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AlloysAbsorbable ImplantsGold AlloysMagnesiumChromium AlloysMagnesium SulfateMagnesium DeficiencyDental ImplantsProstheses and ImplantsTitaniumMetal Ceramic AlloysDrug ImplantsMaterials TestingDental Casting TechniqueMagnesium CompoundsImplants, ExperimentalMagnesium OxideBreast ImplantsDental Implantation, EndosseousDental Casting InvestmentSurface PropertiesOrbital ImplantsDental Implants, Single-ToothPalladiumTinSilverDental Prosthesis DesignElectron Probe MicroanalysisDental Prosthesis, Implant-SupportedAluminum OxideDifferential Thermal AnalysisDental Prosthesis RetentionDental PolishingDental Stress AnalysisMagnesium HydroxideDental AbutmentsNickelEncyclopedias as TopicDrug-Eluting StentsStentsSirolimusMetalsCardiovascular Agents
ScaffoldStentOrthopedic implantMetal implantsStentsSurgicalTitaniumBiodegradable implantsBioresorbable implantsDegradationScaffoldsRisk of complicationsZincDegradeMechanical propertiesVivoClinicallyMethodsFracture fixationMetallic implantsMaterialsTemporarySuitableBoneAdvantagesScrewsTissueRemovalDevelopmentStrengthMadePotentialApplication
Scaffold2
  • The only commercially available magnesium-based scaffold consists of a magnesium alloy, approximately 95% of which resorbs within one year of implantation. (wikipedia.org)
  • Data from the first human trial of the Dreams 2G device were also presented at TCT, and while these were positive this magnesium alloy scaffold is unlikely to reach market within the year. (evaluate.com)
Stent5
  • Metal stent candidates are iron, magnesium, zinc and their alloys. (wikipedia.org)
  • Although, Pure Zn has poor mechanical behavior, with a tensile strength of around 100-150 MPa and an elongation of 0.3-2%, which is far from reaching the strength required as an orthopedic implant or stent material. (wikipedia.org)
  • Biotronik is also developing an absorbable stent, which unlike Absorb and DESolve, is made of metal. (evaluate.com)
  • This article reports a degradation study that was done on stent prototypes made of biodegradable Fe35Mn alloy in a simulated human coronary arterial condition. (afpm.org.my)
  • The degradation rate of stent was higher compared to that of the original alloy, indicating the surface altering effect of stent fabrication processing to degradation. (afpm.org.my)
Orthopedic implant2
  • In comparison to other clinically used products, Bioretec's bioresorbable orthopedic implant RemeOsTM offers significant cost-savings and reduced risk of complications based on the elimination of redundant removal surgeries alone. (mfn.se)
  • A major weakness of current orthopedic implant materials, for instance sintered hydroxyapatite (HA), is that they exist as a hardened form, requiring the surgeon to fit the surgical site around an implant to the desired shape. (afpm.org.my)
Metal implants7
  • Bioretec is the first and currently, the only medical device company to offer bioresorbable metal implants in the United States, the largest single market for orthopedic trauma products globally. (mfn.se)
  • Bioresorbable metals combine the surgical techniques of traditional metal implants and the patient-friendly care and benefits of last-generation bioresorbable polymer implants. (mfn.se)
  • In a clinical environment, the screws have demonstrated the ability to promote extensive new bone growth in the treatment of fractures significantly better than traditional metal implants or other legacy bioresorbable implants on the market. (mfn.se)
  • In the past, bone fractures were fixed by the methods of applying metal implants. (encyclopedia.pub)
  • To substitute the metal implants for internal fracture fixation, numerous biodegradable materials (BMs) were developed. (encyclopedia.pub)
  • Li, Absorbable implants versus metal implants for the treatment of ankle fractures: A meta-analysis, Exp. (dntb.gov.ua)
  • This eliminates the complications associated with permanent metal implants, such as stress shielding or implant-related infections. (boydbiomedical.com)
Stents2
  • Promising clinical results suggest that magnesium-based scaffolds seem to be a viable option in delivering against the drawbacks of permanent stents. (wikipedia.org)
  • Bioresorbable stents, typically made from materials like polyesters or magnesium alloys, provide temporary scaffolding to support the blood vessel during healing. (boydbiomedical.com)
Surgical5
  • A biodegradable magnesium calcium alloy (MgCa0.8) and surgical steel (S316L), as a control, were investigated. (biomedcentral.com)
  • Specification for Wrought Nitrogen Strengthened 21Chromium-10Nickel-3Manganese-2.5Molybdenum Stainless Steel Alloy Bar for Surgical Implants (UNS S31675) (2013). (uran.ua)
  • Biodegradable surgical implants based on magnesium alloys - A review of current research. (uran.ua)
  • RemeOs™ trauma screws are based on a proprietary bioactive and osteopromotive magnesium alloy introducing a new generation of strong bioresorbable materials for enhanced surgical outcomes. (mfn.se)
