AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth CareGeographicals
Diabetic AngiopathiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic RetinopathyDiabetes MellitusHemoglobin A, GlycosylatedDiabetic NephropathiesDiabetes ComplicationsMicrocirculationMicrovesselsBlood GlucoseHypoglycemic AgentsDiabetic NeuropathiesDiabetes Mellitus, ExperimentalInsulinRisk FactorsAlbuminuriaHyperglycemiaDemocratic People's Republic of KoreaVascular DiseasesGlycosylation End Products, AdvancedEndothelium, VascularRetinal VesselsHypoglycemiaCardiovascular DiseasesPostoperative ComplicationsBiological MarkersAldehyde ReductasePrevalenceDiabetes, GestationalHypertensionProspective StudiesTreatment OutcomeTime FactorsBlood PressureFollow-Up StudiesCross-Sectional StudiesRetrospective StudiesCohort StudiesPregnancy in DiabeticsRisk AssessmentDiabetic FootCase-Control StudiesDisease ProgressionStreptozocinErythrocyte CountCreatinineCapillary PermeabilityEndothelial CellsDiabetes InsipidusGenetic Predisposition to DiseaseGliclazideInsulin ResistanceOdds RatioLogistic ModelsMetforminAsian Continental Ancestry GroupObesityPredictive Value of TestsIslets of LangerhansGlucoseMice, Inbred NODGlucose Tolerance TestCapillariesInsulinsCells, CulturedThiazolidinedionesLaser-Doppler FlowmetryPrediabetic StateDiabetic DietBody Mass IndexDiabetic CardiomyopathiesInsulin-Secreting CellsIncidenceHyperemiaVasodilationBlood Glucose Self-MonitoringUnited StatesHyperlipidemiasIntraoperative ComplicationsDisease Models, AnimalC-PeptideReference ValuesUnited Arab EmiratesRegression AnalysisGlucose IntoleranceRats, Sprague-DawleySkinOxidative StressRegional Blood FlowFastingAtherosclerosisMetabolic Syndrome XDyslipidemiasCoronary Artery DiseaseLipidsScleroderma, SystemicBrachial ArteryComorbidityRats, Wistar
MellitusRetinopathyNephropathyPathogenesisEndothelial dysfunctionGlycemic controlProgression of diabeticKetoacidosisUKPDSNeuropathyInsulinEtiologyHypertensionCharacterized by hyperglycemiaProspective Diabetes Study GroupCerebralMorbidityT2DMPreventionDiseaseVascularMETHODSSerumCell in the pancreasClinicalUrinaryDiagnosticDiagnosisPlasma glucoseDestructionRiskRoleRESULTSGlucosePresentationSUBJECTSKidneyStudyControlBloodEffectsTreatmentCostsCare
Mellitus10
Retinopathy3
  • After nine years of follow up the group assigned to tight blood pressure control also had a 34% reduction in risk in the proportion of patients with deterioration of retinopathy by two steps (99% confidence interval 11% to 50%) (P=0.0004) and a 47% reduced risk (7% to 70%) (P=0.004) of deterioration in visual acuity by three lines of the early treatment of diabetic retinopathy study (ETDRS) chart. (ox.ac.uk)
  • CONCLUSION: Tight blood pressure control in patients with hypertension and type 2 diabetes achieves a clinically important reduction in the risk of deaths related to diabetes, complications related to diabetes, progression of diabetic retinopathy, and deterioration in visual acuity. (ox.ac.uk)
  • Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
Nephropathy5
  • Diabetic nephropathy (DN) is one of the most serious complications of DM. (biomedcentral.com)
  • Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
  • We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
  • CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
  • Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)
Pathogenesis3
  • Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)
  • Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
  • We reason that the cerebral arteriole plays a dominant role in the pathogenesis of each type of MVD. (bvsalud.org)
Endothelial dysfunction2
  • Postprandial OBJECTIVE - Diabetes is characterized by marked postprandial endothelial dysfunction induced by hyperglycemia, hypertriglyceridemia, advanced glycation end products (AGEs), and dicarbonyls (e.g., methylglyoxal [MG]). In vitro hyperglycemia-induced MG formation and endothelial dysfunction could be blocked by benfotiamine, but in vivo effects of benfotiamine on and occurs not only in patients with car- postprandial endothelial dysfunction and MG synthesis have not been investigated in humansuntil now. (health-abstracts.com)
