AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
Macular EdemaDiabetic RetinopathyTriamcinolone AcetonideRetinal Vein OcclusionLaser CoagulationVisual AcuityTomography, Optical CoherenceEdemaFluorescein AngiographyVitreous BodyIntravitreal InjectionsMacula LuteaInjectionsFundus OculiPulmonary EdemaVitrectomyBrain EdemaRetinaTriamcinoloneGlucocorticoidsPseudophakiaInjections, IntraocularRetreatmentFluocinolone AcetonideSubretinal FluidFovea CentralisUveitis, IntermediateEpiretinal MembraneBlood-Retinal BarrierUveitisPhotographyAngiogenesis InhibitorsRetinal DiseasesMicroscopy, AcousticDiagnostic Techniques, OphthalmologicalLight CoagulationAntibodies, Monoclonal, HumanizedPanuveitisCataract ExtractionOphthalmoscopyRetinal Photoreceptor Cell Inner SegmentRetinal VesselsRetinal Photoreceptor Cell Outer SegmentTelangiectasisVascular Endothelial Growth Factor AVision DisordersTreatment OutcomeFollow-Up StudiesRetinal VeinCapillary PermeabilityDrug ImplantsRetrospective StudiesCorneal EdemaEdema, CardiacProspective StudiesRetinal DetachmentDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Retinal ArteryEye DiseasesFluorophotometryLasers, Solid-StateAphakia, PostcataractEdema Disease of SwineVisual Field TestsPhacoemulsificationOrbitChoroidVisual FieldsConnective TissueIntraocular PressureUveitis, PosteriorAqueous HumorVitreous DetachmentReproducibility of Results
OcclusionDiabeticRetinaDetachmentIntravitrealCystoidUveitisBRVORanibizumabInjectionsRetinopathyGlaucomaHemorrhageLaser surgery for macular edemaBlindnessDetachmentsIntraocularThicknessVein occlusionsFluidBranchEpithelialMaculaBlood-retinalKeywords macularIrreversibleHemorrhagesComplicationsClinicalDiabetesCataractOcularOptical coherencePatients with retinalNeovascularizationIschemiaDiseasesIschemicDystrophyVitrectomy surgery
Occlusion34
Diabetic34
  • The purpose of this study is to evaluate the impact of navigated retinal photocoagulation on the number of intravitreal anti-VEGF injections necessary to maintain visual gain in patients with diabetic macular edema (DME), compared to anti-VEGF mono-therapy. (arvojournals.org)
  • Diabetic macular edema (DME) is similarly caused by leaking macular capillaries. (wikipedia.org)
  • Diabetic macular edema may be treated with laser photocoagulation, reducing the chance of vision loss. (wikipedia.org)
  • Iluvien, a sustained release intravitreal implant developed by Alimera Sciences, has been approved in Austria, Portugal and the U.K. for the treatment of vision impairment associated with chronic diabetic macular edema (DME) considered insufficiently responsive to available therapies. (wikipedia.org)
  • Each stage of diabetic retinopathy can contribute to the risk of further vision problems and conditions, including diabetic macular edema (DME), glaucoma and even blindness. (allaboutvision.com)
  • To investigate hyperreflective foci (HF) on spectral-domain optical coherence tomography in patients with Type 1 diabetes mellitus across different stages of diabetic retinopathy (DR) and diabetic macular edema (DME) and to study clinical and morphological characteristics associated with HF. (nih.gov)
  • To determine the relationship between the retinal morphologic changes and concentrations of intravitreal cytokines in eyes with diabetic macular edema. (lww.com)
  • The significant association of SRD with intravitreal IL-6 indicates that inflammation may play an important role in the development of SRD in diabetic macular edema. (lww.com)
  • The level of intravitreal interleukin-6 was significantly associated with the serous retinal detachment detected by optical coherence tomography in eyes with diabetic macular edema indicating its important role in the edema. (lww.com)
  • Automated segmentation of the retinal layers of the eyes with subclinical and clinical macular edema was compared with a sample of 31 eyes from diabetic patients with normal OCT and an age-matched control group of 58 healthy eyes. (eyehospital.nl)
  • Thinning of the retina was registered in the retinal nerve fiber, ganglion cells and inner plexiform layers in the diabetic eyes without macular edema. (eyehospital.nl)
  • CONCLUSIONS: The increase in RT occurring in diabetic eyes with macular edema is predominantly located in the INL but extends to neighboring retinal layers indicating that it may be due to extracellular fluid accumulation. (eyehospital.nl)
