AnatomyChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Cysteine DioxygenaseCysteineOxidation-ReductionDioxygenasesSulfenic AcidsOxygenasesTaurineAmino Acids, SulfurDisulfidesSulfinic AcidsOxidative StressSulfhydryl Compounds4-Hydroxyphenylpyruvate DioxygenaseCatalysisCatechol 2,3-DioxygenaseProtocatechuate-3,4-DioxygenaseFerrous CompoundsCarboxy-LyasesCatechol 1,2-DioxygenaseLiverCysteine EndopeptidasesTryptophan OxygenaseMolecular Sequence DataCrystallography, X-RayCysteine ProteasesAmino Acid SequenceModels, MolecularOxygenHomogentisate 1,2-Dioxygenase
Catalyzes the oxidationHydrogenEnzymePancreaticCopperVitroBiological activitiesCompoundSpectrumTargetsBodyStateExhibitShownProcessEffectsDrugsEnzymesSulfide oxidationPathwayPathwaysMitochondrialMoleculeSubunitPeptideSulfurComplexesPlantCellularAntioxidantStabilityStructuralSearchTypeHighSpecificConditions
Catalyzes the oxidation2
Hydrogen4
  • b) They transfer hydrogen from one substrate to another by oxidation-reduction reac-tion not involving a respiratory chain (shown in Fig. 12.4. (biologydiscussion.com)
  • By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS. (lookformedical.com)
  • It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. (lookformedical.com)
  • Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor. (lookformedical.com)
Enzyme1
  • The enzyme responsible for collagen maturation is prolyl 4-hydroxylase, making this enzyme a central activity in cuticle biosynthesis and a potentially important chemotherapeutic target. (embl.de)
Pancreatic1
  • Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries. (lookformedical.com)
Copper1
  • The intrinsic binding ability of 7 natural peptides (oxytocin, arg8 -vasopressin, bradykinin, angiotensin-I, substance-P, somatostatin, and neurotensin) with copper in 2 different oxidation states (CuI/II ) derived from different Cu+/2+ precursor sources have been investigated for their charge-dependent binding characteristics. (isogem.org)
Vitro2
  • To benefit from those effects, it is required that the multitarget drug exhibit balanced in vitro and in vivo activities to match potency for the corresponding targets, as well as optimized PK and safety profiles. (biomedcentral.com)
  • in vitro activity of anidulafungin. (liverpool.ac.uk)
Biological activities2
  • Although polypharmacology might be associated with compound promiscuity, it should be considered a different category since the so-called promiscuous drugs are instead a class of compound that show a wide spectrum of biological activities and adverse reactions [ 1 ]. (biomedcentral.com)
  • MCE owns a unique collection of 17212 compounds with confirmed biological activities and clear targets. (chemscene.com)
Compound1
  • Our ready-to-use ChemScene compound libraries consist of over 4000 small molecules with validated biological and pharmacological activities. (chemscene.com)
Spectrum1
  • the spectrum of activity of anidulafungin includes candida and aspergillus, the two main etiological agents causing invasive fungal infections. (liverpool.ac.uk)
Targets1
  • This new generation may rival the so-called magic bullets in the treatment of diseases that arise as a consequence of the deregulation of multiple signaling pathways provided the challenge of optimization of the activities shown by the pharmacophores with the different targets is addressed. (biomedcentral.com)
Body3
  • It is also formed in the body by oxidation of the aminoacids cysteine and methionine. (simplymimi.net)
  • Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. (chemscene.com)
  • For a glioblastoma, the tumor microenvironment has been shown to have increased activity of natural immune checkpoints, which as their name implies, helps prevent an overzealous immune response that could hurt the body, like what happens in autoimmune diseases like rheumatoid arthritis. (regenerativemedicine.net)
State1
  • In addition, distinct NOX homologs expressed by non-phagocytic cells and mitochondrial ROS are interlinked with phagocytic NOX functions and thus affect the overall redox state of the tissue and the cellular activity in a complex fashion. (frontiersin.org)
Exhibit1
  • A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. (lookformedical.com)
Shown2
  • c) They perform oxidation of metabolite uti-lizing several components of a respiratory chain (shown in Fig. 12.5). (biologydiscussion.com)
  • Only the main profile, including all conditions, is shown. (ntu.edu.sg)
Process1
  • The following points highlight the five main enzymes involved in oxidative process. (biologydiscussion.com)
Effects1
  • They counteract the harmful and damaging effects of oxidation in animal tissues. (lookformedical.com)
Drugs1
  • Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
Enzymes4
  • Acireductone dioxygenases (ARDs) are enzymes involved in the methionine recycle pathway. (umass.edu)
  • [ 86 ] Moreover, a class of nonpeptidic, low-molecular-weight compounds (M40403) proved to possess comparable catalytic activity with that of the native SOD enzymes. (medscape.com)