  • These approaches aim atreducing postprandial oxidative stress CONCLUSIONS - Our study confirms micro- and macrovascular endothelial dysfunction (vitamins C and E, statins, and partly folic accompanied by increased oxidative stress following a real-life, heat-processed, AGE-rich meal in individuals with type 2 diabetes and suggests benfotiamine as a potential treatment. (health-abstracts.com)
Glycemic control5
  • Survey data (response rate 86.2%) and administrative databases were used to assess diabetes severity, glycemic control, quality of life, microvascular and macrovascular risks and complications, preventive care, utilization, and perceptions of diabetes. (healthpartners.com)
  • RESULTS: Compared to those aged 45-64 years (N = 627), those 65 and older (N = 482) had better glycemic control, better health-related behaviors, and perceived less adverse impacts of diabetes on their quality of life despite longer duration of diabetes and a prevalence of cardiovascular disease twice that of younger patients. (healthpartners.com)
  • A close relationship between poor glycemic control and increased platelet activity (estimated by measuring mean platelet volume-MPV-as part of whole blood count) in patients with type 2 DM has been suggested [ 4 ]. (hindawi.com)
  • [ 5 ] Benefits of tight glycemic control include not only continued reductions in the rates of microvascular complications but also significant differences in cardiovascular events and overall mortality. (medscape.com)
  • Long term diabetes and poor glycemic control are the most important risk factors for DN development ( DCCT Research Group, 1993 ). (scialert.net)
Progression of diabetic2
Ketoacidosis4
UKPDS4
  • Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. (ox.ac.uk)
  • The impact of diabetes-related complications on healthcare costs: results from the United Kingdom Prospective Diabetes Study (UKPDS Study No. 65). (ox.ac.uk)
  • AIMS: To develop a model for estimating the immediate and long-term healthcare costs associated with seven diabetes-related complications in patients with Type 2 diabetes participating in the UK Prospective Diabetes Study (UKPDS). (ox.ac.uk)
  • METHODS: The costs associated with some major complications were estimated using data on 5102 UKPDS patients (mean age 52.4 years at diagnosis). (ox.ac.uk)
Neuropathy4
  • Amyotrophy A type of diabetic neuropathy that causes muscle weakness and wasting. (wikipedia.org)
  • A type of neuropathy resulting in pain, weakness and/or wasting in the muscles. (diabetes.org)
  • In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)
  • Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)
Insulin7
  • For a person with diabetes, this can be caused by insufficient glucose absorption (e.g. from inadequate insulin) combined with metabolic ketosis. (wikipedia.org)
  • Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
  • Optimal diabetic control requires frequent self-monitoring of blood glucose levels, which allows rational adjustments in insulin doses. (medscape.com)
  • All patients with type 1 diabetes should learn how to self-monitor and record their blood glucose levels with home analyzers and adjust their insulin doses accordingly. (medscape.com)
  • Patients with type 1 diabetes require lifelong insulin therapy. (medscape.com)
  • Most require 2 or more injections of insulin daily, with doses adjusted on the basis of self-monitoring of blood glucose levels. (medscape.com)
  • People develop type 1 diabetes when their bodies make antibodies that destroy the body's own insulin-making beta cells. (diabetes.org)
Etiology1
  • Here we briefly reviewed the characteristic and etiology of these complications emphasizing on cerebrospinal fluid. (scialert.net)
Hypertension1
  • Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM [ 3 ], and the concomitant presence of multiple "classical" cardiovascular risk factors (arterial hypertension, cigarette smoking, and hyperlipidemia) in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
Characterized by hyperglycemia1
Prospective Diabetes Study Group1
  • UK Prospective Diabetes Study Group. (ox.ac.uk)
Cerebral1
  • Cerebral microvascular disease (MVD) is an important cause of vascular cognitive impairment. (bvsalud.org)
Morbidity1
  • Cardiovascular (CV) diseases are the leading cause of morbidity and mortality in diabetic patients. (hindawi.com)
T2DM2
  • A large clinical study found that peripheral vascular disease (PAD) in patients with T2DM is a serious complication. (biomedcentral.com)
