Main metabolite. Medical search. Frequent questions

Metabolites are present in these concentrations in more than half of the cantons. (admin.ch)
Four chlorothalonil metabolites are present in concentrations exceeding 0.1 micrograms per litre in groundwater. (admin.ch)
At a small number of monitoring sites, the metabolites R419492 and SYN507900 have also been found in higher concentrations. (admin.ch)
This study investigated the prospective association between plasma metabolite concentrations and prostate cancer risk, both overall and by stratifying for disease aggressiveness and baseline age. (biomedcentral.com)
In a case-control study nested in the Northern Sweden Health and Disease Study, pre-diagnostic concentrations of 148 plasma metabolites were determined using targeted mass spectrometry- and nuclear magnetic resonance-based metabolomics in 777 prostate cancer cases (follow-up ≥ 5 years) and 777 matched controls. (biomedcentral.com)
Associations between prostate cancer risk and metabolite concentrations were investigated using conditional logistic regression conditioned on matching factors (body mass index, age and sample storage time). (biomedcentral.com)
Objective: The objective of this study was to develop a combined pharmacokinetic model for plasma concentrations of alkylresorcinols and their 2 major metabolites, 3,5-dihydroxybenzoic acid (DHBA) and 3-(3,5-dihydroxyphenyl)-propanoic acid (DHPPA). (uaeu.ac.ae)
Plasma concentrations of alkylresorcinols and their metabolites depended on absorption and formation, respectively, and the mean6SEM terminal elimination half-life of alkylresorcinols (1.960.59 h), DHPPA (1.560.26 h), and DHBA (1.360.22 h) did not differ. (uaeu.ac.ae)
Urinary concentrations of eight phthalate metabolites were determined by ultra-performance liquid chromatography. (nature.com)
Higher concentrations of MBP, mono(2-ethylhexyl) phthalate (MEHP), MEHHP, MEOHP and the molar sum of di(2-ethylhexyl) phthalate (DEHP) metabolites (∑DEHPm) were associated with an increased risk of miscarriage exhibiting a dose-response relationship. (nature.com)
Researchers from the German Research Center for Environmental Health, the Technical University Munich, and elsewhere found sex-specific differences in the concentrations of more than 100 metabolites when they used mass spectrometry to test blood samples from thousands of individuals from southern Germany. (genomeweb.com)
When they sifted through their metabolite data, the researchers saw sex-specific differences in the concentrations of 101 of the 131 metabolites tested. (genomeweb.com)
Rolling together data from both KORA F3 and F4 study participants pushed that number even higher, with 113 metabolites showing different concentrations in men and women from the two cohorts. (genomeweb.com)
Arsenic exposure was assessed in urine as the sum of inorganic arsenic metabolite concentrations (U-As) measured by HPLC-HG-ICP-MS, and in whole blood as total arsenic (B-As) measured by ICP-MS. Efficiency of arsenic metabolism was evaluated by a polymorphism (rs3740393) in the main arsenic methylating gene AS3MT measured by TaqMan allelic discrimination, and by the relative fractions of urinary inorganic arsenic metabolites. (lu.se)

This becomes especially important in metabolomics research, where experiments - often measured with the more sensitive mass spectrometry (MS) instruments - detect differential mass signals, but in many cases even tandem MS will not give enough information for a de-novo characterisation of the metabolite. (biomedcentral.com)
Thirty-eight ortho-substituted polychlorinated biphenyls (PCBs), 13 persistent chlorinated pesticides, and selected pesticide metabolites are measured in serum by high-resolution gas chromatography/isotope-dilution high-resolution mass spectrometry (HRGC/ID-HRMS). (cdc.gov)
Plasma metabolites and bile acids were analyzed using liquid chromatography-mass spectrometry. (escholarship.org)
A bioanalytical method using high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated for simultaneous quantification of heroin, its main metabolites and naloxone. (uab.cat)
The teams used LC/MS/MS mass spectrometry to measure the levels of 163 metabolites in blood samples from more than 3,000 individuals (1,452 men and 1,552 women) between the ages of 32 and 81 years old enrolled through the KORA F4 study. (genomeweb.com)
Chicken filets were processed with several innovative food technologies, then extracted and analysed with high-resolution mass spectrometry with the aim to find potential, treatment-dependent differences in the metabolite compositions. (innovativefoodprocessing.no)
All samples were extracted and analysed with liquid chromatography high-resolution mass spectrometry for their contents of small molecules (metabolites). (innovativefoodprocessing.no)
I develop analytical methods based on chromatography and mass spectrometry for analysis of metabolites in various tissue. (lu.se)