  • Bioresorbable implants mitigate some of these risks and eliminate the need for surgical removal. (boydbiomedical.com)
Titanium5
  • The RemeOs™ trauma screw aims to make traditional titanium and steel implants redundant, eliminating the need for implant removal surgery. (mfn.se)
  • Titanium, its alloys, and steel are used worldwide in the treatment of skeletal injuries. (bvsalud.org)
  • It has recently been shown that titanium-based implants both corrode and degrade, generating metallic debris. (kapsalonhilde.nl)
  • Titanium implants are routinely used for bone fractures as well as dental work. (kapsalonhilde.nl)
  • Absorbable and titanium clips were applied across excised canine cystic ducts and both axial and transverse pull-off forces were measured. (kapsalonhilde.nl)
Biodegradable implants9
  • Recent studies have shown the potential suitability of magnesium alloys as biodegradable implants. (biomedcentral.com)
  • To avoid a second surgery and additional inconveniences for the patient as well as unnecessary treatment expenses, it is preferable to choose biodegradable implants. (biomedcentral.com)
  • The development of biodegradable implants demands an appreciation of the cellular and tissue responses that are associated with their implantation and in vivo degradation, because they determine the biocompatibility [ 15 ]. (biomedcentral.com)
  • Biodegradable implants are increasingly used in regenerative medicine and sports medicine [ 1 ] . (encyclopedia.pub)
  • There are several typical clinical indications for the use of biodegradable implants in orthopedics, which are mostly used for fractures stabilization, osteotomy procedures, bone grafts and fusions [ 6 ] [ 7 ] . (encyclopedia.pub)
  • The most common indications for biodegradable implants in orthopedics include anterior cruciate ligament reconstruction, meniscus repair, and ankle fracture treatment [ 9 ] . (encyclopedia.pub)
  • The occurrence of clinical indications for biodegradable implants is comprehensively demonstrated in Figure 1 . (encyclopedia.pub)
  • Current clinical applications of biodegradable implants. (encyclopedia.pub)
  • In the shoulder area, biodegradable implants are applied in fracture fixation of the glenoid fossa and in shoulder lesions repair [ 10 ] . (encyclopedia.pub)
Bioresorbable implants3
  • This includes bioactive scaffolds, bioresorbable implants, injectable hydrogels, "organ-on-a-chip" organ models, and self-healing biomaterials. (boydbiomedical.com)
  • Applications for bioresorbable implants include orthopedics, cardiovascular interventions, and tissue engineering, where they provide temporary support while facilitating tissue regeneration. (boydbiomedical.com)
  • Cardiovascular interventions have also seen notable advancements with the use of bioresorbable implants. (boydbiomedical.com)
Degradation1
  • Experiments on animals confirmed the absence of toxic effect from the products of degradation of the devised magnesium alloy on a living organism. (uran.ua)
Scaffolds3
  • While polymer-based scaffolds had a strong presence at first, they have meanwhile lost some appeal due to safety concerns and focus is now shifted more towards metallic magnesium-based scaffolds. (wikipedia.org)
  • citation needed] Magnesium-based scaffolds have been approved for use in several countries around the world. (wikipedia.org)
  • Thousands of commercially available magnesium-based scaffolds have been implanted. (wikipedia.org)
Risk of complications1
  • This reduces the risk of complications associated with implant removal and eliminates the need for additional procedures, which can save time and resources and minimize patient discomfort. (boydbiomedical.com)
Zinc1
  • Employing the methods of experiment design, we studied the separate and joint influence of zirconium, neodymium and zinc on structure formation and mechanical properties of magnesium alloy. (uran.ua)
Degrade1
  • Over time, these implants gradually degrade, allowing for the natural healing and regeneration of the bone. (boydbiomedical.com)
Mechanical properties4
  • As magnesium alloys have mechanical properties, which are similar to that of cortical bone [ 13 ] and a significant higher stability and Young's modulus than polymers [ 14 ], they could be promising candidates for osteosynthesis of weight bearing bones. (biomedcentral.com)
  • They are bioinert and biocompatible, but their use in osteosynthesis is limited mainly by their inadequate mechanical properties due to the high rate of biodegradation, which requires improving them by changing the chemical composition of the alloy. (uran.ua)
  • Mathematical models have been constructed that describe the influence of the examined alloying elements on the mechanical properties of the metal. (uran.ua)
  • It was established that the implants made from the designed alloy possess the necessary level of mechanical properties that match the mechanical properties of bone tissue. (uran.ua)