  • abstract = "PURPOSE: To identify the retinal layer predominantly affected in eyes with subclinical and clinical macular edema in diabetes type 2.METHODS: A cohort of 194 type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20/35) were examined with Cirrus spectral-domain optical coherence tomography (OCT) at the baseline visit (ClinicalTrials.gov identifier: NCT01145599). (eyehospital.nl)
  • Automated segmentation of the retinal layers of the eyes with subclinical and clinical macular edema was compared with a sample of 31 eyes from diabetic patients with normal OCT and an age-matched control group of 58 healthy eyes.RESULTS: From the 194 eyes in the study, 62 had subclinical macular edema and 12 had clinical macular edema. (eyehospital.nl)
  • Purpose: To investigate retinal fluid features and ellipsoid zone (EZ) integrity dynamics on spectral-domain OCT (SD-OCT) in eyes with diabetic macular edema (DME) treated with intravitreal aflibercept injection (IAI) in the VISTA-DME study. (elsevierpure.com)
  • Anti-VEGF injections are used to treat age-related macular degeneration , as well as macular edema due to other causes, such as diabetic retinopathy. (news-medical.net)
  • Two-year results from the Diabetic Retinopathy Clinical Research network (DRCR.net) Randomized Trial Evaluating Ranibizumab Plus Prompt or Deferred Laser or Triamcinolone Plus Prompt Laser for Diabetic Macular Edema, known as the Laser-Ranibizumab-Triamcinolone for DME Study, demonstrated that ranibizumab paired with prompt or deferred focal/grid laser treatment achieved superior visual acuity and optical coherence tomography (OCT) outcomes compared with focal/grid laser treatment alone. (medscape.com)
  • In a DRCR.net clinical trial comparing Eylea (aflibercept), Lucentis (ranibizumab), and Avastin (bevacizumab) for diabetic macular edema (DME), aflibercept provided greater visual improvement, on average, than did the other 2 drugs for vision of 20/50 or worse at the start of the trial. (medscape.com)
  • DR and diabetic macular edema (DME) are associated with visual complications. (frontiersin.org)
  • AAO 2023: New Modes of Treatments and New Directions for Diabetic Macular Edema Dr Sunir Garg outlines several topics to be addressed at AAO 2023, including enhancements to anti-VEGF therapy and strategies for making clinical trials more representative of the general population. (medscape.com)
  • The Evolving Treatment Landscape of Diabetic Macular Edema SriniVas Sadda, MD, recalls an encounter with a patient with diabetic macular edema and wonders how the patient would have fared differently today with new technologies. (medscape.com)
  • Addressing Disparities and Patient Burdens in Diabetic Macular Edema Sunir Garg, MD, addresses disparities and patient burdens in diabetic macular edema, which affects proper eye care. (medscape.com)
  • DME: Charting the Changing Landscape in Treatment Options Sunir Garg, MD, discusses the evolution of treatment options for patients with diabetic macular edema. (medscape.com)
  • Highlights From ASRS 2023 Former ASRS president Dr Timothy Murray discusses key data from ASRS 2023, including results for faricimab in diabetic macular edema, 8-mg aflibercept in wet AMD, and pegcetacoplan safety reports. (medscape.com)
  • Background/aims To investigate the yearly change of real-world outcomes for best corrected visual acuity (BCVA) after 2-year clinical intervention for treatment-naïve diabetic macular oedema (DMO). (bmj.com)
  • COSTA MESA, Calif., May 22, 2023 (GLOBE NEWSWIRE) -- AiViva Biopharma Inc., a clinical-stage biotechnology company, announced that it has begun a Phase 1 trial and completed dosing the first cohort of patients diagnosed with wet age-related macular degeneration (wAMD), and/or diabetic macular edema (DME). (tmcnet.com)
  • Diabetic macular edema is manifested as retinal thickening and swelling caused by accumulation of intraretinal fluid usually due to blood sugar levels being consistently high. (tmcnet.com)
  • O'Hare JP, Hopper A, Madhaven C, Charny M, Purewell TS, Harney B, Griffiths J. Adding retinal photography to screening for diabetic retinopathy: a prospective study in primary care. (bvs.br)
  • Owens DR, Gibbins RL, Lewis PA, Wall S, Allen JC, Morton R. Screening for diabetic retinopathy by general practitioners: ophthalmoscopy or retinal photography as 35 mm colour transparencies? (bvs.br)
