Major capsid protein. Medical search. Frequent questions

The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
It seems likely that viral structural proteins originated from cellular genes. (virology.ws)
Many of these genes encode proteins (e.g., enzymes involved in protein glycosylation) rarely associated with viruses. (uml.edu)
Analysis of two highly expressed genes from Chlorella virus PBCV-1: Protein characterization and the DNA sequences of the major capsid protein gene and the early/late 33-kDa protein gene. (uml.edu)
ORF-2 contains genes encoding the capsid. (medscape.com)
Here, we build large, intact carboxysome shells (over 90 nm in diameter) in the industrial microorganism Escherichia coli by expressing a set of carboxysome protein-encoding genes. (nature.com)
Some genes no longer code for a protein due to a mutation or error. (rationalwiki.org)
Contrary to what is observed in other isolated viruses of amoeba, Yaravirus is not represented by a large/giant particle and a complex genome, but at the same time carries an important number of previously undescribed genes, including one encoding a novel major capsid protein. (bgr.com)
We cloned and sequenced a 924-nt fragment that covered part of the 5′UTR and the VP4/VP2 capsid genes. (plos.org)

Protein sequences were clustered by the pairwise sequence similarity using CLANS. (biomedcentral.com)
The deduced amino acid sequences of the outer capsid protein, VP7, of serotype G1 rotavirus clinical isolates collected over a 6 year period (1990-1995) in Melbourne, Australia, were examined. (microbiologyresearch.org)
Phylogenetic analysis characterized the sequences into two discrete clusters representing two of the four global lineages of human G1 VP7 proteins. (microbiologyresearch.org)
The extra sequences at the N-termini of viral jelly roll capsid proteins, involved in recognizing the viral genome, likely evolved after the capture of these proteins from cells. (virology.ws)
Nucleotide sequences encoding the major capsid protein VP1 were determined for each isolate. (cdc.gov)
Primers were designed to target sequences in the nodavirus capsid protein gene, yielding an amplification product of 120 nucleotides. (int-res.com)
In general, immunobiologists have developed an integrated method for vaccine development based on analyzing protein sequences and structures of target viruses [ 10 ]. (biomedcentral.com)
Cell receptors recognize certain sequences of the envelope proteins. (futurelearn.com)

The VP1 protein, along with capsid components VP2 and VP3, is expressed from the "late region" of the circular viral genome. (wikipedia.org)
All of the capsid proteins are expressed from the late region of the viral genome, so named because expression occurs only late in the infection process. (wikipedia.org)
Adenovirus major core protein condenses DNA in clusters and bundles, modulating genome release and capsid internal pressure. (csic.es)
One isolate, PBCV-1, for example, (genome size = 330744 bp dsDNA) codes for ~375 proteins, nearly half of which resemble proteins of known function. (uml.edu)
Working with partners at the Pasteur Institute and French National Institute for Agricultural Research (Institut National de la Recherche Agronomique - INRA) we recently published an atomic resolution model of the RSV nucleocapsid - a helical structure comprising the viral genome and N protein. (gla.ac.uk)
We have published structures of FCV decorated with soluble fragments of JAM-A, revealing conformational changes in the capsid that we propose to be the first stages of uncoating (genome release). (gla.ac.uk)
Here, we reported the first Oceanospirillum phage, vB_OliS_GJ44, which was assembled into a 33,786 bp linear dsDNA genome, which includes abundant tail-related and recombinant proteins. (biomedcentral.com)
The arteriviruses are highly species specific, but share many biological and molecular properties, including virion morphology, a unique set of structural proteins, genome organization and replication strategy, and the ability to establish prolonged or true persistent infection in their natural hosts. (bionity.com)

VP1 is the primary component and forms a 360-unit outer capsid layer composed of 72 pentamers. (wikipedia.org)