Vivo1
  • In vitro and in vivo biocompatibility of Mg-Zn-Ca alloy operative clip. (kapsalonhilde.nl)
Clinically1
Methods1
  • Gurgenc, Extreme learning machine and support vector regression wear loss predictions for magnesium alloys coated using various spray coating methods, J. Appl. (dntb.gov.ua)
Fracture fixation2
  • The Breakthrough Device designation from FDA already recognized and validated the benefits of the RemeOs™ trauma screws and furthermore showed that there is a clinical need in the U.S. market for a true alternative for traditional metallic implants and a game changer in the treatment of fracture fixation. (mfn.se)
  • In orthopedics, fracture fixation or bone defect repair procedures utilize bioresorbable materials such as polylactic acid (PLA) and polyglycolic acid (PGA) to create implants that temporarily support the injured bone. (boydbiomedical.com)
Metallic implants1
  • Badhe, Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices - A mini review, Toxicol. (dntb.gov.ua)
Materials3
  • Moderate inflammation was detected in both implant materials and resolved to a minimum during the first weeks indicating comparable biocompatibility for MgCa0.8 and S316L. (biomedcentral.com)
  • It is shown that magnesium alloys are among the most promising biosoluble materials. (uran.ua)
  • The development of suitable absorbable metallic materials would help us to overcome these issues. (bvsalud.org)
Temporary1
  • Natural and synthetic biodegradable polymers and hydrolysable metals make the main components for the creation of temporary medical implants [ 2 ] . (encyclopedia.pub)
Suitable1
  • In order to develop a new magnesium-based biosoluble alloy, we have selected the most suitable doping systems in accordance with the established criteria. (uran.ua)
Bone3
  • Studying the influence of the designed alloy on reparative osteogenesis during experiment on rabbits has shown the positive dynamics of bone tissue regeneration without noticeable changes in its structure, which ensures reliable merging of elements in bones at osteosynthesis. (uran.ua)
  • Bioretec Ltd, a pioneer in bioresorbable[1] orthopedic implants, has today announced receiving the market authorization of the U.S. Food and Drug Administration (FDA) for its pioneering RemeOs™ trauma screw to be used for healing of bone fractures aligned with the clinical trial[2]. (mfn.se)
  • As the bone regains its strength, the need for the implant diminishes, and the body eventually absorbs the implant. (boydbiomedical.com)
Advantages3
  • Absorbable polymeric clips were hemostatically effective in this laparoscopic model and may offer advantages over metallic clips. (kapsalonhilde.nl)
  • Polymeric absorbable clips, which have advantages over metallic clips, are evaluated in this study. (kapsalonhilde.nl)
  • Absorb's chances of taking off in the US are heavily dependent on whether interventional cardiologists see the potential advantages of Absorb as worth switching to a new device, and one that is harder to implant than metallic DESs. (evaluate.com)
Screws1
  • Screws of identical geometrical conformation were implanted into the tibiae of 40 rabbits for a postoperative follow up of two, four, six and eight weeks. (biomedcentral.com)
Tissue3
  • Histology revealed that a layer of fibrous tissue had formed between implant and overlying muscle in MgCa0.8 and S316L, which was demarcated by a layer of synoviocyte-like cells at its interface to the implant. (biomedcentral.com)
  • In MgCa0.8 implants cavities were detected within the fibrous tissue, which were surrounded by the same kind of cell type. (biomedcentral.com)
  • In an ideal scenario, these implants would break down as the wound healed, transferring load gradually to the healing tissue. (encyclopedia.pub)
Removal1
  • For these reasons, implant removal is commonly required after fracture healing is completed [ 5 ]. (biomedcentral.com)
Development1
  • Other, alternative solutions have included the development of magnesium-rare-earth (Mg-RE) alloys, which benefit from the low cytotoxicity of RE elements. (wikipedia.org)
Strength1
  • Absorbable clip strength retention decreased over time as expected with a retention of 11% original strength by the 21st day. (kapsalonhilde.nl)
Made1
  • The industrial and pre-clinical tests of implants made from the designed biosoluble alloy have been performed. (uran.ua)
Potential1
  • Despite widespread use, some problems associated with traditional implants include the potential for long-term relocation, stress shielding, breakage, adverse material reactions, growth complications with young patients, and interfacing issues with imaging devices. (boydbiomedical.com)
Application2
  • Thus, the application of MgCa0.8 as biodegradable implant material seems conceivable. (biomedcentral.com)
  • Additionally, they find application in dental implants and maxillofacial reconstruction, where they play a vital role in restoring functionality and aesthetics. (boydbiomedical.com)