  • A large clinical study found that the prevalence of PAD in patients with T2DM was 23.5% [ 2 ], and diabetic patients with combined PAD are more likely to develop ulceration and gangrene of the limb, significantly increasing the risk of amputation. (biomedcentral.com)
Prevention3
  • The role of chronic administration of antiplatelet drugs in primary prevention of arterial vascular events is known to be less clear than in secondary prevention, and, also in diabetic patients, the decision to give primary prophylaxis should be taken on an individual-patient basis, after a careful evaluation of the balance between the expected benefits and the risk of major bleedings. (hindawi.com)
  • This paper reviews the role of currently available antiplatelet drugs in primary and secondary prevention of vascular events in diabetic patients and the limitations of these drugs, and it discusses the role of novel and more potent antiplatelets and of new agents currently under clinical development. (hindawi.com)
  • Large clinical trials have shown that antiplatelet agents are effective in the prevention of recurrent cardiovascular events in diabetes. (hindawi.com)
Disease4
Vascular2
  • Although, currently, treatment has proven useful in reducing vascular events, diabetic patients continue to have a higher risk of adverse cardiovascular events compared with those in nondiabetic patients. (hindawi.com)
  • The most pronounced deterioration of diurnal arterial stiffness indicators in the group of comorbid patients with EAH and SН, as well as the excess of vascular age over chronological and reliable correlation with the comorbidity index, revealed during the study, suggests an assessment of these indicators in patients with cardioendocrine pathology to assess the true risk cardiovascular complications and the selection of adequate therapy. (orscience.ru)
METHODS1
  • METHODS: IVCCM, nerve conduction velocity (NCV), and serum, urine, and tear samplings were done to 42 diabetic patients. (e-dmj.org)
Serum1
  • We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. (e-dmj.org)
Cell in the pancreas2
Clinical6
  • MAIN OUTCOME MEASURES: Predefined clinical end points, fatal and non-fatal, related to diabetes, deaths related to diabetes, and all cause mortality. (ox.ac.uk)
  • The role of novel and more potent antiplatelet strategies, currently under clinical development, seems attractive in diabetic patients. (hindawi.com)
  • Angle α, k-value and fibrinogen have clinical significance on the risk of occurrence and development of diabetic foot, which can contribute to early diagnosis and early clinical intervention in DF. (biomedcentral.com)
  • The International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) code for type 1 diabetes without complications is E10.9. (medscape.com)
  • Updated clinical guidelines "Standards of specialized diabetes care", 9th Edition. (orscience.ru)
  • The recommendations can be accessed at American Diabetes Association DiabetesPro Professional Resources Online, Clinical Practice Recommendations - 2015. (medscape.com)
Urinary1
  • 60 mL/min/1.73 m 2 for 3 months or more) or albuminuria (urinary albumin-to-creatinine ratio ≥ 30 mg/g) in the setting of DM [ 2 ], is one of the most serious complications of DM. (biomedcentral.com)
Diagnostic1
  • CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)
Diagnosis2
  • Study subjects were a random sample of 1109 adults age 45 and over with an established diagnosis of diabetes using a diabetes identification method with estimated sensitivity 0.91 and positive predictive value 0.94. (healthpartners.com)
  • The International Working Group on the Diabetic Foot has developed guidelines for the diagnosis of the diabetic foot. (biomedcentral.com)
Plasma glucose1
  • Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
Destruction2
  • It is an inappropriate antibody reaction to normal proteins found on beta cells that are thought to be the main mechanism of beta cell destruction in Type 1 diabetes. (wikipedia.org)
  • Diabetic foot (DF) is a serious diabetic complication that refers to the destruction of the skin and deep tissues (including muscle and bone) distal to the ankle joint, often combined with arterial occlusion and infection of the lower extremity [ 1 ]. (biomedcentral.com)
