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  • protein
  • IL12-F8-F8 can be produced in mammalian cells, yielding a product of good pharmaceutical quality, capable of selective localization on the tumor neovasculature in vivo , as judged by quantitative biodistribution analysis with radioiodinated protein preparations. (aacrjournals.org)
  • Several ocular proteins, such as retinal soluble antigen (S-Ag), 5 interphotoreceptor retinoid binding protein (IRBP), 6 and uveal melanin associated proteins, 7 are autoantigens inside the eye. (bmj.com)
  • HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene. (wikipedia.org)
  • These changes transform the MUC1 protein into a highly immunogenic tumor associated antigen (TAA) and make it an attractive target for cancer immunotherapy. (businesswire.com)
  • inflammation
  • There is a growing understanding of the molecular drivers of inflammation and an appreciation that the resolution of inflammation is an active process rather than a passive return to homeostasis, and this has implications for our understanding of the role of macrophages in inflammation. (frontiersin.org)
  • 4 DTaP replaced an older, very reactive whole cell pertussis vaccine - DPT - that was associated with more cases of high fever, collapse/shock, convulsions, brain inflammation and permanent brain damage. (mercola.com)
  • However, IL12 possesses a unique potential for immunocytokine development because of its ability to mediate a potent CD4 + T-cell response and because of its benign effect at sites of inflammation, making IL12-based immunocytokines particularly suited for the treatment of polymorbid patients. (aacrjournals.org)
  • Adaptive
  • These regulatory mechanisms in both adaptive and innate immune cells are known as immunometabolic regulations. (frontiersin.org)
  • however, we are beginning to appreciate the complexity of immunometabolic regulations and the delicate co-regulation between innate and adaptive immune cells. (frontiersin.org)
  • For this Research Topic, we would like to cover immunometabolic regulations in both innate and adaptive immune cells and how these regulatory mechanisms can be exploited in immune response-related diseases and interventions. (frontiersin.org)
  • DCs are initiators of adaptive immunity and unlike macrophages also able to prime naïve T cells. (i-med.ac.at)
  • soluble
  • Tumor types with a high mutational load, such as melanoma and non-small cell lung cancer, can be infiltrated by naturally primed cytotoxic T cells that, unfortunately, tend to be subsequently suppressed by soluble- and contact-dependent factors in the tumor microenvironment. (pubmedcentralcanada.ca)
  • immune system
  • Female hormones have strong influence on the production and functioning of immune system cells and molecules. (hindawi.com)
  • However, like most cells, Schwann cells express major histocompatibility complex class I (MHC I), which occupy the most gene-dense region of the mammalian genome and play an important role in the immune system and autoimmunity. (plos.org)
  • phenotype
  • Here we will briefly review our current understanding of macrophages and macrophage polarization in RA as well as the elements implicated in controlling polarization, such as cytokines and transcription factors like NFκB, IRFs and NR4A, and pro-resolving factors, such as LXA4 and other lipid mediators which may promote a non-inflammatory, pro-resolving phenotype, and may represent a novel therapeutic paradigm. (frontiersin.org)
  • responses
  • Clinical studies have demonstrated the potency of checkpoint inhibitors to unleash endogenous T cell responses against a variety of tumor types [ 1 , 2 ]. (pubmedcentralcanada.ca)
  • These Th cells are further divided into subtypes, that is, the Th1 subset producing interferon (IFN) gamma that promotes cellular immune responses, the Th2 subset producing mainly interleukin-4 (IL-4), IL-13, and IL-5 to aid humoral immune responses, and the Th17 subset producing IL-17, which plays a crucial role in autoimmunity and allergen-specific immune responses. (hindawi.com)
  • However, there are differences in the immune responses evoked by distinct helminths, mainly with regard to leukocyte involvement and the roles of these cells [ 3 ]. (hindawi.com)
  • Thus, the interplay between immune cells and metabolic homeostasis in circulation and periphery lead to effective and detrimental immune responses. (frontiersin.org)
  • The macrophage, one of the first cells infected with HIV-1, plays a key role in determining future immune responses ( 76 ). (asm.org)
  • Antigen-specific immune responses, however, were found to be diminished when HIV-1-infected macrophage hybridomas were used as antigen-presenting cells ( 52 , 68 ). (asm.org)
  • Due to their key roles in immune responses and their involvement in tumor pathogenesis, there is a strong interest in the identification of new factors contributing to the recruitment of macrophages and DCs. (rupress.org)
  • mediate
  • Upon reactivation with checkpoint inhibitors, these effector T cells can mediate regression that, in many cases, has a proven, durable effect. (pubmedcentralcanada.ca)
  • Synovial macrophages are positioned throughout the sub-lining layer and lining layer at the cartilage-pannus junction and mediate articular destruction. (frontiersin.org)
  • Biol
  • Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). (slicksurface.com)
  • spleen
  • Filters aged erythrocytes, platelets and blood-borne antigens.The spleen is the largest lymphatic mass in the body and lies intraperitoneally in the left upper quadrant. (brightkite.com)
  • Macrophagic
  • As a result of these fusions, we generated a series of 11 monocytic and 15 macrophagic cell lines that exhibited normal monocyte and macrophage function and, importantly, could be uniformly infected with HIV-1. (asm.org)
  • accessory cell
  • Multiple defects in accessory cell functions have been previously described for HIV-positive patients ( 3 , 4 , 51 , 54 , 60 , 61 , 66 ). (asm.org)
  • Immunology
  • 2 Correspondence: Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. (pubmedcentralcanada.ca)
  • therapeutic
  • Therapeutic vaccination against cancer will have to rely on efficient Ag loading and activation of DCs to prime powerful antitumor T cell immunity, even in the face of the various immune-suppressive barriers put up by the tumor. (pubmedcentralcanada.ca)
  • mammalian cells
  • for mammalian cells, typical internal concentrations include 140 mM K+, 5-15 mM Na+, 5-15 mM Cl-, and a pH of 7.2, which can be significantly different from their concentrations outside the cell. (thefreedictionary.com)
  • illustration Individual mammalian cells are usually microscopic, typically ranging from 5 µm to 50 µm in diameter. (thefreedictionary.com)
  • major histoco
  • Major histocompatibility complex I (MHC I) molecules were present in significantly increased levels in the DRG and Schwann cell allograft groups compared to the hollow NG conduit and the Sham healthy nerve. (plos.org)
  • populations
  • It has been shown that tremendous functional, morphological, and metabolic diversity exists among these cell populations. (rupress.org)
  • attract
  • Many tumor types have been demonstrated to attract macrophages and DCs through the direct or indirect production of chemoattractant factors ( 4 , 5 ). (rupress.org)
  • specific
  • Exogenous IL-2 restored the capacity of the T cells to be stimulated in response to mitogens but not to specific antigen ( 88 ). (asm.org)