  • Accuracy and reliability of teleophthalmology for diagnosing diabetic retinopathy and macular edema: a review of the literature. (bvs.br)
  • Eye diseases that can affect people with diabetes include diabetic retinopathy, macular edema (which usually develops along with diabetic retinopathy), cataracts, and glaucoma. (cdc.gov)
  • Macular edema is the most common cause of blindness in people with diabetic retinopathy. (cdc.gov)
  • About half of people with diabetic retinopathy will develop macular edema. (cdc.gov)
  • Reattachment of the retina (for retinal detachment, a complication of diabetic retinopathy). (cdc.gov)
Retina13
  • CME arises from the accumulation of fluid within the retina when there is disruption of the normal blood-retinal barrier and abnormal permeability of the perifoveal retinal capillaries. (aao.org)
  • Macular edema occurs when fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken and swell (edema). (wikipedia.org)
  • Blockage of a vein in the retina can cause engorgement of the other retinal veins causing them to leak fluid under or into the retina. (wikipedia.org)
  • A number of drugs can cause changes in the retina that can lead to macular edema. (wikipedia.org)
  • Blockage of smaller veins (branch veins or BRVO) in the retina often occurs in places where retinal arteries that have been thickened or hardened by atherosclerosis cross over and place pressure on a retinal vein. (medlineplus.gov)
  • Initial treatment for uveitis-related macular edema seeks to control inflammation and reduce the fluid under the retina. (news-medical.net)
  • Recently, we generated R91W;Nrl −/− double-mutant mice, which display a well-ordered all-cone retina with normal retinal vasculature and a strong photopic function that generates useful vision. (nature.com)
  • The majority of eyes with retinal breaks do not develop retinal detachment because normal physiological forces keep the retina in place. (aao.org)
  • However, the combination of retinal breaks, vitreous liquefaction and detachment, traction on the retina (vitreoretinal traction), and intraocular fluid currents associated with movement of liquid vitreous and subretinal fluid can overwhelm these "attachment factors," causing retinal detachment. (aao.org)
  • AMD affects the macular, center portion of the retina, that is responsible for central vision and color perception. (tmcnet.com)
  • Retinitis pigmentosa is a slowly progressive, bilateral degeneration of the retina and retinal pigment epithelium caused by various genetic mutations. (msdmanuals.com)
  • Diagnosis is by funduscopy, which shows pigmentation in a bone-spicule configuration in the equatorial retina, narrowing of the retinal arterioles, a waxy pallor of the optic disk, posterior subcapsular cataracts, and cells in the vitreous. (msdmanuals.com)
  • These pouches can leak blood and other fluid, which can cause a part of the retina called the macula to swell (macular edema) and distort your vision. (cdc.gov)
Detachment12
  • These blood vessels are delicate and can eventually lead to retinal detachment . (allaboutvision.com)
  • A serous retinal detachment may be important in determining the type of treatment. (lww.com)
  • Optical coherence tomography showed neurosensory detachment and macular edema. (thepajo.org)
  • Vitrectomy can restore vision in certain patients with recent traction retinal detachment and/or vitreous hemorrhage. (cdc.gov)
  • The essential requirements for a rhegmatogenous retinal detachment include a retinal break (rhegma = rent or rupture) and vitreous liquefaction sufficient to allow fluid in the vitreous cavity to pass through the break(s) into the subretinal space. (aao.org)
  • The usual pathological sequence that results in retinal detachment is vitreous liquefaction followed by a posterior vitreous detachment (PVD), which in turn causes retinal tears at the sites of significant vitreoretinal adhesions (Figure 1). (aao.org)
  • All ocular conditions that are associated with an increased prevalence of vitreous liquefaction and PVD or with an increased number or extent of vitreoretinal adhesions are associated with a higher incidence of retinal detachment, including trauma. (aao.org)
  • Major risk factors have in common an increased incidence of retinal break(s), vitreous liquification and detachment, and abnormal vitreoretinal adhesions. (aao.org)