Calcitriol and other vitamin D metabolites are used in the treatment and prevention of Vit. (e-lactancia.org)
The pasteurization of breast milk decreases the levels of all vitamin D metabolites by 10% to 20% (Gomes 2016). (e-lactancia.org)
Of note, the kidney generates at least 30 other vitamin D metabolites, but their biologic significance is not clear. (medscape.com)
The pathophysiology of rickets is not completely understood, nor is the role of the many vitamin D metabolites. (medscape.com)

There have also been studies of arsenic metabolism suggesting that methylation of inorganic arsenic may be a toxification, rather than a detoxification pathway and that trivalent methylated arsenic metabolites, particularly monomethylarsonous acid (MMA III) and dimethylarsinous acid (DMA III), are "unusually capable of interacting with cellular targets such as proteins and DNA" [Kitchin 2001]. (cdc.gov)

The term secondary metabolite was first coined by Albrecht Kossel, the 1910 Nobel Prize laureate for medicine and physiology. (wikipedia.org)
In the same forest, four separate species of arboreal marsupial folivores reacted differently to a secondary metabolite in eucalypts. (wikipedia.org)
Hesperidin is a flavonoid that is commonly present as a secondary metabolite of citrus fruits. (mnba-journal.com)
This secondary metabolite had a low binding energy (-9.6 kcal/mol) toward the SARS-CoV-2 helicase. (mnba-journal.com)

Secondary metabolites are metabolic intermediates or products which are not essential to growth and life of the producing plants but rather required for interaction of plants with their environment and produced in response to stress. (wikipedia.org)
The purpose of this work was to identify and compare the metabolic and lipid profile between two siblings from a contrasting population for juice content, at harvest and after 30 days at 0°C. A total of 119 metabolites and 189 lipids were identified, which showed significant differences of abundance including mainly in amino acids, sugars and lipids. (preprints.org)
A new time-of-flight mass spectrometer was evaluated for performing simultaneous metabolic stability measurement and metabolite identification with ultrahigh-pressure liquid chromatography. (chromatographyonline.com)
The first is the identification of major metabolites, which provides medicinal chemists with information on the metabolic 'soft spots. (chromatographyonline.com)
We use metabolomics, i.e. the determination of as many metabolites as possible in a tissue, to study metabolic diseases. (lu.se)
Our main focus is on metabolism in enteroendocrine cells, endocrine cells and in blood, and its association with metabolic diseases, primarily type 2 diabetes mellitus. (lu.se)

To look at these issues in more detail, the study authors explained, "we systematically assessed the effect of sex on serum metabolites in a large population-based cohort … [and] investigated whether there are sex-specific differences in the genetic determination of metabotypes. (genomeweb.com)

Thus, we hypothesized that diosgenin is a bioactive metabolite related to the antimyocardial ischemia (MI) activity of DN. (hindawi.com)
We propose that glucuronide conjugates of quercetin function not only as detoxified metabolites but hydrophilic bioactive agents to various ROS-generating systems and precursors of hydrophobic aglycone. (rsc.org)

Human ileostomal effluent and pig bile after high and low alkylresorcinol doses were analyzed to evaluate biliary alkylresorcinol metabolite excretion. (uaeu.ac.ae)

A national data set from the NAQUA monitoring sites has been available for the chlorothalonil metabolite R417888 since 2019, and for the chlorothalonil metabolite R471811 since 2020. (admin.ch)
Metabolites 2020 , 10 , 154. (preprints.org)

The metabolomics were performed untargeted, looking for all metabolites, or targeted by comparison to a reference library containing about 400 important physiological metabolites. (innovativefoodprocessing.no)