Risk6
  • Precisely what causes it is not fully known, but diabetics have increased risk of both heart attack and stroke, so some of the tissue damage diabetes produces may be involved. (wikipedia.org)
  • However, although the currently available treatments have proven to be useful in reducing ischemic events, diabetic patients continue to have a higher risk of adverse events compared with those in non-diabetic patients. (hindawi.com)
  • However, most of the relevant studies have focused on the analysis of risk factors associated with the diabetic foot and comprehensive management. (biomedcentral.com)
  • There is a lack of uniform quantitative standards for biomarkers that predict the risk of diabetic foot occurrence and progression. (biomedcentral.com)
  • Screening for type 1 diabetes in asymptomatic low-risk individuals is not recommended. (medscape.com)
  • [ 2 ] However, in patients at high risk (eg, those who have first-degree relatives with type 1 diabetes), it may be appropriate to perform annual screening for anti-islet antibodies before the age of 10 years, along with 1 additional screening during adolescence. (medscape.com)
Role2
RESULTS2
  • CONCLUSIONS: These results provide estimates of the immediate and long-term healthcare costs associated with seven diabetes-related complications. (ox.ac.uk)
  • A condition of the shoulder associated with diabetes that results in pain and loss of the ability to move the shoulder. (diabetes.org)
Glucose2
  • Anti-diabetic drug A kind of medication that helps a person with diabetes control the level of glucose (sugar) in the blood so that the body works as it should. (wikipedia.org)
  • A fingerstick glucose test is appropriate for virtually all patients with diabetes. (medscape.com)
Presentation1
SUBJECTS1
  • Platelets from subjects with DM, particularly from those with type 2 diabetes, exhibit increased reactivity. (hindawi.com)
Kidney1
  • Adapted from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (diabetes.org)
Study2
  • In this study, we hypothesized that adults age 65 and over receive lower quality diabetes care than adults age 45-64 years old. (healthpartners.com)
  • An international expert committee appointed by the ADA, the European Association for the Study of Diabetes (EASD), and the International Diabetes Association recommended the HbA 1c assay for diagnosing type 1 diabetes only when the condition is suspected but the classic symptoms are absent. (medscape.com)
Control1
  • OBJECTIVE: To determine whether tight control of blood pressure prevents macrovascular and microvascular complications in patients with type 2 diabetes. (ox.ac.uk)
Blood1
Effects3
  • This paper highlights the underlying pharmacological mechanisms of the anti-diabetic effects of ginsenosides. (frontiersin.org)
  • Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. (e-dmj.org)
  • and because of their known susceptibility the fasting state (7:00 A.M.) and 2, 4, and exert different pathological effects (21) in- for cardiovascular complications (30). (health-abstracts.com)
Treatment1
  • Rg1, Rg3, Rb1, and compound K demonstrated the most promising therapeutic prospects as potential adjuvant medicines for the treatment of diabetes. (frontiersin.org)
Costs1
  • Non-in-patient costs for macrovascular complications were pound 315 ( pound 247, pound 394) and for microvascular complications were pound 273 ( pound 215, pound 343) in the year of the event. (ox.ac.uk)
Care4
  • BACKGROUND: The quality of diabetes care provided to older adults has usually been judged to be poor, but few data provide direct comparison to other age groups. (healthpartners.com)
  • Younger adults often had explanatory models of diabetes that interfere with effective and aggressive care, and accessed care less frequently. (healthpartners.com)
  • CONCLUSION: These data demonstrate the need for further improvement in diabetes care for all patients, and suggest that customisation of care based on age and explanatory models of diabetes may be an improvement strategy that merits further evaluation. (healthpartners.com)
  • The American Diabetes Association has released condensed recommendations for Standards of Medical Care in Diabetes: Abridged for Primary Care Providers, highlighting recommendations most relevant to primary care. (medscape.com)