  • As noted above, retinal detachment occurs when the combination of factors that promote retinal detachment overwhelms the normal attachment forces. (aao.org)
  • Vitreous traction usually persists at the edge of a tear, which promotes progression of the retinal detachment. (aao.org)
  • Retinal detachment is usually found in patients with high myopia prescription and those who have not undergone any eye surgery before. (healthpages.org)
  • Retinal detachment can be treated with the help of another surgery. (healthpages.org)
Intravitreal7
  • In 2010, the US FDA approved the use of Lucentis intravitreal injections for macular edema. (wikipedia.org)
  • Conclusions: In macular edema of BRVO, the initial three monthly intravitreal injections of bevacizumab provided superior treatment outcomes regarding short-term functional and anatomical improvements and long-term functional improvement, compared with methods that did not treat with the initial three monthly injections. (gnu.ac.kr)
  • The other morphologic changes, such as retinal cystic changes and retinal swellings, were not significantly associated with the concentrations of intravitreal cytokines. (lww.com)
  • Intravitreal triamcinolone for macular edema showed no significant differences to focal grid laser treatment with respect to visual acuity outcomes in patients with BRVO and was superior to observation with respect to visual acuity outcomes in patients with CRVO. (entokey.com)
  • Compared with standard grid laser, intravitreal ranibizumab provided significant and sustained benefits in visual acuity gain and anatomic improvement in eyes with macular edema secondary to BRVO. (entokey.com)
  • Compared with methotrexate or ranibizumab intravitreal (in-the-eye) injections, the corticosteroid treatment achieved greater reductions in retinal swelling and was the only therapy in the study that improved vision. (news-medical.net)
  • All participants had previously received at least one intravitreal corticosteroid injection for uveitis-related macular edema. (news-medical.net)
Cystoid5
  • Cystoid macular edema (CME) is most commonly seen after cataract surgery. (aao.org)
  • Cystoid macular edema (CME) involves fluid accumulation in the outer plexiform layer secondary to abnormal perifoveal retinal capillary permeability. (wikipedia.org)
  • Cystoid macular edema had improved in 64% (7/11) of eyes at last follow-up as measured by biomicroscopy and optical coherence tomography. (johnshopkins.edu)
  • This was accompanied by retinal swelling and the appearance of cystoid spaces in both inner and ONLs of R91W;Nrl −/− mice indicating edema in affected areas. (nature.com)
  • For patients with cystoid macular edema, carbonic anhydrase inhibitors given orally (eg, acetazolamide ) or topically (eg, dorzolamide ) may yield mild vision improvement. (msdmanuals.com)
Uveitis9
  • It may occur with vascular disease, retinal dystrophy, uveitis, and usage of certain medications. (aao.org)
  • Supplementary video of "DEX Implant for Macular Edema and Uveitis" [ID 209395]. (dovepress.com)
  • Repeat treatment with corticosteroid injections improved vision in people with persistent or recurrent uveitis-related macular edema better than two other therapies, according to results from a clinical trial funded by the National Eye Institute (NEI). (news-medical.net)
  • Prior to this study, we didn't know the best treatment for persistent or recurrent macular edema, a major cause of vision loss in people with uveitis. (news-medical.net)
  • This fluid buildup, called macular edema, is a complication of uveitis that often persists or recurs over time, despite uveitis treatment. (news-medical.net)
  • In this study, researchers compared three treatments for uveitis-related macular edema: an additional intraocular corticosteroid injection, an injection of the anti- vascular endothelial growth factor (anti-VEGF) drug ranibizumab, or an injection of the anti-inflammatory drug methotrexate. (news-medical.net)
  • Earlier, small pilot studies suggested that ranibizumab injections and the anti-inflammatory effects of methotrexate might help reduce uveitis-related macular edema. (news-medical.net)
  • The clinical trial enrolled 194 participants (225 study eyes) with well-controlled uveitis but persistent or recurrent macular edema. (news-medical.net)