VP1 is the major structural component of the polyomavirus icosahedral capsid, which has T=7 symmetry and a diameter of 40-45 nm. (wikipedia.org)
We have previously discussed the idea that viruses originated from selfish genetic elements such as plasmids and transposons when these nucleic acids acquired structural proteins (see A plasmid on the road to becoming a virus ). (virology.ws)
I want to explore in more detail the idea that the structural proteins of viruses likely originated from cell proteins ( link to paper ). (virology.ws)
Missing from these hypothesis is how nucleic acids became virus particles - that is, how they acquired structural proteins. (virology.ws)
The core proteins of alphaviruses (think Semliki Forest virus) has structural similarity with chymotrypsin-like serine proteases. (virology.ws)
Retroviral structural proteins also appear to have originated from cell proteins, with clear homologies with matrix, capsid, and nucleocapsid proteins. (virology.ws)
At some point these genetic elements acquired structural proteins from the cells and became bona fide virus particles. (virology.ws)
SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)
Norovirus is a positive sense RNA virus with 7.5 kb nucleotides, encoding a major structural protein VP1 with 50-55kDa. (prospecbio.com)
We confirmed the close relationship of their structural proteins but showed apparent additional recombination events in the 2A gene and 3′UTR of the HRV-Ca strain. (plos.org)
Nineteen national-level public health laboratories performed routine dengue diagnostic assays on a proficiency testing panel consisting of two modules: one containing commercial serum samples spiked with cultured dengue viruses for the detection of nucleic acid and non-structural protein 1 (NS1) (Module A) and one containing human serum samples for the detection of anti-dengue virus antibodies (Module B). A review of logistics arrangements was also conducted. (who.int)
An international collaboration between the UCL School of Pharmacy, the Lund Protein Production Platform (LP3) and ESS, through its DEMAX platform, have performed biophysical and structural studies of three non-structural proteins from the novel coronavirus, SARS CoV-2, the causative agent of COVID-19. (lu.se)

Anti-Norovirus (VLP major capsid protein of GI and GII) monoclonal antibody, clone C2049N - 1mg - 1 vial is backordered and will ship as soon as it is back in stock. (karlan.com)

CroV MCP gene was codon optimized, synthesized, and amplified by PCR followed by cloning into a bacterial expression system in order to obtain purified protein of high homogeneity. (utep.edu)
However, when recombination analyses were performed using RDP4, no recombination was found in either the partial major capsid protein (MCP) gene or the putative eukaryotic initiation factor 2 - α (eIF2-α) homologue gene. (gaacademy.org)
It also holds a DNA polymerase gene and major capsid protein gene very similar to those of the amoeba. (sciencedaily.com)
HPVs are classified by genotype, and at least 130 types have been identified by sequencing the gene encoding the major capsid protein L1. (biochain.com)
The Capsid Protein of Nervous Necrosis Virus Antagonizes Host Type I IFN Production by a Dual Strategy to Negatively Regulate Retinoic Acid-Inducible Gene-I-like Receptor Pathways. (bvsalud.org)

More to the inside, there is an icosahedral capsid, shaped like a truncated cone. (futurelearn.com)
The virions of Reoviridae family viruses measure 60-80 nm in diameter and possess 2 concentric capsid shells, each of which is icosahedral. (medscape.com)

Major capsid protein VP1 is a viral protein that is the main component of the polyomavirus capsid. (wikipedia.org)
We postulate that the terminal β-hairpin locks other polyomavirus capsids in a stable conformation and that absence of the hairpin leads to the observed capsid size variation in APV. (rcsb.org)

Since the antigens are purified recombinant proteins, Gardasil9 needs a potent adjuvant to enhance the initiation of the immune response through activation of innate immunity of the host to generate high and sustained levels of antibodies for maintaining efficacy of vaccination. (sanevax.org)

The largest, ORF-1, codes for the nonstructural proteins responsible for viral replication. (medscape.com)
The virions also contain 3 nonstructural proteins. (medscape.com)

Chakroborty, Sayan, "Expression and characterization of major capsid protein (MCP) of a giant marine virus: Cafeteria roenbergensis virus (CroV)" (2013). (utep.edu)
Further similarities were uncovered after the discovery and characterization of a type of large DNA virus called "giant virus," which can be up to 2.5 µm in diameter and contain DNA "encoding" information for the production of more than 400 proteins. (sciencedaily.com)

The C-terminus also contains a basic nuclear localization sequence,: 316 while the N-terminus - which is oriented toward the center of the assembled capsid - contains basic residues that facilitate non-sequence-specific interactions with DNA. (wikipedia.org)
This family contains a number of major capsid Gp23 proteins approximately 500 residues long, from T4-like bacteriophages. (nih.gov)