Human gut microbiome composition and tryptophan metabolites were changed differently by fast food and Mediterranean diet in 4 days: a pilot study. (escholarship.org)
In this study, we hypothesized that diets with very different nutrient composition are able to change gut microbiome composition and metabolites in a very short period. (escholarship.org)
In conclusion, an animal fat-rich, low-fiber FF diet v. a high-fiber Med diet altered human gut microbiome composition and its metabolites after just 4 days. (escholarship.org)
The gut microbiome 's metabolites may play a vital role in this communication . (bvsalud.org)
However, the relationship between the gut microbiome and mitochondrial function in the development of DKD is not yet fully understood, and the role of microbial metabolites is still unclear. (bvsalud.org)

Current efforts in Metabolomics, such as the Human Metabolome Project, collect structures of biological metabolites as well as data for their characterisation, such as spectra for identification of substances and measurements of their concentration. (biomedcentral.com)
Metabolism is a complex network involving thousands of enzymes and metabolites - the metabolome. (lu.se)

Acetaldehyde is also an endogenous metabolite produced from ethanol. (who.int)
Ethanol's main metabolite acetaldehyde (AcA) may play a crucial role in head and neck cancers by forming. (who.int)

Secondary metabolites commonly mediate antagonistic interactions, such as competition and predation, as well as mutualistic ones such as pollination and resource mutualisms. (wikipedia.org)
the metabolites, of which, mediate therapeutic effects. (hindawi.com)

The biological effects of plant secondary metabolites on humans have been known since ancient times. (wikipedia.org)
Computer-Assisted Structure Elucidation (CASE) of biological metabolites will be an important tool to leverage this lack of knowledge. (biomedcentral.com)
NMR prediction methods applied in the course of this work delivered precise predictions which can serve as a building block for Computer-Assisted Structure Elucidation for biological metabolites. (biomedcentral.com)
Recently, identification of metabolites involved in the biotransformation of phytochemicals by intestinal microflora has been suggested as a potentially effective means to determine which compounds are active in living systems and to gain a better understanding of how herbs affect biological processes [ 11 , 12 ]. (hindawi.com)
Recent studies have provided new information about individuals' metabolite profiles, genetic variants associated with these profiles, and some of their biological consequences, the researchers explained. (genomeweb.com)
The complete set of metabolites found within a biological sample. (innovativefoodprocessing.no)
Recent studies are highlighted in this review to examine the possible mechanism of the gut microbiota -microbial metabolites-mitochondrial axis in the progression of DKD and the new therapeutic approaches for preventing or reducing DKD based on this biological axis in the future . (bvsalud.org)

We have developed a liquid chromatographic-electrospray ionization mass spectrometric (LC-MS) method for quantifying imatinib and its main metabolite (CGP 74588) in plasma. (elsevierpure.com)
Our recent research further showed that diosgenin, as a main metabolite from DN, was found and quantified in the plasma from the experimental rat group orally receiving DN [ 8 ]. (hindawi.com)
The main metabolites of simvastatin in human plasma are beta-hydroxy acid and four additional active metabolites. (janusinfo.se)

As a means to explore the therapeutic mechanism of Dioscorea nipponica (DN), a medicinal plant used to treat myocardial ischemia (MI), metabolites generated by intestinal microflora from DN were identified, and the cardioprotective efficacy of these metabolites was evaluated. (hindawi.com)
Our results demonstrate that diosgenin is the main metabolite produced by rat intestinal microflora from DN. (hindawi.com)
Nevertheless, quercetin is completely converted into its conjugated metabolites by phase-II enzymes during intestinal absorption. (rsc.org)
They can occur when the marine biotoxin overcomes the intestinal barrier, enters the blood stream, and additional toxic metabolites are then formed in the liver. (bund.de)

Alternatively, microbial protein metabolism results in proteolytic metabolites detrimental to gut health. (lboro.ac.uk)
The potential mechanism of gut microbiota-microbial metabolites-mitochondrial axis in progression of diabetic kidney disease. (bvsalud.org)
Lately, it has been shown that the onset and advancement of DKD are linked to imbalances of gut microbiota and the abnormal generation of microbial metabolites. (bvsalud.org)