  • The acute uveitic stage is heralded by the onset of sequential blurring of vision in both eyes, 1-2 days after the onset of CNS signs, and is marked by bilateral granulomatous anterior uveitis, a variable degree of vitritis, thickening of the posterior choroid, edema of the optic nerve, and multiple serous retinal detachments (Fig 9-52). (aao.org)
BRVO7
  • In 2005, steroids were investigated for the treatment of macular edema due to retinal blood vessel blockage such as CRVO and BRVO. (wikipedia.org)
  • Methods: The clinical records of macular edema patients were analyzed retrospectively for a total of 62 eyes of 62 patients who were injected with bevacizumab into the vitreous as the first treatment for BRVO. (gnu.ac.kr)
  • More recently, several industry-sponsored phase III trials demonstrated significant visual acuity benefit of anti-vascular endothelial growth factor (anti-VEGF) therapy for treatment of macular edema associated with BRVO or CRVO. (entokey.com)
  • A total of 36 patients with vision loss in 1 eye attributable to macular edema following BRVO were recruited from 5 institutions. (entokey.com)
  • The cause for the vision loss in BRVO is predominantly attributable to macular edema. (entokey.com)
  • In this study, treatment of macular edema following BRVO with grid laser resulted in ≥2 lines of visual acuity (VA) improvement in 65% of eyes compared with 37% of untreated eyes at the 3-year primary endpoint. (entokey.com)
  • In the last 5 years, several new treatments for macular edema secondary to BRVO have been evaluated in randomized clinical trials. (entokey.com)
Ranibizumab3
  • Monthly ranibizumab injection until central retinal thickness (CRT) was reduced to 450µm (Spectralis OCT) then navigated laser therapy followed by the application of the observation and retreatment paradigm as in group "1" (n=34). (arvojournals.org)
  • A 2014 Cochrane Systematic Review studied the effectiveness of two anti-VEGF treatments, ranibizumab and pegaptanib, on patients with macular edema caused by CRVO. (wikipedia.org)
  • The ranibizumab group received injections at baseline, four weeks, and eight weeks, even if their macular edema resolved. (news-medical.net)
Injections6
Retinopathy4
  • Laser photocoagulation therapy is effective in reducing the risk of visual loss in patients with high-risk proliferative retinopathy and clinically significant macular edema. (cdc.gov)
  • About half of the people with proliferative retinopathy also have macular edema. (your-diabetes.com)
  • It allows the diagnosis of many eye conditions like diabetes-related retinopathy, glaucoma and macular degeneration. (clevelandclinic.org)
  • Ricardo had severe retinopathy and clinically significant macular edema, which if left untreated, would lead to blindness. (scripps.org)
Glaucoma2
  • It is important to properly manage conditions such as macular edema and glaucoma. (medlineplus.gov)
  • The versatility of MicroPulse to treat retinal disorders and glaucoma allows me to provide my patients with a treatment that's clinically effective, cost effective, and time effective. (iridex.com)
Hemorrhage1
  • We reported the findings of this small case series to highlight the presence of retinal hemorrhage as a manifestation of ophthalmic complication in patients with dengue fever. (cdc.gov)
Laser surgery for macular edema1
  • [ 28 ] has found that laser surgery for macular edema reduces the incidence of moderate visual loss (doubling of visual angle or roughly a 2-line visual loss) from 30% to 15% over a 3-year period. (medscape.com)
Blindness2
  • AMD is a progressive retinal disease that is the leading cause of blindness in adults over the age of 60, affecting up to 15 million U.S. people. (tmcnet.com)
  • SUMMARYGlaucoma is a leading cause of irreversible blindness worldwide, caused by the gradual degeneration of retinal ganglion cells and their axons. (bvsalud.org)
Detachments4
  • The preoperative optical coherence tomography images were evaluated to determine the presence of serous retinal detachments (SRDs), retinal cystic changes, and retinal swelling. (lww.com)
  • The focal serous retinal detachments are often shallow, exhibiting a cloverleaf pattern around the posterior pole, but they may coalesce and evolve into large, bullous, exudative detachments. (aao.org)
  • Scleral buckling is an ophthalmic surgical technique that has been successfully employed as a primary or adjuvant procedure to repair rhegmatogenous retinal detachments for over 60 years. (aao.org)