WB/ELISA positive controls from Made for Virology provide stable, validated protein standards for a wide range of human viruses including respiratory tract pathogens, as well as, animal and marine pathogens. (nanoexpo.eu)
The matrix Z proteins of arenaviruses are related to cellular RING domain proteins, and the matrix proteins of some negative strand RNA viruses are related to cellular cyclophilin. (virology.ws)
There are many more examples, providing support for the hypothesis that viruses evolved on multiple instances by recruiting different cell proteins. (virology.ws)
Given this information on the origin of viral capsid proteins, we can modify the three hypotheses for the origin of viruses into one. (virology.ws)
Now, the question if of course - is it of viral origin or is it a cellular protein co-opted by viruses? (virology.ws)
Some viruses possess an outer envelope, and the outer capsid is composed of major capsid protein (MCP), which appears to be highly conserved among the family and possesses surface binding sites interacting with the surfaces of host's cells [ 2 ]. (biomedcentral.com)

The VP1 protein monomer is primarily composed of beta sheets folded into a jelly roll fold. (wikipedia.org)
A very common motif among viral capsid proteins is called the single jelly roll , made up of eight beta strands in two four-stranded sheets. (virology.ws)

Between the capsid and the envelope, there are filling proteins that constitute the matrix. (futurelearn.com)
pol, that encodes the enzymes such as reverse transcriptase, and env, which encodes the envelope proteins. (futurelearn.com)
After this, the plasma membrane fuses with the viral envelope, the capsid releases the RNA into the cytoplasm, which is always accompanied by the reverse transcriptase, represented by a star. (futurelearn.com)
At a certain time, due to little known circumstances, it uses the cell mechanisms to form molecules of complementary RNA that travel to the cytoplasm to be translated into the proteins of the envelope, the capsid, and the others that we have spoken about. (futurelearn.com)

The immense majority of virus need the cell to be active and multiplying, so that the enzymes and components that form new nucleic acids and proteins are available. (futurelearn.com)

This property of CW3 is dependent on its major capsid protein, a virulence determinant. (broadinstitute.org)

A feature unique to vesiviruses is the presence of a ~14-18 kDa protein of unknown function designated as leader of the capsid (LC) that is expressed as part of a capsid precursor encoded in open reading frame 2 (ORF2). (umd.edu)
The ORF2 precursor contains the LC fused to the major capsid protein, VP1, which is proteolytically cleaved by the viral protease to release the LC and the mature VP1. (umd.edu)

An analysis of the sequence an structure of major virion proteins has identified likely ancestors in cellular proteins. (virology.ws)

The viral core protein retains protease activity, needed for cleavage from a protein precursor. (virology.ws)

Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication. (csic.es)
Both viral and cellular proteins are required for replication and transcription. (bionity.com)
In this study, we reported that capsid protein (CP) of red-spotted grouper NNV (RGNNV) suppressed the IFN antiviral response to promote RGNNV replication in Lateolabrax japonicus brain cells , which depended on the ARM , S, and P domains of CP. (bvsalud.org)

We solved the structure of adenovirus type 5 decorated with FX, showing that it binds to the major capsid protein known as hexon. (gla.ac.uk)
Second, the CAV-2 penton, hexon, and fiber proteins do not contain a known integrin-interacting motif. (cnrs.fr)

CroV is covered by a protein shell (capsid) comprised of major capsid proteins (MCP) and minor capsid proteins (mCP). (utep.edu)
Plug-like density features were observed at the base of the VP1 pentamers, consistent with the known location of minor capsid proteins VP2 and VP3. (rcsb.org)
However, the plug density is more prominent in APV and may include VP4, a minor capsid protein unique to bird polyomaviruses. (rcsb.org)
The core is composed of 3 major (ie, lambda-1, lambda-2, sigma-2) and several minor proteins that surround 10 segments of double-stranded RNA. (medscape.com)

The carboxysome is a specialized bacterial organelle that encapsulates enzymes into a virus-like protein shell and plays essential roles in photosynthetic carbon fixation. (nature.com)
The naturally designed architecture, semi-permeability, and catalytic improvement of carboxysomes have inspired rational design and engineering of new nanomaterials to incorporate desired enzymes into the protein shell for enhanced catalytic performance. (nature.com)

They contain a 'RGD' sequence, identical to the recognition site of many adhesion proteins. (embl.de)

By modeling the interaction at atomic resolution we determined a list of key amino-acids on the capsid surface that mediate the interaction. (gla.ac.uk)

Segment 1 (2.2- cases and from patients involved in outbreaks of diarrhea 2.7 kb) encodes the capsid (Cap) protein and potential hy- and vomiting, for which most common causes of gastroen- pothetical protein(s), and segment 2 (1.2-1.9 kb) encodes teritis had been ruled out. (cdc.gov)