In the present study, we evaluated the docking of hesperidin with helicase, RNA-dependent RNA polymerase (RdRp), papain-like protease (PLpro), and main proteases (Mpro) of SARS-CoV-2 by CB-Dock as a protein-ligand docking method. (mnba-journal.com)
hassan Aubais-aljelehawy, Q. Docking of the main protein receptors of SARS-CoV-2 by hesperidin metabolite: In silico study. (mnba-journal.com)
An increased level of apolipoprotein A-I (apoA-I), which is the main protein of HDL, has also been found to increase breast cancer risk. (news-medical.net)

The amount found in faeces consists of absorbed substance and metabolites excreted in bile and unabsorbed drug. (janusinfo.se)

It heavily relies on plant-based medicines, with nearly 1000 medicinal plants recorded in ancient books and documents as main therapeutic agents. (thieme-connect.de)

Ground water is especially affected by the metabolite chlorothalonil R471811, which exceeds 0.1 micrograms per litre at more than 60% of monitoring sites on the Swiss Plateau. (admin.ch)
The metabolite chlorothalonil R417888 exceeds 0.1 micrograms per litre in groundwater of the Swiss Plateau at over 20% of the monitoring sites. (admin.ch)

Therefore, the identification of metabolites associated with risk of prostate cancer warrants further investigation. (biomedcentral.com)
Meneses, C. Identification of Metabolite and Lipid Profiles in a Segregating Peach Population Associated with Mealiness in Prunus persica (L.) Batsch. (preprints.org)
The identification of relevant metabolites with the help of a reference library can give an indication of the character of the observed changes. (innovativefoodprocessing.no)

Phenolics are the most abundant secondary metabolites of plants ranging from simple molecules such as phenolic acid to highly polymerized substances such as tannins. (wikipedia.org)
7-Keto is a naturally occurring metabolite of DHEA, an abundant hormone in human blood. (vitacost.com)

The 2 main sources of vitamin D in humans are vitamin D 3 ( cholecalciferol ), produced by the skin after ultraviolet (UV) radiation (290-320nm)-dependent conversion of 7-dehydrocholesterol, and dietary intake of either vitamin D 2 (ergocalciferol) or vitamin D 3 . (medscape.com)

Methylation has long been considered the main route of arsenic detoxification, but more recently there has been a growing body of literature supporting other detoxification mechanisms. (cdc.gov)

Plants are capable of producing and synthesizing diverse groups of organic compounds and are divided into two major groups: primary and secondary metabolites. (wikipedia.org)

There were no significant differences in the metabolite composition of non-MAP-treated not-stored (0 days) chicken fillets that were processed with HPP or MW or left un-processed. (innovativefoodprocessing.no)
There were no significant differences in the metabolite composition of MAP-treated not-stored chicken fillets (0 days) that were processed with HPP or MW or left un-processed. (innovativefoodprocessing.no)
There were significant differences in the metabolite composition of not-stored (0 days) and 28 day-stored MW-processed chicken fillets. (innovativefoodprocessing.no)

As the renewal of groundwater takes a relatively long time and the chlorothalonil metabolites are very persistent, it can be assumed that these contaminants significantly impair groundwater for many years. (admin.ch)

Pizarro N, Farre M, Pujadas M, Peiro AM, Roset PN, Joglar J, de la Torre R. "Stereochemical analysis of 3,4-methylenedioxymethamphetamine and its main metabolites in human samples including the catechol-type metabolite (3,4-dihydroxymethamphetamine)" Drug Metab Dispos . (erowid.org)
A far more widely usage of the term contains also the steroid hormone metabolites locally transformed in the CNS in the peripheral way to obtain gonadal human hormones, as steroid human hormones easily combination the blood-brain hurdle because of their lipophilic properties and little molecular size. (nos-nop.org)
During reproductive age group, the gonads Hydroxyphenylacetylglycine will be the main way to obtain human hormones for the transformation to neurosteroids in the CNS. (nos-nop.org)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks have caused a main threat to human health owing to its highly contagious nature. (mnba-journal.com)
17 Accordingly, detoxified metabolites exclusively circulate in the human bloodstream. (rsc.org)
13 Conjugated quercetin metabolites accumulate in human atherosclerotic lesion sites, but not in normal arteries. (rsc.org)
Huang S, Qi Z, Ma S, Li G, Long C, Yu Y. A critical review on human internal exposure of phthalate metabolites and the associated health risks. (nature.com)
Estriol is one of the three main estrogens produced by the human body. (absoluteastronomy.com)
Using human liver cells, the metabolism of this marine biotoxins are additionally investigated, i.e. the formation of metabolites of higher or lower toxicity. (bund.de)