  • Although considerable debate persists regarding the optimal form of treatment for many types of retinal detachments, scleral buckling is declining in popularity, particularly in regard to pseudophakic cases. (aao.org)
Intraocular2
  • Patients should be referred to an ophthalmologist promptly for unexplained visual symptoms, reduced corrected visual acuity, increased intraocular pressure, any retinal abnormalities, or any other ocular pathology that threatens vision. (cdc.gov)
  • This is due to a combination of retinal breaks, vitreous changes inducing a retinal break and vitreoretinal traction, and intraocular fluid currents. (aao.org)
Thickness4
  • Multivariate regression showed that the duration from the onset, the three loadings, BCVA, disorganization of the retinal inner layer (DRIL), and choroidal thickness were predictors related to visual gain (p = 0.044, p = 0.047, p = 0.004, p = 0.045, and p = 0.034, respectively). (gnu.ac.kr)
  • SCORE2 also showed that at 24 months postrandomization (12 months after cessation of the SCORE2 protocol-defined treatment schedule), participants randomized to aflibercept and those randomized to bevacizumab had similar visual acuity and central retinal thickness outcomes. (entokey.com)
  • Central macular mean EZ-RPE thickness (i.e., a surrogate for photoreceptor outer segment length) and central RFI were independently correlated with BCVA at multiple follow-up visits. (elsevierpure.com)
  • Retinal holes are full-thickness retinal defects that are typically not associated with persistent vitreoretinal traction in their vicinity. (aao.org)
Vein occlusions2
  • There are a number of uncommon causes of this condition that make up an extremely small minority of branch retinal vein occlusions. (eyeknowmore.com)
  • Retinal vein occlusions preferred practice pattern. (medlineplus.gov)
Fluid4
  • A blockage of a retinal vein may cause an accumulation of fluid within the macula called macular edema. (eyeknowmore.com)
  • The OCT macular cube datasets were evaluated using a novel software platform to generate retinal layer and fluid boundary lines that were manually corrected for assessment of change in EZ parameters and volumetric fluid parameters from baseline. (elsevierpure.com)
  • The retinal fluid index (i.e., proportion of the retinal volume consisting of cystic fluid) was also calculated at each time point. (elsevierpure.com)
  • In our series of 7 cases, we documented impaired visual acuity, central visual field defects, circumscribed and sometimes complex changes of retinal reflectivity, and intraretinal fluid. (aerzteblatt.de)
Branch1
  • If too much force is applied, it can cause a blockage of a branch of the retinal veins. (eyeknowmore.com)
Epithelial3
  • 1 They also stabilize endothelial and retinal pigment epithelial tight junctions and restore the integrity of blood retinal barrier. (dovepress.com)
  • NEW ORLEANS - Retinal pigment epithelial (RPE) cells derived from human embryonic stem cells can be safely transplanted into the eyes of patients with retinal degeneration, with early signs of vision gain, according to pioneers in the field. (medscape.com)
  • Corneal epithelial edema associated with acutely elevated IOP may give rise to a steamy appearance. (medscape.com)
Macula1
  • If untreated, chronic macular edema can lead to irreversible damage of the macula and permanent vision loss. (tmcnet.com)
Blood-retinal1
  • Collectively, our data suggest that exposure of R91W;Nrl −/− mice to blue light not only induces cone cell death but also disrupts the inner blood-retinal barrier. (nature.com)
Keywords macular1
Irreversible2
  • Recent years have seen a marked increase in laser-pointer-related injuries, which sometimes involve severe retinal damage and irreversible visual impairment. (aerzteblatt.de)
  • Irreversible retinal damage is related to cumulative dosage and treatment duration. (nih.gov)
Hemorrhages9
  • We report a case of bilateral retinal hemorrhages with macular edema in a patient with dengue fever (DF). (thepajo.org)
  • Isolated cases of retinal hemorrhages and macular edema have been reported in the literature. (thepajo.org)
  • Herein, we report a case of bilateral retinal hemorrhages with macular edema in a patient with neurological complications due to DF. (thepajo.org)
  • We thank Su and Chee ( 1 ) for their interest in our article, "Retinal Hemorrhages in 4 Patients with Dengue Fever" ( 2 ). (cdc.gov)