  • Several anaerobic bacteria from the human intestinal tract are capable of reducing azo dyes and nitropolycyclic aromatic hydrocarbons to the corresponding aromatic amines with enzymes that have azoreductase and nitroreductase activities. (nih.gov)
  • Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes HN - 2005 BX - Signal Transducing Adaptor Proteins MH - Adrenogenital Syndrome UI - D047808 MN - C19.391.775.129 MS - Abnormal SEXUAL DIFFERENTIATION caused by disorders of the GONADS or the ADRENAL GLANDS, such as CONGENITAL ADRENAL HYPERPLASIA and ADRENAL CORTEX NEOPLASMS. (nih.gov)
Sulfide oxidation2
  • ETHE1 is an iron-containing protein from the metallo β-lactamase family involved in the mitochondrial sulfide oxidation pathway. (nih.gov)
  • In return, these endosymbionts utilize the energy from sulfide oxidation to fuel the Calvin-Benson cycle. (biomedcentral.com)
Pathway1
  • Our results describe the structural evolution of the molecular system at each step of this catalytic reaction pathway. (bvsalud.org)
Pathways3
  • The existence of two pathways for cysteine synthesis might ensure its participation in the formation of proteins, heavy metal detoxification, and the sulfide-binding function of haemoglobin. (biomedcentral.com)
  • We elucidated several molecular pathways of sulfate activation, cysteine and cholesterol synthesis, and trehalose metabolism. (biomedcentral.com)
  • Contrary to the previous analysis, two pathways for cysteine synthesis and the cycloartenol-C-24-methyltransferase gene were identified in animals for the first time. (biomedcentral.com)
Mitochondrial1
  • Natural formation of oxidants during mitochondrial electron transport, auto-oxidation of some neurotransmitters (e.g. norepinephrine, dopamine) and initiation of events during hypoxia or ischemia, can result in oxidant formation and subsequent tissue damage. (biologists.com)
Molecule1
  • Organoseleno compounds have been observed, including selenomethionine, and possibly the newly-discovered S-(methylseleno)-cysteine molecule. (umass.edu)
Subunit1
  • Analysis of the nucleotide sequence for the terephthalate degradation operon located genes for a regulatory protein, a transport protein, a dioxygenase large subunit, a dioxygenase small subunit, a cis-dihydrodiol dehydrogenase, and a reductase. (nih.gov)
Peptide1
  • PMID- 214395 TI - Chemical modification of peptide antibiotics : Part VII--Biological activity of derivatives of polymyxin B. PMID- 214396 TI - Temporal relations in phosphohydrolases of mouse testes. (nih.gov)
Sulfur2
  • The investigation of two non-heme iron dioxygenases with sulfur-containing substrates is reported along with studies of seleno-compounds by gas chromatography with atomic emission detection (GC-AED). (umass.edu)
  • Moreover, sulfide can serve directly as a sulfur source for cysteine synthesis in L. luymesi . (biomedcentral.com)
Complexes1
  • They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. (nih.gov)
Plant1
  • The activities of plants and plant/microbial associations may offer a viable means of accomplishing the in situ remediation of contaminated soils. (nih.gov)
Cellular1
  • Increased level of reactive oxygen species, malondialdehyde, electrolyte leakage, proline, lipoxygenase (LOX) activity, and decreased catalase activity indicates cellular dysfunction which demonstrates seed deterioration. (bvsalud.org)
Antioxidant1
  • Recently, three new compounds have been synthesized that show antioxidant activity. (medscape.com)
Stability2
  • However, the low activity, poor thermal stability, narrow range of pH stability, as well as undesirable isoenzymes and off-flavors, have hampered the application of current commercial LOX. (bvsalud.org)
  • The purified NsLOX showed the maximum activity at pH 8.0 and 15 °C, with superior stability at a pH range from 6.0 to 13.0, retaining about 40% activity at 40 °C for 90 min. (bvsalud.org)
Structural1
  • the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)
Search1
  • MAIN CONCLUSION: 44 wheat LOX genes were identified by silico genome-wide search method. (bvsalud.org)
Type1
  • AB - Antibody activity to Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) was measured by the indirect hemagglutination (IHA) test in sera from 124 women with squamous-cell carcinoma of the uterine cervix, 46 women with non-cervical cancer and 116 matched normal women. (nih.gov)
High1
  • [ 88 , 89 ] These new SOD mimetics represent a breakthrough in chemical design in that they are stable in vivo , possess high activity and are selective for superoxide with no activity toward H2O2, peroxynitrite, NO or hypochlorite. (medscape.com)
Specific1
  • Notably, NsLOX exhibited the highest specific activity of 78,080 U/mg towards linoleic acid (LA), and the kinetic parameters-Km, kcat, and kcat/Km-attain values of 19.46 µM, 9199.75 s-1, and 473.85 µM-1 s-1, respectively. (bvsalud.org)
Conditions1
  • Only the main profile, including all conditions, is shown. (ntu.edu.sg)