In the general population, diet is the main source of exposure, primarily through the ingestion of fatty foods such as dairy products and fish. (cdc.gov)
We hypothesized that co-exposure to the main metabolite of PPF, 4′-OH-PPF, could exacerbate ZIKV effects through increased MSI1 expression. (eur.nl)
We included 534 women in the main analysis who had available data on both phthalates exposure and complete information on potential confounders. (nature.com)

NEW YORK (GenomeWeb News) - A metabolomic study appearing online last night in PLoS Genetics suggests that differences exist between men and women in metabolite profiles as well as in the genetic variants behind these profiles. (genomeweb.com)
Some metabolites that are responsible for the differences have been identified. (innovativefoodprocessing.no)

Our results indicate that some of the top metabolites and lipids could be used as biomarkers associated with mealiness at harvest and after cold storage. (preprints.org)

The present study was designed to investigate the effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (atorvastatin, pravastatin, simvastatin) on the pharmacokinetics of losartan and its active metabolite EXP-3174 in rats. (karger.com)
The metabolite-parent AUC ratio was significantly decreased by 25.7%, suggesting that metabolism of losartan was inhibited by simvastatin. (karger.com)
According to the report, if possible, simvastatin hydroxy acid and other active metabolites should be measured in wastewater. (janusinfo.se)

Propiverine is rapidly absorbed after oral administration and is extensively biotransformed in the liver, giving rise to several active metabolites (M-1 and M-2). (aspetjournals.org)

The main biochemical changes observed in acute EDB poisoning were an initial decrease of liver sulfhydryl groups and a later increase in liver sulfuryl groups. (cdc.gov)

Metabolite profiling in drug discovery can contribute significantly at the lead optimization stage in two main application areas. (chromatographyonline.com)
We showed that the metabolite profiles of males and females are significantly different and, furthermore, that specific genetic variants in metabolism-related genes depict sexual dimorphism," co-corresponding author Thomas Illig, a molecular epidemiology researcher at the German Research Center for Environmental Health, and co-authors wrote. (genomeweb.com)

Title : One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects Personal Author(s) : Shaw, Gary M.;Yang, Wei;Carmichael, Suzan L.;Vollset, Stein Emil;Hobbs, Charlotte A.;Lammer, Edward J.;Ueland, Per M. (cdc.gov)

After the FSVO reassessed this substance with regard to its potential health risk, attention has focused on chlorothalonil metabolites in drinking water. (admin.ch)
Metabolites of chlorothalonil, a substance found in plant protection products, were detected in groundwater for the first time in 2017 during a pilot study of the NAQUA National Groundwater Monitoring, which is operated by the FOEN in close cooperation with the cantonal authorities. (admin.ch)

By comparing differently processed samples, the up- or down-regulation of specific metabolites can be detected. (innovativefoodprocessing.no)

The pentavalent metabolites MMA V and DMA V are less toxic than arsenite or arsenate [Marafante et al. (cdc.gov)

2004). Relating to hormonal amounts within the mind tissue being a function of estrous routine phases, studies survey (1) dazzling inter-regional distinctions in estradiol and progesterone or its metabolites (e.g., up to 5 flip higher amounts Hydroxyphenylacetylglycine in cortex than in hippocampus), aswell as (2) adjustments in estradiol and progesterone metabolite (allopregnanollone) however, not progesterone itself being a function of estrous routine stage (Koonce et al. (nos-nop.org)
In this paper, we present the results of toxicological analyses of preserved brain tissue and bone samples from the remains of the seventeenth century patients of the Ospedale Maggiore , the main hospital in Milan and one of the most innovative hospitals in Europe from the Renaissance period. (nature.com)

Once they'd tossed out data for metabolites that didn't meet their quality control criteria, the researchers were left with 131 metabolites for which they had information. (genomeweb.com)

Among the phthalate metabolites, mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) had the highest concentration (8.10 ng/mL), followed by mono(2-ethyl-5-oxohexyl) phthalate (MEOHP, 2.68 ng/mL) and monobutyl phthalate (MBP, 2.24 ng/mL). (nature.com)