  • Our article did not attempt to conclude that the retinal hemorrhages were responsible for the patients' visual symptoms, as suggested by Su et al. (cdc.gov)
  • In fact, we stated that in all 4 patients "fundoscopic examination showed macular hemorrhages and exudative maculopathy. (cdc.gov)
  • Chlebicki MP , Ang B , Barkham T , Laude A . Retinal hemorrhages in 4 patients with dengue fever. (cdc.gov)
  • The spectrum of damage ranged from focal photoreceptor defects to macular foramina and retinal hemorrhages associated with loss of visual acuity and central scotoma. (aerzteblatt.de)
  • Macular foramina and extensive hemorrhages can be treated surgically. (aerzteblatt.de)
Complications1
  • Blue light exposure of the R91W;Nrl −/− mouse could therefore be used to study molecular events preceding edema formation in a cone-rich environment, and thus potentially help to develop treatment strategies for edema-based complications in macular degenerations. (nature.com)
Clinical6
  • PURPOSE: To identify the retinal layer predominantly affected in eyes with subclinical and clinical macular edema in diabetes type 2. (eyehospital.nl)
  • RESULTS: From the 194 eyes in the study, 62 had subclinical macular edema and 12 had clinical macular edema. (eyehospital.nl)
  • 33.6% in subclinical macular edema and 81.8% in clinical macular edema). (eyehospital.nl)
  • Investigators included 660 people with macular edema at 88 clinical trial sites across the United States. (medscape.com)
  • AAO 2023: Anticipating New and Real-World Data in AMD Dr Vaidehi Dedania looks ahead to the 2023 AAO meeting expecting updates from trials on geographic atrophy as well as clinical best-practices regarding therapies for exudative macular degeneration. (medscape.com)
  • Exudative Age-Related Macular Degeneration: The Advent of Anti-VEGF Agents Thomas Ciulla, MD, discusses the clinical transition from therapeutically limited laser-based therapies to the introduction of anti-VEGF drugs. (medscape.com)
Diabetes2
  • It can help diagnose conditions like diabetes-related macular edema and macular degeneration. (clevelandclinic.org)
  • Deeply concerned that he would permanently lose his vision, the National City resident learned about a free retinal screening program offered at a nearby community clinic, supported by Scripps Whittier Diabetes Institute . (scripps.org)
Cataract2
  • Replacement of the lens as treatment for cataract can cause pseudophakic macular edema. (wikipedia.org)
  • Macular edema sometimes occurs for a few days or weeks (sometimes even much longer) after cataract surgery, but most such cases can be successfully treated with NSAID or cortisone eye drops. (wikipedia.org)
Ocular1
  • Ocular disturbances: Other ocular disturbances (eg, photophobia, colored halos) may be associated with acute iridocyclitis and corneal edema, respectively. (medscape.com)
Optical coherence1
  • Recently, optical coherence tomography angiography (OCTA) has been introduced as a novel depth-resolved non- invasive technique of retinal vascular imaging. (frontiersin.org)
Patients with retinal1
  • In both studies presented here, human embryonic stem cells were turned into RPE cells and injected into the subretinal space of patients with retinal degeneration at a dose of 50,000 to 200,000 cells. (medscape.com)
Neovascularization1
Ischemia1
  • Although the pathophysiology of RVO is poorly understood, an important final common pathway is retinal ischemia. (openophthalmologyjournal.com)
Diseases3
  • A few congenital diseases are known to be associated with macular edema for example retinitis pigmentosa and retinoschisis. (wikipedia.org)
  • As the incidence of cone degenerative diseases such as age-related macular degeneration is expected to rise in the future, the understanding of cone physiology and pathophysiology is urgently needed to develop therapeutic approaches for the preservation of cone-mediated vision in patients. (nature.com)
  • Nitroxide small molecule agents are in development as preventative or therapeutic pharmaceutical drugs for age-related macular degeneration (AMD) and cardiovascular disease, which are two major diseases of aging. (frontiersin.org)
Ischemic1
Dystrophy1
  • Voretigene neparvovec -rzyl is now available for the treatment of confirmed biallelic RPE65 mutation-associated retinal dystrophy. (msdmanuals.com)
Vitrectomy surgery1