage1

Perfusion1

Transplant rejection1

Insufficiency1

Coronary3

Organ damage3

Interstitial2

Cardiac surgery2

Postrenal1

Tissues2

Graft survival1

Kidney damage1

Histopathological2

Patients14

Neutrophil1

Tissue damage1

Epidemiology3

Hydration1

Necrosis3

Allograft2

Damage1

Diseases3

Syndrome1

Complement system1

Diagnosis1