The results of these studies differ somewhat as regards metabolites associated with disease risk. (biomedcentral.com)

An analytical method has been developed to determine MDMA enantiomers and those from its major metabolites, 3,4-methylenedioxyamphetamine (MDA), 3,4-dihydroxymeth-amphetamine (HHMA), and 4-hydroxy-3-methoxymethamphet-amine (HMMA). (erowid.org)
citation needed] Plant secondary metabolites are classified by their chemical structure and can be divided into four major classes: terpenes, phenylpropanoids (i.e. phenolics), polyketides, and alkaloids. (wikipedia.org)
Major metabolites were identified using the accurate mass product ion spectra. (chromatographyonline.com)
Men getting testosterone supplementation who also got dutasteride a drug usually used to treat an enlarged prostate gland and which blocks the conversion of testosterone to its potent metabolite DHT did not experience a major difference in changes in certain outcomes such as muscle mass, muscle strength, or sexual function in comparison to men who did not receive dutasteride, states study in the March 7 issue of JAMA . (medindia.net)

Various cholesterol metabolites have been found to influence breast cancer risk. (news-medical.net)
D is a natural component of breast milk where it is found primarily as cholecalciferol, but also as ergocalciferol and its respective 25-hydroxylated metabolites. (e-lactancia.org)

Secondary metabolites often play an important role in plant defense against herbivory and other interspecies defenses. (wikipedia.org)
Usually, secondary metabolites are confined to a specific lineage or even species, though there is considerable evidence that horizontal transfer across species or genera of entire pathways plays an important role in bacterial (and, likely, fungal) evolution. (wikipedia.org)
In a review article published in The Journal of Steroid Biochemistry and Molecular Biology , scientists discuss the role of cholesterol and its metabolites in breast cancer. (news-medical.net)

Specific secondary metabolites are often restricted to a narrow set of species within a phylogenetic group. (wikipedia.org)
Additionally, certain species evolve to resist secondary metabolites and even use them for their own benefit. (wikipedia.org)

Several metabolites have been linked to this infection, but these metabolites were treated as individual variables rather than pathway-linked entities. (mdpi.com)
In this study, we used WGCNA, a pathway-resolved data-driven method, to explore the relationship between metabolites and CMV infection. (mdpi.com)
We observed groups of metabolites associated with CMV infection, but also to related clinical factors including graft-versus-host disease (GvHD) and the pre-transplantation conditioning regimen. (mdpi.com)
RePub, Erasmus University Repository: The pyriproxyfen metabolite, 4 '-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. (eur.nl)
Given these effects of the metabolite alone, we considered if combined infection with ZIKV worsened neurogenic events. (eur.nl)

The anticholinergic propiverine (1-methyl-4-piperidyl diphenylpropoxyacetate), which is used for the treatment of overactive bladder syndrome, has functionally active metabolites [M-1 (1-methyl-4-piperidyl diphenylpropoxyacetate N -oxide) and M-2 (1-methyl-4-piperidyl benzilate N -oxide)], but the site of actions of these metabolites is uncertain. (aspetjournals.org)

The metabolite contents in the different sample groups were compared by statistical data analysis. (innovativefoodprocessing.no)

Anatomy12

Organisms14

Chemicals and Drugs149

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes45

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Information Science2

Health Care9

Concentrations14

Mass spectrometry8

Vitamin D metabolites4

Arsenic metabolites1

Secondary metabolite4

Metabolic6

Serum1

Bioactive2

Excretion1

20202

Physiological1

Microbiome5

Metabolome2

Acetaldehyde2

Mediate2

Biological7

Plasma3

Intestinal4

Microbial3

Protein3

Bile1

Medicinal1

Exceeds2

Identification3

Abundant2

Humans1

Mechanisms1

Compounds1

Significant differences3

Persistent1

Human9

Exposure3

Differences2

Biomarkers1

Simvastatin3

Biotransformed in the liver1

Liver1

Significantly2

Levels1

Substance2

Differently1

Toxic1

Tissue2

Researchers1

Concentration1

Results1

Major4

Found2

Role3

Species2

Infection5

Active1

Analysis1