Their proteomes are highly unstudied, with over 200 putative proteins with no known homologs. (frontiersin.org)
The production of 27 of these putative proteins was confirmed by mass spectrometry analysis. (frontiersin.org)

Each WB/ELISA positive control contains purified viral protein that can serve as a binding target or an internal control for antibody validation or any antibody based assay such as western blotting or ELISA. (nanoexpo.eu)

oligomerization to form capsids occurs in the nucleus. (wikipedia.org)
Histones are proteins that keep DNA strands curled up and packed into the cell nucleus. (sciencedaily.com)
Cell macromolecular synthesis may be controlled after CoV infection by locating some virus proteins in the host cell nucleus. (bionity.com)
Evilevitch A. Hohlbauch S.V. ''Intranuclear, HSV-1 DNA ejection induces major mechanical transformations suggesting mechanoprotection of nucleus integrity. (lu.se)

The VP1 C-terminus is disordered and forms interactions between neighboring pentamers in the assembled capsid. (wikipedia.org)

The virus structure contains three domains, including an outer proteinaceous capsid, an intermediate lipid membrane, and a central core. (biomedcentral.com)

CoV N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. (bionity.com)

The capsid not only protects the genetic material of the virus, but also helps in host-virus recognition, which is the critical initial step for viral infection. (utep.edu)

In the spring of 2020, they managed to solve and started to analyse one of these proteins, Nsp10, by using the BioMAX beamline at MAX IV Laboratory. (lu.se)

TF facilitates the proper folding of proteins at low temperature in bacteria. (utep.edu)
Evilevitch A, Sae-Ueng U., ''Mechanical Capsid Maturation Facilitates the Resolution of Conflicting Requirements for Herpesvirus Assembly. (lu.se)

This process occurs concomitantly with the inhibition of cellular protein synthesis, caused by the expression of viral proteases. (bionity.com)

The coxsackievirus-adenovirus receptor (CAR) appears to play a major role during infection of most human serotypes, whereas the alpha (v)beta (3/5) integrins have been reported to play a significant auxiliary role. (cnrs.fr)

Immunoprecipitation of recombinant LC in FCV infected cells identified the cellular protein annexin A2 as a binding partner, providing a potential mechanism for the cell-rounding phenotype observed in transient expression experiments. (umd.edu)

These bacteriophages appear to be most similar to bacteriophages that infect Pseudomonas and Ralstonia rather than Enterobacteriales bacteria by protein similarity, however, we were only able to detect infection of Erwinia and the closely related strains of Pantoea . (frontiersin.org)

Many cell proteins have jelly role motifs, and some form 60-subunit virus-like particles in cells. (virology.ws)
P particle displays an increased binding activity to HBGAs higher than virus-like particle (VLP) formed by the full-length capsid. (prospecbio.com)
Gardasil9 is a recombinant human papillomavirus (HPV) 9-valent vaccine, containing purified major capsid L1 protein of HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58 re-assembled into virus-like particles (VLPs) as the active ingredient. (sanevax.org)
Nervous necrosis virus (NNV), a highly pathogenic RNA virus , is a major pathogen in the global aquaculture industry . (bvsalud.org)
The L1 proteins self-assemble into noninfectious, nononcogenic virus-like particles (VLPs). (msdmanuals.com)
Nous avons déterminé la fréquence des différents sérotypes du virus de la dengue pour mettre en évidence son hyperendémicité à Rawalpindi (Pakistan). (who.int)
Les échantillons de sérum de 140 patients susceptibles d'avoir contracté le virus de la dengue ont été analysés entre mai et octobre 2015 à l'aide du test ELISA et de l'amplification en chaîne par polymérase multiplexe. (who.int)

FCV is the only calicivirus for which a protein cellular receptor has been identified - junctional adhesion molecule A (JAM-A). (gla.ac.uk)

One example is syncytin , a retroviral protein used for the construction of the mammalian placenta. (virology.ws)
Mammalian cells proteolytically release (shed) the extracellular domains of many cell-surface proteins. (embl.de)

We have developed a real-time NASBA procedure for detection of piscine nodaviruses, which have emerged as major pathogens of marine fish. (int-res.com)

Disintegrin-like proteins are found in various species ranging from slime mold to humans. (embl.de)

Villanueva Valencia J. R., Tsimtsirakis E., Krueger S., Evilevitch A., "Temperature-induced DNA density transition in phage λ capsid revealed with contrast-matching SANS. (lu.se)

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